未登录Enabling the First Scale-Up of the Selective HER2 Inhibitor BI-4142实现选择性HER2抑制剂BI-4142的首个规模化生产
Chong, Eugene; Li, Ruoshi; Dong, Weitong; Chevliakov, Maxim; Tampone, Thomas G.; Zhang, Yongda; Qu, Bo; Haddad, Nizar; Lorenz, Jon C.; Sarvestani, Max; Omar, Thuraya; Li, Huayu; Gao, Joe J.; Gao, Donghong A.; Pennino, Scott; Wu, Ling; Spinelli, Earl; Yao, Steven; Lee, Heewon; Buono, Frederic; Song, Jinhua J.; Wilding, Birgit .png)
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收藏分享 收藏 Site-specific template generative approach for retrosynthetic planning用于逆向综合计划的特定于站点的模板生成方法Shee, Yu; Li, Haote; Zhang, Pengpeng; Nikolic, Andrea M.; Lu, Wenxin; Kelly, H. Ray; Manee, Vidhyadhar; Sreekumar, Sanil; Buono, Frederic G.; Song, Jinhua J.; Newhouse, Timothy R.; Batista, Victor S. 分享 收藏 Development of a Scalable Asymmetric Process for the Synthesis of Selective PDE4B Inhibitor Nerandomilast (BI 1015550)Frutos, Rogelio P.; Tampone, Thomas G.; Gerstmann, Frank; Weber, Dirk; Brodmann, Tobias; Hagenko''tter, Robert; Abella, Jocelyn; Yang, Bing-Shiou; Mulder, Jason; Rodriguez, Sonia; Lee, Heewon; Gao, Joe; Song, Jinhua J. 分享 收藏 Development of a Scalable Synthesis toward a KRAS G12C Inhibitor Building Block Bearing an All-Carbon Quaternary Stereocenter, Part 2: Asymmetric Synthesis via Shi EpoxidationTan, Zhulin; Ju, Xuan; Wu, Hao; Dong, Weitong; Leung, Joyce C.; Hou, Xiaowen; Lee, Heewon; Granger, Alice; Paolillo, Joshua M.; Dimeo, Susan V.; Chen, Chengsheng; Wu, Linglin; Lorenz, Jon C.; Sarvestani, Max; Buono, Frederic; Frutos, Rogelio; Tampone, Thomas G.; Huang, Xiaojun; Zhang, Gulin; Wang, Yuwen; Spinelli, Earl; Lei, Zhen; Song, Jinhua J. 分享 收藏 Development of a Scalable Synthesis toward a KRAS G12C Inhibitor Building Block Bearing an All-Carbon Quaternary Stereocenter, Part 1: From Discovery Route to Kilogram-Scale Production开发具有全碳四元立体中心的KRAS G12C抑制剂构建块的可扩展合成，第1部分: 从发现途径到千克规模的生产Leung, Joyce C.; Xu, Yibo; Radomkit, Suttipol; Lee, Jaehee; Kim, Wan Shin; Reeves, Jonathan T.; Dong, Weitong; Jang, Hwanjong; Hou, Xiaowen; Lorenz, Jon C.; Shao, Xiaole; Byrne, Denis; Johnson, Joe; Brundage, Anthony; Valentin, Clement; Beyer, Phouvieng; Dimeo, Susan V.; Qu, Bo; Li, Ruoshi; Sarvestani, Max; Song, Jinhua J. 分享 收藏 Building a Quaternary Stereogenic Center on Dihydroazaindole Carboxylic Acid through Scalable Process DevelopmentLee, Jaehee; Li, Guisheng; Zeng, Xingzhong; Haddad, Nizar; Abeyta, Vincent; Pennino, Scott; Wu, Lifen; Gao, Joe; Jiang, Qi; Lorenz, Jon C.; Wang, Jun; Wu, Jiang-Ping; Brazzillo, Jason; Sarvestani, Max; Wang, Xiao-Jun; El-Awa, Ahmad; Leung, Joyce C.; Qu, Bo; Tan, Zhulin; Song, Jinhua J. 分享 收藏 Feed-Forward Neural Network for Predicting Enantioselectivity of the Asymmetric Negishi ReactionCuomo, Abbigayle E.; Ibarraran, Sebastian; Sreekumar, Sanil; Li, Haote; Eun, Jungmin; Menzel, Jan Paul; Zhang, Pengpeng; Buono, Frederic; Song, Jinhua J.; Crabtree, Robert H.; Batista, Victor S.; Newhouse, Timothy R. 分享 收藏 Development of a Scalable Asymmetric Process for the Synthesis of GLYT1 Inhibitor BI 425809 (Iclepertin)Frutos, Rogelio; Tampone, Thomas G.; Mulder, Jason; Gao, Joe; Sieber, Joshua D.; Rodriguez, Sonia; Haddad, Nizar; Baer, Katrin; Brown, Jack; Yang, Bing-Shiou; Giovannini, Riccardo; Song, Jinhua J.; Grinberg, Nelu; Lee, Heewon; Senanayake, Chris H. 分享 收藏 Process Development of the BACE Inhibitors BI 1147560 BS and BI 1181181 MZLi, Guisheng; Tan, Zhulin; Xu, Yibo; Sidhu, Kanwar P. S.; Qu, Bo; Herbage, Melissa A.; Eriksson, Magnus C.; Zeng, Xingzhong; Busacca, Carl A.; Desrosiers, Jean-Nicolas; Hampel, Thomas; Niemeier, Oliver; Reichel, Carsten; Dang, Mai Thi Quynh; Schoerer, Marvin; Kemmer, Dirk; Eick, Melanie; Werle, Holger; Kim, Soojin; Li, Zhibin; Venkatraman, Shankar; Jia, Lanqi; Claremon, David A.; Fuchs, Klaus; Heine, Niklas; Byrne, Denis; Narayanan, Bikshandarkoil; Sarvestani, Max; Johnson, Joe; Premasiri, Ajith; Nummy, Larry J.; Lorenz, Jon C.; Haddad, Nizar; Gonnella, Nina C.; Pennino, Scott; Krawiec, Mariusz; Senanayake, Chris H.; Buono, Frederic; Lee, Heewon; Hossain, Azad; Song, Jinhua J.; Reeves, Jonathan T. 分享 收藏 Scalable Process of Spiro(cyclopropane)oxazepane Pyridine Carboxylic Acid through Kulinkovich, Mitsunobu, and Pd-Catalyzed Intramolecular C-N CouplingQu, Bo; Lee, Jaehee; Wu, Lifen; Saha, Anjan K.; Li, Guisheng; Xu, Yibo; Tan, Zhulin; Brazzillo, Jason; Haddad, Nizar; Pennino, Scott; Rodriguez, Sonia; Lorenz, Jon C.; Frutos, Rogelio; Sidhu, Kanwar P. S.; Wang, Xiao-Jun; Zhang, Yongda; Senanayake, Chris H.; Song, Jinhua J. 分享 收藏 Large-Scale Enantioselective Reduction of 2,3-Disubstituted Indenopyridine Enables a Practical Manufacturing Process for an 11β-HSD-1 InhibitorQu, Bo; Wei, Xudong; Zeng, Xingzhong; Yang, Bing-Shiou; Desrosiers, Jean-Nicolas; Savoie, Jolaine; Wang, Jun; Marsini, Maurice A.; Li, Zhibin; Haddad, Nizar; Lorenz, Jon C.; Tielmann, Patrick; Maier, Nora; Song, Jinhua J.; Senanayake, Chris H. 分享 收藏 Atom-Economical Cross-Coupling of Internal and Terminal Alkynes to Access 1,3-EnynesLiu, Mingyu; Tang, Tianhua; Apolinar, Omar; Matsuura, Rei; Busacca, Carl A.; Qu, Bo; Fandrick, Daniel R.; Zatolochnaya, Olga, V; Senanayake, Chris H.; Song, Jinhua J.; Engle, Keary M. 分享 收藏 Large Scale Practical Synthesis of Enantiomerically Pure cis-4-Amino-3-fluoro-1-methylpiperidine via Rhodium-Catalyzed Asymmetric Hydrogenation of a Tetrasubstituted Fluoroalkene通过铑催化的四取代氟代烯烃的不对称氢化大规模实际合成对映体纯cis-4-Amino-3-fluoro-1-methylpiperidineQu, Bo; Saha, Anjan; Li, Guisheng; Zeng, Xingzhong; Wang, Xiaojun; Haddad, Nizar; Hou, Xiaowen; Lorenz, Jon C.; Wu, Lifen; Pennino, Scott; Lee, Heewon; Song, Jinhua J.; Senanayake, Chris H. 分享 收藏 分享 收藏 Application of a Preformed Pd-BIDIME Precatalyst to Suzuki-Miyaura Cross-Coupling Reaction in FlowSieber, Joshua D.; Buono, Frederic; Brusoe, Andrew; Desrosiers, Jean-Nicolas; Haddad, Nizar; Lorenz, Jon C.; Xu, Yibo; Wu, Hao; Zhang, Li; Han, Zhengxu Steve; Roschangar, Frank; Song, Jinhua J.; Yee, Nathan K.; Senanayake, Chris H. 分享 收藏 Development of a Large-Scale Asymmetric Process for tert-ButanesulfinamideDeCroos, Philomen; Han, Zhengxu S.; Sidhu, Kanwar; Lorenz, Jon; Nummy, Larry; Byrne, Denis; Qu, Bo; Xu, Yibo; Wu, Ling; Lee, Heewon; Roschangar, Frank; Song, Jinhua J.; Senanayake, Chris H. 分享 收藏 Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki Miyaura and Negishi Cross-Coupling Reactions for Tetra-ortho-Substituted Biaryl Synthesis (vol 8, pg 10190, 2018)Patel, Nitinchandra D.; Sieber, Joshua D.; Tcyrulnikov, Sergei; Simmons, Bryan J.; Rivalti, Daniel; Duvvuri, Krishnaja; Zhang, Yongda; Gao, Donghong A.; Fandrick, Keith R.; Haddad, Nizar; Lao, Kendricks So; Mangunuru, Hari P. R.; Biswas, Soumik; Qu, Bo; Grinberg, Nelu; Pennino, Scott; Lee, Heewon; Song, Jinhua J.; Gupton, Frank; Garg, Neil K.; Kozlowski, Marisa C.; Senanayake, Chris H. 分享 收藏 A versatile catalyst system for enantioselective synthesis of 2-substituted 1,4-benzodioxanesChong, Eugene; Qu, Bo; Zhang, Yongda; Cannone, Zachary P.; Leung, Joyce C.; Tcyrulnikov, Sergei; Nguyen, Khoa D.; Haddad, Nizar; Biswas, Soumik; Hou, Xiaowen; Kaczanowska, Katarzyna; Chwalba, Michal; Tracz, Andrzej; Czarnocki, Stefan; Song, Jinhua J.; Kozlowski, Marisa C.; Senanayake, Chris H. 分享 收藏 Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki-Miyaura and Negishi Cross-Coupling Reactions for Tetra-ortho-Substituted Biaryl Synthesis用于四邻位取代的联芳基合成的Pd催化不对称suzuki-miyaura和Negishi交叉偶联反应的计算辅助机理研究和发展Patel, Nitinchandra D.; Sieber, Joshua D.; Tcyrulnikov, Sergei; Simmons, Bryan J.; Rivalti, Daniel; Duvvuri, Krishnaja; Zhang, Yongda; Gao, Donghong A.; Fandrick, Keith R.; Haddad, Nizar; Lao, Kendricks So; Mangunuru, Hari P. R.; Biswas, Soumik; Qu, Bo; Grinberg, Nelu; Pennino, Scott; Lee, Heewon; Song, Jinhua J.; Gupton, B. Frank; Garg, Neil K.; Kozlowski, Marisa C.; Senanayake, Chris H. 分享 收藏 
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