Alan R. Fersht - Publications, H-index & Citations

Alan R. Fersht

MRC Laboratory Molecular Biology

94H指数

345论文数

2.8W被引数

收录论文 76

发表时间

Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm

ACS CHEMICAL BIOLOGY

IF3.8

2020-01-28

OAAI

Bauer, Matthias R.; Kraemer, Andreas; Settanni, Giovanni; Jones, Rhiannon N.; Ni, Xiaomin; Tareque, Raysa Khan; Fersht, Alan R.; Spencer, John; Joerger, Andreas C.

A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C

FUTURE MEDICINAL CHEMISTRY

IF3.4

2019-10-21

OAAI

Bauer, Matthias R.; Jones, Rhiannon N.; Tareque, Raysa K.; Springett, Bradley; Dingler, Felix A.; Verduci, Lorena; Patel, Ketan J.; Fersht, Alan R.; Joerger, Andreas C.; Spencer, John

Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2018-05-01

OAAI

Baud, Matthias G. J.; Bauer, Matthias R.; Verduci, Lorena; Dingier, Felix A.; Patel, Ketan J.; Roy, Deeptee Horil; Joerger, Andreas C.; Fersht, Alan R.

The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2018-03-01

OAAI

Madan, Esha; Parker, Taylor M.; Bauer, Matthias R.; Dhiman, Alisha; Pelham, Christopher J.; Nagane, Masaki; Kuppusamy, M. Lakshmi; Holmes, Matti; Holmes, Thomas R.; Shaik, Kranti; Shee, Kevin; Kiparoidze, Salome; Smith, Sean D.; Park, Yu-Soon A.; Gomm, Jennifer J.; Jones, Louise J.; Tomas, Ana R.; Cunha, Ana C.; Selvendiran, Karuppaiyah; Hansen, Laura A.; Fersht, Alan R.; Hideg, Kalman; Gogna, Rajan; Kuppusamy, Periannan

Mutant p53 as a therapeutic target for the treatment of triple-negative breast cancer: Preclinical investigation with the anti-p53 drug, PK11007

CANCER LETTERS

IF10.1

2018-02-01

PREAI

Synnott, Naoise C.; Bauer, Matthias R.; Madden, Stephen; Murray, Alyson; Klinger, Rut; O'Donovan, Norma; O'Connor, Darran; Gallagher, William M.; Crown, John; Fersht, Alan R.; Duffy, Michael J.

Structures of closed and open conformations of dimeric human ATM

SCIENCE ADVANCES

IF12.5

2017-05-05

OAAI

Baretic, Domagoj; Pollard, Hannah K.; Fisher, David I.; Johnson, Christopher M.; Santhanam, Balaji; Truman, Caroline M.; Kouba, Tomas; Fersht, Alan R.; Phillips, Christopher; Williams, Roger L.

2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2016-08-22

102

OAAI

Bauer, Matthias R.; Joerger, Andreas C.; Fersht, Alan R.

Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs

ACS CHEMICAL BIOLOGY

IF3.8

2016-06-21

OAAI

Bauer, Matthias R.; Jones, Rhiannon N.; Baud, Matthias G. J.; Wilcken, Rainer; Boeckler, Frank M.; Fersht, Alan R.; Joerger, Andreas C.; Spencer, John

Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere

ACS CHEMICAL BIOLOGY

IF3.8

2015-10-01

OAAI

Wilcken, Rainer; Zimmermann, Markus O.; Bauer, Matthias R.; Rutherford, Trevor J.; Fersht, Alan R.; Joerger, Andreas C.; Boeckler, Frank M.

MDMX contains an autoinhibitory sequence element

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2013-10-14

OAAI

Bista, Michal; Petrovich, Miriana; Fersht, Alan R.

Small molecule induced reactivation of mutant p53 in cancer cells 小分子诱导肿瘤细胞中突变型p53的再活化

NUCLEIC ACIDS RESEARCH

IF13.1

2013-04-27

220

OAAI

Liu, Xiangrui; Wilcken, Rainer; Joerger, Andreas C.; Chuckowree, Irina S.; Amin, Jahangir; Spencer, John; Fersht, Alan R.

Don't waste good methods on bad buffers and ambiguous data

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2013-01-17

OAAI

Huang, Fang; Johnson, Christopher M.; Petrovich, Miriana; Fersht, Alan R.

Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2 石胆酸是MDM4和MDM2的内源性抑制剂

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2012-10-03

OAAI

Vogel, Simon M.; Bauer, Matthias R.; Joerger, Andreas C.; Wilcken, Rainer; Brandt, Tobias; Veprintsev, Dmitry B.; Rutherford, Trevor J.; Fersht, Alan R.; Boeckler, Frank M.

Sequence-dependent sliding kinetics of p53

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2012-09-25

OAAI

Leith, Jason S.; Tafvizi, Anahita; Huang, Fang; Uspal, William E.; Doyle, Patrick S.; Fersht, Alan R.; Mirny, Leonid A.; van Oijen, Antoine M.

Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy 通过甲基NMR光谱探测全长p53和特定DNA复合物中的域-域相互作用

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2012-09-12

OAAI

Bista, Michal; Freund, Stefan M.; Fersht, Alan R.

Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2012-08-06

105

OAAI

Wilcken, Rainer; Wang, GuoZhen; Boeckler, Frank M.; Fersht, Alan R.

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2012-04-05

218

OAAI

Wilcken, Rainer; Liu, Xiangrui; Zimmermann, Markus O.; Rutherford, Trevor J.; Fersht, Alan R.; Joerger, Andreas C.; Boeckler, Frank M.

Electrocatalytic Monitoring of Metal Binding and Mutation-Induced Conformational Changes in p53 at Picomole Level

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2011-04-14

PREAI

Palecek, Emil; Ostatna, Veronika; Cernocka, Hana; Joerger, Andreas C.; Fersht, Alan R.

Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2010-12-22

OAAI

Melero, Roberto; Rajagopalan, Sridharan; Lazaro, Melisa; Joerger, Andreas C.; Brandt, Tobias; Veprintsev, Dmitry B.; Lasso, Gorka; Gil, David; Scheres, Sjors H. W.; Maria Carazo, Jose; Fersht, Alan R.; Valle, Mikel

Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53

NUCLEIC ACIDS RESEARCH

IF13.1

2010-11-18

OAAI

Rajagopalan, Sridharan; Huang, Fang; Fersht, Alan R.

研究方向