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The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling Schmidt, Andree; Hrupka, Brian; van Bebber, Frauke; Kumar, Sanjay Sunil; Feng, Xiao; Tschirner, Sarah K.; Assfalg, Marlene; Mueller, Stephan A.; Hilger, Laura Sophie; Hofmann, Laura I.; Pigoni, Martina; Jocher, Georg; Voytyuk, Iryna; Self, Emily L.; Ito, Mana; Hyakkoku, Kana; Yoshimura, Akimasa; Horiguchi, Naotaka; Feederle, Regina; De Strooper, Bart; Schulte-Merker, Stefan; Lammert, Eckhard; Moechars, Dieder; Schmid, Bettina; Lichtenthaler, Stefan F. 分享 收藏
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Passive immunotherapy with a novel antibody against 3pE-modified A? demonstrates potential for enhanced efficacy and favorable safety in combination with BACE inhibitor treatment in plaque-depositing mice Janssens, Jonathan; Hermans, Bart; Vandermeeren, Marc; Barale-Thomas, Erio; Borgers, Marianne; Willems, Roland; Meulders, Greet; Wintmolders, Cindy; Van den Bulck, Dries; Bottelbergs, Astrid; Ver Donck, Luc; Larsen, Peter; Moechars, Dieder; Edwards, Wilson; Mercken, Marc; Van Broeck, Bianca 分享 收藏
Absence of Uptake and Prion-Like Spreading of Alpha-Synuclein and Tau After Intravitreal Injection of Preformed Fibrils Veys, Lien; Van Houcke, Jessie; Aerts, Jeroen; Van Pottelberge, Sophie; Mahieu, Michel; Coens, Audrey; Melki, Ronald; Moechars, Dieder; De Muynck, Louis; De Groef, Lies 分享 收藏
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Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads Oehlrich, Daniel; Peschiulli, Aldo; Tresadern, Gary; Van Gool, Michiel; Antonio Vega, Juan; Isabel De Lucas, Ana; Alonso de Diego, Sergio A.; Prokopcova, Hana; Austin, Nigel; Van Brandt, Sven; Surkyn, Michel; De Cleyn, Michel; Vos, Ann; Rombouts, Frederik J. R.; Macdonald, Gregor; Moechars, Dieder; Gijsen, Harrie J. M.; Trabanco, Andres A. 分享 收藏
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Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer's Disease Rombouts, Frederik J. R.; Andres, Jose-Ignacio; Ariza, Manuela; Manuel Alonso, Jose; Austin, Nigel; Bottelbergs, Astrid; Chen, Lu; Chupakhin, Vladimir; Cleiren, Erna; Fierens, Katleen; Fontana, Alberto; Langlois, Xavier; Leenaerts, Joseph E.; Marien, Jonas; Lamenca, Carolina Martinez; Salter, Rhys; Schmidt, Mark E.; Te Riele, Paula; Wintmolders, Cindy; Trabanco, Andres A.; Zhang, Wei; Macdonald, Gregor; Moechars, Dieder 分享 收藏
BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer's Disease Markers in Elderly Healthy Participants Timmers, Maarten; Barao, Soraia; Van Broeck, Bianca; Tesseur, Ina; Slemmon, John; De Waepenaert, Katja; Bogert, Jennifer; Shaw, Leslie M.; Engelborghs, Sebastiaan; Moechars, Dieder; Mercken, Marc; Van Nueten, Luc; Tritsmans, Luc; de Strooper, Bart; Streffer, Johannes Rolf 分享 收藏
Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models Malmanche, Nicolas; Dourlen, Pierre; Gistelinck, Marc; Demiautte, Florie; Link, Nichole; Dupont, Cloe; Broeck, Lies Vanden; Werkmeister, Elisabeth; Amouyel, Philippe; Bongiovanni, Antonino; Bauderlique, Helene; Moechars, Dieder; Royou, Anne; Bellen, Hugo J.; Lafont, Frank; Callaerts, Patrick; Lambert, Jean-Charles; Dermaut, Bart 分享 收藏
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1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads Rombouts, Frederik J. R.; Tresadern, Gary; Delgado, Oscar; Martinez-Lamenca, Carolina; Van Gool, Michiel; Garcia-Molina, Aranzazu; de Diego, Sergio A. Alonso; Oehlrich, Daniel; Prokopcova, Hana; Alonso, Jose Manuel; Austin, Nigel; Borghys, Herman; Van Brandt, Sven; Surkyn, Michel; De Cleyn, Michel; Vos, Ann; Alexander, Richard; Macdonald, Gregor; Moechars, Dieder; Gijsen, Harrie; Trabanco, Andres A. 分享 收藏
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Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology Chapuis, J.; Hansmannel, F.; Gistelinck, M.; Mounier, A.; Van Cauwenberghe, C.; Kolen, K. V.; Geller, F.; Sottejeau, Y.; Harold, D.; Dourlen, P.; Grenier-Boley, B.; Kamatani, Y.; Delepine, B.; Demiautte, F.; Zelenika, D.; Zommer, N.; Hamdane, M.; Bellenguez, C.; Dartigues, J-F; Hauw, J-J; Letronne, F.; Ayral, A-M; Sleegers, K.; Schellens, A.; Broeck, L. V.; Engelborghs, S.; De Deyn, P. P.; Vandenberghe, R.; O'Donovan, M.; Owen, M.; Epelbaum, J.; Mercken, M.; Karran, E.; Bantscheff, M.; Drewes, G.; Joberty, G.; Campion, D.; Octave, J-N; Berr, C.; Lathrop, M.; Callaerts, P.; Mann, D.; Williams, J.; Buee, L.; Dewachter, I.; Van Broeckhoven, C.; Amouyel, P.; Moechars, D.; Dermaut, B.; Lambert, J-C 分享 收藏
Inactivation of the Constitutively Active Ghrelin Receptor Attenuates Limbic Seizure Activity in Rodents 组成型活性Ghrelin受体的失活会减弱啮齿动物的边缘癫痫发作活性 Portelli, Jeanelle; Thielemans, Leen; Donck, Luc Ver; Loyens, Ellen; Coppens, Jessica; Aourz, Najat; Aerssens, Jeroen; Vermoesen, Katia; Clinckers, Ralph; Schallier, Anneleen; Michotte, Yvette; Moechars, Dieder; Collingridge, Graham L.; Bortolotto, Zuner A.; Smolders, Ilse 分享 收藏
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Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: A multi-electrode array study Chong, Seon-Ah; Benilova, Iryna; Shaban, Hamdy; De Strooper, Bart; Devijver, Herman; Moechars, Dieder; Eberle, Wolfgang; Bartic, Carmen; Van Leuven, Fred; Callewaert, Geert 分享 收藏
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