Thomas T. MacDonald - Publications, H-index & Citations

Thomas T. MacDonald

university of london

95H指数

593论文数

3.1W被引数

收录论文 128

发表时间

Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy Interleukin-22调节溃疡性结肠炎中性粒细胞募集并与乌司他单抗治疗耐药相关

NATURE COMMUNICATIONS

IF15.7

2022-10-03

OAAI

Pavlidis, Polychronis; Tsakmaki, Anastasia; Pantazi, Eirini; Li, Katherine; Cozzetto, Domenico; Digby-Bell, Jonathan; Yang, Feifei; Lo, Jonathan W.; Alberts, Elena; Sa, Ana Caroline Costa; Niazi, Umar; Friedman, Joshua; Long, Anna K.; Ding, Yuchun; Carey, Christopher D.; Lamb, Christopher; Saqi, Mansoor; Madgwick, Matthew; Gul, Leila; Treveil, Agatha; Korcsmaros, Tamas; Macdonald, Thomas T.; Lord, Graham M.; Bewick, Gavin; Powell, Nick

Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease 双特异性tnf α/IL-23中和域抗体作为炎症性肠病的新型口服疗法的临床前开发

SCIENTIFIC REPORTS

IF3.9

2021-09-30

OAAI

Roberts, Kevin J.; Cubitt, Marion F.; Carlton, Timothy M.; Rodrigues-Duarte, Lurdes; Maggiore, Luana; Chai, Ray; Clare, Simon; Harcourt, Katherine; MacDonald, Thomas T.; Ray, Keith P.; Vossenkamper, Anna; West, Michael R.; Crowe, J. Scott

Spatiotemporal regulation of galectin-1-induced T-cell death in lamina propria from Crohn's disease and ulcerative colitis patients

APOPTOSIS

IF8.1

2021-05-12

PREAI

Papa-Gobbi, Rodrigo; Muglia, Cecilia I.; Rocca, Andres; Curciarello, Renata; Sambuelli, Alicia M.; Yantorno, Martin; Correa, Gustavo; Morosi, Luciano G.; Di Sabatino, Antonio; Biancheri, Paolo; MacDonald, Thomas T.; Toscano, Marta A.; Marino, Karina V.; Rabinovich, Gabriel A.; Docena, Guillermo H.

Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies

inflammation research

IF4.1

2020-05-01

OAAI

Curciarello, Renata; Sobande, Toni; Jones, Samantha; Giuffrida, Paolo; Di Sabatino, Antonio; Docena, Guillermo H.; MacDonald, Thomas T.; Kok, Klaartje

Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2

COMMUNICATIONS BIOLOGY

IF5.1

2020-03-20

160

OAAI

Mares, Alina; Miah, Afjal H.; Smith, Ian E. D.; Rackham, Mark; Thawani, Aditya R.; Cryan, Jenni; Haile, Pamela A.; Votta, Bartholomew J.; Beal, Allison M.; Capriotti, Carol; Reilly, Michael A.; Fisher, Don T.; Zinn, Nico; Bantscheff, Marcus; MacDonald, Thomas T.; Vossenkamper, Anna; Dace, Phoebe; Churcher, Ian; Benowitz, Andrew B.; Watt, Gillian; Denyer, Jane; Scott-Stevens, Paul; Harling, John D.

Editorial: Intestinal Homeostasis and Disease: A Complex Partnership Between Immune Cells, Non-Immune Cells, and the Microbiome 编辑: 肠道稳态和疾病: 免疫细胞，非免疫细胞和微生物组之间的复杂伙伴关系

FRONTIERS IN IMMUNOLOGY

IF5.9

2019-12-13

OAAI

De la Fuente, Marjorie; MacDonald, Thomas Thornton; Hermoso, Marcela A.

Oral Anti-Tumour Necrosis Factor Domain Antibody V565 Provides High Intestinal Concentrations, and Reduces Markers of Inflammation in Ulcerative Colitis Patients

SCIENTIFIC REPORTS

IF3.9

2019-10-01

OAAI

Nurbhai, Suhail; Roberts, Kevin J.; Carlton, Timothy M.; Maggiore, Luana; Cubitt, Marion F.; Ray, Keith P.; Reckless, Jill; Mohammed, Hafeez; Irving, Peter; MacDonald, Thomas T.; Vossenkamper, Anna; West, Michael R.; Parkes, Gareth C.; Crowe, J. Scott

Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-07-02

OAAI

Haile, Pamela A.; Casillas, Linda N.; Votta, Bartholomew J.; Wang, Gren Z.; Charnley, Adam K.; Dong, Xiaoyang; Bury, Michael J.; Romano, Joseph J.; Mehlmann, John F.; King, Bryan W.; Erhard, Karl F.; Hanning, Charles R.; Lipshutz, David B.; Desai, Biva M.; Capriotti, Carol A.; Schaeffer, Michelle C.; Berger, Scott B.; Mahajan, Mukesh K.; Reilly, Michael A.; Nagilla, Rakesh; Rivera, Elizabeth J.; Sun, Helen H.; Kenna, John K.; Beal, Allison M.; Ouellette, Michael T.; Kelly, Mike; Stemp, Gillian; Convery, Maire A.; Vossenkamper, Anna; MacDonald, Thomas T.; Gough, Peter J.; Bertin, John; Marquis, Robert W.

IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2019-04-02

OAAI

Belarif, Lyssia; Danger, Richard; Kermarrec, Laetitia; Nerriere-Daguin, Veronique; Pengam, Sabrina; Durand, Tony; Mary, Caroline; Kerdreux, Elise; Gauttier, Vanessa; Kucik, Aneta; Thepenier, Virginie; Martin, Jerome C.; Chang, Christie; Rahman, Adeeb; Salabert-Le Guen, Nina; Braudeau, Cecile; Abidi, Ahmed; David, Gregoire; Malard, Florent; Takoudju, Celine; Martinet, Bernard; Gerard, Nathalie; Neveu, Isabelle; Neunlist, Michel; Coron, Emmanuel; MacDonald, Thomas T.; Desreumaux, Pierre; Mai, Hoa-Le; Le Bas-Bernardet, Stephanie; Mosnier, Jean-Francois; Merad, Miriam; Josien, Regis; Brouard, Sophie; Soulillou, Jean-Paul; Blancho, Gilles; Bourreille, Arnaud; Naveilhan, Philippe; Vanhove, Bernard; Poirier, Nicolas

Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation

CELL REPORTS

IF6.9

2019-04-01

OAAI

Sun, Dijue; Stopka-Farooqui, Urszula; Barry, Sayka; Aksoy, Ezra; Parsonage, Gregory; Vossenkamper, Anna; Capasso, Melania; Wan, Xinyu; Norris, Sherine; Marshall, Jennifer L.; Clear, Andrew; Gribben, John; MacDonald, Thomas T.; Buckley, Christopher D.; Korbonits, Marta; Haworth, Oliver

The Food Additive Maltodextrion promotes Endoplasmic Reticulum Stress-Driven Mucus Depletion and Exacerbates Intestinal Inflammation

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY

IF7.4

2019-01-01

OAAI

Laudisi, Federica; Di Fusco, Davide; Dinallo, Vincenzo; Stolfi, Carmine; Di Grazia, Antonio; Marafini, Irene; Colantoni, Alfredo; Ortenzi, Angela; Alteri, Claudia; Guerrieri, Francesca; Mavilio, Maria; Ceccherini-Silberstein, Francesca; Federici, Massimo; MacDonald, Thomas Thornton; Monteleone, Ivan; Monteleone, Giovanni

Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease

SCIENTIFIC REPORTS

IF3.9

2018-03-21

OAAI

Crowe, J. Scott; Roberts, Kevin J.; Carlton, Timothy M.; Maggiore, Luana; Cubitt, Marion F.; Clare, Simon; Harcourt, Katherine; Reckless, Jill; MacDonald, Thomas T.; Ray, Keith P.; Vossenkamper, Anna; West, Michael R.

A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis

SCIENTIFIC REPORTS

IF3.9

2017-08-31

OAAI

Diaz-Jimenez, David; Nunez, Lucia; De la Fuente, Marjorie; Dubois-Camacho, Karen; Sepulveda, Hugo; Montecino, Martin; Torres-Riquelme, Alejandro; Garcia-Gonzalez, Paulina; Chnaiderman, Jonas; Vossenkamper, Anna; MacDonald, Thomas T.; Simian, Daniela; Gonzalez, Maria-Julieta; Cidlowski, John A.; Quera, Rodrigo; Hermoso, Marcela A.

The Role of Cytokines in the Fibrotic Responses in Crohn's Disease

FRONTIERS IN MEDICINE

IF3

2017-08-07

OAAI

Curciarello, Renata; Docena, Guillermo H.; MacDonald, Thomas T.

THE PHARMACOLOGICAL PROFILE OF TOP1288, A NARROW SPECTRUM KINASE INHIBITOR (NSKI) IN CLINICAL DEVELOPMENT AS AN ANTI-INFLAMMATORY TREATMENT FOR ULCERATIVE COLITIS

GASTROENTEROLOGY

IF25.1

2017-04-01

PREAI

Foster, Martyn; Biancheri, Paolo; Fyfe, Matthew C.; MacDonald, Thomas T.; Rowley, Adele; Sirohi, Sameer; Solanke, Yemisi; Webber, Steve; Walshe, Claire A.

Homeostasis of the gut barrier and potential biomarkers 肠道屏障的稳态和潜在的生物标志物

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

IF3.3

2017-03-01

492

OAAI

Wells, Jerry M.; Brummer, Robert J.; Derrien, Muriel; MacDonald, Thomas T.; Troost, Freddy; Cani, Patrice D.; Theodorou, Vassilia; Dekker, Jan; Meheust, Agnes; de Vos, Willem M.; Mercenier, Annick; Nauta, Arjen; Garcia-Rodenas, Clara L.

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-02-10

427

PREAI

Harris, Philip A.; Berger, Scott B.; Jeong, Jae U.; Nagilla, Rakesh; Bandyopadhyay, Deepak; Campobasso, Nino; Capriotti, Carol A.; Cox, Julie A.; Dare, Lauren; Dong, Xiaoyang; Eidam, Patrick M.; Finger, Joshua N.; Hoffman, Sandra J.; Kang, James; Kasparcova, Viera; King, Bryan W.; Lehr, Ruth; Lan, Yunfeng; Leister, Lara K.; Lich, John D.; MacDonald, Thomas T.; Miller, Nathan A.; Ouellette, Michael T.; Pao, Christina S.; Rahman, Attiq; Reilly, Michael A.; Rendina, Alan R.; Rivera, Elizabeth J.; Schaeffer, Michelle C.; Sehon, Clark A.; Singhaus, Robert R.; Sun, Helen H.; Swift, Barbara A.; Totoritis, Rachel D.; Vossenkaemper, Anna; Ward, Paris; Wisnoski, David D.; Zhang, Daohua; Marquis, Robert W.; Gough, Peter J.; Bertin, John

Can probiotics modulate human disease by impacting intestinal barrier function?

BRITISH JOURNAL OF NUTRITION

IF3

2017-01-19

362

OAAI

Bron, Peter A.; Kleerebezem, Michiel; Brummer, Robert-Jan; Cani, Patrice D.; Mercenier, Annick; MacDonald, Thomas T.; Garcia-Rodenas, Clara L.; Wells, Jerry M.

Regulation of human intestinal T-cell responses by type 1 interferon-STAT1 signaling is disrupted in inflammatory bowel disease

MUCOSAL IMMUNOLOGY

IF7.6

2017-01-01

OAAI

Giles, E. M.; Sanders, T. J.; McCarthy, N. E.; Lung, J.; Pathak, M.; MacDonald, T. T.; Lindsay, J. O.; Stagg, A. J.

The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2016-05-04

100

PREAI

Haile, Pamela A.; Votta, Bartholomew J.; Marquis, Robert W.; Bury, Michael J.; Mehlmann, John F.; Singhaus, Robert, Jr.; Charnley, Adam K.; Lakdawala, Ami S.; Convery, Maire A.; Lipshutz, David B.; Desai, Biva M.; Swift, Barbara; Capriotti, Carol A.; Berger, Scott B.; Mahajan, Mukesh K.; Reilly, Michael A.; Rivera, Elizabeth J.; Sun, Helen H.; Nagilla, Rakesh; Beal, Allison M.; Finger, Joshua N.; Cook, Michael N.; King, Bryan W.; Ouellette, Michael T.; Totoritis, Rachel D.; Pierdomenico, Maria; Negroni, Anna; Stronati, Laura; Cucchiara, Salvatore; Ziolkowski, Bartlomiej; Vossenkamper, Anna; MacDonald, Thomas T.; Gough, Peter J.; Bertin, John; Casillas, Linda N.

研究方向