未登录 Exploring the Impact of Saccharin on Neovascular Age-Related Macular Degeneration: A Comprehensive Study in Patients and Mice 探索糖精对新生血管性年龄相关性黄斑变性的影响: 患者和小鼠的综合研究 Kuenzel, Steffen E.; Pompoes, Inga-Marie; Flesch, Leonie T. M.; Frentzel, Dominik P.; Knecht, Vitus A.; Winkler, Silvia; Skosyrski, Sergej; Ruebsam, Anne; Dreher, Felix; Kociok, Norbert; Schuette, Moritz; Dubrac, Alexandre; Lange, Bodo; Yaspo, Marie-Laure; Lehrach, Hans; Strauss, Olaf; Joussen, Antonia M.; Zeitz, Oliver 分享 收藏
A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer 一种结合的计算和功能方法将IGF2BP2确定为结直肠癌临床前模型中化疗耐药的驱动因素 Kendzia, Sandra; Franke, Susanne; Kroehler, Tarek; Golob-Schwarzl, Nicole; Schweiger, Caroline; Toeglhofer, Anna M.; Skofler, Christina; Uranitsch, Stefan; El-Heliebi, Amin; Fuchs, Julia; Punschart, Andreas; Stiegler, Philipp; Keil, Marlen; Hoffmann, Jens; Henderson, David; Lehrach, Hans; Yaspo, Marie-Laure; Reinhard, Christoph; Schaefer, Reinhold; Keilholz, Ulrich; Regenbrecht, Christian; Schicho, Rudolf; Fickert, Peter; Lax, Sigurd F.; Erdmann, Frank; Schulz, Marcel H.; Kiemer, Alexandra K.; Haybaeck, Johannes; Kessler, Sonja M. 分享 收藏
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A framework for validating AI in precision medicine: considerations from the European ITFoC consortium 在精准医学中验证AI的框架: 来自欧洲ITFoC联盟的考虑 Tsopra, Rosy; Fernandez, Xose; Luchinat, Claudio; Alberghina, Lilia; Lehrach, Hans; Vanoni, Marco; Dreher, Felix; Sezerman, O. Ugur; Cuggia, Marc; de Tayrac, Marie; Miklasevics, Edvins; Itu, Lucian Mihai; Geanta, Marius; Ogilvie, Lesley; Godey, Florence; Boldisor, Cristian Nicolae; Campillo-Gimenez, Boris; Cioroboiu, Cosmina; Ciusdel, Costin Florian; Coman, Simona; Cubelos, Oliver Hijano; Itu, Alina; Lange, Bodo; Le Gallo, Matthieu; Lespagnol, Alexandra; Mauri, Giancarlo; Soykam, H. Okan; Rance, Bastien; Turano, Paola; Tenori, Leonardo; Vignoli, Alessia; Wierling, Christoph; Benhabiles, Nora; Burgun, Anita 分享 收藏
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Efficient Parameter Estimation Enables the Prediction of Drug Response Using a Mechanistic Pan-Cancer Pathway Model 有效的参数估计可以使用机械泛癌症途径模型预测药物反应 Froehlich, Fabian; Kessler, Thomas; Weindl, Daniel; Shadrin, Alexey; Schmiester, Leonard; Hache, Hendrik; Muradyan, Artur; Schuette, Moritz; Lim, Ji-Hyun; Heinig, Matthias; Theis, Fabian J.; Lehrach, Hans; Wierling, Christoph; Lange, Bodo; Hasenauer, Jan 分享 收藏
Synergistic cross-talk of hedgehog and interleukin-6 signaling drives growth of basal cell carcinoma 刺猬和interleukin-6信号的协同串扰驱动基底细胞癌的生长 Sternberg, Christina; Gruber, Wolfgang; Eberl, Markus; Tesanovic, Suzana; Stadler, Manuela; Elmer, Dominik P.; Schlederer, Michaela; Grund, Sandra; Roos, Simone; Wolff, Florian; Kaur, Supreet; Mangelberger, Doris; Lehrach, Hans; Hache, Hendrik; Wierling, Christoph; Laimer, Josef; Lackner, Peter; Wiederstein, Markus; Kasper, Maria; Risch, Angela; Petzelbauer, Peter; Moriggl, Richard; Kenner, Lukas; Aberger, Fritz 分享 收藏
Xenogeneic Graft-Versus-Host Disease in Humanized NSG and NSG-HLA-A2/HHD Mice Ehx, Gregory; Somja, Joan; Warnatz, Hans-Joerg; Ritacco, Caroline; Hannon, Muriel; Delens, Loic; Fransolet, Gilles; Delvenne, Philippe; Muller, Josephine; Beguin, Yves; Lehrach, Hans; Belle, Ludovic; Humblet-Baron, Stephanie; Baron, Frederic 分享 收藏
Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance 非小细胞肺癌异种移植物的表观基因组分析揭示LRP12 DNA甲基化作为卡铂耐药的预测生物标志物 Grasse, Sabrina; Lienhard, Matthias; Frese, Steffen; Kerick, Martin; Steinbach, Anne; Grimm, Christina; Hussong, Michelle; Rolff, Jana; Becker, Michael; Dreher, Felix; Schirmer, Uwe; Boerno, Stefan; Ramisch, Anna; Leschber, Gunda; Timmermann, Bernd; Grohe, Christian; Lueders, Heike; Vingron, Martin; Fichtner, Iduna; Klein, Sebastian; Odenthal, Margarete; Buettner, Reinhard; Lehrach, Hans; Sueltmann, Holger; Herwig, Ralf; Schweiger, Michal R. 分享 收藏
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Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells Regan, Joseph L.; Schumacher, Dirk; Staudte, Stephanie; Steffen, Andreas; Haybaeck, Johannes; Keilholz, Ulrich; Schweiger, Caroline; Golob-Schwarzl, Nicole; Mumberg, Dominik; Henderson, David; Lehrach, Hans; Regenbrecht, Christian R. A.; Schaefer, Reinhold; Lange, Martin 分享 收藏
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Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors 临床前模型中结直肠癌的分子解剖确定了预测对EGFR抑制剂敏感性的生物标志物 Schuette, Moritz; Risch, Thomas; Abdavi-Azar, Nilofar; Boehnke, Karsten; Schumacher, Dirk; Keil, Marlen; Yildirimman, Reha; Jandrasits, Christine; Borodina, Tatiana; Amstislavskiy, Vyacheslav; Worth, Catherine L.; Schweiger, Caroline; Liebs, Sandra; Lange, Martin; Warnatz, Hans-Joerg; Butcher, Lee M.; Barrett, James E.; Sultan, Marc; Wierling, Christoph; Golob-Schwarzl, Nicole; Lax, Sigurd; Uranitsch, Stefan; Becker, Michael; Welte, Yvonne; Regan, Joseph Lewis; Silvestrov, Maxine; Kehler, Inge; Fusi, Alberto; Kessler, Thomas; Herwig, Ralf; Landegren, Ulf; Wienke, Dirk; Nilsson, Mats; Velasco, Juan A.; Garin-Chesa, Pilar; Reinhard, Christoph; Beck, Stephan; Schaefer, Reinhold; Regenbrecht, Christian R. A.; Henderson, David; Lange, Bodo; Haybaeck, Johannes; Keilholz, Ulrich; Hoffmann, Jens; Lehrach, Hans; Yaspo, Marie-Laure 分享 收藏
Preclinical analysis and characterization of abemaciclib using three-dimensional patient-derived colorectal cancer organoid cultures Boehnke, Karsten; Calsina, Bruna; Amat, Joaquin; Hermoso, Ana; Torres, Raquel; Reinhard, Christoph; Velasco, Juan A.; Iversen, Philip W.; De Dios, Alfonso; Buchanan, Sean; Beckmann, Richard P.; Schumacher, Dirk; Regenbrecht, Christian R. A.; Yaspo, Marie-Laure; Lehrach, Hans; Lallena, Maria Jose 分享 收藏
The role of Hedgehog signaling in the regulation of human colon cancer stem cells Regan, Joseph L.; Staudte, Stephanie; Schumacher, Dirk; Keilholz, Ulrich; Haybaeck, Johannes; Lehrach, Hans; Yaspo, Marie-Laure; Henderson, David; Steffen, Andreas; Toedling, Joern; Lesche, Ralf; Schaefer, Reinhold; Regenbrecht, Christian R.; Mumberg, Dominik; Lange, Martin 分享 收藏
Whole transcriptome analysis of patient-derived 3D in vitro and xenograft models of colon cancer identifies placental genes required for the survival of cancer stem cells Regan, Joseph L.; Staudte, Stephanie; Schumacher, Dirk; Keilholz, Ulrich; Haybaeck, Johannes; Lehrach, Hans; Yaspo, Marie-Laure; Henderson, David; Steffen, Andreas; Toedling, Joern; Lesche, Ralf; Schaefer, Reinhold; Regenbrecht, Christian R.; Mumberg, Dominik; Lange, Martin 分享 收藏
Transcriptional signature induced by a metastasis-promoting c-Src mutant in a human breast cell line Broecker, Felix; Hardt, Christopher; Herwig, Ralf; Timmermann, Bernd; Kerick, Martin; Wunderlich, Andrea; Schweiger, Michal R.; Borsig, Lubor; Heikenwalder, Mathias; Lehrach, Hans; Moelling, Karin 分享 收藏
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The direction of cross affects obesity after puberty in male but not female offspring (vol 16, 904, 2015) Kaerst, Stefan; Arends, Danny; Heise, Sebastian; Trost, Jan; Yaspo, Marie-Laure; Amstislavskiy, Vyacheslav; Risch, Thomas; Lehrach, Hans; Brockmann, Gudrun A. 分享 收藏
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