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Discovery of BW710 as a potent, selective and orally bioavailable fibroblast growth factor receptor 2 (FGFR2) inhibitor 发现BW710是一种有效，选择性和口服生物可利用的成纤维细胞生长因子受体2 (FGFR2) 抑制剂 Yang, Bowen; Xun, Qiuju; Tian, Yuan; Li, Huiqiong; Wu, Pinglian; Zhou, Yang; Chang, Shaohua; Wang, Zhen; Ding, Ke; Ma, Dawei 分享 收藏
Designing Macrocyclic Kinase Inhibitors Using Macrocycle Scaffold Hopping with Reinforced Learning (Macro-Hop) 使用宏观骨架跳跃（Macro-Hop）与强化学习设计大环激酶抑制剂 Liang, Hong; Huang, Shengjie; Xu, Xinxin; Yin, Zhao; Hussain, Muzammal; Song, Xiaojuan; Yi, Jianqiao; He, Yingqi; Guo, Jing; Tu, Zhengchao; Zhang, Zhang; Zhou, Yang; Lu, Xiaoyun 分享 收藏
Discovery of YJZ5118: A Potent and Highly Selective Irreversible CDK12/13 Inhibitor with Synergistic Effects in Combination with Akt Inhibition YJZ5118的发现：一种具有协同效应的强效且高度选择性的不可逆CDK12/13抑制剂，可与Akt抑制联合用药。 Yang, Jianzhang; Chang, Yu; Zhou, Kaijie; Huang, Weixue; Tien, Jean Ching-Yi; Zhang, Pujuan; Liu, Wenyan; Zhou, Licheng; Zhou, Yang; Ren, Xiaomei; Mannan, Rahul; Mahapatra, Somnath; Zhang, Yuping; Hamadeh, Rudana; Ervine, Grafton; Wang, Zhen; Wang, George Xiaoju; Chinnaiyan, Arul M.; Ding, Ke 分享 收藏
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Establishment of Echinococcus granulosus EgM123 Recombinant Gene Rabies Virus SRV9 and Identification of Its Biological Characteristics Yang, Yueqi; Hou, Mengdan; Su, Guicheng; Ma, Xiaoyan; Su, Xiaohui; Li, Kunlei; Liu, Songhan; Xiao, Luheng; Yao, Jingjing; Zhai, Jiahao; Wei, Xiaoying; Zhou, Yang; Lai, Qianqian; Dong, Yuwei; Liu, Jieyu; Zhai, Shaohua 分享 收藏
Structure-Based Design of Head-to-Tail Macrocyclic PROTACs Li, Chungen; Chen, Yihan; Huang, Weixue; Qiu, Yudi; Huang, Shengjie; Zhou, Yang; Zhou, Fengtao; Xu, Jian; Ren, Xiaomei; Zhang, Jinwei; Wang, Zhen; Ding, Ming; Ding, Ke 分享 收藏
Design, Synthesis, and Biological Evaluation of Novel Diaminopyrimidine Macrocycles as Fourth Generation Reversible EGFR Inhibitors That Overcome Clinical Resistance to Osimertinib Mediated by C797S Mutation Hu, Shiliang; Tong, Linjiang; Qin, Qiao; Wen, Jiaxin; Li, Yan; Feng, Fang; Wu, Kunzhong; Zhou, Yang; Shang, Jinsai; Wang, Junjian; Liu, Jinbao; Xie, Hua; Lu, Xiaoyun 分享 收藏
An efficient C-glycoside production platform enabled by rationally tuning the chemoselectivity of glycosyltransferases Li, Min; Zhou, Yang; Wen, Zexing; Ni, Qian; Zhou, Ziqin; Liu, Yiling; Zhou, Qiang; Jia, Zongchao; Guo, Bin; Ma, Yuanhong; Chen, Bo; Zhang, Zhi-Min; Wang, Jian-bo 分享 收藏
Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition 开发口服生物可利用的CDK12/13降解剂并通过AKT途径抑制诱导合成致死率 Chang, Yu; Wang, Xiaoju; Yang, Jianzhang; Tien, Jean Ching-Yi; Mannan, Rahul; Cruz, Gabriel; Zhang, Yuping; Vo, Josh N.; Magnuson, Brian; Mahapatra, Somnath; Cho, Hanbyul; Dhanasekaran, Saravana Mohan; Wang, Cynthia; Wang, Zhen; Zhou, Licheng; Zhou, Kaijie; Zhou, Yang; Zhang, Pujuan; Huang, Weixue; Xiao, Lanbo; Liu, Weihuang Raymond; Hamadeh, Rudana; Su, Fengyun; Wang, Rui; Miner, Stephanie J.; Cao, Xuhong; Cheng, Yunhui; Mehra, Rohit; Ding, Ke; Chinnaiyan, Arul M. 分享 收藏
paper Design, synthesis and biological evaluation of 5-amino-1 H-pyrazole-4-carboxamide derivatives as pan-FGFR covalent inhibitors Deng, Wuqing; Chen, Xiaojuan; Liang, Hong; Song, Xiaojuan; Xiang, Shuang; Guo, Jing; Tu, Zhengchao; Zhou, Yang; Chen, Yongheng; Lu, Xiaoyun 分享 收藏
Human/mouse CD137 agonist, JNU-0921, effectively shrinks tumors through enhancing the cytotoxicity of CD8+ T cells in cis and in trans JNU-0921，人/小鼠CD137激动剂通过增强CD8 T细胞的顺式和反式细胞毒性有效地缩小肿瘤 Liu, Lu; Chen, Fenghua; Li, Shan; Yang, Tong; Chen, Shuzhen; Zhou, Yang; Lin, Zejian; Zeng, Guandi; Feng, Pengju; Shu, Hong-Bing; Zhou, Qian; Ding, Ke; Chen, Liang 分享 收藏
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