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收藏Discovery of Clinical Candidate GDC-8264, a Novel, Potent and Selective RIP1 Inhibitor for Amelioration of Tissue Damage and the Treatment of Inflammatory Diseases
Patel, Snahel; Chen, Huifen; Varfolomeev, Eugene; Kwon, Youngsu; Ramaswamy, Sreemathy; Kohli, Pawan Bir; Quinn, John G.; Webster, Joshua D.; Mao, Jialin; Chen, Yuan; Fong, Rina; Demircioglu, F. Esra; Lupardus, Patrick; Stivala, Craig; Hamilton, Gregory L.; Siu, Michael; Sujatha-Bhaskar, Swathi; Mohanan, Vishnu; Adedeji, Adeyemi O.; Santagostino, Sara F.; Maher, Jonathan; Mckenzie, Brent; Rothenberg, Michael E.; Johnson, Adam; Vucic, Domagoj 分享 收藏 Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancerGalsky, Matthew D.; Guan, Xiangnan; Rishipathak, Deepali; Rapaport, Aaron S.; Shehata, Hesham M.; Banchereau, Romain; Yuen, Kobe; Varfolomeev, Eugene; Hu, Ruozhen; Han, Chia -Jung; Li, Haocheng; Liang, Yuxin; Vucic, Domagoj; Wang, Li; Zhu, Jun; Yu, Haocheng; Herbst, Rebecca H.; Hajaj, Emma; Kiner, Evgeny; Bamias, Aristotelis; De Santis, Maria; Davis, Ian D.; Arranz, Jose Angel; Kikuchi, Eiji; Bernhard, Sandrine; Williams, Patrick; Lee, Chooi; Mellman, Ira; Sanjabi, Shomyseh; Johnston, Robert; Black, Peter C.; Grande, Enrique; Mariathasan, Sanjeev 分享 收藏 APRIL-deficient mice have normal immune system developmentVarfolomeev, E; Kischkel, F; Martin, F; Seshasayee, D; Wang, H; Lawrence, D; Olsson, C; Tom, L; Erickson, S; French, D; Schow, P; Grewal, QS; Ashkenazi, A 分享 收藏 IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibitionAlicke, Bruno; Varfolomeev, Eugene; Lee, Shi Hui Kaylee; Frommlet, Alexandra; Ubhayakar, Savita; Quinn, John G.; Fairbrother, Wayne J.; Jones, Robert; Gould, Stephen E.; Vucic, Domagoj 分享 收藏 Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injuryStark, Kimberly; Goncharov, Tatiana; Varfolomeev, Eugene; Xie, Luke; Ngu, Hai; Peng, Ivan; Anderson, Keith R.; Verschueren, Erik; Choi, Meena; Kirkpatrick, Donald S.; Easton, Amy; Webster, Joshua D.; McKenzie, Brent S.; Vucic, Domagoj; Bingol, Baris 分享 收藏 Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALSDominguez, Sara; Varfolomeev, Eugene; Brendza, Robert; Stark, Kim; Tea, Joy; Imperio, Jose; Ngu, Hai; Earr, Timothy; Foreman, Oded; Webster, Joshua D.; Easton, Amy; Vucic, Domagoj; Bingol, Baris 分享 收藏 The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cellsCorzo, Cesar A.; Varfolomeev, Eugene; Setiadi, A. Francesca; Francis, Ross; Klabunde, Sha; Senger, Kate; Sujatha-Bhaskar, Swathi; Drobnick, Joy; Do, Steven; Suto, Eric; Huang, Zhiyu; Eastham-Anderson, Jeffrey; Katewa, Arna; Pang, Jodie; Domeyer, Melanie; Dela Cruz, Christopher; Paler-Martinez, Andres; Lau, Vivian W. C.; Hadadianpour, Azadeh; Ramirez-Carrozi, Vladimir; Sun, Yonglian; Bao, Katherine; Xu, Daqi; Hunley, Emily; Brightbill, Hans D.; Warming, Soren; Roose-Girma, Merone; Wong, Alfred; Tam, Lucinda; Emson, Claire L.; Crawford, James J.; Young, Wendy B.; Pappu, Rajita; McKenzie, Brent S.; Asghari, Vida; Vucic, Domagoj; Hackney, Jason A.; Austin, Cary D.; Lee, Wyne P.; Lekkerkerker, Annemarie; Ghilardi, Nico; Bryan, Marian C.; Kiefer, James R.; Townsend, Michael J.; Zarrin, Ali A. 分享 收藏 RIP1 kinase activity is critical for skin inflammation but not for viral propagationWebster, Joshua D.; Kwon, Youngsu C.; Park, Summer; Zhang, Hua; Corr, Nick; Ljumanovic, Nina; Adedeji, Adeyemi O.; Varfolomeev, Eugene; Goncharov, Tatiana; Preston, Jessica; Santagostino, Sara F.; Patel, Snahel; Xu, Min; Maher, Jonathan; McKenzie, Brent S.; Vucic, Domagoj 分享 收藏 RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases抑制RIP1可阻断炎症性疾病，但不能阻断肿瘤生长或转移Patel, Snahel; Webster, Joshua D.; Varfolomeev, Eugene; Kwon, Youngsu C.; Cheng, Jason H.; Zhang, Juan; Dugger, Debra L.; Wickliffe, Kate E.; Maltzman, Allie; Sujatha-Bhaskar, Swathi; Kohli, Pawan Bir; Ramaswamy, Sreema; Deshmukh, Gauri; Liederer, Bianca M.; Fong, Rina; Hamilton, Greg; Lupardus, Patrick; Caplazi, Patrick; Lee, Wyne P.; Campagne, Menno van Lookeren; Johnson, Adam; McKenzie, Brent S.; Junttila, Melissa R.; Newton, Kim; Vucic, Domagoj 分享 收藏 The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammationSenger, Kate; Pham, Victoria C.; Varfolomeev, Eugene; Hackney, Jason A.; Corzo, Cesar A.; Collier, Jenna; Lau, Vivian W. C.; Huang, Zhiyu; Hamidzhadeh, Kajal; Caplazi, Patrick; Peng, Ivan; Setiadi, A. Francesca; Francis, Ross; Paler-Martinez, Andres; Kwon, Youngsu C.; Ramirez-Carrozzi, Vladimir; Sun, Yonglian; Grigg, Patricia W.; Roose-Girma, Merone; Jeet, Surinder; Barck, Kai H.; Pham, Anna; Ota, Naruhisa; Ha, Connie; Stinson, Jeremy; Guillory, Joseph; Tam, Lucinda; Modrusan, Zora; Emson, Claire; McKenzie, Brent S.; Townsend, Michael J.; Carano, Richard A. D.; Warming, Soren; Vucic, Domagoj; DeVoss, Jason; Lee, Wyne P.; Lill, Jennie R.; Zarrin, Ali A. 分享 收藏 Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell deathde Almagro, M. Cristina; Goncharov, Tatiana; Izrael-Tomasevic, Anita; Duttler, Stefanie; Kist, Matthias; Varfolomeev, Eugene; Wu, Xiumin; Lee, Wyne P.; Murray, Jeremy; Webster, Joshua D.; Yu, Kebing; Kirkpatrick, Donald S.; Newton, Kim; Vucic, Domagoj 分享 收藏 Ubiquitination profiling identifies sensitivity factors for IAP antagonist treatmentVarfolomeev, Eugene; Izrael-Tomasevic, Anita; Yu, Kebing; Bustos, Daisy; Goncharov, Tatiana; Belmont, Lisa D.; Masselot, Alexandre; Bakalarski, Corey E.; Kirkpatrick, Donald S.; Vucic, Domagoj 分享 收藏 分享 收藏 OTUB1 modulates c-IAP1 stability to regulate signalling pathwaysGoncharov, Tatiana; Niessen, Kyle; de Almagro, Maria Cristina; Izrael-Tomasevic, Anita; Fedorova, Anna V.; Varfolomeev, Eugene; Arnott, David; Deshayes, Kurt; Kirkpatrick, Donald S.; Vucic, Domagoj 分享 收藏 Characterization of ML-IAP protein stability and physiological role in vivoVarfolomeev, Eugene; Moradi, Elham; Dynek, Jasmin N.; Zha, Jiping; Fedorova, Anna V.; Deshayes, Kurt; Fairbrother, Wayne J.; Newton, Kim; Le Couter, Jennifer; Vucic, Domagoj 分享 收藏 Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)Flygare, John A.; Beresini, Maureen; Budha, Nageshwar; Chan, Helen; Chan, Iris T.; Cheeti, Sravanthi; Cohen, Frederick; Deshayes, Kurt; Doerner, Karl; Eckhardt, S. Gail; Elliott, Linda O.; Feng, Bainian; Franklin, Matthew C.; Reisner, Stacy Frankovitz; Gazzard, Lewis; Halladay, Jason; Hymowitz, Sarah G.; La, Hank; LoRusso, Patricia; Maurer, Brigitte; Murray, Lesley; Plise, Emile; Quan, Clifford; Stephan, Jean-Philippe; Young, Shin G.; Tom, Jeffrey; Tsui, Vickie; Um, Joanne; Varfolomeev, Eugene; Vucic, Domagoj; Wagner, Andrew J.; Wallweber, Heidi J. A.; Wang, Lan; Ware, Joseph; Wen, Zhaoyang; Wong, Harvey; Wong, Jonathan M.; Wong, Melisa; Wong, Susan; Yu, Ron; Zobel, Kerry; Fairbrother, Wayne J. 分享 收藏 分享 收藏 分享 收藏 X Chromosome-linked Inhibitor of Apoptosis Regulates Cell Death Induction by Proapoptotic Receptor AgonistsVarfolomeev, Eugene; Alicke, Bruno; Elliott, J. Michael; Zobel, Kerry; West, Kristina; Wong, Harvey; Scheer, Justin M.; Ashkenazi, Avi; Gould, Stephen E.; Fairbrother, Wayne J.; Vucic, Domagoj 分享 收藏 
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