未登录A once-daily GLP-1/GIP/glucagon receptor triagonist (NN1706) lowers body weight in rodents, monkeys and humans一种每日一次的GLP-1/GIP/胰高血糖素受体三激动剂（NN1706）可降低啮齿动物、猴和人体的体重。
Finan, Brian; Douros, Jonathan D.; Goldwater, Ronald; Hansen, Ann Maria Kruse; Hjerpsted, Julie B.; Hjollund, Karina Rahr; Kankam, Martin K.; Knerr, Patrick J.; Konkar, Anish; Mowery, Stephanie A.; Mueller, Timo D.; Nielsen, John Romer; Nygard, Sune Boris; Perez-Tilve, Diego; Raun, Kirsten; Yang, Bin; Tschop, Matthias H.; DiMarchi, Richard D. .png)
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收藏HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male miceContreras, Raian E.; Gruber, Tim; Gonzalez-Garcia, Ismael; Schriever, Sonja C.; De Angelis, Meri; Mallet, Noemi; Bernecker, Miriam; Legutko, Beata; Kabra, Dhiraj; Schmidt, Mathias; Tschoep, Matthias H.; Gutierrez-Aguilar, Ruth; Mellor, Jane; Garcia-Caceres, Cristina; Pfluger, Paul T. 分享 收藏 Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapySanchez-Garrido, Miguel A.; Serrano-Lopez, Victor; Ruiz-Pino, Francisco; Vazquez, Maria Jesus; Rodriguez-Martin, Andrea; Torres, Encarnacion; Velasco, Inmaculada; Rodriguez, Ana Belen; Chicano-Galvez, Eduardo; Mora-Ortiz, Marina; Ohlsson, Claes; Poutanen, Matti; Pinilla, Leonor; Gaytan, Francisco; Douros, Jonathan D.; Yang, Bin; Mueller, Timo D.; Dimarchi, Richard D.; Tschoep, Matthias H.; Finan, Brian; Tena-Sempere, Manuel 分享 收藏 GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease( vol 22 , 217 , 2023)在心脏代谢疾病的临床前小鼠模型中，GIP受体激动作用可改善血脂异常和动脉粥样硬化，而与体重减轻无关 (第22卷，217，2023)Sachs, Stephan; Goetz, Anna; Finan, Brian; Feuchtinger, Annette; Dimarchi, Richard D.; Doering, Yvonne; Weber, Christian; Tschoep, Matthias H.; Mueller, Timo D.; Hofmann, Susanna M. 分享 收藏 分享 收藏 分享 收藏 Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in miceLiskiewicz, Arkadiusz; Khalil, Ahmed; Liskiewicz, Daniela; Novikoff, Aaron; Grandl, Gerald; Maity-Kumar, Gandhari; Gutgesell, Robert M.; Bakhti, Mostafa; Bastidas-Ponce, Aimee; Czarnecki, Oliver; Makris, Konstantinos; Lickert, Heiko; Feuchtinger, Annette; Tost, Monica; Coupland, Callum; Staender, Lisa; Akindehin, Seun; Prakash, Sneha; Abrar, Faiyaz; Castelino, Russell L.; He, Yantao; Knerr, Patrick J.; Yang, Bin; Hogendorf, Wouter F. J.; Zhang, Shiqi; Hofmann, Susanna M.; Finan, Brian; Dimarchi, Richard D.; Tschoep, Matthias H.; Douros, Jonathan D.; Mueller, Timo D. 分享 收藏 Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration调节性T细胞需要IL6受体 α 信号来控制骨骼肌功能和再生Becker, Maike; Joseph, Sini S.; Garcia-Carrizo, Francisco; Tom, Robby Z.; Opaleva, Daria; Serr, Isabelle; Tscho, Matthias H.; Schulz, Tim J.; Hofmann, Susanna M.; Daniel, Carolin 分享 收藏 High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via k-opioid signalingGruber, Tim; Lechner, Franziska; Murat, Cahue; Contreras, Raian E.; Sanchez-Quant, Eva; Miok, Viktorian; Makris, Konstantinos; Le Thuc, Ophelia; Gonzalez-Garcia, Ismael; Garcia-Clave, Elena; Althammer, Ferdinand; Krabichler, Quirin; DeCamp, Lisa M.; Jones, Russell G.; Lutter, Dominik; Williams, Rhiannan H.; Pfluger, Paul T.; Mueller, Timo D.; Woods, Stephen C.; Pospisilik, John Andrew; Martinez-Jimenez, Celia P.; Tschop, Matthias H.; Grinevich, Valery; Garcia-Caceres, Cristina 分享 收藏 分享 收藏 GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease在心脏代谢疾病的临床前小鼠模型中，GIP受体激动可独立于体重减轻而改善血脂异常和动脉粥样硬化Sachs, Stephan; Goetz, Anna; Finan, Brian; Feuchtinger, Annette; DiMarchi, Richard D.; Doering, Yvonne; Weber, Christian; Tschoep, Matthias H.; Mueller, Timo D.; Hofmann, Susanna M. 分享 收藏 分享 收藏 Placebo effects on nausea and motion sickness are resistant to experimentally-induced stressJacob, Carmen; Olliges, Elisabeth; Haile, Anja; Hoffmann, Verena; Jacobi, Benjamin; Steinkopf, Leander; Lanz, Marina; Wittmann, Marc; Tschoep, Matthias H.; Meissner, Karin 分享 收藏 分享 收藏 分享 收藏 Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1Gonzalez-Garcia, Ismael; Garcia-Clave, Elena; Cebrian-Serrano, Alberto; Le Thuc, Ophlia; Contreras, Raian E.; Xu, Yanjun; Gruber, Tim; Schriever, Sonja C.; Legutko, Beata; Lintelmann, Jutta; Adamski, Jerzy; Wurst, Wolfgang; Mueller, Timo D.; Woods, Stephen C.; Pfluger, Paul T.; Tschoep, Matthias H.; Fisette, Alexandre; Garcia-Caceres, Cristina 分享 收藏 Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo脂肪细胞衍生的细胞外囊泡通过转运促胰岛素蛋白货物增加胰岛素分泌Kulaj, Konxhe; Harger, Alexandra; Bauer, Michaela; Caliskan, Oezuem S.; Gupta, Tilak Kumar; Chiang, Dapi Menglin; Milbank, Edward; Reber, Josefine; Karlas, Angelos; Kotzbeck, Petra; Sailer, David N.; Volta, Francesco; Lutter, Dominik; Prakash, Sneha; Merl-Pham, Juliane; Ntziachristos, Vasilis; Hauner, Hans; Pfaffl, Michael W.; Tschoep, Matthias H.; Mueller, Timo D.; Hauck, Stefanie M.; Engel, Benjamin D.; Gerdes, Jantje M.; Pfluger, Paul T.; Krahmer, Natalie; Stemmer, Kerstin 分享 收藏 分享 收藏 Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley SyndromeMaity-Kumar, Gandhari; Staender, Lisa; DeAngelis, Meri; Lee, Sooyeon; Molenaar, Anna; Becker, Lore; Garrett, Lillian; Amerie, Oana, V; Hoelter, Sabine M.; Wurst, Wolfgang; Fuchs, Helmut; Feuchtinger, Annette; Gailus-Durner, Valerie; Garcia-Caceres, Cristina; Othman, Ahmed E.; Brockmann, Caroline; Schoeffling, Vanessa, I; Beiser, Katja; Krude, Heiko; Mroz, Piotr A.; Hofmann, Susanna; Tuckermann, Jan; DiMarchi, Richard D.; de Angelis, Martin Hrabe; Tschoep, Matthias H.; Pfluger, Paul T.; Mueller, Timo D. 分享 收藏 Hypothalamic astrocytes control systemic glucose metabolism and energy balanceChao, Daniela Herrera Moro; Kirchner, Matthew K.; Pham, Cuong; Foppen, Ewout; Denis, Raphael G. P.; Castel, Julien; Morel, Chloe; Montalban, Enrica; Hassouna, Rim; Bui, Linh-Chi; Renault, Justine; Mouffle, Christine; Garcia-Caceres, Cristina; Tschop, Matthias H.; Li, Dongdong; Martin, Claire; Stern, Javier E.; Luquet, Serge H. 分享 收藏 
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