未登录 Discovery of potent and selective pan-TEAD autopalmitoylation inhibitors for the treatment of Hippo-pathway altered cancers Gordon, Jacob A.; Dubauskaite, Jolanta; DuPont, Michelle; Guan, Nin; Holdgate, Geoff; Mlynarski, Scott; Umbreit, Neil; Sanchez, Danielle; Srivastava, Abhishek; Suski, Janek; Su, Nancy; Richards, Ryan; Cosulich, Sabina; Reimer, Corinne; Brownell, James 分享 收藏
Nedd8 modification of Cul-1 activates SCFβTrCp-dependent ubiquitination of IκBα Read, MA; Brownell, JE; Gladysheva, TB; Hottelet, M; Parent, LA; Coggins, MB; Pierce, JW; Podust, VN; Luo, RS; Chau, V; Palombella, VJ 分享 收藏
Gain and loss of function genome-wide CRISPR screens identify Hippo signalling as an important driver of resistance in EGFR mutant lung cancer Pfeifer, Matthias; Brammeld, Jonathan; Price, Stacey; Martin, Matthew; Thorpe, Hannah; Bornot, Aurelie; Banks, Ercia; Guan, Nin; Dunn, Shanade; Guerriero, Maria Lisa; O'Neill, Daniel; Pilling, James; Gianni, Davide; Brownell, James; Smith, Paul; McDermott, Ultan 分享 收藏
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Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors 吡唑并嘧啶氨基磺酸盐作为ATG7抑制剂的发现和优化 Huang, Shih-Chung; Adhikari, Sharmila; Brownell, James E.; Calderwood, Emily F.; Chouitar, Jouhara; D'Amore, Natalie Roy; England, Dylan B.; Foley, Klaudia; Harrison, Sean J.; LeRoy, Patrick J.; Lok, David; Lublinsky, Anna; Ma, Li-Ting; Menon, Saurabh; Yang, Yu; Zhang, Ji; Gould, Alexandra E. 分享 收藏
Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor He, Xingyue; Riceberg, Jessica; Soucy, Teresa; Koenig, Erik; Minissale, James; Gallery, Melissa; Bernard, Hugues; Yang, Xiaofeng; Liao, Hua; Rabino, Claudia; Shah, Pooja; Xega, Kristina; Yan, Zhong-hua; Sintchak, Mike; Bradley, John; Xu, He; Duffey, Matt; England, Dylan; Mizutani, Hirotake; Hu, Zhigen; Guo, Jianping; Chau, Ryan; Dick, Lawrence R.; Brownell, James E.; Newcomb, John; Langston, Steve; Lightcap, Eric S.; Bence, Neil; Pulukuri, Sai M. 分享 收藏
Probing the roles of SUMOylation in cancer cell biology using a selective SUMO activating enzyme inhibitor Pulukuri, Sai M.; He, Xingyue; Grossman, Stephen; Riceberg, Jessica; Koenig, Erik; Soucy, Teresa; Song, Keli; Kreshock, Anna; England, Dylan; Mizutani, Hirotake; Dick, Larry; Brownell, James; Newcomb, John; Langston, Steve; Lightcap, Eric; Galvin, Katherine 分享 收藏
A sensitive immunohistochemistry method for in vivo autophagy biomarker detection and pharmacodynamic studies Yang, Yu; D'Amore, Natalie Roy; Chouitar, Jouhara; Yu, Jie; Burke, Kristine; Xiang, Zhongmin; Yu, Lunyin; Lasky, Kerri; Brownell, James; Simpson, Chris; Luongo, Evan; Bowman, Doug; Tirrell, Stephen; He, Helen 分享 收藏
Mechanistic Studies on Activation of Ubiquitin and Di-ubiquitin-like Protein, FAT10, by Ubiquitin-like Modifier Activating Enzyme 6, Uba6 Gavin, James M.; Chen, Jesse J.; Liao, Hua; Rollins, Neil; Yang, Xiaofeng; Xu, Qing; Ma, Jingya; Loke, Huay-Keng; Lingaraj, Trupti; Brownell, James E.; Mallender, William D.; Gould, Alexandra E.; Amidon, Benjamin S.; Dick, Lawrence R. 分享 收藏
Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues Chen, Jesse J.; Tsu, Christopher A.; Gavin, James M.; Milhollen, Michael A.; Bruzzese, Frank J.; Mallender, William D.; Sintchak, Michael D.; Bump, Nancy J.; Yang, Xiaofeng; Ma, Jingya; Loke, Huay-Keng; Xu, Qing; Li, Ping; Bence, Neil F.; Brownell, James E.; Dick, Lawrence R. 分享 收藏
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Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ Brownell, James E.; Sintchak, Michael D.; Gavin, James M.; Liao, Hua; Bruzzese, Frank J.; Bump, Nancy J.; Soucy, Teresa A.; Milhollen, Michael A.; Yang, Xiaofeng; Burkhardt, Anne L.; Ma, Jingya; Loke, Huay-Keng; Lingaraj, Trupti; Wu, Dongyun; Hamman, Kristin B.; Spelman, James J.; Cullis, Courtney A.; Langston, Steven P.; Vyskocil, Stepan; Sells, Todd B.; Mallender, William D.; Visiers, Irache; Li, Ping; Claiborne, Christopher F.; Rolfe, Mark; Bolen, Joseph B.; Dick, Lawrence R. 分享 收藏
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53 Rajendra, R; Malegaonkar, D; Pungaliya, P; Marshall, H; Rasheed, Z; Brownell, J; Liu, LF; Lutzker, S; Saleem, A; Rubin, EH 分享 收藏
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