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James A. Monn

Eli Lilly

42H指数
180论文数
7.8K被引数
收录论文 30
发表时间
Metabotropic Glutamate Receptors Modulate Exocytotic Tau Release and Propagation
err2022-11-01
err8
errOAAI
errMazzo, Francesca; Butnaru, Ioana; Grubisha, Olivera; Ficulle, Elena; Sanger, Helen; Fitzgerald, Griffin; Pan, Feng; Pasqui, Francesca; Murray, Tracey; Monn, James; Li, Xia; Hutton, Michael; Bose, Suchira; Schiavo, Giampietro; Sher, Emanuele
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The bacterial quorum sensing molecule, 2-heptyl-3-hydroxy-4-quinolone (PQS), inhibits signal transduction mechanisms in brain tissue and is behaviorally active in mice
err2021-08-01
err1
PREAI
errDi Menna, L.; Busceti, C. L.; Ginerete, R. P.; D'Errico, G.; Orlando, R.; Alborghetti, M.; Bruno, V; Battaglia, G.; Fornai, F.; Leoni, L.; Rampioni, G.; Visca, P.; Monn, J. A.; Nicoletti, F.
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Structural Basis for (S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8 Receptor
err2018-10-26
err8
errOAAI
errChen, Qi; Ho, Joseph D.; Ashok, Sheela; Vargas, Michelle C.; Wang, Jing; Atwell, Shane; Bures, Mark; Schkeryantz, Jeffery M.; Monn, James A.; Hao, Junliang
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Synthesis and Pharmacological Characterization of C4β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1S,2S,4S,5R,6S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist
err2018-01-19
err22
PREAI
errMonn, James A.; Henry, Steven S.; Massey, Steven M.; Clawson, David K.; Chen, Qi; Diseroad, Benjamin A.; Bhardwaj, Rajni M.; Atwel, Shane; Lu, Frances; Wang, Jing; Russell, Marijane; Heinz, Beverly A.; Wang, Xu-shan; Carter, Joan H.; Getman, Brian G.; Adragni, Kofi; Broad, Lisa M.; Sanger, Helene E.; Ursu, Daniel; Catlow, John T.; Swanson, Steven; Johnson, Bryan G.; Shaw, David B.; McKinzie, David L.; Hao, Junliang
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Comparative Effects of LY3020371, a Potent and Selective Metabotropic Glutamate (mGlu) 2/3 Receptor Antagonist, and Ketamine, a Noncompetitive N-Methyl-D-Aspartate Receptor Antagonist in Rodents: Evidence Supporting the Use of mGlu2/3 Antagonists, for the Treatment of Depression.
err2017-04-01
err33
errOAAI
errWitkin, J. M.; Mitchell, S. N.; Wafford, K. A.; Carter, G.; Gilmour, G.; Li, J.; Eastwood, B. J.; Overshiner, C.; Li, X.; Rorick-Kehn, L.; Rasmussen, K.; Anderson, W. H.; Nikolayev, A.; Tolstikov, V. V.; Kuo, M. -S.; Catlow, J. T.; Li, R.; Smith, S. C.; Mitch, C. H.; Ornstein, P. L.; Swanson, S.; Monn, J. A.
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Translational Pharmacology of the Metabotropic Glutamate 2 Receptor-Preferring Agonist LY2812223 in the Animal and Human Brain
err2017-04-01
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errOAAI
errFelder, Christian C.; Schober, Douglas A.; Tu, Yuan; Quets, Anne; Xiao, Hongling; Watt, Marla; Siuda, Ed; Nisenbaum, Eric; Xiang, Chuanxi; Heinz, Beverly; Prieto, Lourdes; McKinzie, David L.; Monn, James A.
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Broad spectrum efficacy with LY2969822, an oral prodrug of metabotropic glutamate 2/3 receptor agonist LY2934747, in rodent pain models
err2017-03-13
err18
errOAAI
errJohnson, Michael P.; Muhlhauser, Mark A.; Nisenbaum, Eric S.; Simmons, Rosa M. A.; Forster, Beth M.; Knopp, Kelly L.; Yang, Lijuan; Morrow, Denise; Li, Dominic L.; Kennedy, Jeffrey D.; Swanson, Steven; Monn, James A.
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Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371•HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity
err2016-12-06
err34
errOAAI
errChappell, Mark D.; Li, Renhua; Smith, Stephon C.; Dressman, Bruce A.; Tromiczak, Eric G.; Tripp, Allie E.; Blanco, Maria-Jesus; Vetman, Tatiana; Quimby, Steven J.; Matt, James; Britton, Thomas C.; Fivush, Adam M.; Schkeryantz, Jeffrey M.; Mayhugh, Daniel; Erickson, Jon A.; Bures, Mark G.; Jaramillo, Carlos; Carpintero, Mercedes; Eugenio de Diego, Jose; Barberis, Mario; Garcia-Cerrada, Susana; Soriano, Jose F.; Antonysamy, Stephen; Atwell, Shane; MacEwan, Lain; Condon, Bradley; Sougias, Christine; Wang, Jing; Zhang, Aiping; Conners, Kris; Groshong, Chris; Wasserman, Stephen R.; Koss, John W.; Witkin, Jeffrey M.; Li, Xia; Overshiner, Carl; Wafford, Keith A.; Seidel, Wesley; Wang, Xu-Shan; Heinz, Beverly A.; Swanson, Steven; Catlow, John T.; Bedwell, David W.; Monn, James A.; Mitch, Charles H.; Ornstein, Paul L.
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Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist
err2015-09-14
err41
PREAI
errMonn, James A.; Prieto, Lourdes; Taboada, Lorena; Hao, Junliang; Reinhard, Matthew R.; Hen, Steven S.; Beadle, Christopher D.; Walton, Lesley; Man, Teresa; Rudyk, Helene; Clark, Barry; Tupper, David; Baker, S. Richard; Lamas, Carlos; Montero, Carlos; Marcos, Alicia; Blanco, Jaime; Bures, Mark; Clawson, David K.; Atwell, Shane; Lu, Frances; Wang, Jing; Russell, Marijane; Heinz, Beverly A.; Wang, Xushan; Carter, Joan H.; Getman, Brian G.; Catlow, John T.; Swanson, Steven; Johnson, Bryan G.; Shaw, David B.; McKinzie, David L.
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Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures
err2015-02-05
err50
PREAI
errMonn, James A.; Prieto, Lourdes; Taboada, Lorena; Pedregal, Concepcion; Hao, Junliang; Reinhard, Matt R.; Henry, Steven S.; Goldsmith, Paul J.; Beadle, Christopher D.; Walton, Lesley; Man, Teresa; Rudyk, Helene; Clark, Barry; Tupper, David; Baker, S. Richard; Lamas, Carlos; Montero, Carlos; Marcos, Alicia; Blanco, Jaime; Bures, Mark; Clawson, David K.; Atwell, Shane; Lu, Frances; Wang, Jing; Russell, Marijane; Heinz, Beverly A.; Wang, Xushan; Carter, Joan H.; Xiang, Chuanxi; Catlow, John T.; Swanson, Steven; Sanger, Helen; Broad, Lisa M.; Johnson, Michael P.; Knopp, Kelly L.; Simmons, Rosa M. A.; Johnson, Bryan G.; Shaw, David B.; Mc Kinzie, David L.
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Synthesis and Pharmacological Characterization of 4-Substituted-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: Identification of New Potent and Selective Metabotropic Glutamate 2/3 Receptor Agonists
err2013-06-03
err24
PREAI
errMonn, James A.; Valli, Matthew J.; Massey, Steven M.; Hao, Junliang; Reinhard, Matthew R.; Bures, Mark G.; Heinz, Beverly A.; Wang, Xushan; Carter, Joan H.; Getman, Brian G.; Stephenson, Gregory A.; Herin, Marc; Catlow, John T.; Swanson, Steven; Johnson, Bryan G.; McKinzie, David L.; Henry, Steven S.
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Improved Synthesis of C4α- and C4β-Methyl Analogues of 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate
err2012-05-21
err13
PREAI
errHenry, Steven S.; Brady, Molly D.; Laird, Dana L. T.; Ruble, J. Craig; Varie, David L.; Monn, James A.
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In Vitro and in Vivo Evidence for a Lack of Interaction with Dopamine D2 Receptors by the Metabotropic Glutamate 2/3 Receptor Agonists 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-bicaroxylate Monohydrate (LY354740) and (-)-2-Oxa-4-aminobicyclo[3.1.0] Hexane-4,6-dicarboxylic Acid (LY379268)
err2009-12-01
err50
PREAI
errFell, Matthew J.; Perry, Kenneth W.; Falcone, Julie F.; Johnson, Bryan G.; Barth, Vanessa N.; Rash, Karen S.; Lucaites, Virginia L.; Threlkeld, Penny G.; Monn, James A.; McKinzie, David L.; Marek, Gerard J.; Svensson, Kjell A.; Nelson, David L.
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Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized phase 2 clinical trial (vol 13, pg 1102, 2007)
err2007-10-01
err8
errOAAI
errPatil, Sandeep T.; Zhang, Lu; Martenyi, Ferenc; Lowe, Stephen L.; Jackson, Kimberley A.; Andreev, Boris V.; Avedisova, Alla S.; Bardenstein, Leonid M.; Gurovich, Issak Y.; Morozova, Margarita A.; Mosolov, Sergey N.; Neznanov, Nikolai G.; Reznik, Alexander M.; Smulevich, Anatoly B.; Tochilov, Vladimir A.; Johnson, Bryan G.; Monn, James A.; Schoepp, Darryle D.
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Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial激活mGlu2/3受体作为治疗精神分裂症的新方法: 一项随机2期临床试验
err2007-09-02
err985
PREAI
errPatil, Sandeep T.; Zhang, Lu; Martenyi, Ferenc; Lowe, Stephen L.; Jackson, Kimberley A.; Andreev, Boris V.; Avedisova, Alla S.; Bardenstein, Leonid M.; Gurovich, Issak Y.; Morozova, Margarita A.; Mosolov, Sergey N.; Neznanov, Nikolai G.; Reznik, Alexander M.; Smulevich, Anatoly B.; Tochilov, Vladimir A.; Johnson, Bryan G.; Monn, James A.; Schoepp, Darryle D.
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Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist:: In vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039)
err2007-04-01
err117
PREAI
errRorick-Kehn, Linda M.; Johnson, Bryan G.; Burkey, Jennifer L.; Wright, Rebecca A.; Calligaro, David O.; Marek, Gerard J.; Nisenbaum, Eric S.; Catlow, John T.; Kingston, Ann E.; Giera, Deborah D.; Herin, Marc F.; Monn, James A.; McKinzie, David L.; Schoepp, Darryle D.
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In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders
err2007-03-24
err170
PREAI
errRorick-Kehn, Linda M.; Johnson, Bryan G.; Knitowski, Karen M.; Salhoff, Craig R.; Witkin, Jeffrey M.; Perry, Kenneth W.; Griffey, Kelly I.; Tizzano, Joseph P.; Monn, James A.; McKinzie, David L.; Schoepp, Darryle D.
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Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: Identification of potent, selective, and orally bioavailable agonists for mGlu2/3 receptors
err2006-12-22
err85
PREAI
errMonn, James A.; Massey, Steven M.; Valli, Matthew J.; Henry, Steven S.; Stephenson, Gregory A.; Bures, Mark; Herin, Marc; Catlow, John; Giera, Deborah; Wright, Rebecca A.; Johnson, Bryan G.; Andis, Sherri L.; Kingston, Ann; Schoepp, Darryle D.
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Neuroprotective actions of novel and potent ligands of group I and group II metabotropic glutamate receptors
err2006-02-06
err70
PREAI
errKingston, AE; O'Neill, MJ; Bond, A; Bruno, V; Battaglia, G; Nicoletti, F; Harris, JR; Clark, BP; Monn, JA; Lodge, D; Schoepp, DD
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