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PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites PRMT5通过抑制多个近端内含子多聚腺苷酸化位点来促进全长HTT的表达。 Yadav, Manisha; AlQazzaz, Mona A.; Ciamponi, Felipe E.; Ho, Jolene C.; Maron, Maxim, I; Sababi, Aiden M.; MacLeod, Graham; Ahmadi, Moloud; Bullivant, Garrett; Tano, Vincent; Langley, Sarah R.; Sanchez-Osuna, Maria; Sachamitr, Patty; Kushida, Michelle; Bardile, Costanza Ferrari; Pouladi, Mahmoud A.; Kurtz, Rebecca; Richards, Laura; Pugh, Trevor; Tyers, Mike; Angers, Stephane; Dirks, Peter B.; Bader, Gary D.; Truant, Ray; Massirer, Katlin B.; Barsyte-Lovejoy, Dalia; Shechter, David; Harding, Rachel J.; Arrowsmith, Cheryl H.; Prinos, Panagiotis 分享 收藏
A Novel Confocal Scanning Protein-Protein Interaction Assay (PPI-CONA) Reveals Exceptional Selectivity and Specificity of CC0651, a Small Molecule Binding Enhancer of the Weak Interaction between the E2 Ubiquitin-Conjugating Enzyme CDC34A and Ubiquitin Koszela, Joanna; Pham, Nhan T.; Shave, Steven; St-Cyr, Daniel; Ceccarelli, Derek F.; Orlicky, Steven; Marinier, Anne; Sicheri, Frank; Tyers, Mike; Auer, Manfred 分享 收藏
Reduction in Nuclear Size by DHRS7 in Prostate Cancer Cells and by Estradiol Propionate in DHRS7-Depleted Cells Rizzotto, Andrea; Tollis, Sylvain; Pham, Nhan T.; Zheng, Yijing; Abad, Maria Alba; Wildenhain, Jan; Jeyaprakash, A. Arockia; Auer, Manfred; Tyers, Mike; Schirmer, Eric C. 分享 收藏
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SCFCdc4 Enables Mating Type Switching in Yeast by Cyclin-Dependent Kinase-Mediated Elimination of the Ash1 Transcriptional Repressor Liu, Qingquan; Larsen, Brett; Ricicova, Marketa; Orlicky, Stephen; Tekotte, Hille; Tang, Xiaojing; Craig, Karen; Quiring, Adam; Le Bihan, Thierry; Hansen, Carl; Sicheri, Frank; Tyers, Mike 分享 收藏
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Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality Navare, Arti T.; Mast, Fred D.; Olivier, Jean Paul; Bertomeu, Thierry; Neal, Maxwell L.; Carpp, Lindsay N.; Kaushansky, Alexis; Coulombe-Huntington, Jasmin; Tyers, Mike; Aitchison, John D. 分享 收藏
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Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4 Chana, Chetan K.; Maisonneuve, Pierre; Posternak, Ganna; Grinberg, Nicolas G. A.; Poirson, Juline; Ona, Samara M.; Ceccarelli, Derek F.; Mader, Pavel; St-Cyr, Daniel J.; Pau, Victor; Kurinov, Igor; Tang, Xiaojing; Deng, Dongjing; Cui, Weiren; Su, Wenji; Kuai, Letian; Soll, Richard; Tyers, Mike; Rost, Hannes L.; Batey, Robert A.; Taipale, Mikko; Gingras, Anne-Claude; Sicheri, Frank 分享 收藏
The timing of Start is determined primarily by increased synthesis of the Cln3 activator rather than dilution of the Whi5 inhibitor Litsios, Athanasios; Goswami, Pooja; Terpstra, Hanna M.; Coffin, Carleton; Vuillemenot, Luc-Alban; Rovetta, Mattia; Ghazal, Ghada; Guerra, Paolo; Buczak, Katarzyna; Schmidt, Alexander; Tollis, Sylvain; Tyers, Mike; Royer, Catherine A.; Milias-Argeitis, Andreas; Heinemann, Matthias 分享 收藏
Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion 核大小的化学探询可识别具有癌细胞系特异性影响迁移和侵袭的化合物 Tollis, Sylvain; Rizzotto, Andrea; Pham, Nhan T.; Koivukoski, Sonja; Sivakumar, Aishwarya; Shave, Steven; Wildenhain, Jan; Zuleger, Nikolaj; Keys, Jeremy T.; Culley, Jayne; Zheng, Yijing; Lammerding, Jan; Carragher, Neil O.; Brunton, Valerie G.; Latonen, Leena; Auer, Manfred; Tyers, Mike; Schirmer, Eric C. 分享 收藏
Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia Krosl, Jana; Bordeleau, Marie-Eve; Moison, Celine; MacRae, Tara; Boivin, Isabel; Mayotte, Nadine; Gracias, Deanne; Baccelli, Irene; Lavallee, Vincent-Philippe; Bisaillon, Richard; Lehnertz, Bernhard; Mendoza-Sanchez, Rodrigo; Ruel, Rejean; Bertomeu, Thierry; Coulombe-Huntington, Jasmin; Boucher, Genevieve; Noronha, Nandita; Pabst, Caroline; Tyers, Mike; Gendron, Patrick; Lemieux, Sebastien; Barabe, Frederic; Marinier, Anne; Hebert, Josee; Sauvageau, Guy 分享 收藏
Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex St-Cyr, Daniel; Ceccarelli, Derek F.; Orlicky, Stephen; van der Sloot, Almer M.; Tang, Xiaojing; Kelso, Susan; Moore, Susan; James, Clint; Posternak, Ganna; Coulombe-Huntington, Jasmin; Bertomeu, Thierry; Marinier, Anne; Sicheri, Frank; Tyers, Mike 分享 收藏
A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells Sohail, Muhammad; Shkreta, Lulzim; Toutant, Johanne; Rabea, Safwat; Babeu, Jean-Philippe; Huard, Caroline; Coulombe-Huntington, Jasmin; Delannoy, Aurelie; Placet, Morgane; Geha, Sameh; Gendron, Fernand-Pierre; Boudreau, Francois; Tyers, Mike; Grierson, David S.; Chabot, Benoit 分享 收藏
A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition Benslimane, Yahya; Sanchez-Osuna, Maria; Coulombe-Huntington, Jasmin; Bertomeu, Thierry; Henry, Danielle; Huard, Caroline; Bonneil, Eric; Thibault, Pierre; Tyers, Mike; Harrington, Lea 分享 收藏
PRMT5 inhibition disrupts splicing and stemness in glioblastoma Sachamitr, Patty; Ho, Jolene C.; Ciamponi, Felipe E.; Ba-Alawi, Wail; Coutinho, Fiona J.; Guilhamon, Paul; Kushida, Michelle M.; Cavalli, Florence M. G.; Lee, Lilian; Rastegar, Naghmeh; Vu, Victoria; Sanchez-Osuna, Maria; Coulombe-Huntington, Jasmin; Kanshin, Evgeny; Whetstone, Heather; Durand, Mathieu; Thibault, Philippe; Hart, Kirsten; Mangos, Maria; Veyhl, Joseph; Chen, Wenjun; Tran, Nhat; Duong, Bang-Chi; Aman, Ahmed M.; Che, Xinghui; Lan, Xiaoyang; Whitley, Owen; Zaslaver, Olga; Barsyte-Lovejoy, Dalia; Richards, Laura M.; Restall, Ian; Caudy, Amy; Rost, Hannes L.; Bonday, Zahid Quyoom; Bernstein, Mark; Das, Sunit; Cusimano, Michael D.; Spears, Julian; Bader, Gary D.; Pugh, Trevor J.; Tyers, Mike; Lupien, Mathieu; Haibe-Kains, Benjamin; Luchman, H. Artee; Weiss, Samuel; Massirer, Katlin B.; Prinos, Panagiotis; Arrowsmith, Cheryl H.; Dirks, Peter B. 分享 收藏
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality Mast, Fred D.; Navare, Arti T.; van der Sloot, Almer M.; Coulombe-Huntington, Jasmin; Rout, Michael P.; Baliga, Nitin S.; Kaushansky, Alexis; Chait, Brian T.; Aderem, Alan; Rice, Charles M.; Sali, Andrej; Tyers, Mike; Aitchison, John D. 分享 收藏
G1/S transcription factors assemble in increasing numbers of discrete clusters through G1 phase Black, Labe; Tollis, Sylvain; Fu, Guo; Fiche, Jean-Bernard; Dorsey, Savanna; Cheng, Jing; Ghazal, Ghada; Notley, Stephen; Crevier, Benjamin; Bigness, Jeremy; Nollmann, Marcelo; Tyers, Mike; Royer, Catherine Ann 分享 收藏
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