未登录 BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance Nesic, Ksenija; Krais, John J.; Wang, Yifan; Vandenberg, Cassandra J.; Patel, Pooja; Cai, Kathy Q.; Kwan, Tanya; Lieschke, Elizabeth; Ho, Gwo-Yaw; Barker, Holly E.; Bedo, Justin; Casadei, Silvia; Farrell, Andrew; Radke, Marc; Shield-Artin, Kristy; Penington, Jocelyn S.; Geissler, Franziska; Kyran, Elizabeth; Betsch, Robert; Xu, Lijun; Zhang, Fan; Dobrovic, Alexander; Olesen, Inger; Kristeleit, Rebecca; Oza, Amit; McNeish, Iain; Ratnayake, Gayanie; Traficante, Nadia; DeFazio, Anna; Bowtell, David D. L.; Harding, Thomas C.; Lin, Kevin; Swisher, Elizabeth M.; Kondrashova, Olga; Scott, Clare L.; Johnson, Neil; Wakefield, Matthew J. 分享 收藏
Fibroblast activation protein targeted radiotherapy induces an immunogenic tumor microenvironment and enhances the efficacy of PD-1 immune checkpoint inhibition Zboralski, Dirk; Osterkamp, Frank; Christensen, Esben; Bredenbeck, Anne; Schumann, Anne; Hoehne, Aileen; Schneider, Eberhard; Paschke, Matthias; Ungewiss, Jan; Haase, Christian; Robillard, Liliane; Simmons, Andrew D.; Harding, Thomas C.; Nguyen, Minh 分享 收藏
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Preclinical evaluation of FAP-2286 for fibroblast activation protein targeted radionuclide imaging and therapy Zboralski, Dirk; Hoehne, Aileen; Bredenbeck, Anne; Schumann, Anne; Nguyen, Minh; Schneider, Eberhard; Ungewiss, Jan; Paschke, Matthias; Haase, Christian; von Hacht, Jan L.; Kwan, Tanya; Lin, Kevin K.; Lenore, Jan; Harding, Thomas C.; Xiao, Jim; Simmons, Andrew D.; Mohan, Ajay-Mohan; Beindorff, Nicola; Reineke, Ulrich; Smerling, Christiane; Osterkamp, Frank 分享 收藏
Pan-cancer analysis of fibroblast activation protein alpha (FAP) expression to guide tumor selection for the peptide-targeted radionuclide therapy FAP-2286 Kwan, Tanya T.; Nguyen, Minh; Zboralski, Dirk; Schumann, Anne; Bredenbeck, Anne; Paschke, Matthias; Haase, Christian; Hoehne, Aileen; Reineke, Ulrich; Smerling, Christiane; Osterkamp, Frank; Xiao, Jim; Simmons, Andrew D.; Harding, Thomas C.; Lin, Kevin L. 分享 收藏
Characterization of a RAD51C-silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance Hurley, Rachel M.; McGehee, Cordelia D.; Nesic, Ksenija; Correia, Cristina; Weiskittel, Taylor M.; Kelly, Rebecca L.; Venkatachalam, Annapoorna; Hou, Xiaonan; Pathoulas, Nicholas M.; Meng, X. Wei; Kondrashova, Olga; Radke, Marc R.; Schneider, Paula A.; Flatten, Karen S.; Peterson, Kevin L.; Becker, Marc A.; Wong, Ee Ming; Southey, Melissa S.; Dobrovic, Alexander; Lin, Kevin K.; Harding, Thomas C.; McNeish, Iain; Ross, Christian A.; Wagner, Jill M.; Wakefield, Matthew J.; Scott, Clare L.; Haluska, Paul; Hendrickson, Andrea E. Wahner; Karnitz, Larry M.; Swisher, Elizabeth M.; Li, Hu; Weroha, S. John; Kaufmann, Scott H. 分享 收藏
BET, SRC, and BCL2 family inhibitors are synergistic drug combinations with PARP inhibitors in ovarian cancer BET，SRC和BCL2家族抑制剂与PARP抑制剂在卵巢癌中的协同药物组合 Lui, Goldie Y. L.; Shaw, Reid; Schaub, Franz X.; Stork, Isabella N.; Gurley, Kay E.; Bridgwater, Caroline; Diaz, Robert L.; Rosati, Rachele; Swan, Hallie A.; Ince, Tan A.; Harding, Thomas C.; Gadi, Vijayakrishna K.; Goff, Barbara A.; Kemp, Christopher J.; Swisher, Elizabeth M.; Grandori, Carla 分享 收藏
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BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma Lin, Kevin K.; Harrell, Maria I.; Oza, Amit M.; Oaknin, Ana; Ray-Coquard, Isabelle; Tinker, Anna V.; Helman, Elena; Radke, Marc R.; Say, Carmen; Lan-Thanh Vo; Mann, Elaina; Isaacson, Jeffrey D.; Maloney, Lara; O'Malley, David M.; Chambers, Setsuko K.; Kaufmann, Scott H.; Scott, Clare L.; Konecny, Gottfried E.; Coleman, Robert L.; Sun, James X.; Giordano, Heidi; Brenton, James D.; Harding, Thomas C.; McNeish, Iain A.; Swisher, Elizabeth M. 分享 收藏
Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer Shah, Khyati N.; Bhatt, Roma; Rotow, Julia; Rohrberg, Julia; Olivas, Victor; Wang, Victoria E.; Hemmati, Golzar; Martins, Maria M.; Maynard, Ashley; Kuhn, Jonathan; Galeas, Jacqueline; Donnella, Hayley J.; Kaushik, Swati; Ku, Angel; Dumont, Sophie; Krings, Gregor; Haringsma, Henry J.; Robillard, Liliane; Simmons, Andrew D.; Harding, Thomas C.; McCormick, Frank; Goga, Andrei; Blakely, Collin M.; Bivona, Trever G.; Bandyopadhyay, Sourav 分享 收藏
Cell-Free DNA Next-Generation Sequencing Prediction of Response and Resistance to Third-Generation EGFR Inhibitor Helman, Elena; Minh Nguyen; Karlovich, Chris A.; Despain, Darrin; Choquette, A. Karin; Spira, Alexander, I; Yu, Helena A.; Camidge, D. Ross; Harding, Thomas C.; Lanman, Richard B.; Simmons, Andrew D. 分享 收藏
Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma Kondrashova, Olga; Topp, Monique; Nesic, Ksenija; Lieschke, Elizabeth; Ho, Gwo-Yaw; Harrell, Maria, I; Zapparoli, Giada, V; Hadley, Alison; Holian, Robert; Boehm, Emma; Heong, Valerie; Sanij, Elaine; Pearson, Richard B.; Krais, John J.; Johnson, Neil; McNally, Orla; Ananda, Sumitra; Alsop, Kathryn; Hutt, Karla J.; Kaufmann, Scott H.; Lin, Kevin K.; Harding, Thomas C.; Traficante, Nadia; deFazio, Anna; McNeish, Lain A.; Bowtell, David D.; Swisher, Elizabeth M.; Dobrovic, Alexander; Wakefield, Matthew J.; Scott, Clare L.; Chenevix-Trench, G.; Green, A.; Webb, P.; Gertig, D.; Fereday, S.; Moore, S.; Hung, J.; Harrap, K.; Sadkowsky, T.; Pandeya, N.; Malt, M.; Mellon, A.; Robertson, R.; Vanden Bergh, T.; Jones, M.; Mackenzie, P.; Maidens, J.; Nattress, K.; Chiew, Y. E.; Stenlake, A.; Sullivan, H.; Alexander, B.; Ashover, P.; Brown, S.; Corrish, T.; Green, L.; Jackman, L.; Ferguson, K.; Martin, K.; Martyn, A.; Ranieri, B.; White, J.; Jayde, V; Mamers, P.; Bowes, L.; Galletta, L.; Giles, D.; Hendley, J.; Schmidt, T.; Shirley, H.; Ball, C.; Young, C.; Viduka, S.; Tran, H.; Bilic, S.; Glavinas, L.; Brooks, J.; Stuart-Harris, R.; Kirsten, F.; Rutovitz, J.; Clingan, P.; Glasgow, A.; Proietto, A.; Braye, S.; Otton, G.; Shannon, J.; Bonaventura, T.; Stewart, J.; Begbie, S.; Friedlander, M.; Bell, D.; Baron-Hay, S.; Ferrier, A.; Gard, G.; Nevell, D.; Pavlakis, N.; Valmadre, S.; Young, B.; Camaris, C.; Crouch, R.; Edwards, L.; Hacker, N.; Marsden, D.; Robertson, G.; Beale, P.; Beith, J.; Carter, J.; Dalrymple, C.; Houghton, R.; Russell, P.; Links, M.; Grygiel, J.; Hill, J.; Brand, A.; Byth, K.; Jaworski, R.; Harnett, P.; Sharma, R.; Wain, G.; Ward, B.; Papadimos, D.; Crandon, A.; Cummings, M.; Horwood, K.; Obermair, A.; Perrin, L.; Wyld, D.; Nicklin, J.; Davy, M.; Oehler, M. K.; Hall, C.; Dodd, T.; Healy, T.; Pittman, K.; Henderson, D.; Miller, J.; Pierdes, J.; Blomfield, P.; Challis, D.; Mclntosh, R.; Parker, A.; Brown, B.; Rome, R.; Allen, D.; Grant, P.; Hyde, S.; Laurie, R.; Robbie, M.; Healy, D.; Jobling, T.; Manolitsas, T.; McNealage, J.; Rogers, P.; Susil, B.; Sumithran, E.; Simpson, I; Phillips, K.; Rischin, D.; Fox, S.; Johnson, D.; Lade, S.; Loughrey, M.; O'Callaghan, N.; Murray, W.; Waring, P.; Billson, V; Pyman, J.; Neesham, D.; Quinn, M.; Underhill, C.; Bell, R.; Ng, L. F.; Blum, R.; Ganju, V; Hammond, I; Leung, Y.; McCartney, A.; Buck, M.; Haviv, I; Purdie, D.; Whiteman, D.; Zeps, N. 分享 收藏
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Loss of RAD51C promoter hypermethylation confers PARP inhibitor resistance Hurley, Rachel M.; Nesic, Ksenija; McGehee, Cordelia; Kondrashova, Olga; Harrell, Maria I.; Schneider, Paula A.; Hou, Xiaonan; Correia, Cristina; Flatten, Karen S.; Zapparoli, Giada V.; Dobrovic, Alexander; Lin, Kevin K.; Harding, Thomas C.; Hendrickson, Andrea E. Wahner; Swisher, Elizabeth M.; Wakefield, Matthew; Weroha, S. John; Scott, Clare L.; Kaufmann, Scott H. 分享 收藏
Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer Shah, Khyati N.; Bhatt, Roma; Rotow, Julia; Rohrberg, Julia; Olivas, Victor; Hemmati, Golzar Golzar; Krings, Gregor; Haringsma, Henry J.; Simmons, Andrew D.; Harding, Thomas C.; Goga, Andrei; Blakely, Collin; Bivona, Trever; Bandyopadhyay, Sourav 分享 收藏
A Quantitative Chemotherapy Genetic Interaction Map Reveals Factors Associated with PARP Inhibitor Resistance Hu, Hsien-Ming; Zhao, Xin; Kaushik, Swati; Robillard, Lilliane; Barthelet, Antoine; Lin, Kevin K.; Shah, Khyati N.; Simmons, Andy D.; Raponi, Mitch; Harding, Thomas C.; Bandyopadhyay, Sourav 分享 收藏
Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial Coleman, Robert L.; Oza, Amit M.; Lorusso, Domenico; Aghajanian, Carol; Oaknin, Ana; Dean, Andrew; Colombo, Nicoletta; Weberpals, Johanne, I; Clamp, Andrew; Scambia, Giovanni; Leary, Alexandra; Holloway, Robert W.; Amenedo Gancedo, Margarita; Fong, Peter C.; Goh, Jeffrey C.; O'Malley, David M.; Armstrong, Deborah K.; Garcia-Donas, Jesus; Swisher, Elizabeth M.; Floquet, Anne; Konecny, Gottfried E.; McNeish, lain A.; Scott, Clare L.; Cameron, Terri; Maloney, Lara; Isaacson, Jeff; Goble, Sandra; Grace, Caroline; Harding, Thomas C.; Raponi, Mitch; Sun, James; Lin, Kevin K.; Giordano, Heidi; Ledermann, Jonathan A. 分享 收藏
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