Isabel Nájera - Publications, H-index & Citations

Isabel Nájera

pfizer inc.

38H指数

200论文数

4.8K被引数

收录论文 74

发表时间

Utilizing Virtual Clinical Trials to Inform Target Coverage That Drives RSV Antiviral Efficacy 利用虚拟临床试验指导驱动RSV抗病毒疗效的目标覆盖

CPT-Pharmacometrics & Systems Pharmacology

IF3

2026-09-15

OAAI

J. Cody Herron; Kathryn G. Link; Natalie Meacham; Negar Niki Alami; Daniel W. Brookes; Elaine Thomas; Jan Adams; Sima S. Toussi; Ryan Franke; Cynthia J. Musante; Isabel Najera; Richard Allen; Britton Boras

Antiviral activity of nirmatrelvir against contemporary SARS-CoV-2 variants 奈玛特韦对当代SARS-CoV-2变种的抗病毒活性

Antiviral Research

IF4

2026-08-01

PREAI

Yurgelonis, Irina; Rai, Devendra K.; Lee, Jonathan T.; Li, Zhenghui; McMonagle, Patricia; Yang, Qingyi; Li, Weiqiang; Hao, Li; Rothan, Hussin A.; Washington, Brittany; Titova, Elizabeth; Behzadi, Mohammad Amin; Gribenko, Alexey; White, Kris M.; Kreiswirth, Barry N.; Zhu, Yuao; Najera, Isabel; Thomas, Elaine; Cardin, Rhonda D.; Allerton, Charlotte M. N.; Anderson, Annaliesa S.

Nanoparticle delivery of Tat synergizes with classical latency reversal agents to express HIV antigen targets Tat的纳米颗粒递送与经典的潜伏期逆转剂协同表达HIV抗原靶标

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2024-07-09

PREAI

Raines, Samuel L. M.; Falcinelli, Shane D.; Peterson, Jackson J.; Van Gulck, Ellen; Allard, Brigitte; Kirchherr, Jennifer; Vega, Jerel; Najera, Isabel; Boden, Daniel; Archin, Nancie M.; Margolis, David M.

Spiro-Azetidine Oxindoles as Long-Acting Injectables for Pre-Exposure Prophylaxis against Respiratory Syncytial Virus Infections

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-06-27

PREAI

Kesteleyn, Bart; Herschke, Florence; Darville, Nicolas; Stoops, Bart; Jacobs, Tom; Jacoby, Edgar; Shaffer, Paul; Lammens, Lieve; Van Rompaey, Dries; Matcha, Kiran; Lamenca, Carolina Martinez; Coesemans, Erwin; Hache, Geerwin; Pieters, Serge; Lecomte, Morgan; Hu, Lili; Demin, Samuel; Milligan, Cynthia; Abeywickrema, Pravien; De Bruyn, Suzanne; Van Den Berg, Joke; Ysebaert, Nina; De Zwart, Loeckie; Najera, Isabel; Rigaux, Peter; Roymans, Dirk; Jonckers, Tim H. M.

Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation

JOURNAL OF VIROLOGY

IF3.8

2024-03-19

OAAI

Berke, Jan Martin; Tan, Ying; Sauviller, Sarah; Wu, Dai-tze; Zhang, Ke; Conceicao-Neto, Nadia; Blazquez Moreno, Alfonso; Kong, Desheng; Kukolj, George; Li, Chris; Zhu, Ren; Najera, Isabel; Pauwels, Frederik

mRNA Therapeutic Vaccine for Hepatitis B Demonstrates Immunogenicity and Efficacy in the AAV-HBV Mouse Model 乙型肝炎的mRNA治疗性疫苗在aav-hbv小鼠模型中显示出免疫原性和功效

VACCINES

IF3.4

2024-02-25

OAAI

De Pooter, Dorien; Pierson, Wim; Pourshahian, Soheil; Dockx, Koen; De Clerck, Ben; Najera, Isabel; Davis, Heather; Van Gulck, Ellen; Boden, Daniel

Retreatment with HBV siRNA Results in Additional Reduction in HBV Antigenemia and Immune Stimulation in the AAV-HBV Mouse Model

VIRUSES-BASEL

IF3.5

2024-02-23

OAAI

Van Gulck, Ellen; Conceicao-Neto, Nadia; Aerts, Liese; Pierson, Wim; Verschueren, Lore; Vleeschouwer, Mara; Krishna, Vinod; Najera, Isabel; Pauwels, Frederik

Sustained Liver HBsAg Loss and Clonal T- and B-Cell Expansion upon Therapeutic DNA Vaccination Require Low HBsAg Levels

VACCINES

IF3.4

2023-12-06

OAAI

Conceicao-Neto, Nadia; Pierson, Wim; Vacca, Maurizio; Beyens, Matthias; De Clerck, Ben; Aerts, Liese; Voeten, Birgit; De Pooter, Dorien; Verschueren, Lore; Dockx, Koen; Vandenberk, Mathias; De Troyer, Ewoud; Verwilt, Kato; Van Hove, Carl; Verslegers, Mieke; Bosseler, Leslie; Crabbe, Marjolein; Krishna, Vinod; Najera, Isabel; Van Gulck, Ellen

Machine-learning based patient classification using Hepatitis B virus full-length genome quasispecies from Asian and European cohorts

SCIENTIFIC REPORTS

IF3.9

2019-12-11

OAAI

Mueller-Breckenridge, Alan J.; Garcia-Alcalde, Fernando; Wildum, Steffen; Smits, Saskia L.; de Man, Robert A.; van Campenhout, Margo J. H.; Brouwer, Willem P.; Niu, Jianjun; Young, John A. T.; Najera, Isabel; Zhu, Lina; Wu, Daitze; Racek, Tomas; Hundie, Gadissa Bedada; Lin, Yong; Boucher, Charles A.; van de Vijver, David; Haagmans, Bart L.

Nucleolar Relocalization of RBM14 by Influenza A Virus NS1 Protein

MSPHERE

IF3.1

2018-12-26

OAAI

Beyleveld, Grant; Chin, Daniel J.; Del Olmo, Elena Moreno; Carter, Jade; Najera, Isabel; Cilloniz, Cristian; Shaw, Megan L.

Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors (vol 9, e00a30-18, 2018)

MBIO

IF4.7

2018-12-21

OAAI

Jones, Jeremy C.; Kumar, Gyanendra; Barman, Subrata; Najera, Isabel; White, Stephen W.; Webby, Richard J.; Govorkova, Elena A.

Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors

MBIO

IF4.7

2018-05-02

OAAI

Jones, Jeremy C.; Kumar, Gyanendra; Barman, Subrata; Najera, Isabel; White, Stephen W.; Webby, Richard J.; Govorkova, Elena A.

Interaction between Toll-Like Receptor 9-CpG Oligodeoxynucleotides and Hepatitis B Virus Virions Leads to Entry Inhibition in Hepatocytes and Reduction of Alpha Interferon Production by Plasmacytoid Dendritic Cells Toll样受体9-CpG寡脱氧核苷酸与乙型肝炎病毒病毒粒子之间的相互作用导致肝细胞的进入抑制和浆细胞样树突状细胞减少 α 干扰素的产生

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2018-04-01

OAAI

Aillot, Ludovic; Bonnin, Marc; Ait-Goughoulte, Malika; Bendriss-Vermare, Nathalie; Maadadi, Sarah; Dimier, Laura; Subic, Miroslava; Scholtes, Caroline; Najera, Isabel; Zoulim, Fabien; Lucifora, Julie; Durantel, David

Identification of HCV Resistant Variants against Direct Acting Antivirals in Plasma and Liver of Treatment Naive Patients

SCIENTIFIC REPORTS

IF3.9

2017-07-05

OAAI

Raj, V. Stalin; Hundie, Gadissa Bedada; Schurch, Anita C.; Smits, Saskia L.; Pas, Suzan D.; Le Pogam, Sophie; Janssen, Harry L. A.; de Knegt, Rob J.; Osterhaus, Albert D. M. E.; Najera, Isabel; Boucher, Charles A.; Haagmans, Bart L.

The PA Endonuclease Inhibitor RO-7 Protects Mice from Lethal Challenge with Influenza A or B Viruses PA核酸内切酶抑制剂RO-7保护小鼠免受甲型或乙型流感病毒的致命攻击

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2017-05-01

OAAI

Jones, Jeremy C.; Marathe, Bindumadhav M.; Vogel, Peter; Gasser, Rodolfo; Najera, Isabel; Govorkova, Elena A.

Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms

SCIENTIFIC REPORTS

IF3.9

2017-02-13

132

OAAI

Zhou, Zheng; Hu, Taishan; Zhou, Xue; Wildum, Steffen; Garcia-Alcalde, Fernando; Xu, Zhiheng; Wu, Daitze; Mao, Yi; Tian, Xiaojun; Zhou, Yuan; Shen, Fang; Zhang, Zhisen; Tang, Guozhi; Najera, Isabel; Yang, Guang; Shen, Hong C.; Young, John A. T.; Qin, Ning

Association study between mannose-binding lectin haplotypes and X gene mutation of hepatitis B virus from treatment naive patients

AGING-US

IF3.9

2016-11-07

OAAI

Su, Chenghao; Lin, Yong; Mao, Qianguo; Wu, Daitze; Zhu, Lina; Najera, Isabel; Garcia-Alcalde, Fernando; Niu, Jianjun

Ritonavir-boosted danoprevir plus peginterferon alfa-2a and ribavirin in Asian chronic hepatitis C patients with or without cirrhosis 利托那韦增强的丹诺普韦加聚乙二醇干扰素alfa-2a和利巴韦林在亚洲慢性丙型肝炎患者中有无肝硬化

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

IF3.4

2016-10-27

PREAI

Kao, Jia-Horng; Tung, Shui-Yi; Lee, Younjae; Thongsawat, Satawat; Tanwandee, Tawesak; Sheen, I. -Shyan; Wu, Jinzi J.; Li, Hui; Brennan, Barbara J.; Zhou, Julian; Le Pogam, Sophie; Najera, Isabel; Thommes, James A.; Hill, George

A Novel Endonuclease Inhibitor Exhibits Broad-Spectrum Anti-Influenza Virus Activity In Vitro

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2016-09-01

OAAI

Jones, Jeremy C.; Marathe, Bindumadhav M.; Lerner, Christian; Kreis, Lukas; Gasser, Rodolfo; Pascua, Philippe Noriel Q.; Najera, Isabel; Govorkova, Elena A.

Combinations of Oseltamivir and T-705 Extend the Treatment Window for Highly Pathogenic Influenza A(H5N1) Virus Infection in Mice

SCIENTIFIC REPORTS

IF3.9

2016-05-25

OAAI

Marathe, Bindumadhav M.; Wong, Sook-San; Vogel, Peter; Garcia-Alcalde, Fernando; Webster, Robert G.; Webby, Richard J.; Najera, Isabel; Govorkova, Elena A.

研究方向