Ralph E. Parchment - Publications, H-index & Citations

Ralph E. Parchment

national institutes of health (nih) - usa

44H指数

534论文数

6.6K被引数

收录论文 112

发表时间

Multiplex immunofluorescence microscopy assays for pharmacodynamic assessment of MET tyrosine kinase activation in the plasma membrane and nucleus 多重免疫荧光显微镜检测方法用于评估MET酪氨酸激酶在质膜和细胞核中的药效动力学激活

PLoS One

IF2.6

2026-05-12

OAAI

Navas, Tony; Srivastava, Apurva K.; Lawrence, Scott M.; Hollingshead, Melinda G.; Alcoser, Sergio Y.; Miller, Sarah B.; Kinders, Robert J.; Bottaro, Donald P.; Linehan, W. Marston; Kummar, Shivaani; Doroshow, James H.; Parchment, Ralph E.

Phase I trial of the combination of bortezomib and clofarabine in adults with refractory tumors I期临床试验：评估硼替佐米与克洛拉拉滨联合方案在难治性肿瘤成人患者中的应用

Cancer Chemotherapy and Pharmacology

IF2.3

2026-03-14

OAAI

Jibran Ahmed; Andre DeSouza; Shivaani Kummar; Lawrence Rubinstein; Geraldine O’Sullivan-Coyne; Jeevan Govindharajulu; William Herrick; Kate Ferry-Galow; Li Li; Deborah F. Wilsker; Murielle Hogu; Richard Piekarz; Robert Meehan; Mohamad Adham Salkeni; Sarah Shin; Brandon Miller; Jennifer Zlott; Lamin Juwara; Karen Gray; Laura Kuhlmann; Apurva Srivastava; Ralph E. Parchment; James H. Doroshow; Naoko Takebe; Alice P. Chen

A phase 1 study of orally administered 5-fluoro-2’-deoxycytidine with tetrahydrouridine in patients with refractory solid tumors 一项关于口服给予5-氟-2’-脱氧胞苷与四氢尿嘧啶联合治疗难治性实体瘤的1期研究

Cancer Chemotherapy and Pharmacology

IF2.3

2025-12-22

OAAI

Alice P. Chen; Shivaani Kummar; Larry Rubinstein; Jennifer Zlott; Geraldine O’Sullivan Coyne; Vincent Chung; Edward M. Newman; Heinz-Josef Lenz; Karen Kelly; Liza C. Villaruz; Mariam M. Konaté; Katherine V. Ferry-Galow; Lihua Wang; Robert J. Kinders; Ralph E. Parchment; Joseph M. Covey; Julianne L. Holleran; Richard L. Piekarz; Sarah B. Miller; Lamin Juwara; Jan H. Beumer; James H. Doroshow

ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models

CELL REPORTS

IF6.9

2024-10-01

OAAI

Schmid, Sebastian; Russell, Zachary R.; Yamashita, Alex Shimura; West, Madeline E.; Parrish, Abigail G.; Walker, Julia; Rudoy, Dmytro; Yan, James Z.; Quist, David C.; Gessesse, Betemariyam N.; Alvinez, Neriah; Hill, Kimberly D.; Anderson, Larry W.; Cimino, Patrick J.; Kumasaka, Debra K.; Parchment, Ralph E.; Holland, Eric C.; Szulzewsky, Frank

Atezolizumab clinical trial biopsies reveal varied immune landscapes in clear cell sarcoma and chondrosarcoma

CANCER RESEARCH

IF16.6

2024-04-05

PREAI

Ferry-Galow, Katherine V.; Fino, Kristin K.; Coyne, Geraldine O'Sullivan; Moore, Nancy; Sharon, Elad; Burgess, Melissa; Chen, James; Conley, Anthony P.; Davis, Elizabeth J.; Merriam, Priscilla; Razak, Albiruni R. Abdul; Van Tine, Brian; Foster, Jared C.; Takebe, Naoko; Rosenberger, Christina L.; Doroshow, James H.; Chen, Alice P.; Parchment, Ralph E.

Phase 1 trial of bortezomib and clofarabine combination in adults with refractory solid tumors

CANCER RESEARCH

IF16.6

2024-04-05

PREAI

De Souza, Andre L.; Takebe, Naoko; Chen, Alice P.; Doroshow, James H.; Parchment, Ralph E.; Srivastava, Apurva K.; Rubistein, Lawrence; Wilsker, Deborah; Miller, Brandon L.; Hogu, Murielle; Coney, Geraldine O. Sullivan; Kummar, Shivaani; Govindharajulu, Jeevan; Meehan, Robert; Herrick, William G.; Dull, Angie; Ketchum, Donna; Li, Shaowei; Ji, Jiuping; Piekarz, Richard

A pharmacodynamic pilot study of DS8201a in patients with HER2 expressing advanced solid tumors

MOLECULAR CANCER THERAPEUTICS

IF5.5

2023-12-01

PREAI

Shin, Sarah J.; -Coyne, Geraldine O'Sullivan; Lee, Elizabeth K.; Mittra, Arjun; Sternberg, Cora N.; Ong, Mary Jane; Wilsker, Deborah; Ferry-Galow, Katherine; Foster, Jared; Juwara, Lamin; Takebe, Naoko; Pickett, Cheryl A.; Parchment, Ralph; Doroshow, James; Chen, Alice

Pharmacodynamics-driven phase 2 trial of talazoparib in patients with advanced solid tumors and aberrations in genes involved in DNA damage response

MOLECULAR CANCER THERAPEUTICS

IF5.5

2023-12-01

PREAI

Ko, Brian; Coyne, Geraldine H. O'Sullivan; Nagash, Abdul Rafeh; George, Thomas J.; DeRemer, David; Rubinstein, Larry; Zlott, Jennifer; Wilsker, Deborah; Ketchum, Donna; Runkle, Stephanie; Ferry-Galow, Katherine V.; Parchment, Ralph E.; Takebe, Naoko; Shin, Sarah; Voth, Andrea R.; Ji, Jiuping; Ivy, S. Percy; Doroshow, James H.; Chen, Alice P.

Atezolizumab for Advanced Alveolar Soft Part Sarcoma

NEW ENGLAND JOURNAL OF MEDICINE

IF78.5

2023-09-07

OAAI

Chen, Alice P.; Sharon, Elad; O'Sullivan-Coyne, Geraldine; Moore, Nancy; Foster, Jared C.; Hu, James S.; Van Tine, Brian A.; Conley, Anthony P.; Read, William L.; Riedel, Richard F.; Burgess, Melissa A.; Glod, John; Davis, Elizabeth J.; Merriam, Priscilla; Naqash, Abdul R.; Fino, Kristin K.; Miller, Brandon L.; Wilsker, Deborah F.; Begum, Asma; Ferry-Galow, Katherine V.; Deshpande, Hari A.; Schwartz, Gary K.; Ladle, Brian H.; Okuno, Scott H.; Beck, Jill C.; Chen, James L.; Takebe, Naoko; Fogli, Laura K.; Rosenberger, Christina L.; Parchment, Ralph E.; Doroshow, James H.

Redox phospholipidomics discovers pro-ferroptotic death signals in A375 melanoma cells in vitro and in vivo 氧化还原磷脂组学在体外和体内发现A375黑色素瘤细胞中的亲铁死亡信号

REDOX BIOLOGY

IF11.9

2023-05-01

OAAI

Tyurina, Yulia Y.; Kapralov, Alexandr A.; Tyurin, Vladimir A.; Shurin, Galina; Amoscato, Andrew A.; Rajasundaram, Dhivyaa; Tian, Hua; Bunimovich, Yuri L.; Nefedova, Yulia; Herrick, William G.; Parchment, Ralph E.; Doroshow, James H.; Bayir, Hulya; Srivastava, Apurva K.; Kagan, Valerian E.

Novel multiplexed assays of ferroptosis, pyroptosis and necroptosis biomarkers for translational studies

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Herrick, William G.; Govindharajulu, Jeevan; Parchment, Ralph E.; Doroshow, James H.; Srivastava, Apurva K.

Establishment and characterization of a novel clear cell sarcoma organoid model derived from a human biopsy

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Campbell, Petreena S.; Harris, Erik D.; Moore, Nancy; Parchment, Ralph E.; Coussens, Nathan P.; Teicher, Beverly A.; Chen, Alice; Doroshow, James H.; Rapisarda, Annamaria

Biochemical inhibition profiles of 370 wild type human kinases provide a basis for selecting alternative combinations of EGFR and VEGFR inhibitors

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Coussens, Nathan P.; Dexheimer, Thomas S.; Silvers, Thomas; Uzelac, Shannon; Georgius, Kyle; Carter, John; Shearer, Tia; Rao, Rekha; Gray, Karen; Srivastava, Apurva K.; Kinders, Robert J.; Evrard, Yvonne A.; Hollingshead, Melinda G.; Morris, Joel; Moscow, Jeffrey A.; Parchment, Ralph E.; Teicher, Beverly A.; Doroshow, James H.

Combination therapies in matched 3D in vitro and in vivo preclinical models of rare and recalcitrant cancers from the National Cancer Institute's Patient-Derived Models Repository

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Dexheimer, Thomas S.; Silvers, Thomas; Delosh, Rene; Reinhart, Russell; Ogle, Chad; Davoudi, Zahra; Jones, Eric; Trail, Debbie; Carter, John; Mills, Justine; Georgius, Kyle; Stotler, Howard; Norris, Michelle; Uzelac, Shannon; Borgel, Suzanne; Minor, Tiffanie; Stockwin, Luke; Mullendore, Michael; Plater, Kevin; Kalmbach, Keegan; Steed, Jessica; Murphy, Matthew; Bliss, Gareth; Bonomi, Carrie; Dougherty, Kelly; Gibson, Marion; Cooper, Kevin; Newton, Dianne; Timme, Cindy R.; Evrard, Yvonne A.; Hollingshead, Melinda G.; Coussens, Nathan P.; Parchment, Ralph E.; Doroshow, James H.; Teicher, Beverly A.

Advancing a screening platform with panels of patient-derived organoid models for drug discovery and development

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Rapisarda, Annamaria; Jones, Eric; Hose, Curtis; Harris, Erik; Campbell, Petreena S.; Ortiz, Mariaestela; Connelly, John; Mahashetty, Nanda; Silvers, Thomas; Davoudi, Zahra; Brady, Penny Sellers; Rohrer, Tiffany Nikirk; Grams, Julie; Martin, Karen; Ramsey, Patricia; Bowles, Lori; Britt, John R.; Parchment, Ralph E.; Dexheimer, Thomas S.; Teicher, Beverly A.; Doroshow, James H.; Coussens, Nathan P.

Antibody validation for clinical pharmacodynamic assay reveals cross-reactivity of commercial DNMT3B clones

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Benton, Gabriel J.; Mohandoss, Manisha; Doroshow, James H.; Parchment, Ralph E.; Ferry-Galow, Katherine V.

Determinants of birinapant efficacy in triple negative breast cancer

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Brown, Elisabeth A.; Yang, Chieh-Hsiang; Cortes-Sanchez, Emilio; Chu, Zhengtao; Govindharajulu, Jeevan; Parchment, Ralph; Doroshow, James; Srivastava, Apurva; Welm, Alana

Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis

CANCER BIOLOGY & THERAPY

IF4.6

2022-04-07

OAAI

Chen, Zibo; Zheng, Lin; Chen, Yulong; Liu, Xiuxia; Kawakami, Masanori; Mustachio, Lisa Maria; Roszik, Jason; Ferry-Galow, Katherine V.; Parchment, Ralph E.; Liu, Xin; Andresson, Thorkell; Duncan, Gerard; Kurie, Jonathan M.; Rodriguez-Canales, Jaime; Liu, Xi; Dmitrovsky, Ethan

Phase II trial of TRC102 (methoxyamine HCl) in combination with temozolomide (TMZ) in patients with advanced non-small cell lung cancer

MOLECULAR CANCER THERAPEUTICS

IF5.5

2021-12-01

PREAI

Salkeni, Mohamad A.; Coyne, Geraldine O'Sullivan; Zlott, Jennifer; Takebe, Naoko; Ma, Ning; Rubinstein, Larry; Piekarz, Richard; Foster, Jared; Miller, Brandon; Parchment, Ralph; Naqash, Abdul R.; Voth, Andrea; Doroshow, James; Chen, Alice

Combination therapy with pazopanib and tivantinib modulates VEGF and c-MET levels in refractory advanced solid tumors

INVESTIGATIONAL NEW DRUGS

IF2.7

2021-06-28

OAAI

Kummar, Shivaani; Srivastava, Apurva K.; Navas, Tony; Cecchi, Fabiola; Lee, Young H.; Bottaro, Donald P.; Park, Sook Ryun; Do, Khanh T.; Jeong, Woondong; Johnson, Barry C.; Voth, Andrea R.; Rubinstein, Larry; Wright, John J.; Parchment, Ralph E.; Doroshow, James H.; Chen, Alice P.

研究方向