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Preemptive optimization of a clinical antibody for broad neutralization of SARS-CoV-2 variants and robustness against viral escape 针对SARS-CoV-2变体广泛中和及抗病毒逃逸的临床抗体前瞻性优化 Zhu, Fangqiang; Rajan, Saravanan; Hayes, Conor F.; Kwong, Ka Yin; Goncalves, Andre R.; Zemla, Adam T.; Lau, Edmond Y.; Zhang, Yi; Cai, Yingyun; Goforth, John W.; Landajuela, Mikel; Gilchuk, Pavlo; Kierny, Michael; Dippel, Andrew; Amofah, Bismark; Kaplan, Gilad; Peano, Vanessa Cadevilla; Morehouse, Christopher; Sparklin, Ben; Gopalakrishnan, Vancheswaran; Tuffy, Kevin M.; Nguyen, Amy; Beloor, Jagadish; Kijak, Gustavo; Liu, Chang; Dijokaite-Guraliuc, Aiste; Mongkolsapaya, Juthathip; Screaton, Gavin R.; Petersen, Brenden K.; Desautels, Thomas A.; Bennett, Drew; Segelke, Brent W.; Arrildt, Kathryn T.; Kaul, Samantha; Grzesiak, Emilia A.; da Silva, Felipe Leno; Bates, Thomas W.; Earnhart, Christopher G.; Hopkins, Svetlana; Sundaram, Shivshankar; Esser, Mark T.; Francica, Joseph R.; Faissol, Daniel M.; LLNL Generative Unconstrained Intelligent Drug Engn GUIDE Consortium 分享 收藏
The molecular reach of antibodies crucially underpins their viral neutralisation capacity (vol 16, 338, 2025) 抗体的分子作用范围对其病毒中和能力至关重要 (vol 16, 338, 2025) Huhn, Anna; Nissley, Daniel; Wilson, Daniel B.; Kutuzov, Mikhail A.; Donat, Robert; Tan, Tiong Kit; Zhang, Ying; Barton, Michael I.; Liu, Chang; Dejnirattisai, Wanwisa; Supasa, Piyada; Mongkolsapaya, Juthathip; Townsend, Alain; James, William; Screaton, Gavin; van der Merwe, P. Anton; Isaacson, Samuel A. 分享 收藏
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Oligomerization- driven avidity correlates with SARS- CoV-2 cellular binding and inhibition Asor, Roi; Olerinyova, Anna; Burnap, Sean A.; Kushwah, Manish S.; Soltermann, Fabian; Rudden, Lucas S. P.; Hensen, Mario; Vasiljevic, Snezana; Brun, Juliane; Hill, Michelle; Chang, Liu; Dejnirattisai, Wanwisa; Supasa, Piyada; Mongkolsapaya, Juthathip; Zhou, Daming; Stuart, David I.; Screaton, Gavin R.; Degiacomi, Matteo T.; Zitzmann, Nicole; Benesch, Justin L. P.; Struwe, Weston B.; Kukura, Philipp 分享 收藏
AZD3152 neutralizes SARS-CoV-2 historical and contemporary variants and is protective in hamsters and well tolerated in adults Cai, Yingyun; Diallo, Seme; Rosenthal, Kim; Ren, Kuishu; Flores, Daniel J.; Dippel, Andrew; Oganesyan, Vaheh; van Dyk, Nydia; Chen, Xiaoru; Cantu, Erin; Choudhary, Rakesh; Sulikowski, Michal; Adissu, Hibret; Chawla, Bhavna; Kar, Swagata; Liu, Chang; Dijokaite-Guraliuc, Aiste; Mongkolsapaya, Juthathip; Rajan, Saravanan; Loo, Yueh-Ming; Beavon, Rohini; Webber, Chris; Chang, Lee-Jah; Thomas, Steven; Clegg, Lindsay; Zhang, Huixia; Screaton, Gavin R.; Philbin, Nora; Harre, Mark; Selim, Abdulhafez; Martinez-Alier, Nuria; Uriel, Alison; Cohen, Taylor S.; Perez, John L.; Esser, Mark T.; Blair, Wade; Francica, Joseph R. 分享 收藏
Comparative analysis of SARS-CoV-2 neutralization titers reveals consistency between human and animal model serum and across assays Muehlemann, Barbara; Wilks, Samuel H.; Baracco, Lauren; Bekliz, Meriem; Carreno, Juan Manuel; Corman, Victor M.; Davis-Gardner, Meredith E.; Dejnirattisai, Wanwisa; Diamond, Michael S.; Douek, Daniel C.; Drosten, Christian; Eckerle, Isabella; Edara, Venkata-Viswanadh; Ellis, Madison; Fouchier, Ron A. M.; Frieman, Matthew; Godbole, Sucheta; Haagmans, Bart; Halfmann, Peter J.; Henry, Amy R.; Jones, Terry C.; Katzelnick, Leah C.; Kawaoka, Yoshihiro; Kimpel, Janine; Krammer, Florian; Lai, Lilin; Liu, Chang; Lusvarghi, Sabrina; Meyer, Benjamin; Mongkolsapaya, Juthathip; Montefiori, David C.; Mykytyn, Anna; Netzl, Antonia; Pollett, Simon; Roessler, Annika; Screaton, Gavin R.; Shen, Xiaoying; Sigal, Alex; Simon, Viviana; Subramanian, Rahul; Supasa, Piyada; Suthar, Mehul S.; Tuereli, Sina; Wang, Wei; Weiss, Carol D.; Smith, Derek J. 分享 收藏
A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity Liu, Chang; Zhou, Daming; Dijokaite-Guraliuc, Aiste; Supasa, Piyada; Duyvesteyn, Helen M. E.; Ginn, Helen M.; Selvaraj, Muneeswaran; Mentzer, Alexander J.; Das, Raksha; de Silva, Thushan I.; Ritter, Thomas G.; Plowright, Megan; Newman, Thomas A. H.; Stafford, Lizzie; Kronsteiner, Barbara; Temperton, Nigel; Lui, Yuan; Fellermeyer, Martin; Goulder, Philip; Klenerman, Paul; Dunachie, Susanna J.; Barton, Michael I.; Kutuzov, Mikhail A.; Dushek, Omer; Fry, Elizabeth E.; Mongkolsapaya, Juthathip; Ren, Jingshan; Stuart, David I.; Screaton, Gavin R. 分享 收藏
Emerging variants develop total escape from potent monoclonal antibodies induced by BA.4/5 infection Liu, Chang; Das, Raksha; Dijokaite-Guraliuc, Aiste; Zhou, Daming; Mentzer, Alexander J.; Supasa, Piyada; Selvaraj, Muneeswaran; Duyvesteyn, Helen M. E.; Ritter, Thomas G.; Temperton, Nigel; Klenerman, Paul; Dunachie, Susanna J.; Paterson, Neil G.; Williams, Mark A.; Hall, David R.; Fry, Elizabeth E.; Mongkolsapaya, Juthathip; Ren, Jingshan; Stuart, David I.; Screaton, Gavin R. 分享 收藏
The SARS-CoV-2 neutralizing antibody response to SD1 and its evasion by BA.2.86 Zhou, Daming; Supasa, Piyada; Liu, Chang; Dijokaite-Guraliuc, Aiste; Duyvesteyn, Helen M. E.; Selvaraj, Muneeswaran; Mentzer, Alexander J.; Das, Raksha; Dejnirattisai, Wanwisa; Temperton, Nigel; Klenerman, Paul; Dunachie, Susanna J.; Fry, Elizabeth E.; Mongkolsapaya, Juthathip; Ren, Jingshan; Stuart, David I.; Screaton, Gavin R. 分享 收藏
Heterologous prime-boost immunization induces protection against dengue virus infection in cynomolgus macaques Keelapang, Poonsook; Ketloy, Chutitorn; Puttikhunt, Chunya; Sriburi, Rungtawan; Prompetchara, Eakachai; Sae-Lim, Malinee; Siridechadilok, Bunpote; Duangchinda, Thaneeya; Noisakran, Sansanee; Charoensri, Nicha; Suriyaphol, Prapat; Suparattanagool, Piyanan; Utaipat, Utaiwan; Masrinoul, Promsin; Avirutnan, Panisadee; Mongkolsapaya, Juthathip; Screaton, Gavin; Auewarakul, Prasert; Malaivijitnond, Suchinda; Yoksan, Sutee; Malasit, Prida; Ruxrungtham, Kiat; Pulmanausahakul, Rojjanaporn; Sittisombut, Nopporn 分享 收藏
Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history 疫苗接种后的Omicron感染可增强依赖于感染史的广泛免疫反应 Hornsby, Hailey R.; Nicols, Alexander R.; Longet, Stephanie; Liu, Chang; Tomic, Adriana; Angyal, Adrienn; Kronsteiner, Barbara K.; Tyerman, Jessica K.; Tipton, Tom; Zhang, Peijun; Gallis, Marta; Supasa, Piyada; Selvaraj, Muneeswaran; Abraham, Priyanka; Neale, Isabel; Ali, Mohammad A.; Barratt, Natalie M.; Nell, Jeremy; Gustafsson, Lotta; Strickland, Scarlett; Grouneva, Irina; Rostron, Timothy C.; Moore, Shona M.; Hering, Luisa L.; Dobson, Susan L.; Bibi, Sagida; Mongkolsapaya, Juthathip; Lambe, Teresa; Wootton, Dan; Hall, Victoria; Hopkins, Susan; Dong, Tao; Barnes, Eleanor; Screaton, Gavin; Richter, Alex; Turtle, Lance; Rowland-Jones, Sarah L.; Carroll, Miles; Duncan, Christopher J. A.; Klenerman, Paul; Dunachie, Susanna J.; Payne, Rebecca P.; de Silva, Thushan, I 分享 收藏
Blockade-of-Binding Activities toward Envelope-Associated, Type-Specific Epitopes as a Correlative Marker for Dengue Virus-Neutralizing Antibody Keelapang, Poonsook; Kraivong, Romchat; Pulmanausahakul, Rojjanaporn; Sriburi, Rungtawan; Prompetchara, Eakachai; Kaewmaneephong, Jutamart; Charoensri, Nicha; Pakchotanon, Pattarakul; Duangchinda, Thaneeya; Suparattanagool, Piyanan; Luangaram, Prasit; Masrinoul, Promsin; Mongkolsapaya, Juthathip; Screaton, Gavin; Ruxrungtham, Kiat; Auewarakul, Prasert; Yoksan, Sutee; Malasit, Prida; Puttikhunt, Chunya; Ketloy, Chutitorn; Sittisombut, Nopporn 分享 收藏
Inhibition of phosphodiesterase 12 results in antiviral activity against several RNA viruses including SARS- CoV-2 Thursz, Mark; Sadiq, Fouzia; Tree, Julia A.; Karayiannis, Peter; Beasley, David W. C.; Dejnirattisai, Wanwissa; Mongkolsapaya, Juthathip; Screaton, Gavin; Wand, Matthew; Elmore, Michael J.; Carroll, Miles W.; Matthews, Ian; Thomas, Howard 分享 收藏
Accelerating drug target inhibitor discovery with a deep generative foundation model Chenthamarakshan, Vijil; Hoffman, Samuel C.; Owen, C. David; Lukacik, Petra; Strain-Damerell, Claire; Fearon, Daren; Malla, Tika R.; Tumber, Anthony; Schofield, Christopher J.; Duyvesteyn, Helen M. E.; Dejnirattisai, Wanwisa; Carrique, Loic; Walter, Thomas S.; Screaton, Gavin R.; Matviiuk, Tetiana; Mojsilovic, Aleksandra; Crain, Jason; Walsh, Martin A.; Stuart, David I.; Das, Payel 分享 收藏
Generation of SARS-CoV-2 escape mutations by monoclonal antibody therapy Ragonnet-Cronin, Manon; Nutalai, Rungtiwa; Huo, Jiandong; Dijokaite-Guraliuc, Aiste; Das, Raksha; Tuekprakhon, Aekkachai; Supasa, Piyada; Liu, Chang; Selvaraj, Muneeswaran; Groves, Natalie; Hartman, Hassan; Ellaby, Nicholas; Sutton, J. Mark; Bahar, Mohammad W.; Zhou, Daming; Fry, Elizabeth; Ren, Jingshan; Brown, Colin; Klenerman, Paul; Dunachie, Susanna J.; Mongkolsapaya, Juthathip; Hopkins, Susan; Chand, Meera; Stuart, David I.; Screaton, Gavin R.; Rokadiya, Sakib 分享 收藏
Persistence of immune response in heterologous COVID vaccination schedules in the Com-COV2 study-A single-blind, randomised trial incorporating mRNA, viral-vector and protein-adjuvant vaccines Com-COV2研究中异源COVID疫苗接种计划中免疫反应的持久性-一项纳入mRNA，病毒载体和蛋白质佐剂疫苗的单盲，随机试验 Shaw, Robert H.; Greenland, Melanie; Stuart, Arabella S. V.; Aley, Parvinder K.; Andrews, Nick J.; Cameron, J. Claire; Charlton, Sue; Clutterbuck, Elizabeth A.; Collins, Andrea M.; Darton, Tom; Dinesh, Tanya; Duncan, Christopher J. A.; Faust, Saul N.; Ferreira, Daniela M.; Finn, Adam; Goodman, Anna L.; Green, Christopher A.; Hallis, Bassam; Heath, Paul T.; Hill, Helen; Lambe, Teresa; Libri, Vincenzo; Lillie, Patrick J.; Morey, Ella; Mujadidi, Yama F.; Payne, Ruth; Plested, Emma L.; Provstgaard-Morys, Samuel; Ramasamy, Maheshi N.; Ramsay, Mary; Read, Robert C.; Robinson, Hannah; Screaton, Gavin R.; Singh, Nisha; Turner, David P. J.; Turner, Paul J.; White, Rachel; Nguyen-Van-Tam, Jonathan S.; Liu, Xinxue; Snape, Matthew D. 分享 收藏
Evaluation of T cell responses to naturally processed variant SARS-CoV-2 spike antigens in individuals following infection or vaccination 评估感染或接种疫苗后个体对自然加工的变异SARS-CoV-2刺突抗原的T细胞反应 Yin, Zixi; Chen, Ji-Li; Lu, Yongxu; Wang, Beibei; Godfrey, Leila; Mentzer, Alexander J.; Yao, Xuan; Liu, Guihai; Wellington, Dannielle; Zhao, Yiqi; Wing, Peter A. C.; Dejnirattisa, Wanwisa; Supasa, Piyada; Liu, Chang; Hublitz, Philip; Beveridge, Ryan; Waugh, Craig; Clark, Sally-Ann; Clark, Kevin; Sopp, Paul; Rostron, Timothy; Mongkolsapaya, Juthathip; Screaton, Gavin R.; Ogg, Graham; Ewer, Katie; Pollard, Andrew J.; Gilbert, Sarah; Knight, Julian C.; Lambe, Teresa; Smith, Geoffrey L.; Dong, Tao; Peng, Yanchun 分享 收藏
Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens 不同新型冠状病毒肺炎疫苗接种方案后医护人员长期疫苗诱导和杂交免疫的演变 Moore, Shona C.; Kronsteiner, Barbara; Longet, Stephanie; Adele, Sandra; Deeks, Alexandra S.; Liu, Chang; Dejnirattisai, Wanwisa; Reyes, Laura Silva; Meardon, Naomi; Faustini, Sian; Al-Taei, Saly; Tipton, Tom; Hering, Luisa M.; Angyal, Adrienn; Brown, Rebecca; Nicols, Alexander R.; Dobson, Susan L.; Supasa, Piyada; Tuekprakhon, Aekkachai; Cross, Andrew; Tyerman, Jessica K.; Hornsby, Hailey; Grouneva, Irina; Plowright, Megan; Zhang, Peijun; Newman, Thomas A. H.; Nell, Jeremy M.; Abraham, Priyanka; Ali, Mohammad; Malone, Tom; Neale, Isabel; Phillips, Eloise; Wilson, Joseph D.; Murray, Sam M.; Zewdie, Martha; Shields, Adrian; Horner, Emily C.; Booth, Lucy H.; Stafford, Lizzie; Bibi, Sagida; Wootton, Daniel G.; Mentzer, Alexander J.; Conlon, Christopher P.; Jeffery, Katie; Matthews, Philippa C.; Pollard, Andrew J.; Brown, Anthony; Rowland-Jones, Sarah L.; Mongkolsapaya, Juthathip; Payne, Rebecca P.; Dold, Christina; Lambe, Teresa; Thaventhiran, James E. D.; Screaton, Gavin; Barnes, Eleanor; Hopkins, Susan; Hall, Victoria; Ducan, Christopher J. A.; Richter, Alex; Carroll, Miles; de Silva, Thushan I.; Klenerman, Paul; Dunachie, Susann; Turtle, Lance; PITCH Consortium 分享 收藏
A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75 Huo Jiandong; Dijokaite-Guraliuc, Aiste; Liu Chang; Zhou Daming; Ginn, Helen M.; Das, Raksha; Supasa, Piyada; Selvaraj, Muneeswaran; Nutalai, Rungtiwa; Tuekprakhon, Aekkachai; Duyvesteyn, Helen M. E.; Mentzer, Alexander J.; Skelly, Donal; Ritter, Thomas G.; Amini, Ali; Bibi, Sagida; Adele, Sandra; Johnson, Sile Ann; Paterson, Neil G.; Williams, Mark A.; Hall, David R.; Plowright, Megan; Newman, Thomas A. H.; Hornsby, Hailey; de Silva, Thushan, I; Temperton, Nigel; Klenerman, Paul; Barnes, Eleanor; Dunachie, Susanna J.; Pollard, Andrew J.; Lambe, Teresa; Goulder, Philip; Fry, Elizabeth E.; Mongkolsapaya, Juthathip; Ren, Jingshan; Stuart, David I.; Screaton, Gavin R. 分享 收藏
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