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Prolonged XPO1 inhibition is essential for optimal antileukemic activity in NPM1-mutated AML Pianigiani, Giulia; Gagliardi, Andrea; Mezzasoma, Federica; Rocchio, Francesca; Tini, Valentina; Bigerna, Barbara; Sportoletti, Paolo; Caruso, Simona; Marra, Andrea; Peruzzi, Sara; Petito, Eleonora; Spinozzi, Giulio; Shacham, Sharon; Landesman, Yosef; Quintarelli, Concetta; Gresele, Paolo; Locatelli, Franco; Brunetti, Lorenzo; Martelli, Maria Paola; Falini, Brunangelo 分享 收藏
Nuclear Export Inhibition for Radiosensitization: A Proof-of-Concept Phase 1 Clinical Trial of Selinexor (KPT-330) Combined With Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer Lawrence, Yaacov R.; Shacham-Shmueli, Einat; Yarom, Nirit; Khaikin, Marat; Venturero, Moris; Apter, Sara; Inbar, Yael; Symon, Zvi; Aderka, Dan; Halpern, Naama; Berger, Raanan; Boursi, Ben; Jacobson, Galia; Raskin, Stephen; Ackerstein, Aliza; Margalit, Ofer; Appel, Sarit; Schvimer, Michael; Crochiere, Marsha; Yang, Fan; Landesman, Yosef; Rashal, Tami; Shacham, Sharon; Golan, Talia 分享 收藏
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Oral eltanexor treatment of patients with higher-risk myelodysplastic syndrome refractory to hypomethylating agents Lee, Sangmin; Mohan, Sanjay; Knupp, Jessica; Chamoun, Kamal; de Jonge, Adrienne; Yang, Fan; Baloglu, Erkan; Shah, Jatin; Kauffman, Michael G.; Shacham, Sharon; Bhatnagar, Bhavana 分享 收藏
A phase 1 study of the safety, pharmacokinetics and pharmacodynamics of escalating doses followed by dose expansion of the selective inhibitor of nuclear export (SINE) selinexor in Asian patients with advanced or metastatic malignancies Ho, Jingshan; Heong, Valerie; Yong, Wei Peng; Soo, Ross; Chee, Cheng Ean; Wong, Andrea; Sundar, Raghav; Thian, Yee Liang; Gopinathan, Anil; Pang, Mei Yan; Koe, Priscillia; Jeraj, Santhiay Nathan; Soe, Phyu Pyar; Soe, Mu Yar; Tang, Tiffany; Ng, Matthew C. H.; Tai, David W. M.; Tan, Tira J. Y.; Xu, Hongmei; Chang, Hua; Landesman, Yosef; Shah, Jatin; Shacham, Sharon; Lee, Soo Chin; Tan, Daniel S. W.; Goh, Boon Cher; Tan, David S. P. 分享 收藏
Efficacy and tolerability of once-weekly selinexor, bortezomib, and dexamethasone in comparison with standard twice-weekly bortezomib and dexamethasone in previously treated multiple myeloma with renal impairment: Subgroup analysis from the BOSTON study Delimpasi, Sosana; Mateos, Maria Victoria; Auner, Holger W.; Gavriatopoulou, Maria; Dimopoulos, Meletios A.; Quach, Hang; Pylypenko, Halyna; Hajek, Roman; Leleu, Xavier; Dolai, Tuphan Kanti; Sinha, Dinesh Kumar; Venner, Christopher P.; Benjamin, Reuben; Garg, Mamta Krishnan; Doronin, Vadim; Levy, Yair; Moreau, Philippe; Chai, Yi; Arazy, Melina; Shah, Jatin; Shacham, Sharon; Kauffman, Michael G.; Richardson, Paul G.; Grosicki, Sebastian 分享 收藏
A phase 1 clinical trial of oral eltanexor in patients with relapsed or refractory multiple myeloma Cornell, Robert Frank; Baz, Rachid; Richter, Joshua R.; Rossi, Adriana; Vogl, Dan T.; Chen, Christine; Shustik, Chaim; Alvarez, Mariano J.; Shen, Yao; Unger, T. J.; Ben-Shahar, Osnat; Wang, Hongwei; Baloglu, Erkan; Senapedis, William; Ma, Xiwen; Landesman, Yosef; Bai, Xiang; Bader, Justin; Xu, Hongmei; Marshall, Tracey; Chang, Hua; Walker, Christopher J.; Shah, Jatin; Shacham, Sharon; Kauffman, Michael G.; Hofmeister, Craig C. 分享 收藏
Once weekly selinexor, carfilzomib and dexamethasone in carfilzomib non-refractory multiple myeloma patients Gasparetto, Cristina; Schiller, Gary J.; Tuchman, Sascha A.; Callander, Natalie S.; Baljevic, Muhamed; Lentzsch, Suzanne; Rossi, Adriana C.; Kotb, Rami; White, Darrell; Bahlis, Nizar J.; Chen, Christine, I; Sutherland, Heather J.; Madan, Sumit; LeBlanc, Richard; Sebag, Michael; Venner, Christopher P.; Bensinger, William, I; Biran, Noa; Ammu, Sonia; Ben-Shahar, Osnat; DeCastro, Andrew; Van Domelen, Dane; Zhou, Tianjun; Zhang, Chris; Bentur, Ohad S.; Shah, Jatin; Shacham, Sharon; Kauffman, Michael; Lipe, Brea 分享 收藏
Quality of life analyses in patients with multiple myeloma: results from the Selinexor (KPT-330) Treatment of Refractory Myeloma (STORM) phase 2b study Tremblay, Gabriel; Daniele, Patrick; Breeze, Janis; Li, Lingling; Shah, Jatin; Shacham, Sharon; Kauffman, Michael; Engelhardt, Monika; Chari, Ajaj; Nooka, Ajay; Vogl, Dan; Gavriatopoulou, Maria; Dimopoulos, Meletios-Athanasios; Richardson, Paul; Biran, Noa; Siegel, David; Vlummens, Philip; Doyen, Chantal; Facon, Thierry; Mohty, Mohamad; Meuleman, Nathalie; Levy, Moshe; Costa, Luciano; Hoffman, James E.; Delforge, Michel; Kaminetzky, David; Weisel, Katja; Raab, Marc; Dingli, David; Tuchman, Sascha; Laurent, Frenzel; Vij, Ravi; Schiller, Gary; Moreau, Philippe; Richter, Joshua; Schreder, Martin; Podar, Klaus; Parker, Terri; Cornell, Robert Frank; Lionel, Karlin; Choquet, Sylvain; Sundar, Jagannath 分享 收藏
Open-label phase I/II study evaluating the tolerability and antitumor activity of selinexor (SEL) and pembrolizumab (pembro) in colorectal cancer (CRC) Shentzer Kutiel, T.; Golan, T.; Geva, R.; Gottfried, M.; Zick, A.; Shai, A.; Dudnik, J.; Netiv, E.; Yang, F.; Sharoni, S.; Meng, C.; Duic, P.; Michel, D.; Sbar, E.; Shah, J.; Kauffman, M. G.; Shacham, S.; Zer, A. 分享 收藏
Open-label phase I/II study evaluating the tolerability and anti-tumor activity of selinexor (SEL) and docetaxel (DTX) in non-small cell lung cancer (NSCLC) Zer, A.; Dudnik, J.; Shamai, S.; Gottfried, M.; Zick, A.; Shai, A.; Kutiel, T. Shentzer; Netiv, E.; Yang, F.; Sharoni, S.; Meng, C.; Duic, P.; Michel, D.; Sbar, E.; Shah, J.; Kauffman, M. G.; Shacham, S.; Golan, T. 分享 收藏
Survival among patients with relapsed/refractory diffuse large B cell lymphoma treated with single-agent selinexor in the SADAL study Maerevoet, Marie; Zijlstra, Josee M.; Follows, George; Casasnovas, Rene-Olivier; Vermaat, J. S. P.; Kalakonda, Nagesh; Goy, Andre; Choquet, Sylvain; Van den Neste, Eric; Hill, Brian; Thieblemont, Catherine; Cavallo, Federica; De la Cruz, Fatima; Kuruvilla, John; Hamad, Nada; Jaeger, Ulrich; Caimi, Paolo; Gurion, Ronit; Warzocha, Krzysztof; Bakhshi, Sameer; Sancho, Juan-Manuel; Schuster, Michael; Egyed, Miklos; Offner, Fritz; Vassilakopoulos, Theodoros P.; Samal, Priyanka; Ku, Matthew; Ma, Xiwen; Corona, Kelly; Chamoun, Kamal; Shah, Jatin; Shacham, Sharon; Kauffman, Michael G.; Canales, Miguel 分享 收藏
Peripheral neuropathy symptoms, pain, and functioning in previously treated multiple myeloma patients treated with selinexor, bortezomib, and dexamethasone Sanchez, Larysa; Leleu, Xavier; Beaumont, Jennifer L.; Yu, Hailin; Hudgens, Stacie; Simonova, Maryana; Auner, Holger W.; Quach, Hang; Delimpasi, Sosana; Spicka, Ivan; Pour, Ludek; Kriachok, Iryna; Dimopoulos, Meletios A.; Usenko, Ganna; Hajek, Roman; Benjamin, Reuben; Sinha, Dinesh Kumar; Venner, Christopher; Illmer, Thomas; Garg, Mamta Krishnan; Stevens, Don Ambrose; Jagannath, Sundar; Levy, Moshe; Anderson, Larry D., Jr.; Bahlis, Nizar Jacques; Facon, Thierry; Cavo, Michele; Chai, Yi; Ma, Xiwen; Tang, Shijie; Leong, Hoyee; Shah, Jatin; Shacham, Sharon; Kauffman, Michael; Richardson, Paul; Grosicki, Sebastian 分享 收藏
Selinexor, bortezomib, and dexamethasone versus bortezomib and dexamethasone in previously treated multiple myeloma: Outcomes by cytogenetic risk Richard, Shambavi; Chari, Ajai; Delimpasi, Sosana; Simonova, Maryana; Spicka, Ivan; Pour, Ludek; Kriachok, Iryna; Dimopoulos, Meletios A.; Pylypenko, Halyna; Auner, Holger W.; Leleu, Xavier; Usenko, Ganna; Hajek, Roman; Benjamin, Reuben; Dolai, Tuphan Kanti; Sinha, Dinesh Kumar; Venner, Christopher P.; Garg, Mamta; Stevens, Don Ambrose; Quach, Hang; Jagannath, Sundar; Moreau, Phillipe; Levy, Moshe; Badros, Ashraf; Anderson, Larry D., Jr.; Bahlis, Nizar J.; Facon, Thierry; Mateos, Maria Victoria; Cavo, Michele; Chang, Hua; Landesman, Yosef; Chai, Yi; Arazy, Melina; Shah, Jatin; Shacham, Sharon; Kauffman, Michael G.; Grosicki, Sebastian; Richardson, Paul G. 分享 收藏
Effect of age and frailty on the efficacy and tolerability of once-weekly selinexor, bortezomib, and dexamethasone in previously treated multiple myeloma Auner, Holger W.; Gavriatopoulou, Maria; Delimpasi, Sosana; Simonova, Maryana; Spicka, Ivan; Pour, Ludek; Dimopoulos, Meletios A.; Kriachok, Iryna; Pylypenko, Halyna; Leleu, Xavier; Doronin, Vadim; Usenko, Ganna; Hajek, Roman; Benjamin, Reuben; Dolai, Tuphan Kanti; Sinha, Dinesh Kumar; Venner, Christopher P.; Garg, Mamta; Stevens, Don Ambrose; Quach, Hang; Jagannath, Sundar; Moreau, Phillipe; Levy, Moshe; Badros, Ashraf; Anderson, Larry D., Jr.; Bahlis, Nizar J.; Facon, Thierry; Victoria Mateos, Maria; Cavo, Michele; Chai, Yi; Arazy, Melina; Shah, Jatin; Shacham, Sharon; Kauffman, Michael G.; Richardson, Paul G.; Grosicki, Sebastian 分享 收藏
Health-related quality of life and pain with selinexor in patients with advanced dedifferentiated liposarcoma Gounder, Mrinal; Abdul Razak, Albiruni R.; Gilligan, Adrienne M.; Leong, Hoyee; Ma, Xiwen; Somaiah, Neeta; Chawla, Sant P.; Martin-Broto, Javier; Grignani, Giovanni; Schuetze, Scott M.; Vincenzi, Bruno; Wagner, Andrew J.; Chmielowski, Bartosz; Jones, Robin L.; Shah, Jatin; Shacham, Sharon; Kauffman, Michael; Riedel, Richard F.; Attia, Steven 分享 收藏
Effect of prior treatments on selinexor, bortezomib, and dexamethasone in previously treated multiple myeloma Mateos, Maria V.; Gavriatopoulou, Maria; Facon, Thierry; Auner, Holger W.; Leleu, Xavier; Hajek, Roman; Dimopoulos, Meletios A.; Delimpasi, Sosana; Simonova, Maryana; Spicka, Ivan; Pour, Ludek; Kriachok, Iryna; Pylypenko, Halyna; Doronin, Vadim; Usenko, Ganna; Benjamin, Reuben; Dolai, Tuphan K.; Sinha, Dinesh K.; Venner, Christopher P.; Garg, Mamta; Stevens, Don A.; Quach, Hang; Jagannath, Sundar; Moreau, Philippe; Levy, Moshe; Badros, Ashraf Z.; Anderson, Larry D., Jr.; Bahlis, Nizar J.; Cavo, Michele; Chai, Yi; Jeha, Jacqueline; Arazy, Melina; Shah, Jatin; Shacham, Sharon; Kauffman, Michael G.; Richardson, Paul G.; Grosicki, Sebastian 分享 收藏
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