未登录 XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer XTX101是一种肿瘤激活的Fc增强anti-CTLA-4单克隆抗体，在小鼠癌症模型中表现出肿瘤生长抑制和肿瘤选择性药效学 Jenkins, Kurt A.; Park, Miso; Pederzoli-Ribeil, Magali; Eskiocak, Ugur; Johnson, Parker; Guzman, Wilson; Mclaughlin, Megan; Moore-Lai, Deborah; O'Toole, Caitlin; Liu, Zhen; Nicholson, Benjamin; Flesch, Veronica; Qiu, Huawei; Clackson, Tim; O'Hagan, Ronan C.; Rodeck, Ulrich; Karow, Margaret; O'Neil, Jennifer; Williams, John C. 分享 收藏
Mobocertinib (TAK-788): A Targeted Inhibitor of EGFR Exon 20 Insertion Mutants in Non-Small Cell Lung Cancer Gonzalvez, Francois; Vincent, Sylvie; Baker, Theresa E.; Gould, Alexandra E.; Li, Shuai; Wardwell, Scott D.; Nadworny, Sara; Ning, Yaoyu; Zhang, Sen; Huang, Wei-Sheng; Hu, Yongbo; Li, Feng; Greenfield, Matthew T.; Zech, Stephan G.; Das, Biplab; Narasimhan, Narayana, I; Clackson, Tim; Dalgarno, David; Shakespeare, William C.; Fitzgerald, Michael; Chouitar, Johara; Griffin, Robert J.; Liu, Shengwu; Wong, Kwok-Kin; Zhu, Xiaotian; Rivera, Victor M. 分享 收藏
XTX201, A PROTEIN-ENGINEERED IL-2, EXHIBITS TUMOR-SELECTIVE ACTIVITY IN MICE WITHOUT PERIPHERAL TOXICITIES IN NON-HUMAN PRIMATES Zhang, Minjie; Guzman, Wilson; Johnson, Parker; McLaughlin, Megan; Jenkins, Kurt; Wu, Hsin-Jung; Madala, Hanumantha Rao; O'Toole, Caitlin; Pederzoli-Ribeil, Magali; Rozenfeld, Raphael; Qiu, Huawei; Karow, Margaret; Clackson, Tim; O'Hagan, Ronan; O'Neil, Jennifer; Eskiocak, Ugur 分享 收藏
The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models Zhang, Sen; Anjum, Rana; Squillace, Rachel; Nadworny, Sara; Zhou, Tianjun; Keats, Jeff; Ning, Yaoyu; Wardwell, Scott D.; Miller, David; Song, Youngchul; Eichinger, Lindsey; Moran, Lauren; Huang, Wei-Sheng; Liu, Shuangying; Zou, Dong; Wang, Yihan; Mohemmad, Qurish; Jang, Hyun Gyung; Ye, Emily; Narasimhan, Narayana; Wang, Frank; Miret, Juan; Zhu, Xiaotian; Clackson, Tim; Dalgarno, David; Shakespeare, William C.; Rivera, Victor M. 分享 收藏
Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase 布格替尼 (AP26113) 的发现，一种含氧化膦的、有效的、口服活性的间变性淋巴瘤激酶抑制剂 Huang, Wei-Sheng; Liu, Shuangying; Zou, Dong; Thomas, Mathew; Wang, Yihan; Zhou, Tianjun; Romero, Jan; Kohlmann, Anna; Li, Feng; Qi, Jiwei; Cai, Lisi; Dwight, Timothy A.; Xu, Yongjin; Xu, Rongsong; Dodd, Rory; Toms, Angela; Parillon, Lois; Lu, Xiaohui; Anjum, Rana; Zhang, Sen; Wang, Frank; Keats, Jeffrey; Wardwell, Scott D.; Ning, Yaoyu; Xu, Qihong; Moran, Lauren E.; Mohemmad, Qurish K.; Jang, Hyun Gyung; Clackson, Tim; Narasimhan, Narayana I.; Rivera, Victor M.; Zhu, Xiaotian; Dalgarno, David; Shakespeare, William C. 分享 收藏
Discovery of AP26113, a potent, orally active inhibitor of anaplastic lymphoma kinase and clinically relevant mutants Huang, Wei-Sheng; Li, Feng; Cai, Lisi; Xu, Yongjin; Zhang, Sen; Wardwell, Scott D.; Ning, Yaoyu; Kohlmann, Anna; Zhou, Tianjun; Ye, Emily Y.; Zhu, Xiaotian; Narasimhan, Narayana I.; Clackson, Tim; Rivera, Victor M.; Dalgarno, David; Shakespeare, William C. 分享 收藏
Ponatinib Inhibits Polyclonal Drug-Resistant KIT Oncoproteins and Shows Therapeutic Potential in Heavily Pretreated Gastrointestinal Stromal Tumor (GIST) Patients Garner, Andrew P.; Gozgit, Joseph M.; Anjum, Rana; Vodala, Sadanand; Schrock, Alexa; Zhou, Tianjun; Serrano, Cesar; Eilers, Grant; Zhu, Meijun; Ketzer, Julia; Wardwell, Scott; Ning, Yaoyu; Song, Youngchul; Kohlmann, Anna; Wang, Frank; Clackson, Tim; Heinrich, Michael C.; Fletcher, Jonathan A.; Bauer, Sebastian; Rivera, Victor M. 分享 收藏
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ALK INHIBITOR AP26113 IN PATIENTS WITH ADVANCED MALIGNANCIES, INCLUDING ALK plus NON-SMALL CELL LUNG CANCER (NSCLC): UPDATED EFFICACY AND SAFETY DATA Gettinger, S.; Bazhenova, L.; Salgia, R.; Langer, C.; Gold, K.; Rosell, R.; Shaw, A.; Weiss, G. J.; Narasimhan, N. I.; Dorer, D. J.; Rivera, V. M.; Clackson, T.; Haluska, F. G.; Camidge, R. 分享 收藏
A Phase 2 Trial of Ponatinib in Philadelphia Chromosome-Positive Leukemias Cortes, J. E.; Kim, D. -W.; Pinilla-Ibarz, J.; le Coutre, P.; Paquette, R.; Chuah, C.; Nicolini, F. E.; Apperley, J. F.; Khoury, H. J.; Talpaz, M.; DiPersio, J.; DeAngelo, D. J.; Abruzzese, E.; Rea, D.; Baccarani, M.; Mueller, M. C.; Gambacorti-Passerini, C.; Wong, S.; Lustgarten, S.; Rivera, V. M.; Clackson, T.; Turner, C. D.; Haluska, F. G.; Guilhot, F.; Deininger, M. W.; Hochhaus, A.; Hughes, T.; Goldman, J. M.; Shah, N. P.; Kantarjian, H. 分享 收藏
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Ponatinib, a pan-BCR-ABL inhibitor, potently inhibits key activating and drug-resistant KIT mutants found in GIST Garner, Andrew P.; Anjum, Rana; Vodala, Sadanand; Schrock, Alexa; Zhou, Tianjun; Clackson, Tim; Gozgit, Joseph M.; Rivera, Victor M. 分享 收藏
Fragment Growing and Linking Lead to Novel Nanomolar Lactate Dehydrogenase Inhibitors Kohlmann, Anna; Zech, Stephan G.; Li, Feng; Zhou, Tianjun; Squillace, Rachel M.; Commodore, Lois; Greenfield, Matthew T.; Lu, Xiaohui; Miller, David P.; Huang, Wei-Sheng; Qi, Jiwei; Thomas, R. Mathew; Wang, Yihan; Zhang, Sen; Dodd, Rory; Liu, Shuangying; Xu, Rongsong; Xu, Yongjin; Miret, Juan J.; Rivera, Victor; Clackson, Tim; Shakespeare, William C.; Zhu, Xiaotian; Dalgarno, David C. 分享 收藏
Ponatinib in Refractory Philadelphia Chromosome-Positive Leukemias Cortes, Jorge E.; Kantarjian, Hagop; Shah, Neil P.; Bixby, Dale; Mauro, Michael J.; Flinn, Ian; O'Hare, Thomas; Hu, Simin; Narasimhan, Narayana I.; Rivera, Victor M.; Clackson, Tim; Turner, Christopher D.; Haluska, Frank G.; Druker, Brian J.; Deininger, Michael W. N.; Talpaz, Moshe 分享 收藏
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Small molecule inhibitors of choline kinase lead to reduced phosphocholine levels and induction of apoptosis in cancer cells Squillace, Rachel M.; Zech, Stephan; Li, Feng; Kohlmann, Anna; Miller, David; Greenfield, Matthew; Ning, Yaoyu; Commodore, Lois; Miret, Juan; Wang, Frank; Zhou, Tianjun; Wang, Yihan; Thomas, Matthew; Qi, Jiwei; Xu, Yongjin; Rivera, Victor; Clackson, Tim; Zhu, Xiaotian; Shakespeare, William; Delgarno, David 分享 收藏
Ponatinib, a potent pan-BCR-ABL inhibitor, retains activity against gatekeeper mutants of FLT3, RET, KIT, PDGFRα/β and FGFR1 Gozgit, Joseph M.; Wong, Matthew J.; Zhu, Xiaotian; Clackson, Tim; Rivera, Victor M. 分享 收藏
AP26113 is a dual ALK/EGFR inhibitor: Characterization against EGFR T790M in cell and mouse models of NSCLC Rivera, Victor M.; Wang, Frank; Anjum, Rana; Zhang, Sen; Squillace, Rachel; Keats, Jeffrey; Miller, David; Ning, Yaoyu; Wardwell, Scott D.; Moran, Lauren; Miret, Juan; Narasimhan, Narayana; Dalgarno, David; Clackson, Tim; Shakepeare, William C. 分享 收藏
Ponatinib (AP24534), a Multitargeted Pan-FGFR Inhibitor with Activity in Multiple FGFR-Amplified or Mutated Cancer Models Gozgit, Joseph M.; Wong, Matthew J.; Moran, Lauren; Wardwell, Scott; Mohemmad, Qurish K.; Narasimhan, Narayana I.; Shakespeare, William C.; Wang, Frank; Clackson, Tim; Rivera, Victor M. 分享 收藏
Crizotinib-Resistant Mutants of EML4-ALK Identified Through an Accelerated Mutagenesis Screen Zhang, Sen; Wang, Frank; Keats, Jeffrey; Zhu, Xiaotian; Ning, Yaoyu; Wardwell, Scott D.; Moran, Lauren; Mohemmad, Qurish K.; Anjum, Rana; Wang, Yihan; Narasimhan, Narayana I.; Dalgarno, David; Shakespeare, William C.; Miret, Juan J.; Clackson, Tim; Rivera, Victor M. 分享 收藏
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