Robert L. Coffman - Publications, H-index & Citations

Robert L. Coffman

dynavax technologies

113H指数

416论文数

7.4W被引数

收录论文 79

发表时间

A narrative review of immune-mediated adverse events in clinical trials of CpG oligonucleotide toll-like receptor 9 agonists 免疫介导的CpG寡核苷酸 toll-like receptor 9激动剂临床试验不良反应的叙事性综述

Vaccine

IF3.5

2026-03-11

OAAI

Robert S. Janssen; Robert L. Coffman

A CpG 1018 adjuvanted neuraminidase vaccine provides robust protection from influenza virus challenge in mice

NPJ VACCINES

IF6.5

2022-07-22

OAAI

Strohmeier, Shirin; Amanat, Fatima; Campbell, John D.; Traquina, Paula; Coffman, Robert L.; Krammer, Florian

Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice 用临床相关佐剂辅助a亚单位SARS-CoV-2疫苗在小鼠中诱导持久保护

NPJ VACCINES

IF6.5

2022-05-23

OAAI

Grigoryan, Lilit; Lee, Audrey; Walls, Alexandra C.; Lai, Lilin; Franco, Benjamin; Arunachalam, Prabhu S.; Feng, Yupeng; Luo, Wei; Vanderheiden, Abigail; Floyd, Katharine; Wrenn, Samuel; Pettie, Deleah; Miranda, Marcos C.; Kepl, Elizabeth; Ravichandran, Rashmi; Sydeman, Claire; Brunette, Natalie; Murphy, Michael; Fiala, Brooke; Carter, Lauren; Coffman, Robert L.; Novack, David; Kleanthous, Harry; O'Hagan, Derek T.; van der Most, Robbert; McLellan, Jason S.; Suthar, Mehul; Veesler, David; King, Neil P.; Pulendran, Bali

Comment on: Repositioning TH cell polarization from single cytokines to complex help

NATURE IMMUNOLOGY

IF27.6

2022-02-21

PREAI

Jankovic, Dragana; Ciucci, Thomas; Coffman, Robert L.; Coquet, Jonathan M.; Le Gros, Graham; Mosmann, Tim R.; Sher, Alan; Ronchese, Franca

A Phase Ib Open-Label, Multicenter Study of Inhaled DV281, a TLR9 Agonist, in Combination with Nivolumab in Patients with Advanced or Metastatic Non-small Cell Lung Cancer

CLINICAL CANCER RESEARCH

IF10.2

2021-06-09

OAAI

Garon, Edward B.; Spira, Alexander, I; Johnson, Melissa; Bazhenova, Lyudmila; Leach, Joseph; Cummings, Amy L.; Candia, Albert; Coffman, Robert L.; Janatpour, Mary J.; Janssen, Robert; Gamelin, Erick; Chow, Laura Q. M.

A Phase 2a, Double-Blind, Placebo-controlled Randomized Trial of Inhaled TLR9 Agonist AZD1419 in Asthma

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IF19.4

2021-02-01

PREAI

Psallidas, Ioannis; Backer, Vibeke; Kuna, Piotr; Palmer, Robert; Necander, Sofia; Aurell, Malin; Korsback, Katarina; Taib, Ziad; Hashemi, Mahdi; Gustafson, Per; Asimus, Sara; Delaney, Stephen; Pardali, Katerina; Jiang, Fanyi; Almquist, Joachim; Jackson, Sam; Coffman, Robert L.; Keeling, David; Sethi, Tariq

Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19

SCIENTIFIC REPORTS

IF3.9

2020-11-18

138

OAAI

Kuo, Tsun-Yung; Lin, Meei-Yun; Coffman, Robert L.; Campbell, John D.; Traquina, Paula; Lin, Yi-Jiun; Liu, Luke Tzu-Chi; Cheng, Jinyi; Wu, Yu-Chi; Wu, Chung-Chin; Tang, Wei-Hsuan; Huang, Chung-Guei; Tsao, Kuo-Chien; Chen, Charles

Tumor abscopal responses induced by the TLR9 agonist, SD-101, are strongly potentiated by a HDAC class I inhibitor, domatinostat

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Degagne, Emilie; Romo, Jose; Gallotta, Marilena; Kannan, Shravan; Coffman, Robert L.; Guiducci, Cristiana

Phase Ib/II, open label, multicenter study of inhaled DV281, a Toll-like receptor 9 agonist, in combination with nivolumab in patients with advanced or metastatic non small cell lung cancer (NSCLC)

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Garon, Edward; Spira, Alexander I.; Johnson, Melissa; Bazhenova, Lyudmila; Leach, Joseph; Candia, Albert; Coffman, Robert; Janatpour, Mary; Gamelin, Erick; Janssen, Robert; Chow, Laura Q.

Preclinical development of the TLR9 agonist DV281 as an inhaled aerosolized immunotherapeutic for lung cancer: Pharmacological profile in mice, non-human primates, and human primary cells

INTERNATIONAL IMMUNOPHARMACOLOGY

IF4.7

2019-01-01

PREAI

Kell, Sariah A.; Kachura, Melissa A.; Renn, Alex; Traquina, Paula; Coffman, Robert L.; Campbell, John D.

SD-101 in Combination with Pembrolizumab in Advanced Melanoma: Results of a Phase Ib, Multicenter Study SD-101联合派姆单抗治疗晚期黑色素瘤: Ib期多中心研究的结果

CANCER DISCOVERY

IF33.3

2018-10-02

243

OAAI

Ribas, Antoni; Medina, Theresa; Kummar, Shivaani; Amin, Asim; Kalbasi, Anusha; Drabick, Joseph J.; Barve, Minat; Daniels, Gregory A.; Wong, Deborah J.; Schmidt, Emmett, V; Candia, Albert F.; Coffmanm, Robert L.; Leung, Abraham C. F.; Janssen, Robert S.

In Situ Vaccination with a TLR9 Agonist and Local Low-Dose Radiation Induces Systemic Responses in Untreated Indolent Lymphoma

CANCER DISCOVERY

IF33.3

2018-10-02

148

OAAI

Frank, Matthew J.; Reagan, Patrick M.; Bartlett, Nancy L.; Gordon, Leo, I; Friedberg, Jonathan W.; Czerwinski, Debra K.; Long, Steven R.; Hoppe, Richard T.; Janssen, Robert; Candia, Albert F.; Coffman, Robert L.; Levy, Ronald

Inhaled TLR9 Agonist Renders Lung Tumors Permissive to PD-1 Blockade by Promoting Optimal CD4+ and CD8+ T-cell Interplay

CANCER RESEARCH

IF16.6

2018-09-04

OAAI

Gallotta, Marilena; Assi, Hikmat; Degagne, Emilie; Kannan, Shravan Kumar; Coffman, Robert L.; Guiducci, Cristiana

First-in-Human Study With the Inhaled TLR9 Oligonucleotide Agonist AZD1419 Results in Interferon Responses in the Lung, and Is Safe and Well-Tolerated

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2017-12-06

PREAI

Jackson, Sam; Candia, Albert F.; Delaney, Stephen; Floettmann, Simone; Wong, Clifford; Campbell, John D.; Kell, Sariah; Lum, Jeremy; Hessel, Edith M.; Traquina, Paula; McHale, Mark; Robinson, Ian; Bell, John; Fuhr, Rainard; Keeling, David; Coffman, Robert L.

Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer 联合免疫疗法与TLR激动剂和检查点抑制剂可抑制头颈癌

JCI INSIGHT

IF6.1

2017-09-21

249

OAAI

Sato-Kaneko, Fumi; Yao, Shiyin; Ahmadi, Alast; Zhang, Shannon S.; Hosoya, Tadashi; Kaneda, Megan M.; Varner, Judith A.; Pu, Minya; Messer, Karen S.; Guiducci, Cristiana; Coffman, Robert L.; Kitaura, Kazutaka; Matsutani, Takaji; Suzuki, Ryuji; Carson, Dennis A.; Hayashi, Tomoko; Cohen, Ezra E. W.

Pharmacodynamic changes confirm the mechanism of action mediating SD-101 efficacy, in combination with pembrolizumab, in a phase 1b/2 study in metastatic melanoma (MEL-01)

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Candia, Albert; Guiducci, Cristiana; Coffman, Robert L.; Currie, Graeme; Leung, Abraham; Janssen, Robert; Kummar, Shivaani; Agarwala, Sanjiv; Nemunaitis, John; Gonzalez, Rene; Drabick, Joseph; Ribas, Antoni

Intratumoral administration of a TLR9-adjuvanted nanoparticle cancer vaccine stimulates more effective immunity in both injected and un-injected tumor sites compared to subcutaneous administration

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Naik, Edwina; Ying, Chi; Milley, Robert; Calacsan, Carlo; Chipman, Stewart; Tuting, Thomas; Coffman, Robert; Guiducci, Cristiana

Development of an inhaled TLR9 agonist for the immunotherapy of lung cancer

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Gallotta, Marilena; Assi, Hikmat; Coffman, Robert L.; Guiducci, Cristiana

Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8+ T cells 肿瘤内注射CpG寡核苷酸可通过扩增多功能CD8 T细胞来恢复对PD-1阻断的抵抗力

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2016-10-31

206

OAAI

Wang, Shu; Campos, Jose; Gallotta, Marilena; Gong, Mei; Crain, Chad; Naik, Edwina; Coffman, Robert L.; Guiducci, Cristiana

Phase 1b/2, open-label, multicenter, dose escalation and expansion trial of intratumoral SD 101 in combination with pembrolizumab in patients with metastatic melanoma

ANNALS OF ONCOLOGY

IF65.4

2016-10-01

OAAI

Ribas, A.; Gonzalez, R.; Drabick, J.; Kummar, S.; Agarwala, S.; Nemunaitis, J.; Coffman, R.; Berman, C. J.; Schmidt, E.; Chartash, E.; Guiducci, C.; Candia, A.; Janssen, R.

研究方向