未登录 Discovery and Characterization of Small Molecule Inhibitors Targeting Exonuclease 1 for Homologous Recombination-Deficient Cancer Therapy 靶向Exonuclease 1的小分子抑制剂的发现与表征及其在缺乏同源重组的癌症治疗中的应用 Wang, YX; Hess, JD; Wang, C; Ma, LZ; Luo, MG; Jossart, J; Perry, JJ; Kwon, D; Wang, Z; Pei, XY; Shen, CX; Wang, YY; Zhou, M; Yin, HLY; Horne, D; Nussenzweig, A; Zheng, L; Shen, BH 分享 收藏
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination 转录延伸因子ELOF1对于高效的体细胞超突变和类别转换重组是必需的。 Wu, Lizhen; Yadavalli, Anurupa Devi; Senigl, Filip; Matos-Rodrigues, Gabriel; Xu, Dijin; Pintado-Urbanc, Andreas P.; Simon, Matthew D.; Wu, Wei; Nussenzweig, Andre; Schatz, David G. 分享 收藏
Assessment of the Clinical Interactions of GAA Repeat Expansions in FGF14 and FXN Gerhart, Brandon J.; Pellerin, David; Danzi, Matt C.; Zuchner, Stephan; Brais, Bernard; Matos-Rodrigues, Gabriel; Nussenzweig, Andre; Usdin, Karen; Park, Courtney C.; Napierala, Jill S.; Lynch, David R.; Napierala, Marek 分享 收藏
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HLTF disrupts Cas9-DNA post-cleavage complexes to allow DNA break processing Reginato, Giordano; Dello Stritto, Maria Rosaria; Wang, Yanbo; Hao, Jingzhou; Pavani, Raphael; Schmitz, Michael; Halder, Swagata; Morin, Vincent; Cannavo, Elda; Ceppi, Ilaria; Braunshier, Stefan; Acharya, Ananya; Ropars, Virginie; Charbonnier, Jean-Baptiste; Jinek, Martin; Nussenzweig, Andre; Ha, Taekjip; Cejka, Petr 分享 收藏
A common flanking variant is associated with enhanced stability of the FGF14-SCA27B repeat locus 一个常见的侧翼变异与FGF14-SCA27B重复基因座的稳定性增强有关 Pellerin, David; Del Gobbo, Giulia F.; Couse, Madeline; Dolzhenko, Egor; Nageshwaran, Sathiji K.; Cheung, Warren A.; Xu, Isaac R. L.; Dicaire, Marie-Josee; Spurdens, Guinevere; Matos-Rodrigues, Gabriel; Stevanovski, Igor; Scriba, Carolin K.; Rebelo, Adriana; Roth, Virginie; Wandzel, Marion; Bonnet, Celine; Ashton, Catherine; Agarwal, Aman; Peter, Cyril; Hasson, Dan; Tsankova, Nadejda M.; Dewar, Ken; Lamont, Phillipa J.; Laing, Nigel G.; Renaud, Mathilde; Houlden, Henry; Synofzik, Matthis; Usdin, Karen; Nussenzweig, Andre; Napierala, Marek; Chen, Zhao; Jiang, Hong; Deveson, Ira W.; Ravenscroft, Gianina; Akbarian, Schahram; Eberle, Michael A.; Boycott, Kym M.; Pastinen, Tomi; Brais, Bernard; Zuchner, Stephan; Danzi, Matt C. 分享 收藏
SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells Zhang, Linda; Hsu, Joanne, I; Braekeleer, Etienne D.; Chen, Chun-Wei; Patel, Tajhal D.; Martell, Alejandra G.; Guzman, Anna G.; Wohlan, Katharina; Waldvogel, Sarah M.; Uryu, Hidetaka; Tovy, Ayala; Callen, Elsa; Murdaugh, Rebecca L.; Richard, Rosemary; Jansen, Sandra; Vissers, Lisenka; de Vries, Bert B. A.; Nussenzweig, Andre; Huang, Shixia; Coarfa, Cristian; Anastas, Jamie; Takahashi, Koichi; Vassiliou, George; Goodell, Margaret A. 分享 收藏
EXO1 protects BRCA1-deficient cells against toxic DNA lesions van de Kooij, Bert; Schreuder, Anne; Pavani, Raphael; Garzero, Veronica; Uruci, Sidrit; Wendel, Tiemen J.; Hoeck, Arne van; Alonso, Marta San Martin; Everts, Marieke; Koerse, Dana; Callen, Elsa; Boom, Jasper; Mei, Hailiang; Cuppen, Edwin; Luijsterburg, Martijn S.; van Vugt, Marcel A. T. M.; Nussenzweig, Andre; van Attikum, Haico; Noordermeer, Sylvie M. 分享 收藏
Replication-coupled and canonical DNA double strand breaks are processed by distinct mechanisms Pavani, Raphael; Tripathi, Veenu; Zong, Dali; Callen, Elsa; Pankajam, Ajith; Nussenzweig, Andre; Wu, Wei; Vrtis, Kyle; Chari, Raj; Walter, Johannes C. 分享 收藏
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53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice Ward, IM; Difilippantonio, S; Minn, K; Mueller, MD; Molina, JR; Yu, XC; Frisk, CS; Ried, T; Nussenzweig, A; Chen, JJ 分享 收藏
Functional Intersection of ATM and DNA-Dependent Protein Kinase Catalytic Subunit in Coding End Joining during V(D)J Recombination Lee, Baeck-Seung; Gapud, Eric J.; Zhang, Shichuan; Dorsett, Yair; Bredemeyer, Andrea; George, Rosmy; Callen, Elsa; Daniel, Jeremy A.; Osipovich, Oleg; Oltz, Eugene M.; Bassing, Craig H.; Nussenzweig, Andre; Lees-Miller, Susan; Hammel, Michal; Chen, Benjamin P. C.; Sleckman, Barry P. 分享 收藏
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Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization Zagelbaum, Jennifer; Schooley, Allana; Zhao, Junfei; Schrank, Benjamin R.; Callen, Elsa; Zha, Shan; Gottesman, Max E.; Nussenzweig, Andre; Rabadan, Raul; Dekker, Job; Gautier, Jean 分享 收藏
S1-END-seq reveals DNA secondary structures in human cells Matos-Rodrigues, Gabriel; van Wietmarschen, Niek; Wu, Wei; Tripathi, Veenu; Koussa, Natasha C.; Pavani, Raphael; Nathan, William J.; Callen, Elsa; Belinky, Frida; Mohammed, Ashraf; Napierala, Marek; Usdin, Karen; Ansari, Aseem Z.; Mirkin, Sergei M.; Nussenzweig, Andre 分享 收藏
DNA-PK promotes DNA end resection at DNA double strand breaks in G0 cells Dna-pk促进G0细胞DNA双链断裂处的DNA末端切除 Fowler, Faith C.; Chen, Bo-Ruei; Zolnerowich, Nicholas; Wu, Wei; Pavani, Raphael; Paiano, Jacob; Peart, Chelsea; Chen, Zulong; Nussenzweig, Andre; Sleckman, Barry P.; Tyler, Jessica K. 分享 收藏
Disrupted control of origin activation compromises genome integrity upon destabilization of Pole and dysfunction of the TRP53-CDKN1A/P21 axis 在极不稳定和TRP53-CDKN1A/P21轴功能障碍时，起源激活的控制中断会损害基因组的完整性 Borel, Valerie; Boeing, Stefan; Van Wietmarschen, Niek; Sridharan, Sriram; Hill, Bethany Rebekah; Ombrato, Luigi; Perez-Lloret, Jimena; Jackson, Deb; Goldstone, Robert; Boulton, Simon J.; Nussenzweig, Andre; Bellelli, Roberto 分享 收藏
RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1 Setiaputra, Dheva; Escribano-Diaz, Cristina; Reinert, Julia K.; Sadana, Pooja; Zong, Dali; Callen, Elsa; Sifri, Cherine; Seebacher, Jan; Nussenzweig, Andre; Thoma, Nicolas H.; Durocher, Daniel 分享 收藏
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