未登录 The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results Lewis, Gail D.; Li, Guangmin; Guo, Jun; Yu, Shang-Fan; Fields, Carter T.; Lee, Genee; Zhang, Donglu; Dragovich, Peter S.; Pillow, Thomas; Wei, Binqing; Sadowsky, Jack; Leipold, Douglas; Wilson, Tim; Kamath, Amrita; Mamounas, Michael; Lee, M. Violet; Saad, Ola; Choeurng, Voleak; Ungewickell, Alexander; Monemi, Sharareh; Crocker, Lisa; Kalinsky, Kevin; Modi, Shanu; Jung, Kyung Hae; Hamilton, Erika; LoRusso, Patricia; Krop, Ian; Schutten, Melissa M.; Commerford, Renee; Sliwkowski, Mark X.; Cho, Eunpi 分享 收藏
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Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody-Drug Conjugates Caculitan, Nina G.; Chuh, Josefa dela Cruz; Ma, Yong; Zhang, Donglu; Kozak, Katherine R.; Liu, Yichin; Pillow, Thomas H.; Sadowsky, Jack; Cheung, Tommy K.; Phung, Qui; Haley, Benjamin; Lee, Byoung-Chul; Akita, Robert W.; Sliwkowski, Mark X.; Polson, Andrew G. 分享 收藏
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Preclinical development of 2nd generation HE antibody-drug conjugates Phillips, Gail D. Lewis; Li, Guangmin; Guo, Jun; Lau, Jeffrey; Yu, Shang-Fan; Pillow, Thomas; Lee, Byoung-Chul; Sadowsky, Jack; Schutten, Melissa; Fields, Carter; Sliwkowski, Mark X. 分享 收藏
Antitumor Effects of MEHD7945A, a Dual-Specific Antibody against EGFR and HER3, in Combination with Radiation in Lung and Head and Neck Cancers Li, Chunrong; Huang, Shyhmin; Armstrong, Eric A.; Francis, David M.; Werner, Lauryn R.; Sliwkowski, Mark X.; van der Kogel, Albert; Harari, Paul M. 分享 收藏
Potential Mechanisms for Thrombocytopenia Development with Trastuzumab Emtansine (T-DM1) Uppal, Hirdesh; Doudement, Estelle; Mahapatra, Kaushiki; Darbonne, Walter C.; Bumbaca, Daniela; Shen, Ben-Quan; Du, Xiaoyan; Saad, Ola; Bowles, Kristin; Olsen, Steve; Phillips, Gail D. Lewis; Hartley, Dylan; Sliwkowski, Mark X.; Girish, Sandhya; Dambach, Donna; Ramakrishnan, Vanitha 分享 收藏
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Site-Specific Trastuzumab Maytansinoid Antibody-Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering Pillow, Thomas H.; Tien, Janet; Parsons-Reponte, Kathryn L.; Bhakta, Sunil; Li, Hao; Staben, Leanna R.; Li, Guangmin; Chuh, Josefa; Fourie-O'Donohue, Aimee; Darwish, Martine; Yip, Victor; Liu, Luna; Leipold, Douglas D.; Su, Dian; Wu, Elmer; Spencer, Susan D.; Shen, Ben-Quan; Xu, Keyang; Kozak, Katherine R.; Raab, Helga; Vandlen, Richard; Phillips, Gail D. Lewis; Scheller, Richard H.; Polakis, Paul; Sliwkowski, Mark X.; Flygare, John A.; Junutula, Jagath R. 分享 收藏
Dual Targeting of HER2-Positive Cancer with Trastuzumab Emtansine and Pertuzumab: Critical Role for Neuregulin Blockade in Antitumor Response to Combination Therapy 曲妥珠单抗Emtansine和帕妥珠单抗双重靶向HER2-Positive: 神经调节素阻断在联合治疗抗肿瘤反应中的关键作用 Phillips, Gail D. Lewis; Fields, Carter T.; Li, Guangmin; Dowbenko, Donald; Schaefer, Gabriele; Miller, Kathy; Andre, Fabrice; Burris, Howard A., III; Albain, Kathy S.; Harbeck, Nadia; Dieras, Veronique; Crivellari, Diana; Fang, Liang; Guardino, Ellie; Olsen, Steven R.; Crocker, Lisa M.; Sliwkowski, Mark X. 分享 收藏
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Analysis of Fcγ Receptor IIIa and IIa Polymorphisms: Lack of Correlation with Outcome in Trastuzumab-Treated Breast Cancer Patients Fc γ 受体IIIa和IIa多态性分析: 与曲妥珠单抗治疗的乳腺癌患者预后缺乏相关性 Hurvitz, Sara A.; Betting, David J.; Stem, Howard M.; Quinaux, Emmanuel; Stinson, Jeremy; Seshagiri, Somasekar; Zhao, Ying; Buyse, Marc; Mackey, John; Driga, Adrian; Damaraju, Sambasivarao; Sliwkowski, Mark X.; Robert, Nicholas J.; Valero, Vicente; Crown, John; Falkson, Carla; Brufsky, Adam; Pienkowski, Tadeusz; Eiermann, Wolfgang; Martin, Miguel; Bee, Valerie; Marathe, Omkar; Slamon, Dennis J.; Timmerman, John M. 分享 收藏
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Effects of Anti-VEGF on Pharmacokinetics, Biodistribution, and Tumor Penetration of Trastuzumab in a Preclinical Breast Cancer Model Pastuskovas, Cinthia V.; Mundo, Eduardo E.; Williams, Simon P.; Nayak, Tapan K.; Ho, Jason; Ulufatu, Sheila; Clark, Suzanna; Ross, Sarajane; Cheng, Eric; Parsons-Reponte, Kathryn; Cain, Gary; Van Hoy, Marjie; Majidy, Nicholas; Bheddah, Sheila; Chuh, Josefa dela Cruz; Kozak, Katherine R.; Lewin-Koh, Nicholas; Nauka, Peter; Bumbaca, Daniela; Sliwkowski, Mark; Tibbitts, Jay; Theil, Frank-Peter; Fielder, Paul J.; Khawli, Leslie A.; Boswell, C. Andrew 分享 收藏
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates Shen, Ben-Quan; Xu, Keyang; Liu, Luna; Raab, Helga; Bhakta, Sunil; Kenrick, Margaret; Parsons-Reponte, Kathryn L.; Tien, Janet; Yu, Shang-Fan; Mai, Elaine; Li, Dongwei; Tibbitts, Jay; Baudys, Jakub; Saadi, Ola M.; Scales, Suzie J.; McDonald, Paul J.; Hass, Philip E.; Eigenbrot, Charles; Trung Nguyen; Solis, Willy A.; Fuji, Reina N.; Flagella, Kelly M.; Patel, Darshana; Spencer, Susan D.; Khawlil, Leslie A.; Ebens, Allen; Wong, Wai Lee; Vandlen, Richard; Kaur, Surinder; Sliwkowski, Mark X.; Scheller, Richard H.; Polakis, Paul; Junutula, Jagath R. 分享 收藏
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