Karen Block - Publications, H-index & Citations

Karen Block

university of texas system

36H指数

106论文数

5.6K被引数

收录论文 40

发表时间

Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-21

199

OAAI

Sudarshan, Sunil; Sourbier, Carole; Kong, Hye-Sik; Block, Karen; Romero, Vladimir A. Valera; Yang, Youfeng; Galindo, Cynthia; Mollapour, Mehdi; Scroggins, Bradley; Goode, Norman; Lee, Min-Jung; Gourlay, Campbell W.; Trepel, Jane; Linehan, W. Marston; Neckers, Len

Nuclear NADPH oxidase-4 associated with disease progression in renal cell carcinoma

TRANSLATIONAL RESEARCH

IF5.9

2020-09-01

OAAI

Kaushik, Dharam; Ashcraft, Keith A.; Wang, Hanzhang; Shanmugasundaram, Karthigayan; Shah, Pankil K.; Gonzalez, Gabriela; Nazarullah, Alia; Tye, Cooper B.; Liss, Michael A.; Pruthi, Deepak K.; Mansour, Ahmed M.; Chowdhury, Wasim; Bacich, Dean; Zhang, Hao; Watson, Amanda L.; Block, Karen; O'Keefe, Denise; Rodriguez, Ronald

NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance

NATURE COMMUNICATIONS

IF15.7

2017-10-19

166

OAAI

Shanmugasundaram, Karthigayan; Nayak, Bijaya K.; Friedrichs, William E.; Kaushik, Dharam; Rodriguez, Ronald; Block, Karen

mTORC2 Signaling Regulates Nox4-Induced Podocyte Depletion in Diabetes mTORC2信号调节糖尿病Nox4-Induced足细胞耗竭

ANTIOXIDANTS & REDOX SIGNALING

IF6.1

2016-11-01

OAAI

Eid, Stephanie; Boutary, Suzan; Braych, Kawthar; Sabra, Ramzi; Massaad, Charbel; Hamdy, Ahmed; Rashid, Awad; Moodad, Sarah; Block, Karen; Gorin, Yves; Abboud, Hanna E.; Eid, Assaad A.

Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes 用新型双重Nox1/Nox4抑制剂靶向NADPH氧化酶可减轻1型糖尿病的肾脏病理

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY

IF3.4

2015-06-01

160

OAAI

Gorin, Yves; Cavaglieri, Rita C.; Khazim, Khaled; Lee, Doug-Yoon; Bruno, Francesca; Thakur, Sachin; Fanti, Paolo; Szyndralewiez, Cedric; Barnes, Jeffrey L.; Block, Karen; Abboud, Hanna E.

L-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer

CANCER DISCOVERY

IF33.3

2014-11-02

242

OAAI

Shim, Eun-Hee; Livi, Carolina B.; Rakheja, Dinesh; Tan, Jubilee; Benson, Daniel; Parekh, Vishwas; Kho, Eun-Young; Ghosh, Arindam P.; Kirkman, Richard; Velu, Sadanan; Dutta, Shilpa; Chenna, Balachandra; Rea, Shane L.; Mishur, Robert J.; Li, Qiuhua; Johnson-Pais, Teresa L.; Guo, Lining; Bae, Sejong; Wei, Shi; Block, Karen; Sudarshan, Sunil

Elevated (L)-2-hydroxyglutarate promotes loss of 5-hydroxymethylcytosine in clear cell renal cancer

CANCER RESEARCH

IF16.6

2014-10-01

PREAI

Shim, Eun-Hee; Livi, Carolina B.; Knight, John; Holmes, Ross P.; Rakheja, Dinesh; Velu, Sadanan; Kho, Eun-Young; Chenna, Balachandra; Rea, Shane L.; Benson, Daniel; Kirkman, Richard; Ghosh, Arindam; Li, Qiuhua; Bae, Sejong; Wei, Shi; Block, Karen L.; Sudarshan, Sunil

The Oncometabolite Fumarate Promotes Pseudohypoxia Through Noncanonical Activation of NF-κB Signaling

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2014-08-01

OAAI

Shanmugasundaram, Karthigayan; Nayak, Bijaya; Shim, Eun-Hee; Livi, Carolina B.; Block, Karen; Sudarshan, Sunil

Nox4 NADPH Oxidase Mediates Peroxynitrite-dependent Uncoupling of Endothelial Nitric-oxide Synthase and Fibronectin Expression in Response to Angiotensin II ROLE OF MITOCHONDRIAL REACTIVE OXYGEN SPECIES

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2013-10-01

122

OAAI

Lee, Doug-Yoon; Wauquier, Fabien; Eid, Assaad A.; Roman, Linda J.; Ghosh-Choudhury, Goutam; Khazim, Khaled; Block, Karen; Gorin, Yves

Nox4 and diabetic nephropathy: With a friend like this, who needs enemies?

FREE RADICAL BIOLOGY AND MEDICINE

IF8.2

2013-08-01

113

OAAI

Gorin, Yves; Block, Karen

Mammalian Target of Rapamycin Regulates Nox4-Mediated Podocyte Depletion in Diabetic Renal Injury

DIABETES

IF7.5

2013-07-17

132

OAAI

Eid, Assaad A.; Ford, Bridget M.; Bhandary, Basant; Cavaglieri, Rita de Cassia; Block, Karen; Barnes, Jeffrey L.; Gorin, Yves; Choudhury, Goutam Ghosh; Abboud, Hanna E.

Nox as a target for diabetic complications Nox作为糖尿病并发症的目标

CLINICAL SCIENCE

IF7.7

2013-06-14

116

PREAI

Gorin, Yves; Block, Karen

CONCURRENT METABOLIC AND TRANSCRIPTOMIC ANALYSIS OF CLEAR CELL RENAL CANCER

JOURNAL OF UROLOGY

IF6.8

2013-04-01

PREAI

Sudarshan, Sunil; Livi, Carolina; Shim, EunHee; Ghosh, Arindam; Kirkman, Richard; Parekh, Dipen; Block, Karen

In search of solutions to grapevine trunk diseases through crowd-sourced science

FRONTIERS IN PLANT SCIENCE

IF4.8

2013-01-01

OAAI

Block, Karen L.; Rolshausen, Philippe E.; Cantu, Dario

Aiding and abetting roles of NOX oxidases in cellular transformation

NATURE REVIEWS CANCER

IF66.8

2012-08-24

247

OAAI

Block, Karen; Gorin, Yves

Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation

ONCOGENE

IF7.3

2012-08-06

OAAI

Nayak, B. K.; Feliers, D.; Sudarshan, S.; Friedrichs, W. E.; Day, R. T.; New, D. D.; Fitzgerald, J. P.; Eid, A.; DeNapoli, T.; Parekh, D. J.; Gorin, Y.; Block, K.

PI3K regulation of the SKP-2/p27 axis through mTORC2

ONCOGENE

IF7.3

2012-06-25

OAAI

Shanmugasundaram, K.; Block, K.; Nayak, B. K.; Livi, C. B.; Venkatachalam, M. A.; Sudarshan, S.

PI3K REGULATES P27 THROUGH MTORC2 IN RENAL CELL CARCINOMA

JOURNAL OF UROLOGY

IF6.8

2012-04-01

PREAI

Shanmugasundaram, Karthigayan; Block, Karen; Livi, Carolina; Venkatachalam, Manjeri; Sudarshan, Sunil