Christopher J. Kirk - Publications, H-index & Citations

Christopher J. Kirk

onyx pharmaceuticals inc.

52H指数

316论文数

1.1W被引数

收录论文 61

发表时间

Global signal peptide profiling reveals principles of selective Sec61 inhibition

NATURE CHEMICAL BIOLOGY

IF13.7

2024-03-22

PREAI

Wenzell, Nicole A.; Tuch, Brian B.; McMinn, Dustin L.; Lyons, Matthew J.; Kirk, Christopher J.; Taunton, Jack

Signal peptide mimicry primes Sec61 for client-selective inhibition

NATURE CHEMICAL BIOLOGY

IF13.7

2023-05-11

OAAI

Rehan, Shahid; Tranter, Dale; Sharp, Phillip P. P.; Craven, Gregory B. B.; Lowe, Eric; Anderl, Janet L. L.; Muchamuel, Tony; Abrishami, Vahid; Kuivanen, Suvi; Wenzell, Nicole A. A.; Jennings, Andy; Kalyanaraman, Chakrapani; Strandin, Tomas; Javanainen, Matti; Vapalahti, Olli; Jacobson, Matthew P. P.; McMinn, Dustin; Kirk, Christopher J. J.; Huiskonen, Juha T.; Taunton, Jack; Paavilainen, Ville O. O.

Zetomipzomib (KZR-616) attenuates lupus in mice via modulation of innate and adaptive immune responses

FRONTIERS IN IMMUNOLOGY

IF5.9

2023-03-10

OAAI

Muchamuel, Tony; Fan, R. Andrea; Anderl, Janet L.; Bomba, Darrin J.; Johnson, Henry W. B.; Lowe, Eric; Tuch, Brian B.; McMinn, Dustin L.; Millare, Beatriz; Kirk, Christopher J.

Co-inhibition of immunoproteasome subunits LMP2 and LMP7 enables prevention of transplant arteriosclerosis

CARDIOVASCULAR RESEARCH

IF13.3

2022-12-05

PREAI

Li, Jun; Hu, Shaobo; Johnson, Henry W. B.; Kirk, Christopher J.; Xian, Peng; Song, Yanping; Li, Yuan; Liu, Nan; Groettrup, Marcus; Basler, Michael

KZR-540 IS A NOVEL ORAL SMALL MOLECULE INHIBITOR OF SEC61 COTRANSLATIONAL TRANSLOCATION THAT POTENTLY AND SELECTIVELY BLOCKS PD-1 EXPRESSION

JOURNAL FOR IMMUNOTHERAPY OF CANCER

IF10.6

2022-11-07

OAAI

Delgado-Martin, Cristina; Anand, Neel; Anderl, Janet; Dong, Chengguo; Fan, Andrea; Fang, Ying; Kirk, Christopher; Muchamuel, Tony; Qian, Yu; Wang, Jinhai; Whang, Jennifer; Zuno-Mitchell, Patricia

Discovery and Early Clinical Development of Selective Immunoproteasome Inhibitors

CELLS

IF5.2

2021-12-21

OAAI

Kirk, Christopher J.; Muchamuel, Tony; Wang, Jinhai; Fan, R. Andrea

SMALL MOLECULE INHIBITORS OF SEC61 COTRANSLATIONAL TRANSLOCATION REGULATE THE PHAGOCYTOSIS CHECKPOINT MOLECULE CD47

JOURNAL FOR IMMUNOTHERAPY OF CANCER

IF10.6

2020-11-09

PREAI

Whang, Jennifer; Fan, Andrea; Kirk, Christopher; Lowe, Eric; McMinn, Dustin; Millare, Beatriz; Rao, Meera

KZR-8834: A novel, small molecule inhibitor of Sec61-dependent protein secretion with anti-tumor activity

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Lowe, Eric; Anderl, Janet L.; Fan, Andrea R.; Jiang, Jing; Johnson, Henry W.; Kirk, Christopher J.; McMinn, Dustin; Muchamuel, Tony; Taunton, Jack; Whang, Jennifer A.

Discovery and characterization of novel anti-cancer small molecule inhibitors of Sec61

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Lowe, Eric; Anderl, Janet L.; Fan, Andrea R.; Fang, Ying; Jiang, Jing; Johnson, Henry W.; Kirk, Christopher J.; McMinn, Dustin; Muchamuel, Tony; Rao, Meera; Sharp, Phillip P.; Taunton, Jack; Wang, Jinhai; Whang, Jennifer A.

Immunoproteasome inhibition induces plasma cell apoptosis and preserves kidney allografts by activating the unfolded protein response and suppressing plasma cell survival factors

KIDNEY INTERNATIONAL

IF12.6

2019-03-01

OAAI

Li, Jun; Koerner, Julia; Basler, Michael; Brunner, Thomas; Kirk, Christopher J.; Groettrup, Marcus

Diagnostic accuracy of intraoral photographic orthodontic records

JOURNAL OF ESTHETIC AND RESTORATIVE DENTISTRY

IF4.1

2018-10-31

OAAI

Jackson, Tate H.; Kirk, Christopher J.; Phillips, Ceib; Koroluk, Lorne D.

Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2S,3R)-N-((S)-3-(Cyclopent-1-en-1-yl)-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propenannide)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-10-31

PREAI

Johnson, Henry W. B.; Lowe, Eric; Anderl, Janet L.; Fan, Andrea; Muchamuel, Tony; Bowers, Simeon; Moebius, David C.; Kirk, Christopher; McMinn, Dustin L.

Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity

EMBO REPORTS

IF6.2

2018-10-02

OAAI

Basler, Michael; Lindstrom, Michelle M.; LaStant, Jacob J.; Bradshaw, J. Michael; Owens, Timothy D.; Schmidt, Christian; Maurits, Elmer; Tsu, Christopher; Overkleeft, Herman S.; Kirk, Christopher J.; Langrish, Claire L.; Groettrup, Marcus

Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation

KIDNEY INTERNATIONAL

IF12.6

2018-03-01

OAAI

Li, Jun; Basler, Michael; Alvarez, Gerardo; Brunner, Thomas; Kirk, Christopher J.; Groettrup, Marcus

Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2017-03-13

OAAI

Johnson, Henry W. B.; Anderl, Janet L.; Bradley, Erin K.; Bui, John; Jones, Jeffrey; Arastu-Kapur, Shirin; Kelly, Lisa M.; Lowe, Eric; Moebius, David C.; Muchamuel, Tony; Kirk, Christopher; Wang, Zhengping; McMinn, Dustin

The next generation proteasome inhibitors carfilzomib and oprozomib activate prosurvival autophagy via induction of the unfolded protein response and ATF4

AUTOPHAGY

IF14.3

2014-10-27

OAAI

Zang, Yan; Thomas, Sufi M.; Chan, Elena T.; Kirk, Christopher J.; Freilino, Maria L.; DeLancey, Hannah M.; Grandis, Jennifer R.; Li, Changyou; Johnson, Daniel E.

Expression of immunoglobulin and its receptor are major determinants of multiple myeloma patient sensitivity to proteasome inhibitors

CANCER RESEARCH

IF16.6

2014-10-01

PREAI

Tuch, Brian B.; Loehr, Andrea; Degenhardt, Jeremiah D.; Kwei, Kevin A.; Lowe, Eric; Stephenson, Kristi; Keats, Jonathan J.; Kirk, Christopher J.

Carfilzomib and oprozomib synergize with histone deacetylase inhibitors in head and neck squamous cell carcinoma models of acquired resistance to proteasome inhibitors

CANCER BIOLOGY & THERAPY

IF4.6

2014-06-10

OAAI

Zang, Yan; Kirk, Christopher J.; Johnson, Daniel E.

Anti-leukemic activity and mechanisms underlying resistance to the novel immunoproteasome inhibitor PR-924

BIOCHEMICAL PHARMACOLOGY

IF5.6

2014-05-01

PREAI

Niewerth, Denise; van Meerloo, Johan; Jansen, Gerrit; Assaraf, Yehuda G.; Hendrickx, Tessa C.; Kirk, Christopher J.; Anderl, Janet L.; Zweegrnan, Sonja; Kaspers, Gertjan J. L.; Cloos, Jacqueline

A novel Bruton's tyrosine kinase inhibitor CC-292 in combination with the proteasome inhibitor carfilzomib impacts the bone microenvironment in a multiple myeloma model with resultant antimyeloma activity

LEUKEMIA

IF13.4

2014-02-12

OAAI

Eda, H.; Santo, L.; Cirstea, D. D.; Yee, A. J.; Scullen, T. A.; Nemani, N.; Mishima, Y.; Waterman, P. R.; Arastu-Kapur, S.; Evans, E.; Singh, J.; Kirk, C. J.; Westlin, W. F.; Raje, N. S.

研究方向