未登录 Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial 个性化新抗原疫苗和pembrolizumab治疗晚期肝细胞癌: 1/2期试验 Yarchoan, Mark; Gane, Edward J.; Marron, Thomas U.; Perales-Linares, Renzo; Yan, Jian; Cooch, Neil; Shu, Daniel H.; Fertig, Elana J.; Kagohara, Luciane T.; Bartha, Gabor; Northcott, Josette; Lyle, John; Rochestie, Sarah; Peters, Joann; Connor, Jason T.; Jaffee, Elizabeth M.; Csiki, Ildiko; Weiner, David B.; Perales-Puchalt, Alfredo; Sardesai, Niranjan Y. 分享 收藏
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Personalized neoantigen DNA vaccine GNOS-PV02 and pembrolizumab as second-line treatment for advanced hepatocellular carcinoma Yarchoan, Mark; Gane, Edward J.; Marron, Thomas U.; Perales-Linares, Renzo; Yan, Jian; Cooch, Neil; Shu, Daniel; Fertig, Elana J.; Kagohara, Luciane T.; Bartha, Gabor; Northcott, Josette; Lyle, John; Rochestie, Sarah; Peters, Joann; Connor, Jason; Jaffee, Elizabeth; Perales-Puchalt, Alfredo; Weiner, David B.; Csiki, Ildiko; Sardesai, Niranjan Y. 分享 收藏
Detection of MRD assessment with the Personalis NeXT Personal assay using MATRIX plasma-in-plasma contrived samples Labrousse, Paul; Russell, Hugh; Hamid, Sobia; Bartha, Gabor; Lyle, John; Norton, Dan; Northcott, Josette; Boyle, Sean Michael; Chen, Richard; Stetson, Dan; Hadfield, James 分享 收藏
Analytical performance of an ultra-sensitive, tumor-informed liquid biopsy platform for molecular residual disease detection and clinical guidance Chen, Rui; Bartha, Gabor; Lyle, John; Harris, Jason; Boyle, Sean M.; Northcott, Josette; Norton, Dan; Pyke, Rachel M.; Navarro, Fabio C.; Abbott, Charles W.; Haudenschild, Christian; Santiago, Rose; Nichols, Darren; Huang, Stephanie; Nelson, Christopher; Chinnappa, Manju; Chen, Yi; Wang, Yuker; Goodman, Laurie; Zhang, Qi; Hong, Manqing; Chen, Xiaoji; Ayash, Erin 分享 收藏
Precision Neoantigen Discovery Using Large-scale Immunopeptidomes and Composite Modeling of MHC Peptide Presentation (Withdrawal of Vol 20, art no 100111, 2021) Pyke, Rachel Marty; Mellacheruvu, Dattatreya; Dea, Steven; Abbott, Charles W.; Zhang, Simo, V; Phillips, Nick A.; Harris, Jason; Bartha, Gabor; Desai, Sejal; McClory, Rena; West, John; Snyder, Michael P.; Chen, Richard; Boyle, Sean Michael 分享 收藏
Precision Neoantigen Discovery Using Large-Scale Immunopeptidomes and Composite Modeling of MHC Peptide Presentation Pyke, Rachel Marty; Mellacheruvu, Datta; Dea, Steven; Abbott, Charles; Zhang, Simo V.; Phillips, Nick A.; Harris, Jason; Bartha, Gabor; Desai, Sejal; McClory, Rena; West, John; Snyder, Michael P.; Chen, Richard; Boyle, Sean Michael 分享 收藏
IMMUNE PRESSURE IN AN ADVANCED HEPATOCELLULAR CANCER PATIENT FOLLOWING TREATMENT WITH PERSONALIZED NEOANTIGEN DNA VACCINE (GNOS-PV02) IN COMBINATION WITH PLASMID IL-12 (PIL12) AND ANTI-PD1 (PEMBROLIZUMAB) Yarchoan, Mark; Gane, Edward; Perales, Renzo; Perales-Puchalt, Alfredo; Bartha, Gabor; Rochestie, Sarah; Cooch, Neil; Peters, Joann; Csiki, Ildiko; Yan, Jian; Sardesai, Niranjan 分享 收藏
CIRCULATING TUMOR DNA ANALYSIS OF ADVANCED HEPATOCELLULAR CANCER (HCC) PATIENTS TREATED WITH NEOANTIGEN TARGETED PERSONALIZED CANCER DNA VACCINE (GNOS-PV02) IN COMBINATION WITH PLASMID IL-12 (PIL12) AND ANTI-PD1 (PEMBROLIZUMAB) Perales, Renzo; Perales-Puchalt, Alfredo; Bartha, Gabor; Northcott, Josette; Chen, Richard; Lyle, John; Norton, Dan; Cooch, Neil; Gane, Edward; Yarchoan, Mark; Marron, Thomas; Rochestie, Sarah; Peters, Joann; Csiki, Ildiko; Yan, Jian; Sardesai, Niranjan 分享 收藏
A machine learning algorithm with subclonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity Pyke, Rachel Marty; Mellacheruvu, Dattatreya; Dea, Steven; Abbott, Charles W.; McDaniel, Lee; Bhave, Devayani P.; Zhang, Simo, V; Levy, Eric; Bartha, Gabor; West, John; Snyder, Michael P.; Chen, Richard O.; Boyle, Sean Michael 分享 收藏
EXTENSIVELY VALIDATED HLA LOH ALGORITHM DEMONSTRATES AN ASSOCIATION BETWEEN HLA LOH AND GENOMIC INSTABILITY Pyke, Rachel; Dea, Steven; Mellacheruvu, Dattatreya; Abbott, Charles; Zhang, Simo; McDaniel, Lee; Levy, Eric; Bartha, Gabor; West, John; Snyder, Michael; Chen, Richard; Boyle, Sean 分享 收藏
COMPREHENSIVE PROFILING OF THE TUMOR-IMMUNE MICROENVIRONMENT USING AN AUGMENTED TRANSCRIPTOME Levy, Eric; Milani, Pamela; Navarro, Fabio; Bartha, Gabor; Abbott, Charles; Jacob, Jose; McClory, Rena; Li, Robin; West, John; Lyle, John; Boyle, Sean; Chen, Richard 分享 收藏
Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms Abbott, Charles W.; Boyle, Sean M.; Pyke, Rachel Marty; McDaniel, Lee D.; Levy, Eric; Navarro, Fabio C. P.; Mellacheruvu, Dattatreya; Zhang, Simo V.; Tan, Mengyao; Santiago, Rose; Rusan, Zeid M.; Milani, Pamela; Bartha, Gabor; Harris, Jason; McClory, Rena; Snyder, Michael P.; Jang, Sekwon; Chen, Richard 分享 收藏
Precision Neoantigen Discovery Using Large-scale Immunopeptidomes and Composite Modeling of MHC Peptide Presentation (Withdrawn Publication. See vol. 22, 2023) Pyke, Rachel Marty; Mellacheruvu, Dattatreya; Dea, Steven; Abbott, Charles W.; Zhang, Simo, V; Phillips, Nick A.; Harris, Jason; Bartha, Gabor; Desai, Sejal; McClory, Rena; West, John; Snyder, Michael P.; Chen, Richard; Boyle, Sean Michael 分享 收藏
B-CELL RECEPTOR HEAVY CHAIN REPERTOIRE PROFILING USING AN AUGMENTED TRANSCRIPTOME Levy, Eric; Milani, Pamela; Bartha, Gabor; Abbott, Charles; Power, Robert; McClory, Rena; Li, Robin; West, John; Lyle, John; Boyle, Sean; Chen, Richard 分享 收藏
An augmented exome/transcriptome-based platform for precision cancer therapy selection, clinical trial matching, and oncology research applications, enabling next-generation composite biomarkers by combining tumour and immune features Power, R.; Bartha, G.; Harris, J.; Boyle, S. M.; Levy, E.; Milani, P.; Tandon, P.; McNitt, P.; Morra, M.; Desai, S.; Saldivar, S.; Clark, M.; Haudenschild, C.; West, J.; Chen, R. 分享 收藏
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ORTHOGONALLY AND FUNCTIONALLY VALIDATED ALGORITHM FOR DETECTING HLA LOSS OF HETEROZYGOSITY Pyke, Rachel; Mellacheruvu, Dattatreya; Abbott, Charles; Levy, Eric; Zhang, Simo; Bhave, Devayani; Chinnappa, Manjula; Bartha, Gabor; Lyle, John; West, John; Chen, Richard; Boyle, Sean 分享 收藏
PROFILING TUMOR CIRCULATING CELL-FREE DNA WITH AN ENHANCED WHOLE-EXOME TO ENABLE SENSITIVE ASSESSMENT OF SOMATIC MUTATIONS Zhang, Simo; Tan, Mengyao; Navarro, Fabio C. P.; Northcott, Josette; Ma, Shuyuan; Nelson, Christopher; Bhave, Devayani; Bentley, L. Gordon; Chinnappa, Manju; Norton, Dan; Bartha, Gabor; Harris, Jason; Lyle, John; Boyle, Sean; West, John; Chen, Richard 分享 收藏
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