未登录 Evaluation of STK17B as a cancer immunotherapy target utilizing highly potent and selective small molecule inhibitors Scheuplein, Felix; Renner, Florian; Campbell, John E.; Campbell, Robert; De Savi, Chris; Eckmann, Jan; Fischer, Holger; Ge, Jie; Green, Luke; Jakob, Peter; Kim, Joseph L.; Kinkema, Caitlin; McGinn, Katie; Medina, Ricardo; Mueller, Annemarie; Perez, Nisha; Perola, Emanuele; Timsit, Yoav; Traore, Tary; Hopfer, Ulrike; Tyanova, Stefka; Tzouros, Manuel; Wang, Ruduan; Woessner, Richard; Dorsch, Marion; Bischoff, James R. 分享 收藏
ATV-1601 is a Potent and Selective Allosteric Inhibitor of AKT1-E17K and Shows Profound and Durable Regressions in AKT1-E17K-Driven Patient Derived Xenograft Models Schinzel, A. C.; Coffin, A.; Pham, T.; Brigham, B.; Iantosca, G.; Govindaraj, R.; LaPointe, J.; Prescott-Roy, J.; Church, D.; Murray, G.; Roddy, T.; Padyana, A. K.; Dorsch, M.; Sengupta, S.; Blanco, M. J. 分享 收藏
Identifying functional allosteric binding sites using a systematic and scalable AMPS screening platform for drug discovery Padyana, Anil K.; Schinzel, Anna; Murray, Gordon; LaPointe, Joseph H.; Selmer, Kaitlyn; Truc Pham; Buskes, Melissa J.; Sengupta, Shomit; Blanco, Maria-Jesus; Roddy, Thomas; Dorsch, Marion 分享 收藏
BLU-945, a highly potent and selective 4th generation EGFR TKI for the treatment of EGFR T790M/C797S resistant NSCLC Schalm, S. S.; Dineen, T.; Lim, S. M.; Park, C. W.; Hsieh, J.; Woessner, R.; Zhang, Z.; Wilson, K.; Eno, M.; Wilson, D.; Williams, B.; Campbell, J.; de Savi, C.; Stevison, F.; Utt, C.; Guzi, T.; Dorsch, M.; Hoeflich, K.; Cho, B. C. 分享 收藏
BLU-945, a highly potent and selective 4th generation EGFR TKI for the treatment of EGFR T790M/C797S resistant NSCLC BLU-945，高效和选择性的第四代EGFR TKI治疗EGFR T790M/C797S耐药的NSCLC Schalm, S. S.; Dineen, T.; Lim, S. M.; Park, C-W.; Hsieh, J.; Woessner, R.; Zhang, Z.; Wilson, K.; Eno, M.; Wilson, D.; Williams, B.; Campbell, J.; De Savi, C.; Stevison, F.; Utt, C.; Guzi, T.; Dorsch, M.; Hoeflich, K.; Cho, B. C. Chul 分享 收藏
Acquired On-Target Clinical Resistance Validates FGFR4 as a Driver of Hepatocellular Carcinoma Hatlen, Megan A.; Schmidt-Kittler, Oleg; Sherwin, Cori Ann; Rozsahegyi, Emily; Rubin, Nooreen; Sheets, Michael P.; Kim, Joseph L.; Miduturu, Chandrasekhar; Bifulco, Neil; Brooijmans, Natasja; Shi, Hongliang; Guzi, Timothy; Boral, Andy; Lengauer, Christoph; Dorsch, Marion; Kim, Richard D.; Kang, Yoon-Koo; Wolf, Beni B.; Hoeflich, Klaus P. 分享 收藏
Identification of resistance mechanisms to FGFR4 targeted therapy in hepatocellular carcinoma Hatlen, Megan A.; Schmidt-Kittler, Oleg; Sherwin, Cori-Ann; Rozsahegyi, Emily; Rubin, Nooreen; Sheets, Michael; Kim, Joseph L.; Miduturu, Chandra; Bifulco, Neil; Brooijmans, Natasja; Shi, Hongliang; Guzi, Timothy; Boral, Andy; Lengauer, Christoph; Dorsch, Marion; Kim, Richard D.; Kang, Yoon-Koo; Wolf, Beni B.; Hoeflich, Klaus P. 分享 收藏
Evaluating PRKACA as a therapeutic target for Fibrolamellar Carcinoma Schalm, Stefanie S.; O'Hearn, Erin; Wilson, Kevin; LaBranche, Timothy; Silva, Grace; DiPietro, Lucian; Bifulco, Neil; Woessner, Richard; Stransky, Nicolas; Sappal, Darshan; Shutes, Adam; Campbell, Robert; Lobbardi, Riadh; Palmer, Michael; Kim, Joseph; Miller, Stephen; Dorsch, Marion; Lengauer, Christoph; Guzi, Timothy; Kadambi, Vivek; Garner, Andrew; Hoeflich, Klaus P. 分享 收藏
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition 化学生物学筛选确定了神经内分泌癌细胞对SQLE抑制的脆弱性 Mahoney, Christopher E.; Pirman, David; Chubukov, Victor; Sleger, Taryn; Hayes, Sebastian; Fan, Zi Peng; Allen, Eric L.; Chen, Ying; Huang, Lingling; Liu, Meina; Zhang, Yingjia; McDonald, Gabrielle; Narayanaswamy, Rohini; Choe, Sung; Chen, Yue; Gross, Stefan; Cianchetta, Giovanni; Padyana, Anil K.; Murray, Stuart; Liu, Wei; Marks, Kevin M.; Murtie, Joshua; Dorsch, Marion; Jin, Shengfang; Nagaraja, Nelamangala; Biller, Scott A.; Roddy, Thomas; Popovici-Muller, Janeta; Smolen, Gromoslaw A. 分享 收藏
Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate 癌代谢物 (R)-2-羟基戊二酸酯抑制抗肿瘤T细胞免疫 Bunse, Lukas; Pusch, Stefan; Bunse, Theresa; Sahm, Felix; Sanghvi, Khwab; Friedrich, Mirco; Alansary, Dalia; Sonner, Jana K.; Green, Edward; Deumelandt, Katrin; Kilian, Michael; Neftel, Cyril; Uhlig, Stefanie; Kessler, Tobias; von Landenberg, Anna; Berghoff, Anna S.; Marsh, Kelly; Steadman, Mya; Zhu, Dongwei; Nicolay, Brandon; Wiestler, Benedikt; Breckwoldt, Michael O.; Al-Ali, Ruslan; Karcher-Bausch, Simone; Bozza, Matthias; Oezen, Iris; Kramer, Magdalena; Meyer, Jochen; Habel, Antje; Eisel, Jessica; Poschet, Gernot; Weller, Michael; Preusser, Matthias; Nadji-Ohl, Minou; Thon, Niklas; Burger, Michael C.; Harter, Patrick N.; Ratliff, Miriam; Harbottle, Richard; Benner, Axel; Schrimpf, Daniel; Okun, Jurgen; Herold-Mende, Christel; Turcan, Sevin; Kaulfuss, Stefan; Hess-Stumpp, Holger; Bieback, Karen; Cahill, Daniel P.; Plate, Karl H.; Haenggi, Daniel; Dorsch, Marion; Suva, Mario L.; Niemeyer, Barbara A.; von Deimling, Andreas; Wick, Wolfgang; Platten, Michael 分享 收藏
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AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations Yen, Katharine; Travins, Jeremy; Wang, Fang; David, Muriel D.; Artin, Erin; Straley, Kimberly; Padyana, Anil; Gross, Stefan; DeLaBarre, Byron; Tobin, Erica; Chen, Yue; Nagaraja, Raj; Choe, Sung; Jin, Lei; Konteatis, Zenon; Cianchetta, Giovanni; Saunders, Jeffrey O.; Salituro, Francesco G.; Quivoron, Cyril; Opolon, Paule; Bawa, Olivia; Saada, Veronique; Paci, Angelo; Broutin, Sophie; Bernard, Olivier A.; de Botton, Stephane; Marteyn, Benoit S.; Pilichowska, Monika; Xu, YingXia; Fang, Cheng; Jiang, Fan; Wei, Wentao; Jin, Shengfang; Silverman, Lee; Liu, Wei; Yang, Hua; Dang, Lenny; Dorsch, Marion; Penard-Lacronique, Virginie; Biller, Scott A.; Su, Shin-San Michael 分享 收藏
Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH Allen, Eric L.; Ulanet, Danielle B.; Pirman, David; Mahoney, Christopher E.; Coco, John; Si, Yaguang; Chen, Ying; Huang, Lingling; Ren, Jinmin; Choe, Sung; Clasquin, Michelle F.; Artin, Erin; Fan, Zi Peng; Cianchetta, Giovanni; Murtie, Joshua; Dorsch, Marion; Jin, Shengfang; Smolen, Gromoslaw A. 分享 收藏
A mouse model of a human congenital disorder of glycosylation caused by loss of PMM2 Chan, Barden; Clasquin, Michelle; Smolen, Gromoslaw A.; Histen, Gavin; Powe, Josh; Chen, Yue; Lin, Zhizhong; Lu, Chenming; Liu, Yan; Cang, Yong; Yan, Zhonghua; Xia, Yuanfeng; Thompson, Ryan; Singleton, Chris; Dorsch, Marion; Silverman, Lee; Su, Shin-San Michael; Freeze, Hudson H.; Jin, Shengfang 分享 收藏
MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis Marjon, Katya; Cameron, Michael J.; Quang, Phong; Clasquin, Michelle F.; Mandley, Everton; Kunii, Kaiko; Mcvay, Michael; Choe, Sung; Kernytsky, Andrew; Gross, Stefan; Konteatis, Zenon; Murtie, Joshua; Blake, Michelle L.; Travins, Jeremy; Dorsch, Marion; Biller, Scott A.; Marks, Kevin M. 分享 收藏
ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis Jin, Shengfang; Chen, Jiang; Chen, Lizao; Histen, Gavin; Lin, Zhizhong; Gross, Stefan; Hixon, Jeffrey; Chen, Yue; Kung, Charles; Chen, Yiwei; Fu, Yufei; Lu, Yuxuan; Lin, Hui; Cai, Xiujun; Yang, Hua; Cairns, Rob A.; Dorsch, Marion; Su, Shinsan M.; Biller, Scott; Mak, Tak W.; Cang, Yong 分享 收藏
IDH2 mutation induced histone and DNA hypermethylation is progressively reversed by small molecule inhibition Kernytsky, Andrew; Wang, Fang; Hansen, Erica; Schalm, Stefanie; Straley, Kimberly; Gliser, Camelia; Yang, Hua; Travins, Jeremy; Murray, Stuart; Dorsch, Marion; Agresta, Sam; Schenkein, David P.; Biller, Scott A.; Su, Shinsan M.; Liu, Wei; Yen, Katharine E. 分享 收藏
AG-221 offers a survival advantage in a primary human IDH2 mutant AML xenograft model Ellwood-Yen, Kate; Wang, Fang; Travins, Jeremy; Chen, Yue; Yang, Hua; Straley, Kim; Choe, Sung; Dorsch, Marion; Agresta, Sam; Schenkein, David; Biller, Scott; Su, Michael 分享 收藏
IDH1 mutant inhibitor induces cellular differentiation and offers a combination benefit with Ara-C in a primary human Idh1 mutant AML xenograft model Ellwood-Yen, Kate; Chen, Yue; Wang, Fang; Lemieux, Rene; Popovici-Muller, Janeta; Yang, Hua; Straley, Kimberly; Choe, Sung; Dorsch, Marion; Agresta, Sam; Schenkein, David; Biller, Scott; Su, Michael 分享 收藏
IDH mutations and tumorigenicity Wang, F.; Travins, J.; DeLaBarre, B.; Penard-Lacronigue, V.; Schalm, S.; Hansen, E.; Staley, K.; Kernytsky, A.; Liu, W.; Gliser, C.; Yang, H.; Gross, S.; Artin, E.; Saada, V.; Mylonas, E.; Quivoron, C.; Popovici-Muller, J.; Saunders, J. O.; Salituro, F. G.; Yan, S.; Murray, S.; Wei, W.; Gao, Y.; Dang, L.; Dorsch, M.; Agresta, S.; Schenkein, D. P.; Biller, S. A.; Su, S. M.; de Botton, S.; Yen, Katharine E. 分享 收藏
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