未登录Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy用于癌症免疫治疗的选择性IKZF2胶降解剂的发现和表征
Bonazzi, Simone; d'Hennezel, Eva; Beckwith, Rohan E. J.; Xu, Lei; Fazal, Aleem; Magracheva, Anna; Ramesh, Radha; Cernijenko, Artiom; Antonakos, Brandon; Bhang, Hyo-eun C.; Caro, Roxana Garcia; Cobb, Jennifer S.; Ornelas, Elizabeth; Ma, Xiaolei; Wartchow, Charles A.; Clifton, Matthew C.; Forseth, Ry R.; Fortnam, Bethany Hughes; Lu, Hongbo; Csibi, Alfredo; Tullai, Jennifer; Carbonneau, Seth; Thomsen, Noel M.; Larrow, Jay; Chie-Leon, Barbara; Hainzl, Dominik; Gu, Yi; Lu, Darlene; Meyer, Matthew J.; Alexander, Dylan; Kinyamu-Akunda, Jacqueline; Sabatos-Peyton, Catherine A.; Dales, Natalie A.; Zecri, Frederic J.; Jain, Rishi K.; Shulok, Janine; Wang, Y. Karen; Briner, Karin; Porter, Jeffery A.; Tallarico, John A.; Engelman, Jeffrey A.; Dranoff, Glenn; Bradner, James E.; Visser, Michael; Solomon, Jonathan M. .png)
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收藏Systematic Chemogenetic Library AssemblyCanham, Stephen M.; Wang, Yuan; Cornett, Allen; Auld, Douglas S.; Baeschlin, Daniel K.; Patoor, Maude; Skaanderup, Philip R.; Honda, Ayako; Llamas, Luis; Wendel, Greg; Mapa, Felipa A.; Aspesi, Peter, Jr.; Labbe-Giguere, Nancy; Gamber, Gabriel G.; Palacios, Daniel S.; Schuffenhauer, Ansgar; Deng, Zhan; Nigsch, Florian; Frederiksen, Mathias; Bushell, Simon M.; Rothman, Deborah; Jain, Rishi K.; Hemmerle, Horst; Briner, Karin; Porter, Jeffery A.; Tallarico, John A.; Jenkins, Jeremy L. 分享 收藏 Discovery of a ZIP7 inhibitor from a Notch pathway screenNolin, Erin; Gans, Sara; Llamas, Luis; Bandyopadhyay, Somnath; Brittain, Scott M.; Bernasconi-Elias, Paula; Carter, Kyle P.; Loureiro, Joseph J.; Thomas, Jason R.; Schirle, Markus; Yang, Yi; Guo, Ning; Roma, Guglielmo; Schuierer, Sven; Beibel, Martin; Lindeman, Alicia; Sigoillot, Frederic; Chen, Amy; Xie, Kevin X.; Ho, Samuel; Reece-Hoyes, John; Weihofen, Wilhelm A.; Tyskiewicz, Kayla; Hoepfner, Dominic; McDonald, Richard, I; Guthrie, Nicolette; Dogra, Abhishek; Guo, Haibing; Shao, Jian; Ding, Jian; Canham, Stephen M.; Boynton, Geoff; George, Elizabeth L.; Karig, Zhao B.; Antcza, Christophe; Porter, Jeffery A.; Wallace, Owen; Tallarico, John A.; Palmer, Amy E.; Jenkins, Jeremy L.; Jain, Rishi K.; Bushell, Simon M.; Fryer, Christyj 分享 收藏 Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62DeJesus, Rowena; Moretti, Francesca; McAllister, Gregory; Wang, Zuncai; Bergman, Phil; Liu, Shanming; Frias, Elizabeth; Alford, John; Reece-Hoyes, John S.; Lindeman, Alicia; Kelliher, Jennifer; Russ, Carsten; Knehr, Judith; Carbone, Walter; Beibel, Martin; Roma, Guglielmo; Ng, Aylwin; Tallarico, John A.; Porter, Jeffery A.; Xavier, Ramnik J.; Mickanin, Craig; Murphy, Leon O.; Hoffman, Gregory R.; Nyfeler, Beat 分享 收藏 SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice (vol 11, pg 511, 2015)Palacino, James; Swalley, Susanne E.; Song, Cheng; Cheung, Atwood K.; Shu, Lei; Zhang, Xiaolu; Van Hoosear, Mailin; Shin, Youngah; Chin, Donovan N.; Keller, Caroline Gubser; Beibel, Martin; Renaud, Nicole A.; Smith, Thomas M.; Salcius, Michael; Shi, Xiaoying; Hild, Marc; Servais, Rebecca; Jain, Monish; Deng, Lin; Bullock, Caroline; McLellan, Michael; Schuierer, Sven; Murphy, Leo; Blommers, Marcel J. J.; Blaustein, Cecile; Berenshteyn, Frada; Lacoste, Arnaud; Thomas, Jason R.; Roma, Guglielmo; Michaud, Gregory A.; Tseng, Brian S.; Porter, Jeffery A.; Myer, Vic E.; Tallarico, John A.; Hamann, Lawrence G.; Curtis, Daniel; Fishman, Mark C.; Dietrich, William F.; Dales, Natalie A.; Sivasankaran, Rajeev 分享 收藏 SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice (vol 11, pg 511, 2015)Palacino, James; Swalley, Susanne E.; Song, Cheng; Cheung, Atwood K.; Shu, Lei; Zhang, Xiaolu; Van Hoosear, Mailin; Shin, Youngah; Chin, Donovan N.; Keller, Gubser; Beibel, Martin; Renaud, Nicole A.; Smith, Thomas M.; Salcius, Michael; Shi, Xiaoying; Hild, Marc; Servais, Rebecca; Jain, Monish; Deng, Lin; Bullock, Caroline; McLellan, Michael; Schuierer, Sven; Murphy, Leo; Blommers, Marcel J. J.; Blaustein, Cecile; Berenshteyn, Frada; Lacoste, Arnaud; Thomas, Jason R.; Roma, Guglielmo; Michaud, Gregory A.; Tseng, Brian S.; Porter, Jeffery A.; Myer, Vic E.; Tallarico, John A.; Hamann, Lawrence G.; Curtis, Daniel; Fishman, Mark C.; Dietrich, William F.; Dales, Natalie A.; Sivasankaran, Rajeev 分享 收藏 SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA micePalacino, James; Swalley, Susanne E.; Song, Cheng; Cheung, Atwood K.; Shu, Lei; Zhang, Xiaolu; Van Hoosear, Mailin; Shin, Youngah; Chin, Donovan N.; Keller, Caroline Gubser; Beibel, Martin; Renaud, Nicole A.; Smith, Thomas M.; Salcius, Michael; Shi, Xiaoying; Hild, Marc; Servais, Rebecca; Jain, Monish; Deng, Lin; Bullock, Caroline; McLellan, Michael; Schuierer, Sven; Murphy, Leo; Blommers, Marcel J. J.; Blaustein, Cecile; Berenshteyn, Frada; Lacoste, Arnaud; Thomas, Jason R.; Roma, Guglielmo; Michaud, Gregory A.; Tseng, Brian S.; Porter, Jeffery A.; Myer, Vic E.; Tallarico, John A.; Hamann, Lawrence G.; Curtis, Daniel; Fishman, Mark C.; Dietrich, William F.; Dales, Natalie A.; Sivasankaran, Rajeev 分享 收藏 Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo选择性VPS34抑制剂阻断自噬并揭示NCOA4在体内铁蛋白降解和铁稳态中的作用Dowdle, William E.; Nyfeler, Beat; Nagel, Jane; Elling, Robert A.; Liu, Shanming; Triantafellow, Ellen; Menon, Suchithra; Wang, Zuncai; Honda, Ayako; Pardee, Gwynn; Cantwell, John; Luu, Catherine; Cornella-Taracido, Ivan; Harrington, Edmund; Fekkes, Peter; Lei, Hong; Fang, Qing; Digan, Mary Ellen; Burdick, Debra; Powers, Andrew F.; Helliwell, Stephen B.; D'Aquin, Simon; Bastien, Julie; Wang, Henry; Wiederschain, Dmitri; Kuerth, Jenny; Bergman, Philip; Schwalb, David; Thomas, Jason; Ugwonali, Savuth; Harbinski, Fred; Tallarico, John; Wilson, Christopher J.; Myer, Vic E.; Porter, Jeffery A.; Bussiere, Dirksen E.; Finan, Peter M.; Labow, Mark A.; Mao, Xiaohong; Hamann, Lawrence G.; Manning, Brendan D.; Valdez, Reginald A.; Nicholson, Thomas; Schirle, Markus; Knapp, Mark S.; Keaney, Erin P.; Murphy, Leon O. 分享 收藏 Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancersHoffman, Gregory R.; Rahal, Rami; Buxton, Frank; Xiang, Kay; McAllister, Gregory; Frias, Elizabeth; Bagdasarian, Linda; Huber, Janina; Lindeman, Alicia; Chen, Dongshu; Romero, Rodrigo; Ramadan, Nadire; Phadke, Tanushree; Haas, Kristy; Jaskelioff, Mariela; Wilson, Boris G.; Meyer, Matthew J.; Saenz-Vash, Veronica; Zhai, Huili; Myer, Vic E.; Porter, Jeffery A.; Keen, Nicholas; McLaughlin, Margaret E.; Mickanin, Craig; Roberts, Charles W. M.; Stegmeier, Frank; Jagani, Zainab 分享 收藏 Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinomaJiang, Xiaomo; Hao, Huai-Xiang; Growney, Joseph D.; Woolfenden, Steve; Bottiglio, Cindy; Ng, Nicholas; Lu, Bo; Hsieh, Mindy H.; Bagdasarian, Linda; Meyer, Ronald; Smith, Timothy R.; Avello, Monika; Charlat, Olga; Xie, Yang; Porter, Jeffery A.; Pan, Shifeng; Liu, Jun; McLaughlin, Margaret E.; Cong, Feng 分享 收藏 RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signallingZhang, Yue; Liu, Shanming; Mickanin, Craig; Feng, Yan; Charlat, Olga; Michaud, Gregory A.; Schirle, Markus; Shi, Xiaoying; Hild, Marc; Bauer, Andreas; Myer, Vic E.; Finan, Peter M.; Porter, Jeffery A.; Huang, Shih-Min A.; Cong, Feng 分享 收藏 Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodiesEttenberg, Seth A.; Charlat, Olga; Daley, Michael P.; Liu, Shanming; Vincent, Karen J.; Stuart, Darrin D.; Schuller, Alwin G.; Yuan, Jing; Ospina, Beatriz; Green, John; Yu, Qunyan; Walsh, Renee; Li, Sharon; Schmitz, Rita; Heine, Holger; Bilic, Sanela; Ostrom, Lance; Mosher, Rebecca; Hartlepp, K. Felix; Zhu, Zhenping; Fawell, Stephen; Yao, Yung-Mae; Stover, David; Finan, Peter M.; Porter, Jeffery A.; Sellers, William R.; Klagge, Ingo M.; Cong, Feng 分享 收藏 Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signalingKusano, KF; Pola, R; Murayama, T; Curry, C; Kawamoto, A; Iwakura, A; Shintani, S; Ii, M; Asai, J; Tkebuchava, T; Thorne, T; Takenaka, H; Aikawa, R; Goukassian, D; von Samson, P; Hamada, H; Yoon, YS; Silver, M; Eaton, E; Ma, H; Heyd, L; Kearney, M; Munger, W; Porter, JA; Kishore, R; Losordo, DW 分享 收藏 Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell nichesMachold, R; Hayashi, S; Rutlin, M; Muzumdar, MD; Nery, S; Corbin, JG; Gritli-Linde, A; Dellovade, T; Porter, JA; Rubin, LL; Dudek, H; McMahon, AP; Fishell, G 分享 收藏 Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches (Vol 39, pg 937, 2003)Machold, R; Hayashi, S; Rutlin, M; Muzumdar, MD; Nery, S; Corbin, JG; Gritli-Linde, A; Dellovade, T; Porter, JA; Rubin, LL; Dudek, H; McMahon, AP; Fishell, G 分享 收藏 Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesionsWilliams, JA; Guicherit, OM; Zaharian, BI; Xu, Y; Chai, L; Wichterle, H; Kon, C; Gatchalian, C; Porter, JA; Rubin, LL; Wang, FY 分享 收藏 分享 收藏 分享 收藏 
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