未登录 Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNa-driven lupus nephritis Katewa, Arna; Wang, Yugang; Hackney, Jason A.; Huang, Tao; Suto, Eric; Ramamoorthi, Nandhini; Austin, Cary D.; Bremer, Meire; Chen, Jacob Zhi; Crawford, James J.; Currie, Kevin S.; Blomgren, Peter; DeVoss, Jason; DiPaolo, Julie A.; Hau, Jonathan; Johnson, Adam; Lesch, Justin; DeForge, Laura E.; Lin, Zhonghua; Liimatta, Marya; Lubach, Joseph W.; McVay, Sami; Modrusan, Zora; Nguyen, Allen; Poon, Chungkee; Wang, Jianyong; Liu, Lichuan; Lee, Wyne P.; Wong, Harvey; Young, Wendy B.; Townsend, Michael J.; Reif, Karin 分享 收藏
Dual B Cell Immunotherapy Is Superior to Individual Anti-CD20 Depletion or BAFF Blockade in Murine Models of Spontaneous or Accelerated Lupus Lin, WeiYu; Seshasayee, Dhaya; Lee, Wyne P.; Caplazi, Patrick; McVay, Sami; Suto, Eric; Nguyen, Allen; Lin, Zhonghua; Sun, Yonglian; DeForge, Laura; Balazs, Mercedesz; Martin, Flavius; Zarrin, Ali A. 分享 收藏
Complement Inhibition in Cynomolgus Monkeys by Anti-Factor D Antigen-Binding Fragment for the Treatment of an Advanced Form of Dry Age-Related Macular Degeneration Loyet, Kelly M.; Good, Jeremy; Davancaze, Teresa; Sturgeon, Lizette; Wang, Xiangdan; Yang, Jihong; Le, Kha N.; Wong, Maureen; Hass, Philip E.; Campagne, Menno van Lookeren; Haughney, Peter C.; Morimoto, Alyssa; Damico-Beyer, Lisa A.; DeForge, Laura E. 分享 收藏
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Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice Deng, Rong; Meng, Y. Gloria; Hoyte, Kwame; Lutman, Jeff; Lu, Yanmei; Iyer, Suhasini; DeForge, Laura E.; Theil, Frank-Peter; Fielder, Paul J.; Prabhu, Saileta 分享 收藏
Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination Misaghi, Shahram; Senger, Kate; Sai, Tao; Qu, Yan; Sun, Yonglian; Hamidzadeh, Kajal; Nguyen, Allen; Jin, Zhaoyu; Zhou, Meijuan; Yan, Donghong; Lin, Wei Yu; Lin, Zhonghua; Lorenzo, Maria N.; Sebrell, Andrew; Ding, Jiabing; Xu, Min; Caplazi, Patrick; Austin, Cary D.; Balazs, Mercedesz; Roose-Girma, Merone; DeForge, Laura; Warming, Soren; Lee, Wyne P.; Dixit, Vishva M.; Zarrin, Ali A. 分享 收藏
Micro-volume wall-less immunoassays using patterned planar plates Kozak, Katherine R.; Wang, Jianyong; Lye, Melvin; Chuh, Josefa dela Cruz; Takkar, Rashi; Kim, Namyong; Lee, Hyunjae; Jeon, Noo Li; Lin, Kedan; Zhang, Crystal; Wong, Wai Lee T.; DeForge, Laura E. 分享 收藏
Activation of the Alternative Complement Pathway in Vitreous is Controlled by Genetics in Age-Related Macular Degeneration Loyet, Kelly M.; DeForge, Laura E.; Katschke, Kenneth J., Jr.; Diehl, Lauri; Graham, Robert R.; Pao, Lily; Sturgeon, Lizette; Lewin-Koh, Sock-Cheng; Hollyfield, Joe G.; Campagne, Menno van Lookeren 分享 收藏
Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis Di Paolo, Julie A.; Huang, Tao; Balazs, Mercedesz; Barbosa, James; Barck, Kai H.; Bravo, Brandon J.; Carano, Richard A. D.; Darrow, James; Davies, Douglas R.; DeForge, Laura E.; Diehl, Lauri; Ferrando, Ronald; Gallion, Steven L.; Giannetti, Anthony M.; Gribling, Peter; Hurez, Vincent; Hymowitz, Sarah G.; Jones, Randall; Kropf, Jeffrey E.; Lee, Wyne P.; Maciejewski, Patricia M.; Mitchell, Scott A.; Rong, Hong; Staker, Bart L.; Whitney, J. Andrew; Yeh, Sherry; Young, Wendy B.; Yu, Christine; Zhang, Juan; Reif, Karin; Currie, Kevin S. 分享 收藏
Increased Targeting of Donor Switch Region and IgE in Sγ1-Deficient B Cells Misaghi, Shahram; Garris, Christopher S.; Sun, Yonglian; Nguyen, Allen; Zhang, Juan; Sebrell, Andrew; Senger, Kate; Yan, Donghong; Lorenzo, Maria N.; Heldens, Sherry; Lee, Wyne P.; Xu, Min; Wu, Jiansheng; DeForge, Laura; Sai, Tao; Dixit, Vishva M.; Zarrin, Ali A. 分享 收藏
Lymphotoxin-αβ heterotrimers are cleaved by metalloproteinases and contribute to synovitis in rheumatoid arthritis Young, Judy; Yu, Xin; Wolslegel, Kristen; Nguyen, Allen; Kung, Catherine; Chiang, Eugene; Kolumam, Ganesh; Wei, Nathan; Wong, Wai Lee; DeForge, Laura; Townsend, Michael J.; Grogan, Jane L. 分享 收藏
Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice 对人膜IgE片段具有特异性的抗体会消耗人源化小鼠中产生IgE的b细胞 Brightbill, Hans D.; Jeet, Surinder; Lin, Zhonghua; Yan, Donghong; Zhou, Meijuan; Tan, Martha; Nguyen, Allen; Yeh, Sherry; Delarosa, Donnie; Leong, Steven R.; Wong, Terence; Chen, Yvonne; Ultsch, Mark; Luis, Elizabeth; Ramani, Sree Ranjani; Jackman, Janet; Gonzalez, Lino; Dennis, Mark S.; Chuntharapai, Anan; DeForge, Laura; Meng, Y. Gloria; Xu, Min; Eigenbrot, Charles; Lee, Wyne P.; Refino, Canio J.; Balazs, Mercedesz; Wu, Lawren C. 分享 收藏
Improving Therapeutic Efficacy of a Complement Receptor by Structure-based Affinity Maturation Li, Bing; Xi, Hongkang; Diehl, Lauri; Lee, Wyne P.; Sturgeon, Lizette; Chinn, Jason; DeForge, Laura; Kelley, Robert F.; Wiesmann, Christian; Campagne, Menno van Lookeren; Sidhu, Sachdev S. 分享 收藏
Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement Katschke, Kenneth J., Jr.; Stawicki, Scott; Yin, Jianping; Steffek, Micah; Xi, Hongkang; Sturgeon, Lizette; Hass, Philip E.; Loyet, Kelly M.; DeForge, Laura; Wu, Yan; Campagne, Menno van Lookeren; Wiesmann, Christian 分享 收藏
Lymphotoxin-α β heterotrimers are shed from the surface of activated human lymphocytes and circulate in human serum Young, Judy; Nguyen, Allen; Yu, Xin; Chiang, Eugene; Corpuz, Racquel; Yin, JianPing; Kung, Catherine; Vandien, Richard; Yansura, Dan; DeForge, Laura; Wong, Wai Lee; Grogan, Jane 分享 收藏
Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5 Adams, C.; Totpal, K.; Lawrence, D.; Marsters, S.; Pitti, R.; Yee, S.; Ross, S.; Deforge, L.; Koeppen, H.; Sagolla, M.; Compaan, D.; Lowman, H.; Hymowitz, S.; Ashkenazi, A. 分享 收藏
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Design, construction, and in vitro analyses of multivalent antibodies Miller, K; Meng, G; Liu, J; Hurst, A; Hsei, V; Wong, WL; Ekert, R; Lawrence, D; Sherwood, S; DeForge, L; Gaudreault, J; Keller, G; Sliwkowski, M; Ashkenazi, A; Presta, L 分享 收藏
Adapting pharmacokinetic properties of a humanized anti-interleukin-8 antibody for therapeutic applications using site-specific pegylation Leong, SR; DeForge, L; Presta, L; Gonzalez, T; Fan, A; Reichert, M; Chuntharapai, A; Kim, KJ; Tumas, DB; Lee, WP; Gribling, P; Snedecor, B; Chen, H; Hsei, V; Schoenhoff, M; Hale, V; Deveney, J; Koumenis, I; Shahrokh, Z; McKay, P; Galan, W; Wagner, B; Narindray, D; Hébert, C; Zapata, G 分享 收藏
Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions Lawrence, D; Shahrokh, Z; Marsters, S; Achilles, K; Shih, D; Mounho, B; Hillan, K; Totpal, K; DeForge, L; Schow, P; Hooley, J; Sherwood, S; Pai, R; Leung, S; Khan, LL; Gliniak, B; Bussiere, J; Smith, CA; Strom, SS; Kelley, S; Fox, JA; Thomas, D; Ashkenazi, A 分享 收藏
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