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Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B-8800 in myeloid neoplasms 骨髓肿瘤中口服SF3B1调节剂H3B-8800的I期首次人体剂量递增研究 Steensma, David P.; Wermke, Martin; Klimek, Virginia M.; Greenberg, Peter L.; Font, Patricia; Komrokji, Rami S.; Yang, Jay; Brunner, Andrew M.; Carraway, Hetty E.; Ades, Lionel; Al-Kali, Aref; Alonso-Dominguez, Juan M.; Alfonso-Pierola, Ana; Coombs, Catherine C.; Deeg, H. Joachim; Flinn, Ian; Foran, James M.; Garcia-Manero, Guillermo; Maris, Michael B.; McMasters, Malgorzata; Micol, Jean-Baptiste; De Oteyza, Jaime Perez; Thol, Felicitas; Wang, Eunice S.; Watts, Justin M.; Taylor, Justin; Stone, Richard; Gourineni, Vikram; Marino, Alyssa J.; Yao, Huilan; Destenaves, Benoit; Yuan, Xiaobin; Yu, Kun; Dar, Sara; Ohanjanian, Lernik; Kuida, Keisuke; Xiao, Jianjun; Scholz, Catherine; Gualberto, Antonio; Platzbecker, Uwe 分享 收藏
A phase Ib/II study of rebastinib and paclitaxel in advanced or metastatic platinum-resistant ovarian cancer Hamilton, E. P.; Goel, S.; Arend, R.; Chu, C.; Richardson, D. L.; Diamond, J. R.; John, V.; Janku, F.; Matthews, C.; JeBailey, L.; Kuida, K.; Achour, H.; Ruiz-Soto, R.; Hays, J. 分享 收藏
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Phase 1b/2 study of rebastinib (DCC-2036) in combination with paclitaxel: Preliminary safety, efficacy, pharmacokinetics and pharmacodynamics in patients with advanced or metastatic solid tumors Janku, Filip; Birrer, Michael; Richardson, Debra; Chu, Christina; Goel, Sanjay; Su, Ying; Matin, Bahar; Kuida, Keisuke; Ruiz-Soto, Rodrigo; Hamilton, Erika Paige 分享 收藏
Phase 1 study of DCC-3014, an oral inhibitor of CSF1R, to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics in patients with advanced solid tumors, including diffuse type tenosynovial giant cell tumor Taylor, Matthew H.; Leong, Stephen; Su, Ying; Leary, Cynthia B.; Li, Xiaoyan; Kuida, Keisuke; Ruiz-Soto, Rodrigo; Bauer, Todd 分享 收藏
Pharmacokinetic (PK), safety, and tolerability profile of DCC-2618 in a phase I trial supports 150mg QD selected for a pivotal phase III trial in gastrointestinal stromal tumor (GIST) Janku, Filip; Heinrich, Michael; Razak, Albiruni; Gordon, Michael; Chi, Ping; Ganjoo, Kristen; von Mehren, Margaret; Somaiah, Neeta; Lee, Jongtae; Kuida, Keisuke; Soto, Rodrigo Ruiz; Rosen, Oliver; George, Suzanne 分享 收藏
Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation 用于临床翻译的多参数单细胞分析平台实施的机遇和挑战 Keating, Susan M.; Taylor, D. Lansing; Plant, Anne L.; Litwack, E. David; Kuhn, Peter; Greenspan, Emily J.; Hartshorn, Christopher M.; Sigman, Caroline C.; Kelloff, Gary J.; Chang, David D.; Friberg, Gregory; Lee, Jerry S. H.; Kuida, Keisuke 分享 收藏
Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer Klauck, Peter J.; Bagby, Stacey M.; Capasso, Anna; Bradshaw-Pierce, Erica L.; Selby, Heather M.; Spreafico, Anna; Tentler, John J.; Tan, Aik Choon; Kim, Jihye; Arcaroli, John J.; Purkey, Alicia; Messersmith, Wells A.; Kuida, Keisuke; Eckhardt, S. Gail; Pitts, Todd M. 分享 收藏
A First-in-Human, Phase I, Dose-Escalation Study of TAK-117, a Selective PI3Kα Isoform Inhibitor, in Patients with Advanced Solid Malignancies Juric, Dejan; de Bono, Johann S.; LoRusso, Patricia M.; Nemunaitis, John; Heath, Elisabeth I.; Kwak, Eunice L.; Macarulla Mercade, Teresa; Geuna, Elena; de Miguel-Luken, Maria Jose; Patel, Chirag; Kuida, Keisuke; Sankoh, Serap; Westin, Eric H.; Zohren, Fabian; Shou, Yaping; Tabernero, Josep 分享 收藏
A phase 1b multicenter, open-label study of investigational TAK-228 (MLN0128) plus TAK-117 (MLN1117) in adult patients with advanced nonhematologic malignancies Juric, D.; Lopez, J.; Rasco, D.; Mercade, T. Macarulla; Xu, Q.; Brittany, B.; Kuida, K.; Patel, C.; Neuwirth, R.; Enke, A.; Zohren, F.; Burris, H. A., III 分享 收藏
Automated immunohistochemistry of phosphobiomarkers: Case study of MTOR (MLN0128) and PI3Kα (MLN1117) investigational inhibitors, single agent and in combination, on xenografts and mouse skin Kreshock, Anna; Iartchouk, Natalia; Cao, Yueying; Szwaya, Jeffrey; Gao, Feng; Simpson, Christopher; Luongo, Evan; Burke, Kristine; Gangolli, Esha; Kuida, Keisuke; Brake, Rachael; Tirrell, Stephen; Shinde, Vaishali 分享 收藏
Choosing the right schedule for progression free survival: A systems pharmacology approach Patel, Mayankbhai; Mettetal, Jerome; Cohen, Matthew; Palani, Santhosh; Kuida, Keisuke; Hixon, Mark; Bolen, Joseph; Shyu, Wen Chyi; Noe, Dennis; Chakravarty, Arijit 分享 收藏
Local Apoptosis Modulates Early Mammalian Brain Development through the Elimination of Morphogen-Producing Cells Nonomura, Keiko; Yamaguchi, Yoshifumi; Hamachi, Misato; Koike, Masato; Uchiyama, Yasuo; Nakazato, Kenichi; Mochizuki, Atsushi; Sakaue-Sawano, Asako; Miyawaki, Atsushi; Yoshida, Hiroki; Kuida, Keisuke; Miura, Masayuki 分享 收藏
Treatment with targeted anticancer agent affects rapidly growing subclones: An integrated in vitro/in silico analysis of clonal heterogeneity in soft agar. Zopf, Christopher J.; Szynal, Carmin; Palani, Santhosh; Bowman, Doug; Bradley, John; Mettetal, Jerome; Ecsedy, Jeffrey; Darner, Andy; Shyu, Wen Chyi; Kuida, Keisuke; Blair, Derek; Chakravarty, Arijit 分享 收藏
Combination schedule optimization through preclinical PK-efficacy modeling of an investigational novel-novel combination: A case study of MLN0128 an mTORC1/2 inhibitor with MLN1117 a PI3Kα isoform selective inhibitor. Zopf, Christopher; Patel, Mayank; Kadakia, Ekta; Fabry, Robyn; Chakravarty, Arijit; Chowdhury, Swapan; Wu, Jing-Tao; Shyu, Wen Chyi; Manfredi, Mark; Zohren, Fabian; Patel, Chirag; Kuida, Keisuke; Iartchouk, Natasha; Brake, Rachael; Mettetal, Jerome 分享 收藏
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Antitumor Activity of the Polo-like Kinase (PLK) Inhibitor, TAK-960, Alone and in Combination with Standard Agents Against KRAS WT and MT Colorectal Cancer (CRC) Models Pitts, T.; McPhillips, K. L.; Selby, H. M.; Spreafico, A.; Bagby, S. M.; Britt, B. C.; Tentler, J. J.; Tan, A. C.; Kuida, K.; Eckhardt, S. G. 分享 收藏
TAK-960, a Novel, Orally Available, Selective Inhibitor of Polo-Like Kinase 1, Shows Broad-spectrum Preclinical Antitumor Activity in Multiple Dosing Regimens Hikichi, Yuichi; Honda, Kohei; Hikami, Kouki; Miyashita, Hitoshi; Kaieda, Isao; Murai, Saomi; Uchiyama, Noriko; Hasegawa, Maki; Kawamoto, Tomohiro; Sato, Takashi; Ichikawa, Takashi; Cao, Sheldon; Nie, Zhe; Zhang, Lilly; Yang, Johnny; Kuida, Keisuke; Kupperman, Erik 分享 收藏
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