未登录 Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators Shaw, Simon J.; Goff, Dane A.; Boralsky, Luke A.; Singh, Rajinder; Sweeny, David J.; Park, Gary; Sun, Tian-Qiang; Jenkins, Yonchu; Markovtsov, Vadim; Issakani, Sarkiz D.; Payan, Donald G.; Hitoshi, Yasumichi 分享 收藏
Optimization of Pyrimidine Compounds as Potent JAK1 Inhibitors and the of R507 as a Clinical Candidate Chen, Yan; Li, Hui; Yen, Rose; Heckrodt, Thilo J.; McMurtrie, Darren; Singh, Rajinder; Taylor, Vanessa; Masuda, Esteban S.; Park, Gary; Payan, Donald G. 分享 收藏
Structure activity relationships leading to the identification of the indirect activator of AMPK, R419 Shaw, Simon J.; Goff, Dane A.; Carroll, David C.; Singh, Rajinder; Sweeny, David J.; Park, Gary; Jenkins, Yonchu; Markovtsov, Vadim; Sun, Tian-Qiang; Issakani, Sarkiz D.; Hitoshi, Yasumichi; Payan, Donald G. 分享 收藏
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Potential role for R191 potent and selective IRAK4 kinase inhibitor, in treatment of hematologic malignancies Markovtsov, Vadim V.; Lamagna, Chrystelle; Chan, Meagan; Yi, Sothy; Young, Chi; Frances, Roy; Siu, Stacey; Braselmann, Sylvia; Li, Hui; Singh, Rajinder; Park, Gary; Masuda, Esteban; Taylor, Vanessa; Payan, Donald G. 分享 收藏
Small molecule inhibitors of the anti-inflammatory TAM receptor MerTK Holland, Sacha J.; Owyang, Alex M.; Yi, Sothy; Young, Chi; Braselmann, Sylvia; Frances, Roy; Bagos, Arthur; Tai, Ernest; Siu, Stacey; Park, Gary; Lau, David; Duan, Matt; Kolluri, Rao; Bhamidipati, Somasekhar; Darwish, Ihab; Duncton, Matthew; Singh, Rajinder; Masuda, Esteban; Payan, Donald G. 分享 收藏
Development of small molecule direct AMPK activators for the treatment of cancer Hitoshi, Yasumichi; Jenkins, Yonchu; Li, Yingwu; Sampang, Elmer; Xu, Xiang; Dong, Guodong; Huang, Jianing; Lin, Nan; Goff, Dane; Shaw, Simon; Boralsky, Luke; Singh, Rajinder; Issakani, Sarkiz D.; Payan, Donald G. 分享 收藏
The JAK-STAT Pathway Is Critical in Ventilator-Induced Diaphragm Dysfunction Tang, Huibin; Smith, Ira J.; Hussain, Sabah N. A.; Goldberg, Peter; Lee, Myung; Sugiarto, Sista; Godinez, Guillermo L.; Singh, Baljit K.; Payan, Donald G.; Rando, Thomas A.; Kinsella, Todd M.; Shrager, Joseph B. 分享 收藏
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Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction Smith, Ira J.; Godinez, Guillermo L.; Singh, Baljit K.; McCaughey, Kelly M.; Alcantara, Raniel R.; Gururaja, Tarikere; Ho, Melissa S.; Nguyen, Henry N.; Friera, Annabelle M.; White, Kathy A.; McLaughlin, John R.; Hansen, Derek; Romero, Jason M.; Baltgalvis, Kristen A.; Claypool, Mark D.; Li, Wei; Lang, Wayne; Yam, George C.; Gelman, Marina S.; Ding, Rongxian; Yung, Stephanie L.; Creger, Daniel P.; Chen, Yan; Singh, Rajinder; Smuder, Ashley J.; Wiggs, Michael P.; Kwon, Oh-Sung; Sollanek, Kurt J.; Powers, Scott K.; Masuda, Esteban S.; Taylor, Vanessa C.; Payan, Donald G.; Kinoshita, Taisei; Kinsella, Todd M. 分享 收藏
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R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer Holland, Sacha J.; Pan, Alison; Franci, Christian; Hu, Yuanming; Chang, Betty; Li, Weiqun; Duan, Matt; Torneros, Allan; Yu, Jiaxin; Heckrodt, Thilo J.; Zhang, Jing; Ding, Pingyu; Apatira, Ayodele; Chua, Joanne; Brandt, Ralf; Pine, Polly; Goff, Dane; Singh, Rajinder; Payan, Donald G.; Hitoshi, Yasumichi 分享 收藏
JAK3 Inhibition Significantly Attenuates Psoriasiform Skin Inflammation in CD18 Mutant PL/J Mice Chang, Betty Y.; Zhao, Feifei; He, Xiaodong; Ren, Hong; Braselmann, Sylvia; Taylor, Vanessa; Wicks, Joan; Payan, Donald G.; Grossbard, Elliott B.; Pine, Polly R.; Bullar, Daniel C. 分享 收藏
Discovery and characterization of substituted diphenyl heterocyclic compounds as potent and selective inhibitors of hepatitis C virus replication Huang, Peiyong; Goff, Dane A.; Huang, Qi; Martinez, Anthony; Xu, Xiang; Crowder, Scott; Issakani, Sarkiz D.; Anderson, Emily; Sheng, Ning; Achacoso, Philip; Yen, Ann; Kinsella, Todd; Darwish, Ihab S.; Kolluri, Rao; Hong, Hui; Qu, Kunbin; Stauffer, Emily; Goldstein, Eileen; Singh, Rajinder; Payan, Donald G.; Lu, H. Henry 分享 收藏
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A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD and RIP1 Gururaja, Tarikere L.; Yung, Stephanie; Ding, Rongxian; Huang, Jianing; Zhou, Xiulan; McLaughlin, John; Daniel-Tssakani, Sarkiz; Sing, Rajinder; Cooper, Robin D. G.; Payan, Donald G.; Masuda, Esteban; Kinoshita, Taisei 分享 收藏
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R406, an orally available spleen tyrosine kinase inhibitor blocks Fc receptor signaling and reduces immune complex-mediated inflammation R406，一种口服脾酪氨酸激酶抑制剂阻断Fc受体信号传导并减少免疫复合物介导的炎症 Braselmann, Sylvia; Taylor, Vanessa; Zhao, Haoran; Wang, Su; Sylvain, Catherine; Baluom, Muhammad; Qu, Kunbin; Herlaar, Ellen; Lau, Angela; Young, Chi; Wong, Brian R.; Lovell, Scott; Sun, Thomas; Park, Gary; Argade, Ankush; Jurcevic, Stipo; Pine, Polly; Singh, Rajinder; Grossbard, Elliott B.; Payan, Donald G.; Masuda, Esteban S. 分享 收藏
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