未登录 Furmonertinib is a brain-penetrant EGFR TKI highly active in uncommon EGFR mutations, including PACC and exon 20 insertions Nilsson, Monique B.; Mounir, Zineb; Musib, Luna; He, Junqin; Yu, Xiaoxing; Li, Qing; Luo, Huibing; Heymach, John V.; Hsu, Jerry Y.; Lutzker, Stuart; Le, Xiuning; Kowanetz, Marcin 分享 收藏
IDE161, a potential first-in-class clinical candidate PARG inhibitor, selectively targets homologous-recombination-deficient and PARP inhibitor resistant breast and ovarian tumors Abed, Monah; Munoz, Diana; Seshadri, Vidya; Federowicz, Steve; Rao, Arjun A.; Bhupathi, Deepthi; Liimatta, Marya; Ousterhout, Rita; Jaipuri, Firoz; Neilan, Claire; Lackner, Mark; White, Mike; Mounir, Zineb 分享 收藏
Dual inhibition of MAT2A and PRMT5 delivers synergistic anti-tumor responses in preclinical models of MTAP-deleted cancer Fischer, Marcus M.; Gerrick, Kimberline; Belmontes, Brian; Slemmons, Katherine; Freyman, Yevgeniy; Jain, Jay; Federowicz, Steve; Bishof, Isaac; Rao, Arjun A.; Fleury, Melissa; Mounir, Zineb; Lackner, Mark R.; Hughes, Paul E.; White, Mike; Neilan, Claire L. 分享 收藏
MAT2A inhibition in MTAP-/- tumors confers mechanistic vulnerabilities to multiple clinically actionable synthetic lethal drug combinations Gerrick, Kimberline Y.; Laraio, Jenny; Annen, Kelsey; Tran, Hoang; Fischer, Marcus M.; Freyman, Yevgeniy; Sharma, Geeta; Bishof, Isaac; Federowicz, Stephen; Pankajakshan, Divya; Neilan, Claire L.; Mangatt, Biju; Mazurek, Anthony; Lackner, Mark R.; White, Michael; Mounir, Zineb 分享 收藏
A phase I study of synthetic lethal, IDE397 (MAT2A inhibitor) as a monotherapy and in combination with chemotherapy in advanced solid tumors harboring MTAP deletion Johnson, M. L.; Rodon, J.; Aljumaily, R.; Villalona-Calero, M.; Borazanci, E.; Pishvaian, M.; Turk, A.; Carvajal, R. D.; Mantia, C.; Giaccone, G.; Mounir, Z.; Patel, A.; Maurer, M.; Neilan, C.; Rajendran, D.; Ganesan, U.; Hinkle, J.; Tolcher, A. W. 分享 收藏
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In vitro and in vivo characterization of novel MAT2A allosteric inhibitors Pei, Zhonghua; Alam, Muzaffar; Bhola, Neil; Cleary, Leah; Drummond, Jake; Fisher, Marcus; Fleury, Melissa; Garcia, Candy; Givmanesh, Atieh; Xin Linghu; McSpadden, Ethan; Mounir, Zineb; Neilan, Claire; Newby, Zach; Perumal, Senthil; Steel, Richard; Sutton, James; Vaidya, Kedar; Wagle, Marie-Claire; Wang, Jianhong; Yao, Bing; Lackner, Mark; Dillon, Michael P. 分享 收藏
Mat2A Inhibitors decrease growth, increase senescence and p53 stability in MTAP-deleted cancer cells Bhola, Neil; Givmanesh, Atieh; Wagle, Marie-Claire; Garcia, Candy; Vaidya, Kedar; Cleary, Leah; Pei, Zhonghua; Lackner, Mark; Mounir, Zineb 分享 收藏
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CBP/p300 Drives the Differentiation of Regulatory T Cells through Transcriptional and Non-Transcriptional Mechanisms Castillo, Joseph; Wu, Esther; Lowe, Christopher; Srinivasan, Shrividhya; McCord, Ron; Wagle, Marie-Claire; Jayakar, Sangeeta; Edick, Melissa Gonzalez; Eastham-Anderson, Jeffrey; Liu, Bonnie; Hutchinson, Katherine E.; Jones, Wendell; Stokes, Matthew P.; Tarighat, Somayeh S.; Holcomb, Thomas; Glibicky, Andrew; Romero, F. Anthony; Magnuson, Steven; Huang, Shih-Min A.; Plaks, Vicki; Giltnane, Jennifer M.; Lackner, Mark R.; Mounir, Zineb 分享 收藏
Association of tumor fusion burden with immune presence and androgen sensitivity in prostate cancer Wagle, Marie; Yuen, Kobe; Kadel, Edward E.; Holcomb, Thomas; Srinivasan, Shrividhya; Castillo, Joseph; Halligan, Dan; Carr, Adrian; Bylesjo, Max; Augley, Julian; Daminelli, Simone; Kockx, Mark; Waumans, Yannick; Giltnane, Jennifer; Mounir, Zineb 分享 收藏
Transcriptomic analysis of hepatocellular carcinoma reveals molecular features of disease progression and tumor immune biology Okrah, K.; Tarighat, S.; Liu, B.; Koeppen, H.; Wagle, M. C.; Cheng, G.; Sun, C.; Dey, A.; Chang, M. T.; Sumiyoshi, T.; Mounir, Z.; Cummings, C.; Hampton, G.; Amler, L.; Fridlyand, J.; Hegde, P. S.; Turley, S. J.; Lackner, M. R.; Huang, S. M. 分享 收藏
A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types Wagle, Marie-Claire; Kirouac, Daniel; Klijn, Christiaan; Liu, Bonnie; Mahajan, Shilpi; Junttila, Melissa; Moffat, John; Merchant, Mark; Huw, Ling; Wongchenko, Matthew; Okrah, Kwame; Srinivasan, Shrividhya; Mounir, Zineb; Sumiyoshi, Teiko; Haverty, Peter M.; Yauch, Robert L.; Yan, Yibing; Kabbarah, Omar; Hampton, Garret; Amler, Lukas; Ramanujan, Saroja; Lackner, Mark R.; Huang, Shih-Min A. 分享 收藏
Comprehensive RNA-seq transcriptome interrogation of paired hepatocellular carcinoma and cirrhosis tissues revealed significant molecular features of disease evolution and modulation of tumor immunity Liu, Bonnie P.; Okrah, Kwame; Cheng, Jeff; Motlhabi, Maipelo; Sun, Charlie; Sumiyoshi, Teiko; Ikeda, Shoji; Koeppen, Hartmut; Mounir, Zineb; Cummings, Craig; Hague, Nadia; Hampton, Garret; Amler, Lukas; Lackner, Mark; Huang, Shih-Min A. 分享 收藏
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ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor 前列腺癌中的ERG信号是通过雄激素受体的PRMT5-dependent甲基化驱动的 Mounir, Zineb; Korn, Joshua M.; Westerling, Thomas; Lin, Fallon; Kirby, Christina A.; Schirle, Markus; McAllister, Gregg; Hoffman, Greg; Ramadan, Nadire; Hartung, Anke; Feng, Yan; Kipp, David Randal; Quinn, Christopher; Fodor, Michelle; Baird, Jason; Schoumacher, Marie; Meyer, Ronald; Deeds, James; Buchwalter, Gilles; Stems, Travis; Keen, Nicholas; Sellers, William R.; Brown, Myles; Pagliarini, Raymond A. 分享 收藏
mTORC2 Balances AKT Activation and eIF2α Serine 51 Phosphorylation to Promote Survival under Stress Tenkerian, Clara; Krishnamoorthy, Jothilatha; Mounir, Zineb; Kazimierczak, Urszula; Khoutorsky, Arkady; Staschke, Kirk A.; Kristof, Arnold S.; Wang, Shuo; Hatzoglou, Maria; Koromilas, Antonis E. 分享 收藏
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TMPRSS2: ERG blocks neuroendocrine and luminal cell differentiation to maintain prostate cancer proliferation Mounir, Z.; Lin, F.; Lin, V. G.; Korn, J. M.; Yu, Y.; Valdez, R.; Aina, O. H.; Buchwalter, G.; Jaffe, A. B.; Korpal, M.; Zhu, P.; Brown, M.; Cardiff, R. D.; Rocnik, J. L.; Yang, Y.; Pagliarini, R. 分享 收藏
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