David J. Chaplin - Publications, H-index & Citations

Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization

IF3.6

2020-03-20

OAAI

Winn, Blake A.; Devkota, Laxman; Kuch, Bunnarack; MacDonough, Matthew T.; Strecker, Tracy E.; Wang, Yifan; Shi, Zhe; Gerberich, Jeni L.; Mondal, Deboprosad; Ramirez, Alejandro J.; Hamel, Ernest; Chaplin, David J.; Davis, Peter; Mason, Ralph P.; Trawick, Mary Lynn; Pinney, Kevin G.

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-05-06

OAAI

Niu, Haichan; Strecker, Tracy E.; Gerberich, Jeni L.; Campbell, James W., III; Saha, Debabrata; Mondal, Deboprosad; Hamel, Ernest; Chaplin, David J.; Mason, Ralph P.; Trawick, Mary Lynn; Pinney, Kevin G.

Targeting tumor hypoxia with prodrug conjugates of potent small-molecule inhibitors of tubulin polymerization

Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents 基于combretastatin，二氢萘和苯并二烯的母体血管破坏剂衍生的水溶性氨基酸前药缀合物的设计，合成和生物学评估

IF16.6

2017-07-01

PREAI

Pinney, Kevin G.; Trawick, Mary Lynn; Mason, Ralph P.; Liu, Li; Chaplin, David J.; Winn, Blake A.; Devkota, Laxman; Strecker, Tracy E.; Gerberich, Jeni; Winters, Alex; Wang, Yifan; MacDonough, Matthew T.

Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization

IF3

2016-03-01

OAAI

Devkota, Laxman; Lin, Chen-Ming; Strecker, Tracy E.; Wang, Yifan; Tidmore, Justin K.; Chen, Zhi; Guddneppanavar, Rajsekhar; Jelinek, Christopher J.; Lopez, Ramona; Liu, Li; Hamel, Ernest; Mason, Ralph P.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.

The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts

IF3

2015-12-01

OAAI

Herdman, Christine A.; Devkota, Laxman; Lin, Chen-Ming; Niu, Haichan; Strecker, Tracy E.; Lopez, Ramona; Liu, Li; George, Clinton S.; Tanpure, Rajendra P.; Hamel, Ernest; Chaplin, David J.; Mason, Ralph P.; Trawick, Mary Lynn; Pinney, Kevin G.

CANCER LETTERS

IF10.1

2015-12-01

OAAI

Strecker, Tracy E.; Odutola, Samuel O.; Lopez, Ramona; Cooper, Morgan S.; Tidmore, Justin K.; Charlton-Sevcik, Amanda K.; Li, Li; MacDonough, Matthew T.; Hadimani, Mallinath B.; Ghatak, Anjan; Liu, Li; Chaplin, David J.; Mason, Ralph P.; Pinney, Kevin G.; Trawick, Mary Lynn

Exaggerated hypertensive response to combretastatin A-4 phosphate in hypertensive rats: Effective pharmacological inhibition by diltiazem

VASCULAR PHARMACOLOGY

IF3.5

2015-11-01

PREAI

Ke, Qingen; Samad, Mohammed A.; Bae, Soochan; Chaplin, David J.; Kang, Peter M.

Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L 苯甲酰基二苯酮缩氨基硫脲类似物作为组织蛋白酶L的有效和选择性抑制剂的合成和生化评估

Assessment of anti-tumor activity of the cathepsin L inhibitor, KGP94

IF3

2015-11-01

OAAI

Parker, Erica N.; Song, Jiangli; Kumar, G. D. Kishore; Odutola, Samuel O.; Chavarria, Gustavo E.; Charlton-Sevcik, Amanda K.; Strecker, Tracy E.; Barnes, Ashleigh L.; Sudhan, Dhivya R.; Wittenborn, Thomas R.; Siemann, Dietmar W.; Horsman, Michael R.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.

Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents

IF16.6

2014-10-01

PREAI

Wittenborn, Thomas R.; Stratford, Michael; Trawick, Mary Lynn; Pinney, Kevin G.; Chaplin, David J.; Siemann, Dietmar W.; Horsman, Michael R.

Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3′-hydroxy-4′-methoxyphenyl)-3-(3,4,5-trimethoxybenzoyl)-6-methoxyindole (OXi8006)

IF3

2013-12-01

OAAI

Tanpure, Rajendra P.; George, Clinton S.; Strecker, Tracy E.; Devkota, Laxman; Tidmore, Justin K.; Lin, Chen-Ming; Herdman, Christine A.; MacDonough, Matthew T.; Sriram, Madhavi; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.

Synthesis of a 2-Aryl-3-aroyl Indole Salt (OXi8007) Resembling Combretastatin A-4 with Application as a Vascular Disrupting Agent 类似于Combretastatin A-4的2-芳基-3-芳酰基吲哚盐 (OXi8007) 的合成，并用作血管破坏剂

IF3

2013-11-01

OAAI

MacDonough, Matthew T.; Strecker, Tracy E.; Hamel, Ernest; Hall, John J.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.

KGP94, a small-molecule cathepsin L inhibitor with antitumor activity.

IF3.6

2013-09-09

OAAI

Hadimani, Mallinath B.; MacDonough, Matthew T.; Ghatak, Anjan; Strecker, Tracy E.; Lopez, Ramona; Sriram, Madhavi; Nguyen, Benson L.; Hall, John J.; Kessler, Raymond J.; Shirali, Anupama R.; Liu, Li; Garner, Charles M.; Pettit, George R.; Hame, Ernest; Chaplin, David J.; Mason, Ralph P.; Trawick, Mary Lynn; Pinney, Kevin G.

Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L KGP94的抗肿瘤活性的初步评估，KGP94是组织蛋白酶L的功能化二苯甲酮缩氨基硫脲抑制剂

IF16.6

2013-04-01

PREAI

Wittenborn, Thomas; Trawick, Mary Lynn; Pinney, Kevin G.; Chaplin, David J.; Siemann, Dietmar W.; Horsman, Michael R.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2012-12-01

PREAI

Chavarria, Gustavo E.; Horsman, Michael R.; Arispe, Wara M.; Kumar, G. D. Kishore; Chen, Shen-En; Strecker, Tracy E.; Parker, Erica N.; Chaplin, David J.; Pinney, Kevin G.; Trawick, Mary Lynn

Synthesis and Biochemical Evaluation of Thiochromanone Thiosemicarbazone Analogues as Inhibitors of Cathepsin L

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2012-04-30

OAAI

Song, Jiangli; Jones, Lindsay M.; Kumar, G. D. Kishore; Conner, Elizabeth S.; Bayeh, Liela; Chavarria, Gustavo E.; Charlton-Sevcik, Amanda K.; Chen, Shen-En; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.

Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer combretastatin A4磷酸盐，卡铂和紫杉醇在铂类耐药卵巢癌患者中的II期试验

ANNALS OF ONCOLOGY

IF65.4

2011-09-01

144

OAAI

Zweifel, M.; Jayson, G. C.; Reed, N. S.; Osborne, R.; Hassan, B.; Ledermann, J.; Shreeves, G.; Poupard, L.; Lu, S. -P.; Balkissoon, J.; Chaplin, D. J.; Rustin, G. J. S.

Regioselective Synthesis of Water-Soluble Monophosphate Derivatives of Combretastatin A-1

Development and initial evaluation of the antitumor activity of a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L

IF3.6

2011-06-30

OAAI

Tanpure, Rajendra P.; Nguyen, Benson L.; Strecker, Tracy E.; Aguirre, Savannah; Sharma, Suman; Chaplin, David J.; Siim, Bronwyn G.; Hamel, Ernest; Lippert, John W., III; Pettit, George R.; Trawick, Mary Lynn; Pinney, Kevin G.

Regio- and Stereospecific Synthesis of Mono-β-D-Glucuronic Acid Derivatives of Combretastatin A-1

IF16.6

2011-04-01

PREAI

Trawick, Mary Lynn; Pinney, Kevin G.; Chaplin, David J.; Horsman, Michael R.; Chavarria, Gustavo E.; Arispe, Wara M.; Kumar, G. D. Kishore