Philip J. Hajduk - Publications, H-index & Citations

Philip J. Hajduk

abbott laboratories

59H指数

166论文数

1.7W被引数

收录论文 45

发表时间

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-12-30

PREAI

Dietrich, Justin D.; Longenecker, Kenton L.; Wilson, Noel S.; Goess, Christian; Panchal, Sanjay C.; Swann, Steven L.; Petros, Andrew M.; Hobson, Adrian D.; Ihle, David; Song, Danying; Richardson, Paul; Comess, Kenneth M.; Cox, Philip B.; Dombrowski, Amanda; Sarris, Kathy; Donnelly-Roberts, Diana L.; Duignan, David B.; Gomtsyan, Arthur; Jung, Paul; Krueger, A. Chris; Mathieu, Suzanne; McClure, Andrea; Stoll, Vincent S.; Wetter, Jill; Mankovich, John A.; Hajduk, Philip J.; Vasudevan, Anil; Stoffel, Robert H.; Sun, Chaohong

Identification and Preliminary Characterization of a Potent, Safe, and Orally Efficacious Inhibitor of Acyl-CoA:Diacylglycerol Acyltransferase 1

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2012-02-10

PREAI

Yeh, Vince S. C.; Beno, David W. A.; Brodjian, Sevan; Brune, Michael E.; Cullen, Steven C.; Dayton, Brian D.; Dhaon, Madhup K.; Falls, Hugh D.; Gao, Ju; Grihalde, Nelson; Hajduk, Philip; Hansen, T. Matthew; Judd, Andrew S.; King, Andrew J.; Klix, Russel C.; Larson, Kelly J.; Lau, Yau Y.; Marsh, Kennan C.; Mittelstadt, Scott W.; Plata, Dan; Rozema, Michael J.; Segreti, Jason A.; Stoner, Eric J.; Voorbach, Martin J.; Wang, Xiaojun; Xin, Xili; Zhao, Gang; Collins, Christine A.; Cox, Bryan F.; Reilly, Regina M.; Kym, Philip R.; Souers, Andrew J.

Fragment-based lead discovery: challenges and opportunities

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

IF3.1

2011-07-06

PREAI

Sun, Chaohong; Petros, Andrew M.; Hajduk, Philip J.

Navigating the kinome

NATURE CHEMICAL BIOLOGY

IF13.7

2011-02-20

240

PREAI

Metz, James T.; Johnson, Eric F.; Soni, Niru B.; Merta, Philip J.; Kifle, Lemma; Hajduk, Philip J.

A Unified, Probabilistic Framework for Structure- and Ligand-Based Virtual Screening

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2011-02-10

PREAI

Swann, Steven L.; Brown, Scott P.; Muchmore, Steven W.; Patel, Hetal; Merta, Philip; Locklear, John; Hajduk, Philip J.

Forum Drug discovery A question of library design

NATURE

IF48.5

2011-02-02

122

OAAI

Hajduk, Philip J.

Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases

ACS CHEMICAL BIOLOGY

IF3.8

2011-01-20

PREAI

Comess, Kenneth M.; Sun, Chaohong; Abad-Zapatero, Cele; Goedken, Eric R.; Gum, Rebecca J.; Borhani, David W.; Argiriadi, Maria; Groebe, Duncan R.; Jia, Yong; Clampit, Jill E.; Haasch, Deanna L.; Smith, Harriet T.; Wang, Sanyi; Song, Danying; Coen, Michael L.; Cloutier, Timothy E.; Tang, Hua; Cheng, Xueheng; Quinn, Christopher; Liu, Bo; Xin, Zhili; Liu, Gang; Fry, Elizabeth H.; Stoll, Vincent; Ng, Teresa I.; Banach, David; Marcotte, Doug; Burns, David J.; Calderwood, David J.; Hajduk, Philip J.

Labeled Ligand Displacement: Extending NMR-Based Screening of Protein Targets

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2010-06-24

OAAI

Swann, Steven L.; Song, Danying; Sun, Chaohong; Hajduk, Philip J.; Petros, Andrew M.

Cheminformatic Tools for Medicinal Chemists

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2010-03-24

PREAI

Muchmore, Steven W.; Edmunds, Jeremy J.; Stewart, Kent D.; Hajduk, Philip J.

Healthy skepticism: assessing realistic model performance 健康的怀疑论: 评估现实的模型性能

DRUG DISCOVERY TODAY

IF7.5

2009-04-01

100

PREAI

Brown, Scott P.; Muchmore, Steven W.; Hajduk, Philip J.

Application of belief theory to similarity data fusion for use in analog searching and lead hopping

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2008-04-17

143

PREAI

Muchmore, Steven W.; Debe, Derek A.; Metz, James T.; Brown, Scott P.; Martin, Yvonne C.; Hajduk, Philip J.

Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies

CHEMICAL BIOLOGY & DRUG DESIGN

IF3.3

2007-07-11

114

PREAI

Huth, Jeffrey R.; Park, Chang; Petros, Andrew M.; Kunzer, Aaron R.; Wendt, Michael D.; Wang, Xilu; Lynch, Christopher L.; Mack, Jamey C.; Swift, Kerry M.; Judge, Russell A.; Chen, Jun; Richardson, Paul L.; Jin, Sha; Tahir, Stephen K.; Matayoshi, Edward D.; Dorwin, Sarah A.; Ladror, Uri S.; Severin, Jean M.; Walter, Karl A.; Bartley, Diane M.; Fesik, Stephen W.; Elmore, Steven W.; Hajduk, Philip J.

From bacterial genomes to novel antibacterial agents:: discovery, characterization, and antibacterial activitv of compounds that bind to HI0065 (YjeE) from Haemophilus influenzae

CHEMICAL BIOLOGY & DRUG DESIGN

IF3.3

2007-06-06

PREAI

Lerner, Claude G.; Hajduk, Philip J.; Wagner, Rolf; Wagenaar, Frank L.; Woodall, Charlotte; Gu, Yu-Gui; Searle, Xenia B.; Florjancic, Alan S.; Zhang, Tianyuan; Clark, Richard F.; Cooper, Curt S.; Mack, Jamey C.; Yu, Liping; Cai, Mengli; Betz, Steven F.; Chovan, Linda E.; McCall, J. Owen; Black-Schaefer, Candace L.; Kakavas, Stephan J.; Schurdak, Mark E.; Comess, Kenneth M.; Walter, Karl A.; Edalji, Rohinton; Dorwin, Sarah A.; Smith, Richard A.; Hebert, Eric J.; Harlan, John E.; Metzger, Randy E.; Marta, Philip J.; Baranowski, John L.; Coen, Michael L.; Thornewell, Susan J.; Shivakumar, Annapur G.; Saiki, Anne Y.; Soni, Niru; Bui, Mai; Balli, Darlene J.; Sanders, William J.; Nilius, Angela M.; Holzman, Thomas F.; Fesik, Stephen W.; Beutel, Bruce A.

Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-Rs

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2007-05-08

152

OAAI

Sun, Chaohong; Song, Danying; Davis-Taber, Rachel A.; Barrett, Leo W.; Scott, Victoria E.; Richardson, Paul L.; Pereda-Lopez, Ana; Uchic, Marie E.; Solomon, Larry R.; Lake, Marc R.; Walter, Karl A.; Hajduk, Philip J.; Olejniczak, Edward T.

Effects of conformational dynamics on predicted protein druggability

CHEMMEDCHEM

IF3.4

2006-01-05

OAAI

Brown, Scott P.; Hajduk, Philip J.

Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2005-12-20

324

PREAI

Petros, AM; Dinges, J; Augeri, DJ; Baumeister, SA; Betebenner, DA; Bures, MG; Elmore, SW; Hajduk, PJ; Joseph, MK; Landis, SK; Nettesheim, DG; Rosenberg, SH; Shen, W; Thomas, S; Wang, XL; Zanze, I; Zhang, HC; Fesik, SW

Structure-based optimization of MurF inhibitors

CHEMICAL BIOLOGY & DRUG DESIGN

IF3.3

2005-12-16

OAAI

Stamper, GF; Longenecker, KL; Fry, EH; Jakob, CG; Florjancic, AS; Gu, YG; Anderson, DD; Cooper, CS; Zhang, T; Clark, RF; Cia, Y; Black-Schaefer, CL; McCall, JO; Lerner, CG; Hajduk, PJ; Beutel, BA; Stoll, VS

Druggability indices for protein targets derived from NMR-based screening data

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2005-02-24

491

PREAI

Hajduk, PJ; Huth, JR; Fesik, SW

ALARM NMR: A rapid and robust experimental method to detect reactive false positives in biochemical screens

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2004-12-02

216