未登录High-affinity agonists reveal recognition motifs for the MRGPRD GPCR高亲和力激动剂揭示了MRGPRD GPCR的识别基序
Wang, Chunyu; Liu, Yongfeng; Lanier, Marion; Yeager, Adam; Singh, Isha; Gumpper, Ryan H.; Krumm, Brian E.; Deleon, Chelsea; Zhang, Shicheng; Boehm, Marcus; Pittner, Richard; Baron, Alain; Dvorak, Lisa; Bacon, Corinne; Shoichet, Brain K.; Martinborough, Esther; Fay, Jonathan F.; Cao, Can; Roth, Bryan L. .png)
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收藏分享 收藏 Blood pressure and renal function changes in patients with severe chronic kidney disease undergoing radiofrequency renal denervation: 12 months outcomes from the Global SYMPLICITY Registry DEFINESchlaich, M.; Mahfoud, F.; Narkiewicz, K.; Ruilope, L. M.; Williams, B.; Mancia, G.; Sharif, F.; Ribichini, F. L.; Fahy, M.; Boehm, M. 分享 收藏 Inhibition of mast cell degranulation by novel small molecule MRGPRX2 antagonists新型小分子MRGPRX2拮抗剂对肥大细胞脱颗粒的抑制作用Wollam, Joshua; Solomon, Michelle; Villescaz, Christiane; Lanier, Marion; Evans, Samantha; Bacon, Corinne; Freeman, David; Vasquez, Alexis; Vest, Alan; Napora, Jim; Charlot, Brittney; Cavarlez, Christine; Kim, Andrew; Dvorak, Lisa; Selfridge, Brandon; Huang, Liming; Nevarez, Andres; Dedman, Harry; Brooks, Jennifer; Frischbutter, Stefan; Metz, Martin; Serhan, Nadine; Gaudenzio, Nicolas; Timony, Gregg; Martinborough, Esther; Boehm, Marcus F.; Viswanath, Veena 分享 收藏 Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1) and receptor-5 (S1P5) agonist with autoimmune disease-modifying activityScott, F. L.; Clemons, B.; Brooks, J.; Brahmachary, E.; Powell, R.; Dedman, H.; Desale, H. G.; Timony, G. A.; Martinborough, E.; Rosen, H.; Roberts, E.; Boehm, M. F.; Peach, R. J. 分享 收藏 分享 收藏 EC144 Is a Potent Inhibitor of the Heat Shock Protein 90Shi, Jiandong; Van de Water, Ryan; Hong, Kevin; Lamer, Ryan B.; Weichert, Kenneth W.; Sandoval, Cristina M.; Kasibhatla, Srinivas R.; Boehm, Marcus F.; Chao, Jianhua; Lundgren, Karen; Timple, Noelito; Lough, Rachel; Ibanez, Gerardo; Boykin, Christina; Burrows, Francis J.; Kehry, Marilyn R.; Yun, Theodore J.; Harning, Erin K.; Ambrose, Christine; Thompson, Jeffrey; Bixler, Sarah A.; Dunah, Anthone; Snodgrass-Belt, Pamela; Arndt, Joseph; Enyedy, Istvan J.; Li, Ping; Hong, Victor S.; McKenzie, Andres; Biamonte, Marco A. 分享 收藏 BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90Lundgren, Karen; Zhang, Hong; Brekken, John; Huser, Nanni; Powell, Rachel E.; Timple, Noel; Busch, David J.; Neely, Laura; Sensintaffar, John L.; Yang, Yong-ching; McKenzie, Andres; Friedman, Jessica; Scannevin, Robert; Kamal, Adeela; Hong, Kevin; Kasibhatla, Srinivas R.; Boehm, Marcus F.; Burrows, Francis J. 分享 收藏 分享 收藏 Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activityKasibhatla, Srinivas R.; Hong, Kevin; Biamonte, Marco A.; Busch, David J.; Karjian, Patricia L.; Sensintaffar, John L.; Kamal, Adeela; Lough, Rachel E.; Brekken, John; Lundgren, Karen; Grecko, Roy; Timony, Gregg A.; Ran, Yingqing; Mansfield, Robert; Fritz, Lawrence C.; Ulm, Edgar; Burrows, Francis J.; Boehm, Marcus F. 分享 收藏 Dimeric ansamycins - A new class of antitumor Hsp90 modulators with prolonged inhibitory activityZhang, Hong; Yang, Yong-Ching; Zhang, Lin; Fan, Junhua; Chung, Daun; Choi, Diana; Grecko, Roy; Timony, Gregg; Karjian, Patricia; Boehm, Marcus; Burrows, Francis 分享 收藏 7′-substituted benzothiazolothio- and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitorsZhang, Lin; Fan, Junhua; Vu, Khang; Hong, Kevin; Le Brazidec, Jean-Yves; Shi, Jiandong; Biamonte, Marco; Busch, David J.; Lough, Rachel E.; Grecko, Roy; Ran, Yingqing; Sensintaffar, John L.; Kamal, Adeela; Lundgren, Karen; Burrows, Francis J.; Mansfield, Robert; Timony, Gregg A.; Ulm, Edgar H.; Kasibhatla, Srinivas R.; Boehm, Marcus F. 分享 收藏 Biological characterization of a heterodimer-selective retinoid X receptor modulator: Potential benefits for the treatment of type 2 diabetesLeibowitz, MD; Ardecky, RJ; Boehm, MF; Broderick, CL; Carfagna, MA; Crombie, DL; D'Arrigo, J; Etgen, GJ; Faul, MM; Grese, TA; Havel, H; Hein, NI; Heyman, RA; Jolley, D; Klausing, K; Liu, S; Mais, DE; Mapes, CM; Marschke, KB; Michellys, PV; Montrose-Rafizadeh, C; Ogilvie, KM; Pascual, B; Rungta, D; Tyhonas, JS; Urcan, MS; Wardlow, M; Yumibe, N; Reifel-Miller, A 分享 收藏 Orally active purine-based inhibitors of the heat shock protein 90Biamonte, MA; Shi, JD; Hong, K; Hurst, DC; Zhang, L; Fan, JH; Busch, DJ; Karjian, PL; Maldonado, AA; Sensintaffar, JL; Yang, YC; Kamal, A; Lough, RE; Lundgren, K; Burrows, FJ; Timony, GA; Boehm, MF; Kasibhatla, SR 分享 收藏 分享 收藏 Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90Le Brazidec, JY; Kamal, A; Busch, D; Thao, L; Zhang, L; Timony, G; Grecko, R; Trent, K; Lough, R; Salazar, T; Khan, S; Burrows, F; Boehm, MF 分享 收藏 分享 收藏 Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acidsMichellys, PY; Ardecky, RJ; Chen, JH; D'Arrigo, J; Grese, TA; Karanewsky, DS; Leibowitz, MD; Liu, S; Mais, DA; Mapes, CM; Montrose-Rafizadeh, C; Ogilvie, KM; Reifel-Miller, A; Rungta, D; Thompson, AW; Tyhonas, JS; Boehm, MF 分享 收藏 Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetesMichellys, PY; Ardecky, RJ; Chen, JH; Crombie, DL; Etgen, GJ; Faul, MM; Faulkner, AL; Grese, TA; Heyman, RA; Karanewsky, DS; Klausing, K; Leibowitz, MD; Liu, S; Mais, DA; Mapes, CM; Marschke, KB; Reifel-Miller, A; Ogilvie, KM; Rungta, D; Thompson, AW; Tyhonas, JS; Boehm, MF 分享 收藏 分享 收藏 
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