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B

Bryan L. Roth

University of North Carolina at Chapel Hill
H指数:139
被引数:8.2万

个人简介

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教育背景

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工作经历

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荣誉奖项

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Development of a random background to understand ligand optimization

开发随机背景以理解配体优化

Nature
IF48.5
2026-09-160
OAAI
Xinyu Xu; Olivier Mailhot; Galen J. Correy; Xi-Ping Huang; Joao M. Braz; Da Shi; Karthik Srinivasan; Kara Zielinski; Yuliia Holota; Yuliia Kuziv; Christos Iliopoulos-Tsoutsouvas; Nathan D. Levinzon; Yagmur U. Doruk; Moira M. Rachman; Morgan E. Diolaiti; Maisie G. V. Stevens; Fangyu Liu; Katie L. Holland; Harald Hübner; Jing Wang; Yujin Wu; Alan Ashworth; Alexandros Makriyannis; Yuqi Zhang; Yurii S. Moroz; Peter Gmeiner; Robert Abel; Aashish Manglik; Allan I. Basbaum; Bryan L. Roth; James S. Fraser; Brian K. Shoichet
A suite of engineered mice for interrogating psychedelic drug actions

一套用于探究迷幻药物作用机制的工程小鼠

Nature Neuroscience
IF20
2026-08-060
OA
Yi-Ting Chiu; Ariel Y. Deutch; Wei Wang; Gavin P. Schmitz; Karen Lu Huang; D. Dewran Kocak; Pierre Llorach; Kasey R. Bowyer; Bei Liu; Noah Sciaky; Kunjie Hua; Chongguang Chen; Sarah E. Mott; Jesse Niehaus; Jeffrey F. DiBerto; Justin English; Jessica J. Walsh; Grégory Scherrer; Melissa A. Herman; Zhuhao Wu; William C. Wetsel; Bryan L. Roth
De novo design of miniproteins targeting GPCRs

从头设计靶向GPCRs的迷你蛋白

Nature
IF48.5
2026-05-210
PRE
Edin Muratspahić; David Feldman; David E. Kim; Xiangli Qu; Ana-Maria Bratovianu; Paula Rivera-Sánchez; Jan Hendrik Voss; Emil P. T. Hertz; Mads Jeppesen; Federica Dimitri; Kensuke Sakamoto; Amrita Nallathambi; Pia Peceli; Jianjun Cao; Brian P. Cary; Matthew J. Belousoff; Peter Keov; Phuc N. H. Trinh; Qingchao Chen; Yue Ren; Justyn Fine; Sudha Mishra; Annu Dalal; Shachie Sinha; Ramanuj Banerjee; Manisankar Ganguly; Karthik Varappalayam Karuppusamy; Isaac Sappington; Thomas Schlichthaerle; Jason Z. Zhang; Arvind Pillai; Brian Coventry; Ljubica Mihaljević; Magnus Bauer; Susana Vázquez Torres; Amir Motmaen; Gyu Rie Lee; Long Tran; Xinru Wang; Inna Goreshnik; Dionne K. Vafeados; Justin E. Svendsen; Parisa Hosseinzadeh; Nicolai Lindegaard; Matthäus Brandt; Yann Waltenspühl; Kristine Deibler; Lukas Deweid; Anja Bennett; Jendrik Schöppe; Tiantang Dong; Xiaoli Yan; Luke Oostdyk; William Cao; Lakshmi Anantharaman; Johan J. Weisser; Jesper Frank Bastlund; Christoffer Bundgaard; Ayodeji A. Asuni; Justin G. English; Lance Stewart; Lauren Halloran; Jamie B. Spangler; André Lieber; Arun K. Shukla; Patrick M. Sexton; Bryan L. Roth; Brian E. Krumm; Denise Wootten; Christopher G. Tate; Christoffer Norn; David Baker
Structure-based design of an opioid receptor modulator for enhanced morphine analgesia

基于结构的阿片受体调节剂的设计，以增强吗啡镇痛效果

Science Advances
IF12.5
2026-02-110
OA
Yue Wang; Ping Luo; Haiyan Xu; Li Zhan; Kensuke Sakamoto; Mingyu Li; Jing Wang; Xi-Ping Huang; Jianhui Zhou; Tao Liu; Yanrui Suo; Wenjia Fan; Xinheng He; Youwei Xu; Yongjie Cai; Chao Wang; Yuxi Zhao; Antao Dai; Yali Lai; Qingning Yuan; Wen Hu; Kai Wu; Dehua Yang; Xi Cheng; Xiaojie Lu; Brian Krumm; Terry Kenakin; Jian Zhang; Bryan L. Roth; Zhaobing Gao; H. Eric Xu; Youwen Zhuang
The polypharmacology of psychedelics reveals multiple targets for potential therapeutics

致幻剂的药物多效性揭示了潜在治疗药物的多重靶点

Neuron
IF15
2025-07-180
PRE
Manish K. Jain; Ryan H. Gumpper; Samuel T. Slocum; Gavin P. Schmitz; Jakob S. Madsen; Tia A. Tummino; Carl-Mikael Suomivuori; Xi-Ping Huang; Laura Shub; Jeffrey F. DiBerto; Kuglae Kim; Chelsea DeLeon; Brain E. Krumm; Jonathan F. Fay; Michael Keiser; Alexander S. Hauser; Ron O. Dror; Brian Shoichet; David E. Gloriam; David E. Nichols; Bryan L. Roth
High-affinity agonists reveal recognition motifs for the MRGPRD GPCR

高亲和力激动剂揭示了MRGPRD GPCR的识别基序

CELL REPORTS
IF6.9
2024-12-010
OAAI
Wang, Chunyu; Liu, Yongfeng; Lanier, Marion; Yeager, Adam; Singh, Isha; Gumpper, Ryan H.; Krumm, Brian E.; Deleon, Chelsea; Zhang, Shicheng; Boehm, Marcus; Pittner, Richard; Baron, Alain; Dvorak, Lisa; Bacon, Corinne; Shoichet, Brain K.; Martinborough, Esther; Fay, Jonathan F.; Cao, Can; Roth, Bryan L.
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state

神经发育障碍突变将g蛋白锁定在短暂的预激活状态

NATURE COMMUNICATIONS
IF15.7
2024-08-050
OAAI
Knight, Kevin M.; Krumm, Brian E.; Kapolka, Nicholas J.; Ludlam, W. Grant; Cui, Meng; Mani, Sepehr; Prytkova, Iya; Obarow, Elizabeth G.; Lefevre, Tyler J.; Wei, Wenyuan; Ma, Ning; Huang, Xi-Ping; Fay, Jonathan F.; Vaidehi, Nagarajan; Smrcka, Alan V.; Slesinger, Paul A.; Logothetis, Diomedes E.; Martemyanov, Kirill A.; Roth, Bryan L.; Dohlman, Henrik G.

研究方向

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