Michael J. Hope - Publications, H-index & Citations

Michael J. Hope

University of East Anglia

60H指数

152论文数

2.4W被引数

收录论文 28

发表时间

Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema

NATURE COMMUNICATIONS

IF15.7

2021-06-08

OAAI

Szoke, Daniel; Kovacs, Gabor; Kemecsei, Eva; Balint, Laszlo; Szotak-Ajtay, Kitti; Aradi, Petra; Dinnyes, Andrea Styevkone; Mui, Barbara L.; Tam, Ying K.; Madden, Thomas D.; Kariko, Katalin; Kataru, Raghu P.; Hope, Michael J.; Weissman, Drew; Mehrara, Babak J.; Pardi, Norbert; Jakus, Zoltan

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs 含核酸药物的纳米药物的Onpattro故事和临床翻译

NATURE NANOTECHNOLOGY

IF34.9

2019-12-04

995

PREAI

Akinc, Akin; Maier, Martin A.; Manoharan, Muthiah; Fitzgerald, Kevin; Jayaraman, Muthusamy; Barros, Scott; Ansell, Steven; Du, Xinyao; Hope, Michael J.; Madden, Thomas D.; Mui, Barbara L.; Semple, Sean C.; Tam, Ying K.; Ciufolini, Marco; Witzigmann, Dominik; Kulkarni, Jayesh A.; van der Meel, Roy; Cullis, Pieter R.

Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques

MOLECULAR THERAPY-NUCLEIC ACIDS

IF0

2019-04-01

OAAI

Pardi, Norbert; LaBranche, Celia C.; Ferrari, Guido; Cain, Derek W.; Tombacz, Istvan; Parks, Robert J.; Muramatsu, Hiromi; Mui, Barbara L.; Tam, Ying K.; Kariko, Katalin; Polacino, Patricia; Barbosa, Christopher J.; Madden, Thomas D.; Hope, Michael J.; Haynes, Barton F.; Montefiori, David C.; Hu, Shiu-Lok; Weissman, Drew

Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2019-02-04

OAAI

Lee, Mitchell B.; Dowsett, Ian T.; Carr, Daniel T.; Wasko, Brian M.; Stanton, Sarah G.; Chung, Michael S.; Ghodsian, Niloufar; Bode, Anna; Kiflezghi, Michael G.; Uppal, Priya A.; Grayden, Katherine A.; Elala, Yordanos C.; Tang, Thao T.; Tran, Ngoc H. B.; Tran, Thu H. B.; Diep, Anh B.; Hope, Michael; Promislow, Daniel E. L.; Kennedy, Scott R.; Kaeberlein, Matt; Herr, Alan J.

PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake 外源mRNA的PECAM-1定向重新靶向提供了两个数量级的血管递送增强和肺中的表达，而与载脂蛋白E介导的摄取无关

JOURNAL OF CONTROLLED RELEASE

IF11.5

2018-12-01

136

OAAI

Parhiz, Hamideh; Shuvaev, Vladimir V.; Pardi, Norbert; Khoshnejad, Makan; Kiseleva, Raisa Yu; Brenner, Jacob S.; Uhler, Thomas; Tuyishime, Steven; Mui, Barbara L.; Tam, Ying K.; Madden, Thomas D.; Hope, Michael J.; Weissman, Drew; Muzykantov, Vladimir R.

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies

NATURE COMMUNICATIONS

IF15.7

2018-08-22

230

OAAI

Pardi, Norbert; Parkhouse, Kaela; Kirkpatrick, Ericka; McMahon, Meagan; Zost, Seth J.; Mui, Barbara L.; Tam, Ying K.; Kariko, Katalin; Barbosa, Christopher J.; Madden, Thomas D.; Hope, Michael J.; Krammer, Florian; Hensley, Scott E.; Weissman, Drew

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses 核苷修饰的mRNA疫苗可诱导有效的T滤泡辅助和生发中心b细胞反应

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2018-05-08

383

OAAI

Pardi, Norbert; Hogan, Michael J.; Naradikian, Martin S.; Parkhouse, Kaela; Cain, Derek W.; Jones, Letitia; Moody, M. Anthony; Verkerke, Hans P.; Myles, Arpita; Willis, Elinor; LaBranche, Celia C.; Montefiori, David C.; Lobby, Jenna L.; Saunders, Kevin O.; Liao, Hua-Xin; Korber, Bette T.; Sutherland, Laura L.; Scearce, Richard M.; Hraber, Peter T.; Tombacz, Istvan; Muramatsu, Hiromi; Ni, Houping; Balikov, Daniel A.; Li, Charles; Mui, Barbara L.; Tam, Ying K.; Krammer, Florian; Kariko, Katalin; Polacino, Patricia; Eisenlohr, Laurence C.; Madden, Thomas D.; Hope, Michael J.; Lewis, Mark G.; Lee, Kelly K.; Hu, Shiu-Lok; Hensley, Scott E.; Cancro, Michael P.; Haynes, Barton F.; Weissman, Drew

Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines

NPJ VACCINES

IF6.5

2017-10-19

212

OAAI

Lutz, Johannes; Lazzaro, Sandra; Habbeddine, Mohamed; Schmidt, Kim Ellen; Baumhof, Patrick; Mui, Barbara L.; Tam, Ying K.; Madden, Thomas D.; Hope, Michael J.; Heidenreich, Regina; Fotin-Mleczek, Mariola

mRNA mediates passive vaccination against infectious agents, toxins, and tumors

EMBO MOLECULAR MEDICINE

IF8.3

2017-08-09

130

OAAI

Thran, Moritz; Mukherjee, Jean; Poenisch, Marion; Fiedler, Katja; Thess, Andreas; Mui, Barbara L.; Hope, Michael J.; Tam, Ying K.; Horscroft, Nigel; Heidenreich, Regina; Fotin-Mleczek, Mariola; Shoemaker, Charles B.; Schlake, Thomas

Lipid Nanoparticle Systems for Enabling Gene Therapies 用于实现基因治疗的脂质纳米颗粒系统

MOLECULAR THERAPY

IF12

2017-07-01

799

OAAI

Cullis, Pieter R.; Hope, Michael J.

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

NATURE COMMUNICATIONS

IF15.7

2017-03-02

284

OAAI

Pardi, Norbert; Secreto, Anthony J.; Shan, Xiaochuan; Debonera, Fotini; Glover, Joshua; Yi, Yanjie; Muramatsu, Hiromi; Ni, Houping; Mui, Barbara L.; Tam, Ying K.; Shaheen, Farida; Collman, Ronald G.; Kariko, Katalin; Danet-Desnoyers, Gwenn A.; Madden, Thomas D.; Hope, Michael J.; Weissman, Drew

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

JOURNAL OF CONTROLLED RELEASE

IF11.5

2015-11-01

758

OAAI

Pardi, Norbert; Tuyishime, Steven; Muramatsu, Hiromi; Kariko, Katalin; Mui, Barbara L.; Tam, Ying K.; Madden, Thomas D.; Hope, Michael J.; Weissman, Drew

Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

MOLECULAR THERAPY

IF12

2015-09-01

487

OAAI

Thess, Andreas; Grund, Stefanie; Mui, Barbara L.; Hope, Michael J.; Baumhof, Patrick; Fotin-Mleczek, Mariola; Schlake, Thomas

Sequence-Engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

MOLECULAR THERAPY

IF12

2015-05-01

OAAI

Thess, Andreas; Grund, Stefanie; Mui, Barbara L.; Hope, Michael J.; Baumhof, Patrick; Fotin-Mleczek, Mariola; Schlake, Thomas

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

MOLECULAR THERAPY

IF12

2013-08-01

529

OAAI

Maier, Martin A.; Jayaraman, Muthusamy; Matsuda, Shigeo; Liu, Ju; Barros, Scott; Querbes, William; Tam, Ying K.; Ansell, Steven M.; Kumar, Varun; Qin, June; Zhang, Xuemei; Wang, Qianfan; Panesar, Sue; Hutabarat, Renta; Carioto, Mary; Hettinger, Julia; Kandasamy, Pachamuthu; Butler, David; Rajeev, Kallanthottathil G.; Pang, Bo; Charisse, Klaus; Fitzgerald, Kevin; Mui, Barbara L.; Du, Xinyao; Cullis, Pieter; Madden, Thomas D.; Hope, Michael J.; Manoharan, Muthiah; Akinc, Akin

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles 聚乙二醇脂质解吸速率对siRNA脂质纳米粒药动学和药效学的影响

MOLECULAR THERAPY-NUCLEIC ACIDS

IF0

2013-01-01

357

OAAI

Mui, Barbara L.; Tam, Ying K.; Jayaraman, Muthusamy; Ansell, Steven M.; Du, Xinyao; Tam, Yuen Yi C.; Lin, Paulo J. C.; Chen, Sam; Narayanannair, Jayaprakash K.; Rajeev, Kallanthottathil G.; Manoharan, Muthiah; Akinc, Akin; Maier, Martin A.; Cullis, Pieter; Madden, Thomas D.; Hope, Michael J.

Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core (vol 116, pg 18440, 2012)

JOURNAL OF PHYSICAL CHEMISTRY C

IF3.2

2012-10-04

OAAI

Leung, Alex K. K.; Hafez, Ismail M.; Baoukina, Svetlana; Belliveau, Nathan M.; Zhigaltsev, Igor V.; Afshinmanesh, Elham; Tieleman, D. Peter; Hansen, Carl L.; Hope, Michael J.; Cullis, Pieter R.

Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core

JOURNAL OF PHYSICAL CHEMISTRY C

IF3.2

2012-08-21

304

OAAI

Leung, Alex K. K.; Hafez, Ismail M.; Baoukina, Svetlana; Belliveau, Nathan M.; Zhigaltsev, Igor V.; Afshinmanesh, Elham; Tieleman, D. Peter; Hansen, Carl L.; Hope, Michael J.; Cullis, Pieter R.

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo 最大化siRNA脂质纳米粒体内肝基因沉默的效力

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2012-07-10

1.1K

OAAI

Jayaraman, Muthusamy; Ansell, Steven M.; Mui, Barbara L.; Tam, Ying K.; Chen, Jianxin; Du, Xinyao; Butler, David; Eltepu, Laxman; Matsuda, Shigeo; Narayanannair, Jayaprakash K.; Rajeev, Kallanthottathil G.; Hafez, Ismail M.; Akinc, Akin; Maier, Martin A.; Tracy, Mark A.; Cullis, Pieter R.; Madden, Thomas D.; Manoharan, Muthiah; Hope, Michael J.

Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells

MOLECULAR THERAPY

IF12

2011-12-01

251

OAAI

Basha, Genc; Novobrantseva, Tatiana I.; Rosin, Nicole; Tam, Yuen Yi C.; Hafez, Ismail M.; Wong, Matthew K.; Sugo, Tsukasa; Ruda, Vera M.; Qin, June; Klebanov, Boris; Ciufolini, Marco; Akinc, Akin; Tam, Ying K.; Hope, Michael J.; Cullis, Pieter R.

研究方向