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Dual mechanism: Epigenetic inhibitor apabetalone reduces SARS-CoV-2 Delta and Omicron variant spike binding and attenuates SARS-CoV-2 RNA induced inflammation Fu, Li; Gilham, Dean; Stotz, Stephanie C.; Sarsons, Christopher D.; Rakai, Brooke D.; Tsujikawa, Laura M.; Wasiak, Sylwia; Johansson, Jan O.; Sweeney, Michael; Wong, Norman C. W.; Kulikowski, Ewelina 分享 收藏
Epigenetic BET reader inhibitor apabetalone (RVX-208) counters proinflammatory aortic gene expression in a diet induced obesity mouse model and in human endothelial cells Wasiak, Sylwia; Tsujikawa, Laura M.; Daze, Emily; Gilham, Dean; Stotz, Stephanie C.; Rakai, Brooke D.; Sarsons, Chris D.; Fu, Li; Azhar, Salman; Jahagirdar, Ravi; Sweeney, Michael; Johansson, Jan O.; Wong, Norman C. W.; Kulikowski, Ewelina 分享 收藏
Reduction in the risk of major adverse cardiovascular events with the BET protein inhibitor apabetalone in patients with recent acute coronary syndrome, type 2 diabetes, and moderate to high likelihood of non-alcoholic fatty liver disease Toth, Peter P.; Schwartz, Gregory G.; Nicholls, Stephen J.; Khan, Aziz; Szarek, Michael; Ginsberg, Henry N.; Johansson, Jan O.; Kalantar-Zadeh, Kamyar; Kulikowski, Ewelina; Lebioda, Ken; Wong, Norman C. W.; Sweeney, Michael; Ray, Kausik K. 分享 收藏
Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators Tsujikawa, Laura M.; Kharenko, Olesya A.; Stotz, Stephanie C.; Rakai, Brooke D.; Sarsons, Christopher D.; Gilham, Dean; Wasiak, Sylwia; Fu, Li; Sweeney, Michael; Johansson, Jan O.; Wong, Norman C. W.; Kulikowski, Ewelina 分享 收藏
Cognitive Effects of the BET Protein Inhibitor Apabetalone: A Prespecified Montreal Cognitive Assessment Analysis Nested in the BETonMACE Randomized Controlled Trial Cummings, Jeffrey; Schwartz, Gregory G.; Nicholls, Stephen J.; Khan, Aziz; Halliday, Chris; Toth, Peter P.; Sweeney, Michael; Johansson, Jan O.; Wong, Norman C. W.; Kulikowski, Ewelina; Kalantar-Zadeh, Kamyar; Lebioda, Kenneth; Ginsberg, Henry N.; Winblad, Bengt; Zetterberg, Henrik; Ray, Kausik K. 分享 收藏
Relation of insulin treatment for type 2 diabetes to the risk of major adverse cardiovascular events after acute coronary syndrome: an analysis of the BETonMACE randomized clinical trial Schwartz, Gregory G.; Nicholls, Stephen J.; Toth, Peter P.; Sweeney, Michael; Halliday, Christopher; Johansson, Jan O.; Wong, Norman C. W.; Kulikowski, Ewelina; Kalantar-Zadeh, Kamyar; Ginsberg, Henry N.; Ray, Kausik K. 分享 收藏
Effect of Apabetalone on Cardiovascular Events in Diabetes, CKD, and Recent Acute Coronary Syndrome Results from the BETonMACE Randomized Controlled Trial Kalantar-Zadeh, Kamyar; Schwartz, Gregory G.; Nicholls, Stephen J.; Buhr, Kevin A.; Ginsberg, Henry N.; Johansson, Jan O.; Kulikowski, Ewelina; Lebioda, Kenneth; Toth, Peter P.; Wong, Norman; Sweeney, Michael; Ray, Kausik K. 分享 收藏
Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro Gilham, Dean; Smith, Audrey L.; Fu, Li; Moore, Dalia Y.; Muralidharan, Abenaya; Reid, St. Patrick M.; Stotz, Stephanie C.; Johansson, Jan O.; Sweeney, Michael; Wong, Norman C. W.; Kulikowski, Ewelina; El-Gamal, Dalia 分享 收藏
BET Protein Inhibitor Apabetalone Suppresses Inflammatory Hyperactivation of Monocytes From Patients With Cardiovascular Disease and Type 2 Diabetes Wasiak, Sylwia; Dzobo, Kim; Rakai, Brooke; Kaiser, Yannick; Versloot, Miranda; Bahjat, Mahnoush; Stotz, Stephanie; Fu, Li; Sweeney, Michael; Johansson, Jan; Wong, Norman; Stroes, Erik; Kroon, Jeffrey; Kulikowski, Ewelina 分享 收藏
BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes Wasiak, Sylwia; Dzobo, Kim E.; Rakai, Brooke D.; Kaiser, Yannick; Versloot, Miranda; Bahjat, Mahnoush; Stotz, Stephanie C.; Fu, Li; Sweeney, Michael; Johansson, Jan O.; Wong, Norman C. W.; Stroes, Erik S. G.; Kroon, Jeffrey; Kulikowski, Ewelina 分享 收藏
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Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease Wasiak, Sylwia; Gilham, Dean; Daze, Emily; Tsujikawa, Laura M.; Halliday, Christopher; Stotz, Stephanie C.; Rakai, Brooke D.; Fu, Li; Jahagirdar, Ravi; Sweeney, Michael; Johansson, Jan O.; Wong, Norman C. W.; Kulikowski, Ewelina 分享 收藏
Apabetalone lowers serum alkaline phosphatase and improves cardiovascular risk in patients with cardiovascular disease Mathias, Haarhaus; Ray, Kausik K.; Nicholls, Stephen J.; Schwartz, Gregory G.; Kulikowski, Ewelina; Johansson, Jan O.; Sweeney, Michael; Halliday, Christopher; Lebioda, Kenneth; Wong, Norman; Brandenburg, Vincent; Beddhu, Srinivasan; Tonelli, Marcello; Zoccali, Carmine; Kalantar-Zadeh, Kamyar 分享 收藏
Effect of selective BET protein inhibitor apabetalone on cardiovascular outcomes in patients with acute coronary syndrome and diabetes: Rationale, design, and baseline characteristics of the BETonMACE trial Ray, Kausik K.; Nicholls, Stephen J.; Ginsberg, Henry D.; Johansson, Jan O.; Kalantar-Zadeh, Kamyar; Kulikowski, Ewelina; Toth, Peter P.; Wong, Norman; Cummings, Jeffrey L.; Sweeney, Michael; Schwartz, Gregory G. 分享 收藏
Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism Tsujikawa, Laura M.; Fu, Li; Das, Shovon; Halliday, Christopher; Rakai, Brooke D.; Stotz, Stephanie C.; Sarsons, Christopher D.; Gilham, Dean; Daze, Emily; Wasiak, Sylwia; Studer, Deborah; Rinker, Kristina D.; Sweeney, Michael; Johansson, Jan O.; Wong, Norman C. W.; Kulikowski, Ewelina 分享 收藏
Apabetalone downregulates factors and pathways associated with vascular calcification Gilham, Dean; Tsujikawa, Laura M.; Sarsons, Christopher D.; Halliday, Christopher; Wasiak, Sylwia; Stotz, Stephanie C.; Jahagirdar, Ravi; Sweeney, Michael; Johansson, Jan O.; Wong, Norman C. W.; Kalantar-Zadeh, Kamyar; Kulikowski, Ewelina 分享 收藏
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Apabetalone (RVX-208) Reduces Pathologic Cell-Cell Adhesion and Expression of Key Vascular Inflammation Markers in Monocytes, Endothelial Cells and Mouse Aorta Tsujikawa, Laura; Wasiak, Sylwia; Daze, Emily; Sarsons, Chris D.; Stotz, Stephanie C.; Jahagirdar, Ravi; Studer, Deborah; Rinker, Kristina D.; Sweeney, Michael; Johansson, Jan O.; Wong, Norman C.; Kulikowski, Ewelina 分享 收藏
Benefit of Apabetalone on Plasma Proteins in Renal Disease Wasiak, Sylwia; Tsujikawa, Laura M.; Halliday, Christopher; Stotz, Stephanie C.; Gilham, Dean; Jahagirdar, Ravi; Kalantar-Zadeh, Kamyar; Robson, Richard; Sweeney, Michael; Johansson, Jan O.; Wong, Norman C.; Kulikowski, Ewelina 分享 收藏
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