未登录 Pharmacological Characterization of GSK573719 (Umeclidinium): A Novel, Long-Acting, Inhaled Antagonist of the Muscarinic Cholinergic Receptors for Treatment of Pulmonary Diseases Salmon, Michael; Luttmann, Mark A.; Foley, James J.; Buckley, Peter T.; Schmidt, Dulcie B.; Burman, Miriam; Webb, Edward F.; DeHaas, Christopher J.; Kotzer, Charles J.; Barrett, Victoria J.; Slack, Robert J.; Sarau, Henry M.; Palovich, Michael R.; Laine, Dramane I.; Hay, Douglas W. P.; Rumsey, William L. 分享 收藏
Design, Synthesis, and Structure-Activity Relationship of Tropane Muscarinic Acetylcholine Receptor Antagonists Laine, Dramane I.; Wan, Zehong; Yan, Hongxing; Zhu, Chongjie; Xie, Haibo; Fu, Wei; Busch-Petersen, Jakob; Neipp, Christopher; Davis, Roderick; Widdowson, Katherine L.; Blaney, Frank E.; Foley, James; Bacon, Alicia M.; Webb, Edward F.; Luttmann, Mark A.; Burman, Miriam; Sarau, Henry M.; Salmon, Michael; Palovich, Michael R.; Belmonte, Kristen 分享 收藏
The peptidic urotensin-II receptor ligand GSK248451 possesses less intrinsic activity than the low-efficacy partial agonists SB-710411 and urantide in native mammalian tissues and recombinant cell systems Behm, David J.; Stankus, Gerald; Doe, Christopher P. A.; Willette, Robert N.; Sarau, Henry M.; Foley, James J.; Schmidt, Dulcie B.; Nuthulaganti, Parvathi; Fornwald, James A.; Ames, Robert S.; Lambert, David G.; Calo', Girolamo; Camarda, Valeria; Aiyar, Nambi V.; Douglas, Stephen A. 分享 收藏
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Nonpeptidic urotensin-II receptor antagonists I:: in vitro pharmacological characterization of SB-706375 Douglas, SA; Behm, DJ; Aiyar, NV; Naselsky, D; Disa, J; Brooks, DP; Ohlstein, EH; Gleason, JG; Sarau, HM; Foley, JJ; Buckley, PT; Schmidt, DB; Wixted, WE; Widdowson, K; Riley, G; Jin, J; Gallagher, TF; Schmidt, SJ; Ridgers, L; Christmann, LT; Keenan, RM; Knight, SD; Dhanak, D 分享 收藏
Discovery of biphenyl piperazines as novel and long acting muscarinic acetylcholine receptor antagonists Jin, Jian; Budzik, Brian; Wang, Yonghui; Shi, Dongchuan; Wang, Feng; Xie, Haibo; Wan, Zehong; Zhu, Chongye; Foley, James J.; Webb, Edward F.; Berlanga, Manuela; Burman, Miriam; Sarau, Henry M.; Morrow, Dwight M.; Moore, Michael L.; Rivero, Ralph A.; Palovich, Michael; Salmon, Michael; Belmonte, Kristen E.; Laine, Dramane I. 分享 收藏
Discovery of novel and long acting muscarinic acetylcholine receptor antagonists Jin, Jian; Wang, Yonghui; Shi, Dongchuan; Wang, Feng; Davis, Roderick S.; Jin, Qi; Fu, Wei; Foley, James J.; Webb, Edward F.; Dehaas, Chris J.; Berlanga, Manuela; Burman, Miriam; Sarau, Henry M.; Morrow, Dwight M.; Rao, Parvathi; Kallal, Loretta A.; Moore, Michael L.; Rivero, Ralph A.; Palovich, Michael; Salmon, Michael; Belmonte, Kristen E.; Busch-Petersen, Jakob 分享 收藏
A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels: Upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonist 人全血中性粒细胞和单核细胞CD11b水平的新型流式细胞术测定: 趋化因子的上调与受体表达，与中性粒细胞形状变化的比较以及趋化因子受体 (CXCR2) 拮抗剂的作用有关 Nicholson, Grant C.; Tennant, Rachel C.; Carpenter, Donald C.; Sarau, Henry M.; Kon, Onn Min; Barnes, Peter J.; Salmon, Michael; Vessey, Rupert S.; Tal-Singer, Ruth; Hansel, Trevor T. 分享 收藏
Cloning and pharmacological characterization of the cat urotensin-II receptor (UT) Aiyar, N; Johns, DG; Ao, ZH; Disa, J; Behm, DJ; Foley, JJ; Buckley, PT; Sarau, HM; van-der-Keyl, HK; Elshourbagy, NA; Douglas, SA 分享 收藏
Neuromedin U elicits cytokine release in murine Th2-type T cell clone D10.G4.1 Johnson, EN; Appelbaum, ER; Carptenter, DC; Cox, RF; Disa, J; Foley, JJ; Ghosh, SK; Naselsky, DP; Pullen, MA; Sarau, HM; Scheff, SR; Steplewski, KM; Zaks-Zilberman, M; Aiyar, N 分享 收藏
Angiotensin II induces neutrophil accumulation in vivo through generation and release of CXC chemokines Abu Nabah, YN; Mateo, T; Estellés, R; Mata, M; Zagorski, J; Sarau, H; Cortijo, J; Morcillo, EJ; Jose, PJ; Sanz, MJ 分享 收藏
Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats Gartlon, J; Szekeres, P; Pullen, M; Sarau, HM; Aiyar, N; Shabon, U; Michalovich, D; Steplewski, K; Ellis, C; Elshourbagy, N; Duxon, M; Ashmeade, TE; Harrison, DC; Murdock, P; Wilson, S; Ennaceur, A; Atkins, A; Heidbreder, C; Hagan, JJ; Hunter, AJ; Jones, DNC 分享 收藏
Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor Widdowson, KL; Elliott, JD; Veber, DF; Nie, H; Rutledge, MC; McCleland, BW; Xiang, JN; Jurewicz, AJ; Hertzberg, RP; Foley, JJ; Griswold, DE; Martin, L; Lee, JM; White, JR; Sarau, HM 分享 收藏
Regulation of TNF-α and IFN-γ induced CXCL10 expression: participation of the airway smooth muscle in the pulmonary inflammatory response in chronic obstructive pulmonary disease Hardaker, EL; Bacon, AM; Carlson, K; Roshak, AK; Foley, JJ; Schmidt, DB; Buckley, PT; Comegys, M; Panettieri, RA; Sarau, HM; Belmonte, KE 分享 收藏
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A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit Podolin, PL; Bolognese, BJ; Foley, JJ; Schmidt, DB; Buckley, PT; Widdowson, KL; Jin, Q; White, JR; Lee, JM; Goodman, RB; Hagen, TR; Kajikawa, O; Marshall, LA; Hay, DWP; Sarau, HM 分享 收藏
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Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pig's Hay, DWP; Giardina, GAM; Griswold, DE; Underwood, DC; Kotzer, CJ; Bush, B; Potts, W; Sandhu, P; Lundberg, D; Foley, JJ; Schmidt, DB; Martin, LD; Kilian, D; Legos, JJ; Barone, FC; Luttmann, MA; Grugni, M; Raveglia, LF; Sarau, HM 分享 收藏
Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs Freeman, K; Tsui, P; Moore, D; Emson, PC; Vawter, L; Naheed, S; Lane, P; Bawagan, H; Herrity, N; Murphy, K; Sarau, HM; Ames, RS; Wilson, S; Livi, GP; Chambers, JK 分享 收藏
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