arrow
返回
J

Joseph J. Lynch

merck & company

47H指数
253论文数
6.6K被引数
收录论文 41
发表时间
The new antiarrhythmic drug vernakalant: ex vivo study of human atrial tissue from sinus rhythm and chronic atrial fibrillation
err2013-01-22
err88
errOAAI
errWettwer, Erich; Christ, Torsten; Endig, Sebastian; Rozmaritsa, Nadiia; Matschke, Klaus; Lynch, Joseph J.; Pourrier, Marc; Gibson, John K.; Fedida, David; Knaut, Michael; Ravens, Ursula
err分享
err收藏
MK-0448, a Specific Kv1.5 Inhibitor Safety, Pharmacokinetics, and Pharmacodynamic Electrophysiology in Experimental Animal Models and Humans
err2012-12-01
err46
errOAAI
errPavri, Behzad B.; Greenberg, Howard E.; Kraft, Walter K.; Lazarus, Nicole; Lynch, Joseph J.; Salata, Joseph J.; Bilodeau, Mark T.; Regan, Christopher P.; Stump, Gary; Fan, Li; Mehta, Anish; Wagner, John A.; Gutstein, David E.; Bloomfield, Daniel
err分享
err收藏
Comparison of electrophysiological and antiarrhythmic effects of vernakalant, ranolazine, and sotalol in canine pulmonary vein sleeve preparations
err2012-03-01
err17
errOAAI
errSicouri, Serge; Pourrier, Marc; Gibson, John K.; Lynch, Joseph J.; Antzelevitch, Charles
err分享
err收藏
Characterization of the Calcitonin Gene-Related Peptide Receptor Antagonist Telcagepant (MK-0974) in Human Isolated Coronary Arteries
err2010-09-01
err63
PREAI
errChan, K. Y.; Edvinsson, L.; Eftekhari, S.; Kimblad, P. O.; Kane, S. A.; Lynch, J.; Hargreaves, R. J.; de Vries, R.; Garrelds, I. M.; van den Bogaerdt, A. J.; Danser, A. H. J.; MaassenVanDenBrink, A.
err分享
err收藏
Pharmacological Properties of MK-3207, a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist
err2010-04-01
err81
PREAI
errSalvatore, Christopher A.; Moore, Eric L.; Calamari, Amy; Cook, Jacquelynn J.; Michener, Maria S.; O'Malley, Stacey; Miller, Patricia J.; Sur, Cyrille; Williams, David L., Jr.; Zeng, Zhizhen; Danziger, Andrew; Lynch, Joseph J.; Regan, Christopher P.; Fay, John F.; Tang, Yui S.; Li, Chi-Chung; Pudvah, Nicole T.; White, Rebecca B.; Bell, Ian M.; Gallicchio, Steven N.; Graham, Samuel L.; Selnick, Harold G.; Vacca, Joseph P.; Kane, Stefanie A.
err分享
err收藏
Discovery of MK-3207: A Highly Potent, Orally Bioavailable CGRP Receptor Antagonist
err2010-01-12
err56
errOAAI
errBell, Ian M.; Gallicchio, Steven N.; Wood, Michael R.; Quigley, Amy G.; Stump, Craig A.; Zartman, C. Blair; Fay, John F.; Li, Chi-Chung; Lynch, Joseph J.; Moore, Eric L.; Mosser, Scott D.; Prueksaritanont, Thomayant; Regan, Christopher P.; Roller, Shane; Salvatore, Christopher A.; Kane, Stefanie A.; Vacca, Joseph P.; Selnick, Harold G.
err分享
err收藏
Effects of the prototype serotonin 5-HT1B/1D receptor agonist sumatriptan and the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP8-37 on myocardial reactive hyperemic response in conscious dogs
err2009-11-01
err18
PREAI
errLynch, Joseph J.; Shen, You-Tang; Pittman, Tamara J.; Anderson, Kenneth D.; Koblan, Kenneth S.; Gould, Robert J.; Regan, Christopher P.; Kane, Stefanie A.
err分享
err收藏
Dose-response effects of sotalol on cardiovascular function in conscious, freely moving cynomolgus monkeys
err2009-01-29
err11
errOAAI
errLynch, J. J., III; Wilson, A. W.; Hernandez, L. E.; Nelson, R. A.; Marsh, K. C.; Cox, B. F.; Mittelstadt, S. W.
err分享
err收藏
err分享
err收藏
Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist
err2007-01-24
err56
PREAI
errLiverton, Nigel J.; Bednar, Rodney A.; Bednar, Bohumil; Butcher, John W.; Claiborne, Christopher F.; Claremon, David A.; Cunningham, Michael; DiLella, Anthony G.; Gaul, Stanley L.; Libby, Brian E.; Lyle, Elizabeth A.; Lynch, Joseph J.; McCauley, John A.; Mosser, Scott D.; Nguyen, Kevin T.; Stump, Gary L.; Sun, Hong; Wang, Hao; Yergey, James; Koblan, Kenneth S.
err分享
err收藏
Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation
err2006-10-27
err105
PREAI
errTrotter, B. Wesley; Nanda, Kausik K.; Kett, Nathan R.; Regan, Christopher P.; Lynch, Joseph J.; Stump, Gary L.; Kiss, Laszlo; Wang, Jixin; Spencer, Robert H.; Kane, Stefanie A.; White, Rebecca B.; Zhang, Rena; Anderson, Kenneth D.; Liverton, Nigel J.; McIntyre, Charles J.; Beshore, Douglas C.; Hartman, George D.; Dinsmore, Christopher J.
err分享
err收藏
Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats
err2006-03-01
err57
PREAI
errBrochu, RM; Dick, IE; Tarpley, JW; McGowan, E; Gunner, D; Herrington, J; Shao, PP; Ok, D; Li, CS; Parsons, WH; Stump, GL; Regan, CP; Lynch, JJ; Lyons, KA; McManus, OB; Clark, S; Ali, Z; Kaczorowski, GJ; Martin, WJ; Priest, BT
err分享
err收藏
9-hydroxyazafluorenes and their use in thrombin inhibitors
err2005-02-24
err43
PREAI
errStauffer, KJ; Williams, PD; Selnick, HG; Nantermet, PG; Newton, CL; Homnick, CF; Zrada, MM; Lewis, SD; Lucas, BJ; Krueger, JA; Pietrak, BL; Lyle, EA; Singh, R; Miller-Stein, C; White, RB; Wong, B; Wallace, AA; Sitko, GR; Cook, JJ; Holahan, MA; Stranieri-Michener, M; Leonard, YM; Lynch, JJ; McMasters, DR; Yan, YM
err分享
err收藏
Potent N-(1,3-thiazol-2-yl)pyridin-2-amine vascular endothelial growth factor receptor tyrosine kinase inhibitors with excellent pharmacokinetics and low affinity for the hERG ion channel
err2004-10-29
err60
PREAI
errBilodeau, MT; Balitza, AE; Koester, TJ; Manley, PJ; Rodman, LD; Buser-Doepner, C; Coll, KE; Fernandes, C; Gibbs, JB; Heimbrook, DC; Huckel, WR; Kohl, N; Lynch, JJ; Mao, XZ; McFall, RC; McLoughlin, D; Miller-Stein, CM; Rickert, KW; Sepp-Lorenzino, L; Shipman, JM; Subramanian, R; Thomas, KA; Wong, BK; Yu, S; Hartman, GD
err分享
err收藏
NR2B-selective N-methyl-D-aspartate antagonists:: Synthesis and evaluation of 5-substituted benzimidazoles
err2004-03-11
err62
PREAI
errMcCauley, JA; Theberge, CR; Romano, JJ; Billings, SB; Anderson, KD; Claremon, DA; Freidinger, RM; Bednar, RA; Mosser, SD; Gaul, SL; Connolly, TM; Condra, CL; Xia, MH; Cunningham, ME; Bednar, B; Stump, GL; Lynch, JJ; Macaulay, A; Wafford, KA; Koblan, KS; Liverton, NJ
err分享
err收藏
Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors:: Structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity
err2003-05-08
err73
PREAI
errFriesen, RW; Ducharme, Y; Ball, RG; Blouin, M; Boulet, L; Côté, B; Frenette, R; Girard, M; Guay, D; Huang, Z; Jones, TR; Laliberté, F; Lynch, JJ; Mancini, J; Martins, E; Masson, P; Muise, E; Pon, DJ; Siegl, PKS; Styhler, A; Tsou, NN; Turner, MJ; Young, RN; Girard, Y
err分享
err收藏