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Epigenetic drift score captures directional methylation variability and links aging to transcriptional, metabolic, and genetic alterations 表观遗传漂移评分捕获方向性甲基化变异性，并将衰老与转录、代谢和遗传改变联系起来。 Fan, Xiu; Qian, Qili; Li, Wenran; Liu, Tianzi; Zeng, Changqing; Jia, Peilin; Lin, Huandong; Gao, Xin; Jin, Li; Xia, Mingfeng; Wang, Sijia; Liu, Fan 分享 收藏
Common cis-regulatory variation modifies the penetrance of pathogenic SHROOM3 variants in craniofacial microsomia 常见的顺式调控变异改变了致病性SHROOM3变异在颅面微小型中的外显率 Zhu, Hao; Zhang, Jiao; Rao, Soumya; Durbin, Matthew D.; Li, Ying; Lang, Ruirui; Liu, Jiqiang; Xiao, Baichuan; Shan, Hailin; Meng, Ziqiu; Wang, Jinmo; Tang, Xiaokai; Shi, Zhenni; Cox, Liza L.; Zhao, Shouqin; Ware, Stephanie M.; Tan, Tiong Y.; de Silva, Michelle; Gallacher, Lyndon; Liu, Ting; Mi, Jie; Zeng, Changqing; Zheng, Hou-Feng; Zhang, Qingguo; Antonarakis, Stylianos E.; Cox, Timothy C.; Zhang, Yong-Biao 分享 收藏
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Novel Genetic Loci in Early-Onset Gout Derived From Whole-Genome Sequencing of an Adolescent Gout Cohort Ji, Aichang; Sui, Yang; Xue, Xiaomei; Ji, Xiapeng; Shi, Wenrui; Shi, Yongyong; Terkeltaub, Robert; Dalbeth, Nicola; Takei, Riku; Yan, Fei; Sun, Mingshu; Li, Maichao; Lu, Jie; Cui, Lingling; Liu, Zhen; Wang, Can; Li, Xinde; Han, Lin; Fang, Zhanjie; Sun, Wenyan; Liang, Yue; He, Yuwei; Zheng, Guangmin; Wang, Xuefeng; Wang, Jiayi; Zhang, Hui; Pang, Lei; Qi, Han; Li, Yushuang; Cheng, Zan; Li, Zhiqiang; Xiao, Jingfa; Zeng, Changqing; Merriman, Tony R.; Qu, Hongzhu; Fang, Xiangdong; Li, Changgui 分享 收藏
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Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits Peng, Qianqian; Liu, Xinxuan; Li, Wenran; Jing, Han; Li, Jiarui; Gao, Xingjian; Luo, Qi; Breeze, Charles E.; Pan, Siyu; Zheng, Qiwen; Li, Guochao; Qian, Jiaqiang; Yuan, Liyun; Yuan, Na; You, Chenglong; Du, Siyuan; Zheng, Yuanting; Yuan, Ziyu; Tan, Jingze; Jia, Peilin; Wang, Jiucun; Zhang, Guoqing; Lu, Xianping; Shi, Leming; Guo, Shicheng; Liu, Yun; Ni, Ting; Wen, Bo; Zeng, Changqing; Jin, Li; Teschendorff, Andrew E.; Liu, Fan; Wang, Sijia 分享 收藏
A Proactive Intervention Study in Metabolic Syndrome High-Risk Populations Using Phenome-Based Actionable P4 Medicine Strategy 使用基于表型组的可行P4药物策略对代谢综合征高危人群进行的积极干预研究 Huang, Qiongrong; Hu, Zhiyuan; Zheng, Qiwen; Mao, Xuemei; Lv, Wenxi; Wu, Fei; Fu, Dapeng; Lu, Cuihong; Zeng, Changqing; Wang, Fei; Zeng, Qiang; Fang, Qiaojun; Hood, Leroy 分享 收藏
Searching across-cohort relatives in 54,092 GWAS samples via encrypted genotype regression 通过加密基因型回归在54,092个ghis样本中搜索跨队列亲属 Zhang, Qi-Xin; Liu, Tianzi; Guo, Xinxin; Zhen, Jianxin; Yang, Meng-yuan; Khederzadeh, Saber; Zhou, Fang; Han, Xiaotong; Zheng, Qiwen; Jia, Peilin; Ding, Xiaohu; He, Mingguang; Zou, Xin; Liao, Jia-Kai; Zhang, Hongxin; He, Ji; Zhu, Xiaofeng; Lu, Daru; Chen, Hongyan; Zeng, Changqing; Liu, Fan; Zheng, Hou-Feng; Liu, Siyang; Xu, Hai-Ming; Chen, Guo-Bo 分享 收藏
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Novel loci for ocular axial length identified through extreme-phenotype genome-wide association study in Chinese populations Han, Xiaotong; Pan, Siyu; Liu, Jialin; Ding, Xiaohu; Lin, Xingyan; Wang, Decai; Xie, Zhi; Zeng, Changqing; Liu, Fan; He, Mingguang; Zhou, Xiangtian; Liu, Tianzi; Luo, Lixia; Liu, Yizhi 分享 收藏
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How Placenta Promotes the Successful Reproduction in High-Altitude Populations: A Transcriptome Comparison between Adaptation and Acclimatization Wu, Deng; Liu, Yunao; Chen, Wei; Shao, Jianming; Zhuoma, Pubu; Zhao, Dexiong; Yu, Yang; Liu, Tianzi; Yu, Ruoxuan; Gan, Yongna; Yuzheng, Baima; Huang, Yongshu; Zhang, Haikun; Bi, Xiaoman; Tao, Chengcheng; Lai, Shujuan; Luo, Qiaoxia; Zhang, Dake; Wang, Hongmei; Zhaxi, Pingcuo; Zhang, Jianqing; Qiao, Jie; Zeng, Changqing 分享 收藏
Identification of novel loci influencing refractive error in East Asian populations using an extreme phenotype design Han, Xiaotong; Liu, Tianzi; Ding, Xiaohu; Liu, Jialin; Lin, Xingyan; Wang, Decai; Riaz, Moeen; Baird, Paul N.; Xie, Zhi; Cheng, Yuan; Li, Yi; Mori, Yuki; Miyake, Masahiro; Li, Hengtong; Cheng, Ching-Yu; Zeng, Changqing; Ohno-Matsui, Kyoko; Zhou, Xiangtian; Liu, Fan; He, Mingguang 分享 收藏
Declines in PDE4B activity promote myopia progression through downregulation of scleral collagen expression PDE4B活性下降通过下调巩膜胶原表达促进近视进展 Zhao, Fuxin; Zhou, Hui; Chen, Wei; Zhao, Chenchen; Zheng, Yangyang; Tao, Yijin; Pan, Miaozhen; Reinach, Peter S.; Zhu, Jiadi; An, Jianhong; Lu, Runxia; Chen, Jiang-fan; Tang, Huifang; Zeng, Changqing; Qu, Jia; Zhou, Xiangtian 分享 收藏
Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia Hong, Yaqiang; Zhang, Dake; Zhou, Xiangtian; Chen, Aili; Abliz, Amir; Bai, Jian; Wang, Liang; Hu, Qingtao; Gong, Kenan; Guan, Xiaonan; Liu, Mengfei; Zheng, Xinchang; Lai, Shujuan; Qu, Hongzhu; Zhao, Fuxin; Hao, Shuang; Wu, Zhen; Cai, Hong; Hu, Shaoyan; Ma, Yue; Zhang, Junting; Ke, Yang; Wang, Qian-Fei; Chen, Wei; Zeng, Changqing 分享 收藏
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TGFB3 downregulation causing chordomagenesis and its tumor suppression role maintained by Smad7 Wang, Liang; Guan, Xiaonan; Hu, Qingtao; Wu, Zhen; Chen, Wei; Song, Lairong; Wang, Ke; Tian, Kaibing; Cao, Chunwei; Zhang, Dake; Ma, Junpeng; Tong, Xiangjun; Zhang, Bo; Zhang, Junting; Zeng, Changqing 分享 收藏
Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color 近195,000个人的全基因组关联研究确定了50个以前未确定的眼睛颜色遗传位点 Simcoe, Mark; Valdes, Ana; Liu, Fan; Furlotte, Nicholas A.; Evans, David M.; Hemani, Gibran; Ring, Susan M.; Smith, George Davey; Duffy, David L.; Zhu, Gu; Gordon, Scott D.; Medland, Sarah E.; Vuckovic, Dragana; Girotto, Giorgia; Sala, Cinzia; Catamo, Eulalia; Concas, Maria Pina; Brumat, Marco; Gasparini, Paolo; Toniolo, Daniela; Cocca, Massimiliano; Robino, Antonietta; Yazar, Seyhan; Hewitt, Alex; Wu, Wenting; Kraft, Peter; Hammond, Christopher J.; Shi, Yuan; Chen, Yan; Zeng, Changqing; Klaver, Caroline C. W.; Uitterlinden, Andre G.; Ikram, M. Arfan; Hamer, Merel A.; van Duijn, Cornelia M.; Nijsten, Tamar; Han, Jiali; Mackey, David A.; Martin, Nicholas G.; Cheng, Ching-Yu; Hinds, David A.; Spector, Timothy D.; Kayser, Manfred; Hysi, Pirro G. 分享 收藏
Dysfunction of VIPR2 leads to myopia in humans and mice Zhao, Fuxin; Li, Qihang; Chen, Wei; Zhu, He; Zhou, Dengke; Reinach, Peter Sol; Yang, Zhenglin; He, Mingguang; Xue, Anquan; Wu, Deng; Liu, Tianzi; Fu, Qian; Zeng, Changqing; Qu, Jia; Zhou, Xiangtian 分享 收藏
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