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J

Jiangqing Chen

Liangzhu Laboratory
H指数:7
被引数:454
浏览量:0

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Calibration of CAR signaling promotes asymmetric cell division to direct CAR-T cell fate and antitumor potency

CAR信号校准促进不对称细胞分裂以指导CAR-T细胞命运和抗肿瘤效力

Cell Reports
IF6.9
2026-08-010
OAAI
Shen, Xiaolin; Xu, Xiaobao; Jiang, Jie; Zhang, Shize; Chen, Jiangqing; Chen, Ruoqi; Gu, Ying; Zhou, Chun; Xiao, Gang; Huang, He; Huse, Morgan; Sadelain, Michel; Zhang, Jiawei; Sun, Jie
CAR-adapted PIK3CD base editing enhances T cell anti-tumor potency

CAR适应的PIK3CD碱基编辑增强T细胞抗肿瘤效力

Nature Cancer
IF28.5
2026-01-060
OAAI
Philip Bucher; Nadine Brückner; Jule Kortendieck; Melanie Grimm; Jan T. Schleicher; Karlotta Bartels; Steffen Hardy; Martina Rausch; Hannah Wurzer; Meike Thiemann; Celina May; Mara Mitstorfer; Dennis Letzgus; Julia Quach; Carolin Schneider; Denis A. Ispan; Irene Gonzalez-Menendez; Nayan Jain; Yu-Jui Ho; Jiangqing Chen; Francisco J. Sánchez-Rivera; Jie Sun; Leticia Quintanilla-Martinez; Christoph Trautwein; Bettina Weigelin; Manfred Claassen; Michel Sadelain; Judith Feucht; Josef Leibold
Bispecific killer cell engager-secreting CAR-T cells redirect natural killer specificity to enhance antitumour responses

分泌双特异性杀伤细胞接合器的car-t细胞重定向自然杀伤特异性以增强抗肿瘤反应

Nature Biomedical Engineering
IF26.6
2025-07-140
PRE
Ya Fan; Yanting Duan; Jiangqing Chen; Yajie Wang; Kai Shang; Jie Jiang; Lu Su; Chun Zhou; Michel Sadelain; He Huang; Jie Sun
CD97-directed CAR-T cells with enhanced persistence eradicate acute myeloid leukemia in diverse xenograft models

靶向CD97的CAR-T细胞通过增强的持久性在多种异种移植模型中清除急性髓系白血病

Cell Reports Medicine
IF10.6
2025-05-260
OA
Kai Shang; Deyu Huang; Jun Liu; Zebin Yu; Wei Bian; Jiangqing Chen; Yin Zhao; Lina Liu; Jie Jiang; Yajie Wang; Yanting Duan; Jingyu Ge; Shize Zhang; Chun Zhou; Yingli Han; Yongxian Hu; Weiyan Zheng; Jie Sun; He Huang; Shanshan Pei; Pengxu Qian; Jie Sun
IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases

IL-10-expressing cart细胞抵抗功能障碍并介导实体瘤和转移灶的持久清除

NATURE BIOTECHNOLOGY
IF41.7
2024-01-0247
PRE
Zhao, Yang; Chen, Jiangqing; Andreatta, Massimo; Feng, Bing; Xie, Yu-Qing; Wenes, Mathias; Wang, Yi; Gao, Min; Hu, Xiaomeng; Romero, Pedro; Carmona, Santiago; Sun, Jie; Guo, Yugang; Tang, Li
CD38-Specific CAR Integrated into CD38 Locus Driven by Different Promoters Causes Distinct Antitumor Activities of T and NK Cells

由不同启动子驱动的整合到CD38基因座中的CD38-Specific CAR导致T和NK细胞的不同抗肿瘤活性

ADVANCED SCIENCE
IF14.1
2023-07-2311
OA
Liao, Chan; Wang, Yajie; Huang, Yanjie; Duan, Yanting; Liang, Yan; Chen, Jiangqing; Jiang, Jie; Shang, Kai; Zhou, Chun; Gu, Ying; Liu, Nan; Zeng, Xun; Gao, Xiaofei; Tang, Yongmin; Sun, Jie
Inserting EF1α-driven CD7-specific CAR at CD7 locus reduces fratricide and enhances tumor rejection
LEUKEMIA
IF13.4
2023-06-307
PRE
Jiang, Jie; Chen, Jiangqing; Liao, Chan; Duan, Yanting; Wang, Yajie; Shang, Kai; Huang, Yanjie; Tang, Yongming; Gao, Xiaofei; Gu, Ying; Sun, Jie
Balancing activation and co-stimulation of CAR tunes signaling dynamics and enhances therapeutic potency
MOLECULAR THERAPY
IF12
2023-01-018
OA
Duan, Yanting; Chen, Jiangqing; Meng, Xianhui; Liu, Longwei; Shang, Kai; Wu, Xiaoyan; Wang, Yajie; Huang, Zihan; Liu, Houyu; Huang, Yanjie; Zhou, Chun; Gao, Xiaofei; Wang, Yingxiao; Sun, Jie
Tuning the ignition of CAR: optimizing the affinity of scFv to improve CAR-T therapy
CELLULAR AND MOLECULAR LIFE SCIENCES
IF6.2
2021-12-2942
PREAI
Duan, Yanting; Chen, Ruoqi; Huang, Yanjie; Meng, Xianhui; Chen, Jiangqing; Liao, Chan; Tang, Yongmin; Zhou, Chun; Gao, Xiaofei; Sun, Jie
Cas9-Cleavage Sequences in Size-Reduced Plasmids Enhance Nonviral Genome Targeting of CARs in Primary Human T Cells
SMALL METHODS
IF9.1
2021-05-1920
OA
Jing, Ruirui; Jiao, Peng; Chen, Jiangqing; Meng, Xianhui; Wu, Xiaoyan; Duan, Yanting; Shang, Kai; Qian, Liling; Huang, Yanjie; Liu, Junwei; Huang, Tao; Jin, Jin; Chen, Wei; Zeng, Xun; Yin, Weiwei; Gao, Xiaofei; Zhou, Chun; Sadelain, Michel; Sun, Jie
Maternal l-proline supplementation during gestation alters amino acid and polyamine metabolism in the first generation female offspring of C57BL/6J mice
AMINO ACIDS
IF2.4
2019-03-1614
PREAI
Liu, Ning; Dai, Zhaolai; Zhang, Yunchang; Jia, Hai; Chen, Jiangqing; Sun, Shiqiang; Wu, Guoyao; Wu, Zhenlong

研究方向

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J
Jie Sun
H 指数:40论文数:269被引数:7,344
周纯 封面图
周纯
H 指数:27论文数:135被引数:3,177
Y
Yanting Duan
H 指数:15论文数:46被引数:625
X
Xiaofei Gao
H 指数:38论文数:240被引数:5,483
Y
Yajie Wang
H 指数:16论文数:66被引数:956
K
Kai Shang
H 指数:10论文数:54被引数:279
J
Jie Jiang
H 指数:13论文数:36被引数:764
Y
Yanjie Huang
H 指数:20论文数:50被引数:1,035
M
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H 指数:105论文数:651被引数:6.2万
Huang He 封面图
Huang He
H 指数:67论文数:1,107被引数:2.1万