未登录 US immigration order strikes against biotech Levin, Jeremy M.; Holtzman, Steven H.; Maraganore, John; Hastings, Paul J.; Cohen, Ron; Dahiyat, Bassil; Adams, Julian; Adams, Chris; Ahrens, Brett; Albers, Jeff; Aspinall, Mara G.; Audia, James E.; Babler, Martin; Barrett, Peter; Barry, Zoe; Bermingham, Nessan; Blocha, Stephen; Blum, Robert I.; Bolno, Paul B.; Bonney, Michael W.; Booth, Bruce; Bradbury, Daniel M.; Brauer, Steven K.; Byers, Brook; Cagnoni, Pablo J.; Cali, Brian M.; Ciechanover, Isaac; Clark, Chip; Clayman, Michael D.; Cleland, Jeff L.; Cobb, Paula; Cooper, Ron; Currie, Mark G.; Diekman, John; Dobmeier, Eric L.; Doerfler, Doug; Donley, Elizabeth L. R.; Dunsire, Deborah; During, Matthew; Eckstein, Jens W.; Elenko, Eric; Exter, Neil A.; Fleming, Jonathan J.; Flesher, Gregory J.; Formela, Jean-Francois; Forrester, Robert; Francois, Cedric; Franklin, Heather; Freemana, Mason W.; Furst, Howard; Gage, Leonard Patrick; Galakatos, Nicholas; Gallagher, Brian M.; Geraghty, James A.; Gill, Simba; Goeddel, David V.; Goldsmith, Mark A.; Gowen, Maxine; Goyal, Vikas; Graney, Tom; Grayzel, David; Greene, Barry; Grint, Paul; Gutierrez-Ramos, J. C.; Haney, Bill; Tuan Ha-Ngoc; Harris, Tim; Hasnain, Faheem; Hata, Yujiro Steve; Hecht, Peter; Henshaw, Leslie; Heyman, Rich; Hoppenot, Herve; Horvitz, H. Robert; Hughes, Thomas E.; Hutton, Wende S.; Isaacs, Stephen T.; Jenkins, Annalisa; Jonker, Jeff; Kaplan, Jeff; Karsen, Perry; Keiper, Jeb; Kim, Jean; Kindler, Jeff; King, Rachel; King, Vanessa; Kjellson, Nina; Koenig, Scott; Koenig, Gerhard; Kolchinsky, Peter; Laikind, Paul; Langer, Robert (Bob); Lee, John J.; Leff, Jonathan S.; Leicher, Bruce A.; Leschly, Nick; Levin, Andrew; Levin, Mark; Levine, Arnold J.; Levy, Alan; Liu, David R.; Lodish, Harvey F.; Lopatin, Uri; Love, Ted W.; Macdonald, Guy; Maderis, Gail J.; Mahadevia, Ankit; Mahanthappa, Nagesh K.; Martin, Joel F.; Martin, Alex; Martucci, W. Eddie; McArthur, James G.; McCann, Corey M.; McCarthy, Sean A.; McDonough, C. Geoffrey; Mendlein, John; Miller, Larry; Miralles, Diego; Moch, Kenneth I.; More, Bob; Myers, Andrew G.; Narachi, Michael A.; Nashat, Amir; Nelson, Wendy; Newell, William J.; Olle, Bernat; Osborn, John E.; Owens, Julia C.; Pande, Atul; Papadopoulos, Stelios; Parker, H. Stewart; Parmara, Kush M.; Patterson, Matthew R.; Paul, Steve M.; Perez, Rob; Perry, Matthew; Pfeffer, Cary G.; Powell, Mike; Pruzanski, Mark; Purcell, Dennis J.; Rakhit, Amit; Ramamoorthi, Kartik; Rastetter, William; Rawcliffe, Adrian (Ad); Reid, Laurence E.; Renaud, Ron C.; Rhodes, Jason P.; Rieflin, William J.; Robins, Chad; Rocklageb, Scott M.; Rosenblatt, Michael; Rosin, Jonathan G.; Rutter, William J.; Saha, Saurabh; Samuels, Camille; Sato, Vicki L.; Scangos, George; Scarlett, John A.; Schenkein, David; Schreiber, Stuart L.; Schwabb, Andrew; Sekhri, Paul; Shah, Rajeev; Shenk, Thomas; Siegall, Clay B.; Simon, Nick J.; Simonian, Nancy; Stein, Jeff; Su, Michael; Szela, Mary T.; Taglietti, Marco; Tandon, Nina; Termeer, Henri; Thornberry, Nancy A.; Tolar, Martin; Ulevitchc, Richard; Vaishnaw, Akshay K.; VanLent, Anne; Varsavsky, Martin; Vlasuk, George P.; Vounatsos, Michel; Waksal, Samuel G.; Warma, Neil; Watts, Ryan J.; Werber, Yaron; Westphal, Christoph; Wierenga, Wendell; Williams, Doug E.; Williams, Lewis (Rusty); Xanthopoulos, Kleanthis G.; Zohar, Daphne; Zweifach, Sandford (Sandy) 分享 收藏
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TRV120027, a β-Arrestin Biased Ligand at the Angiotensin II Type 1 Receptor, Produces Unique Pharmacology and Is a Novel Potential Therapy for Heart Failure Violin, Jonathan D.; Soergel, David G.; DeWire, Scott M.; Yamashita, Dennis; Rominger, David; Whalen, Erin J.; Gowen, Maxine; Lark, Michael W. 分享 收藏
An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation Kumar, Sanjay; Matheny, Christopher J.; Hoffman, Sandra J.; Marquis, Robert W.; Schultz, Maggie; Liang, Xiaoguang; Vasko, Janice A.; Stroup, George B.; Vaden, Vernal R.; Haley, Hyking; Fox, John; DelMar, Eric G.; Nemeth, Edward F.; Lago, Amparo M.; Callahan, James F.; Bhatnagar, Pradip; Huffman, William F.; Gowen, Maxine; Yi, Bingming; Danoff, Theodore M.; Fitzpatrick, Lorraine A. 分享 收藏
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Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vitro and in vivo Votta, BJ; Levy, MA; Badger, A; Bradbeer, J; Dodds, RA; James, IE; Thompson, S; Bossard, MJ; Carr, T; Connor, JR; Tomaszek, TA; Szewczuk, L; Drake, FH; Veber, DF; Gowen, M 分享 收藏
Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization Gowen, M; Lazner, F; Dodds, R; Kapadia, R; Feild, J; Tavaria, M; Bertoncello, I; Drake, F; Zavarselk, S; Tellis, I; Hertzog, P; Debouck, C; Kola, I 分享 收藏
Antagonism of the osteoclast vitronectin receptor with an orally active nonpeptide inhibitor prevents cancellous bone loss in the ovariectomized rat Lark, MW; Stroup, GB; Dodds, RA; Kapadia, R; Hoffman, SJ; Hwang, SM; James, IE; Lechowska, B; Liang, XG; Rieman, DJ; Salyers, KL; Ward, K; Smith, BR; Miller, WH; Huffman, WF; Gowen, M 分享 收藏
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Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption Dodds, RA; James, IE; Rieman, D; Ahern, R; Hwang, SM; Connor, JR; Thompson, SD; Veber, DF; Drake, FH; Holmes, S; Lark, MW; Gowen, M 分享 收藏
Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate 人组织蛋白酶K的有效和选择性抑制导致非人灵长类动物体内骨吸收的抑制 Stroup, GB; Lark, MW; Veber, DF; Bhattacharyya, A; Blake, S; Dare, LC; Erhard, KF; Hoffman, SJ; James, IE; Marquis, RW; Ru, Y; Vasko-Moser, JA; Smith, BR; Tomaszek, T; Gowen, M 分享 收藏
Antagonists of the Calcium Receptor. 2. Amino Alcohol-Based Parathyroid Hormone Secretagogues Marquis, Robert W.; Lago, Amparo M.; Callahan, James F.; Rahman, Attiq; Dong, Xiaoyang; Stroup, George B.; Hoffman, Sandra; Gowen, Maxine; DelMar, Eric G.; Van Wagenen, Bradford C.; Logan, Sarah; Shimizu, Scott; Fox, John; Nemeth, Edward F.; Roethke, Theresa; Smith, Brian R.; Ward, Keith W.; Bhatnagar, Pradip 分享 收藏
Antagonists of the Calcium Receptor I. Amino Alcohol-Based Parathyroid Hormone Secretagogues Marquis, Robert W.; Lago, Amparo M.; Callahan, James F.; Trout, Robert E. Lee; Gowen, Maxine; DelMar, Eric G.; Van Wagenen, Bradford C.; Logan, Sarah; Shimizu, Scott; Fox, John; Nemeth, Edward F.; Yang, Zheng; Roethke, Theresa; Smith, Brian R.; Ward, Keith W.; Lee, John; Keenan, Richard M.; Bhatnagar, Pradip 分享 收藏
A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys 组织蛋白酶K的高效抑制剂 (relacatib) 在体外和猴子体内骨转换升高的急性模型中均降低了骨吸收的生物标志物 Kumar, S.; Dare, L.; Vasko-Moser, J. A.; James, I. E.; Blake, S. M.; Rickard, D. J.; Hwang, S. -M.; Tomaszek, T.; Yamashita, D. S.; Marquis, R. W.; Oh, H.; Jeong, J. U.; Veber, D. F.; Gowen, M.; Lark, M. W.; Stroup, G. 分享 收藏
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A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat Lark, MW; Stroup, GB; James, IE; Dodds, RA; Hwang, SN; Blake, SM; Lechowska, BA; Hoffman, SJ; Smith, BR; Kapadia, R; Liang, X; Erhard, K; Ru, Y; Dong, X; Marquis, RW; Veber, D; Gowen, M 分享 收藏
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Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries Kumar, S; Connor, JR; Dodds, RA; Halsey, W; Van Horn, M; Mao, J; Sathe, G; Mui, P; Agarwal, P; Badger, AM; Lee, JC; Gowen, M; Lark, MW 分享 收藏
Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro James, IE; Marquis, RW; Blake, SM; Hwang, SM; Gress, CJ; Ru, Y; Zembryki, D; Yamashita, DS; McQueney, MS; Tomaszek, TA; Oh, HJ; Gowen, M; Veber, DF; Lark, MW 分享 收藏
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