未登录 Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers Gregson, Stephen J.; Masterson, Luke A.; Wei, Binqing; Pillow, Thomas H.; Spencer, Susan D.; Kang, Gyoung-Dong; Yu, Shang -Fan; Raab, Helga; Lau, Jeffrey; Li, Guangmin; Phillips, Gail D. Lewis; Gunner-Toste, Janet; Safina, Brian S.; Ohri, Rachana; Darwish, Martine; Kozak, Katherine R.; dela Cruz-Chuh, Josefa; Poison, Andrew; Flygare, John A.; Howard, Philip W. 分享 收藏
Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers Pillow, Thomas H.; Schutten, Melissa; Yu, Shang-Fan; Ohri, Rachana; Sadowsky, Jack; Poon, Kirsten Achilles; Solis, Willy; Zhong, Fiona; Del Rosario, Geoffrey; Go, Mary Ann T.; Lau, Jeffrey; Yee, Sharon; He, Jintang; Liu, Luna; Ng, Carl; Xu, Keyang; Leipold, Douglas D.; Kamath, Amrita V.; Zhang, Donglu; Masterson, Luke; Gregson, Stephen J.; Howard, Philip W.; Fang, Fan; Chen, Jinhua; Gunzner-Toste, Janet; Kozak, Katherine K.; Spencer, Susan; Polakis, Paul; Polson, Andrew G.; Flygare, John A.; Junutula, Jagath R. 分享 收藏
A Novel Anti-CD22 Anthracycline-Based Antibody-Drug Conjugate (ADC) That Overcomes Resistance to Auristatin-Based ADCs Yu, Shang-Fan; Zheng, Bing; Go, MaryAnn; Lau, Jeff; Spencer, Susan; Raab, Helga; Soriano, Robert; Jhunjhunwala, Suchit; Cohen, Robert; Caruso, Michele; Polakis, Paul; Flygare, John; Polson, Andrew G. 分享 收藏
An Antibody-Drug Conjugate Directed against Lymphocyte Antigen 6 Complex, Locus E (LY6E) Provides Robust Tumor Killing in a Wide Range of Solid Tumor Malignancies Asundi, Jyoti; Crocker, Lisa; Tremayne, Jarrod; Chang, Peter; Sakanaka, Chie; Tanguay, Josh; Spencer, Susan; Chalasani, Sreedevi; Luis, Elizabeth; Gascoigne, Karen; Desai, Rupal; Raja, Rajiv; Friedman, Brad A.; Haverty, Peter M.; Polakis, Paul; Firestein, Ron 分享 收藏
分享 收藏
An Antimesothelin-Monomethyl Auristatin E Conjugate with Potent Antitumor Activity in Ovarian, Pancreatic, and Mesothelioma Models Scales, Suzie J.; Gupta, Nidhi; Pacheco, Glenn; Firestein, Ron; French, Dorothy M.; Koeppen, Hartmut; Rangell, Linda; Barry-Hamilton, Vivian; Luis, Elizabeth; Chuh, Josefa; Zhang, Yin; Ingle, Gladys S.; Fourie-O'Donohue, Aimee; Kozak, Katherine R.; Ross, Sarajane; Dennis, Mark S.; Spencer, Susan D. 分享 收藏
Nonclinical characterization and tolerability of a surrogate anti-mesothelin-MMAE antibody-drug conjugate Gupta, Nidhi; Solis, Willy A.; Fuji, Reina N.; Oldendorp, Amy; Pacheco, Glenn; Luis, Elizabeth; Chuh, Josefa; French, Dorothy M.; Drake, Elizabeth; Dennis, Mark S.; Kozak, Katherine R.; Ross, Sarajane; Tibbitts, Jay; Spencer, Susan D.; Scales, Suzie J. 分享 收藏
A clinical candidate anti-mesothelin-MMAE antibody-drug conjugate (ADC) for therapy of mesothelin-expressing cancers Scales, Suzie J.; Gupta, Nidhi; Pacheco, Glenn; Firestein, Ron; French, Dorothy M.; Chuh, Josefa; Zhang, Yin; Berry, Leanne; Bostrom, Jenny; Luis, Elizabeth; O'Donohue, Aimee Fourie; Kozak, Katherine R.; Ross, Sarajane; Dennis, Mark S.; Tibbitts, Jay; Spencer, Susan D. 分享 收藏
Site-Specific Trastuzumab Maytansinoid Antibody-Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering Pillow, Thomas H.; Tien, Janet; Parsons-Reponte, Kathryn L.; Bhakta, Sunil; Li, Hao; Staben, Leanna R.; Li, Guangmin; Chuh, Josefa; Fourie-O'Donohue, Aimee; Darwish, Martine; Yip, Victor; Liu, Luna; Leipold, Douglas D.; Su, Dian; Wu, Elmer; Spencer, Susan D.; Shen, Ben-Quan; Xu, Keyang; Kozak, Katherine R.; Raab, Helga; Vandlen, Richard; Phillips, Gail D. Lewis; Scheller, Richard H.; Polakis, Paul; Sliwkowski, Mark X.; Flygare, John A.; Junutula, Jagath R. 分享 收藏
分享 收藏
The effect of controllable thin film crystal growth on the aggregation of a novel high panchromaticity squaraine viable for organic solar cells Spencer, Susan D.; Bougher, Cortney; Heaphy, Patrick J.; Murcia, Victor M.; Gallivan, Cameron P.; Monfette, Amber; Andersen, John D.; Cody, Jeremy A.; Conrad, Brad R.; Collison, Christopher J. 分享 收藏
Anthracycline based antibody-drug conjugates (ADCs) for the treatment of non-Hodgkin's lymphoma are effective in cell lines resistant to auristatin based ADCs. Polson, Andrew G.; Zheng, Bing; Go, MaryAnn; Lau, Jeffery; Yu, Shang-Fan; Spencer, Susan; Cohen, Robert; Caruso, Michele; Flygare, John; Polakis, Paul 分享 收藏
分享 收藏
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates Shen, Ben-Quan; Xu, Keyang; Liu, Luna; Raab, Helga; Bhakta, Sunil; Kenrick, Margaret; Parsons-Reponte, Kathryn L.; Tien, Janet; Yu, Shang-Fan; Mai, Elaine; Li, Dongwei; Tibbitts, Jay; Baudys, Jakub; Saadi, Ola M.; Scales, Suzie J.; McDonald, Paul J.; Hass, Philip E.; Eigenbrot, Charles; Trung Nguyen; Solis, Willy A.; Fuji, Reina N.; Flagella, Kelly M.; Patel, Darshana; Spencer, Susan D.; Khawlil, Leslie A.; Ebens, Allen; Wong, Wai Lee; Vandlen, Richard; Kaur, Surinder; Sliwkowski, Mark X.; Scheller, Richard H.; Polakis, Paul; Junutula, Jagath R. 分享 收藏
Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Junutula, Jagath R.; Flagella, Kelly M.; Graham, Richard A.; Parsons, Kathryn L.; Ha, Edward; Raab, Helga; Bhakta, Sunil; Nguyen, Trung; Dugger, Debra L.; Li, Guangmin; Mai, Elaine; Phillips, Gail D. Lewis; Hiraragi, Hajime; Fuji, Reina N.; Tibbitts, Jay; Vandlen, Richard; Spencer, Susan D.; Scheller, Richard H.; Polakis, Paul; Sliwkowski, Mark X. 分享 收藏
Early study on LGR5/GPR49 molecule as a potential colon cancer stem cell target for the antibody conjugated drug treatment Mao, Weiguang; Tien, Janet; Goldenberg, David; Stawicki, Scott; Vij, Rajesh; Xia, Xiaoling; Hongo, Jo-Anne; Ross, Sarajane; Kozak, Kathy; Firestein, Ron; Wu, Yan; Spencer, Susan; Polakis, Paul 分享 收藏
Preclinical evaluation of carcinoembryonic cell adhesion molecule (CEACAM) 6 as potential therapy target for pancreatic adenocarcinoma Strickland, Laura A.; Ross, Jed; Williams, Simon; Ross, Sarajane; Romero, Maria; Spencer, Susan; Erickson, Rich; Sutcliffe, Julie; Verbeke, Caroline; Polakis, Paul; van Bruggen, Nicholas; Koeppen, Hartmut 分享 收藏
Antibody-Drug Conjugates for the Treatment of Non-Hodgkin's Lymphoma: Target and Linker-Drug Selection Polson, Andrew G.; Calemine-Fenaux, Jill; Chan, Pamela; Chang, Wesley; Christensen, Erin; Clark, Suzanna; de Sauvage, Frederic J.; Eaton, Dan; Elkins, Kristi; Elliott, J. Michael; Frantz, Gretchen; Fuji, Reina N.; Gray, Alane; Harden, Kristin; Ingle, Gladys S.; Kljavin, Noelyn M.; Koeppen, Hartmut; Nelson, Christopher; Prabhu, Saileta; Raab, Helga; Ross, Sarajane; Stephan, Jean-Philippe; Scales, Suzie J.; Spencer, Susan D.; Vandlen, Richard; Wranik, Bernd; Yu, Shang-Fan; Zheng, Bing; Ebens, Allen 分享 收藏
Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody-Cytotoxic Drug Conjugate Phillips, Gail D. Lewis; Li, Guangmin; Dugger, Debra L.; Crocker, Lisa M.; Parsons, Kathryn L.; Mai, Elaine; Blattler, Walter A.; Lambert, John M.; Chari, Ravi V. J.; Lutz, Robert J.; Wong, Wai Lee T.; Jacobson, Frederic S.; Koeppen, Hartmut; Schwall, Ralph H.; Kenkare-Mitra, Sara R.; Spencer, Susan D.; Sliwkowski, Mark X. 分享 收藏
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index Junutula, Jagath R.; Raab, Helga; Clark, Suzanna; Bhakta, Sunil; Leipold, Douglas D.; Weir, Sylvia; Chen, Yvonne; Simpson, Michelle; Tsai, Siao Ping; Dennis, Mark S.; Lu, Yanmei; Meng, Y. Gloria; Ng, Carl; Yang, Jihong; Lee, Chien C.; Duenas, Eileen; Gorrell, Jeffrey; Katta, Viswanatham; Kim, Amy; McDorman, Kevin; Flagella, Kelly; Venook, Rayna; Ross, Sarajane; Spencer, Susan D.; Wong, Wai Lee; Lowman, Henry B.; Vandlen, Richard; Sliwkowski, Mark X.; Scheller, Richard H.; Polakis, Paul; Mallet, William 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
