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收藏c-Met antagonist Avimer™ polypeptide that exhibits potent in vivo and in vitro inhibitor activity
Cho, Song; Smith, Richard; Duguay, Amy; Li, Peng; Bakker, Alice; Alba, Ben; Thomas, Melissa; To, Wayne; Silverman, Josh; Swimmer, Candace; Moore, Kevin; Strout, Patrick; Bobofchak, Kevin; McCarthy, Mike; Pemmaraju, Kalyani; Lacourciere, Gerard; Zhou, Qin; Damschroder, Melissa; Wu, Herren; Coats, Steve; Kamal, Adeela 分享 收藏 Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains (vol 23, pg 1556, 2005)Silverman, J; Lu, Q; Bakker, A; To, W; Duguay, A; Alba, BM; Smith, R; Rivas, A; Li, P; Le, H; Whitehorn, E; Moore, KW; Swimmer, C; Perlroth, V; Vogt, M; Kolkman, J; Stemmer, WPC 分享 收藏 Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains通过人类受体结构域家族的外显子改组进化出的多价avmer蛋白Silverman, J; Lu, Q; Bakker, A; To, W; Duguay, A; Alba, BM; Smith, R; Rivas, A; Li, P; Le, H; Whitehorn, E; Moore, KW; Swimmer, C; Perlroth, V; Vogt, M; Kolkman, J; Stemmer, WPC 分享 收藏 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine:: A functionally selective γ-aminobutyric acidA (GABAA) α2/α3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal modelsCarling, RW; Madin, A; Guiblin, A; Russell, MGN; Moore, KW; Mitchinson, A; Sohal, B; Pike, A; Cook, SM; Ragan, IC; McKernan, RM; Quirk, K; Ferris, P; Marshall, G; Thompson, SA; Wafford, KA; Dawson, GR; Atack, JR; Harrison, T; Castro, JL; Street, LJ 分享 收藏 Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABAA receptor agonists at the α3 subunitRussell, MGN; Carling, RW; Atack, JR; Bromidge, FA; Cook, SM; Hunt, P; Isted, C; Lucas, M; McKernan, RM; Mitchinson, A; Moore, KW; Narquizian, R; Macaulay, AJ; Thomas, D; Thompson, SA; Wafford, KA; Castro, JL 分享 收藏 Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABAAα5 benzodiazepine binding siteStreet, LJ; Sternfeld, F; Jelley, RA; Reeve, AJ; Carling, RW; Moore, KW; McKernan, RM; Sohal, B; Cook, S; Pike, A; Dawson, GR; Bromidge, FA; Wafford, KA; Seabrook, GR; Thompson, SA; Marshall, G; Pillai, GV; Castro, JL; Atack, JR; MacLeod, AM 分享 收藏 Selective, orally active γ-aminobutyric acidA α5 receptor inverse agonists as cognition enhancersSternfeld, F; Carling, RW; Jelley, RA; Ladduwahetty, T; Merchant, KJ; Moore, KW; Reeve, AJ; Street, LJ; O'Connor, D; Sohal, B; Atack, JR; Cook, S; Seabrook, G; Wafford, K; Tattersall, FD; Collinson, N; Dawson, GR; Castro, JL; MacLeod, AM 分享 收藏 3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-α]phthalazines and analogues:: High-affinity γ-aminobutyric acid-A benzodiazepine receptor ligands with α2, α3, and α5-subtype binding selectivity over α1Carling, RW; Moore, KW; Street, LJ; Wild, D; Isted, C; Leeson, PD; Thomas, S; O'Connor, D; McKernan, RM; Quirk, K; Cook, SM; Atack, JR; Wafford, KA; Thompson, SA; Dawson, GR; Ferris, P; Castro, JL 分享 收藏 A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R异二聚体细胞因子IL-23的受体由IL-12Rβ1和一种新的细胞因子受体亚基IL-23RParham, C; Chirica, M; Timans, J; Vaisberg, E; Travis, M; Cheung, J; Pflanz, S; Zhang, R; Singh, KP; Vega, F; To, W; Wagner, J; O'Farrell, AM; McClanahan, T; Zurawski, S; Hannum, C; Gorman, D; Rennick, DM; Kastelein, RA; Malefyt, RD; Moore, KW 分享 收藏 分享 收藏 Up-regulation of IL-10R1 expression is required to render human neutrophils fully responsive to IL-10Crepaldi, L; Gasperini, S; Lapinet, JA; Calzetti, F; Pinardi, C; Liu, Y; Zurawski, S; de Waal Malefyt, R; Moore, KW; Cassatella, MA 分享 收藏 分享 收藏 Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12新型p19蛋白与IL-12p40结合形成细胞因子IL-23，具有与IL-12相似和不同的生物学活性。Oppmann, B; Lesley, R; Blom, B; Timans, JC; Xu, YM; Hunte, B; Vega, F; Yu, N; Wang, J; Singh, K; Zonin, F; Vaisberg, E; Churakova, T; Liu, MR; Gorman, D; Wagner, J; Zurawski, S; Liu, YJ; Abrams, JS; Moore, KW; Rennick, D; de Waal-Malefyt, R; Hannum, C; Bazan, JF; Kastelein, RA 分享 收藏 IL-18 receptors, their role in ligand binding and function: Anti-IL-1RAcPL antibody, a potent antagonist of IL-18Debets, R; Timans, JC; Churakowa, T; Zurawski, S; Malefyt, RD; Moore, KW; Abrams, JS; O'Garra, A; Bazan, JF; Kastelein, RA 分享 收藏 分享 收藏 1-(3-cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1,3-dihydroimidazol-2-one:: A selective high-affinity antagonist for the human dopamine D4 receptor with excellent selectivity over ion channelsCarling, RW; Moore, KW; Moyes, CR; Jones, EA; Bonner, K; Emms, F; Marwood, R; Patel, S; Patel, S; Fletcher, AE; Beer, M; Sohal, B; Pike, A; Leeson, PD 分享 收藏 Altered immune responses in interleukin 10 transgenic miceHagenbaugh, A; Sharma, S; Dubinett, SM; Wei, SHY; Aranda, R; Cheroutre, H; Fowell, DJ; Binder, S; Tsao, B; Locksley, RM; Moore, KW; Kronenberg, M 分享 收藏 4-substituted-3-phenylquinolin-2(1H)-ones: Acidic and nonacidic glycine site N-methyl-D-aspartate antagonists with in vivo activityCarling, RW; Leeson, PD; Moore, KW; Moyes, CR; Duncton, M; Hudson, ML; Baker, R; Foster, AC; Grimwood, S; Kemp, JA; Marshall, GR; Tricklebank, MD; Saywell, KL 分享 收藏 Follicular dendritic cells specifically express the long CR2/CD21 isoformLiu, YJ; Xu, JC; deBouteiller, O; Parham, CL; Grouard, G; Djossou, O; deSaintVis, B; Lebecque, S; Banchereau, J; Moore, KW 分享 收藏 
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