未登录(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists
Buzard, Daniel J.; Lopez, Luis; Moody, Jeanne; Kawasaki, Andrew; Schrader, Thomas O.; Kasem, Michelle; Johnson, Ben; Zhu, Xiuwen; Thoresen, Lars; Kim, Sun Hee; Gharbaoui, Tawfik; Sengupta, Dipanjan; Calvano, Lorene; Krishnan, Ashwin; Gao, Yinghong; Semple, Graeme; Edwards, Jeff; Barden, Jeremy; Morgan, Michael; Usmani, Khawja; Chen, Chuan; Sadeque, Abu; Chen, Weichao; Christopher, Ronald J.; Thatte, Jayant; Fu, Lixia; Solomon, Michelle; Whelan, Kevin; Al-Shamma, Hussien; Gatlin, Joel; Gaidarov, Ibragim; Anthony, Todd; Minh Le; Unett, David J.; Stirn, Scott; Blackburn, Anthony; Behan, Dominic P.; Jones, Robert M. .png)
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收藏Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 ReceptorBuzard, Daniel J.; Kim, Sun Hee; Lopez, Luis; Kawasaki, Andrew; Zhu, Xiuwen; Moody, Jeanne; Thoresen, Lars; Calderon, Imelda; Ullman, Brett; Han, Sangdon; Lehmann, Juerg; Gharbaoui, Tawfik; Sengupta, Dipanjan; Calvano, Lorene; Montalban, Antonio Garrido; Ma, You-An; Sage, Carleton; Gao, Yinghong; Semple, Graeme; Edwards, Jeff; Barden, Jeremy; Morgan, Michael; Chen, Weichao; Usmani, Khawja; Chen, Chuan; Sadeque, Abu; Christopher, Ronald J.; Thatte, Jayant; Fu, Lixia; Solomon, Michelle; Mills, David; Whelan, Kevin; Al-Shamma, Hussien; Gatlin, Joel; Minh Le; Gaidarov, Ibragim; Anthony, Todd; Unett, David J.; Blackburn, Anthony; Rueter, Jaimie; Stirn, Scott; Behan, Dominic P.; Jones, Robert M. 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Determination of the binding mode of thienopyrimidinedione antagonists to the human gonadotropin releasing hormone receptor using structure-activity relationships, site-directed mutagenesis, and homology modelingBetz, Stephen F.; Lio, Francisco M.; Gao, Yinghong; Reinhart, Greg J.; Guo, Zhiqiang; Mesleh, Michael F.; Zhu, Yun-Fei; Struthers, R. Scott 分享 收藏 分享 收藏 3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor.: Design, synthesis, and in vitro and in vivo characterizationTucci, FC; Zhu, YF; Struthers, RS; Guo, ZQ; Gross, TD; Rowbottom, MW; Acevedo, O; Gao, YH; Saunders, J; Xie, Q; Reinhart, GJ; Liu, XJ; Ling, N; Bonneville, AKL; Chen, TK; Bozigian, H; Chen, C 分享 收藏 4-{(2R)-[3-aminopropionylamido]-3-(2,4-dichlorophenyl)propionyl}-1-{2-[(2-thienyl)ethylaminomethyl]phenyl}piperazine as a potent and selective melanocortin-4 receptor antagonist-design, synthesis, and characterizationChen, C; Pontillo, J; Fleck, BA; Gao, YH; Wen, J; Tran, JA; Tucci, FC; Marinkovic, D; Foster, AC; Saunders, J 分享 收藏 Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonistsGuo, ZQ; Zhu, YF; Gross, TD; Tucci, FC; Gao, YH; Moorjani, M; Connors, PJ; Rowbottom, MW; Chen, YS; Struthers, RS; Xie, Q; Saunders, J; Reinhart, G; Chen, TK; Bonneville, ALK; Chen, C 分享 收藏 Identification of 1-arylmethyl-3-(2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonistsZhu, YF; Gross, TD; Guo, ZQ; Connors, PJ; Gao, YH; Tucci, FC; Struthers, RS; Reinhart, GJ; Saunders, J; Chen, TK; Bonneville, ALK; Chen, C 分享 收藏 Design and structure-activity relationships of 2-alkyl-3-aminomethyl-6(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-α]pyrimid-5-ones as potent GnRH receptor antagonistsZhu, YF; Guo, ZQ; Gross, TD; Gao, YH; Connors, PJ; Struthers, RS; Xie, Q; Tucci, FC; Reinhart, GJ; Wu, DP; Saunders, J; Chen, C 分享 收藏 分享 收藏 
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