Konstantinos Tzelepis - Publications, H-index & Citations

Konstantinos Tzelepis

University of Cambridge

25H指数

99论文数

5.5K被引数

收录论文 23

发表时间

Ribosomal RNA methylation in HSCs: it's so “good for you”Hsc中的核糖体RNA甲基化: 它对你有好处

Blood

IF23.1

2026-01-29

PREAI

Judith López; Konstantinos Tzelepis

GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling 与硫酸乙酰肝素复合的GlycoRNA调节vegf-a信号传导

Nature

IF48.5

2026-01-28

OAAI

Peiyuan Chai; Sina Kheiri; Andrew Kuo; Jessica Shah; Lauren Kageler; Ruiqi Ge; Jonathan Perr; Jennifer Porat; Charlotta G. Lebedenko; Joao M. L. Dias; Eliza Yankova; Sandeep K. Rai; Christopher P. Watkins; Petar Hristov; Konstantinos Tzelepis; Timothy Hla; Ritu Raman; Eliezer Calo; Jeffrey D. Esko; Ryan A. Flynn

CDK7-targeted therapy effectively disrupts cell cycle progression and oncogenic signaling in head and neck cancer CDK7-targeted疗法可有效破坏头颈癌的细胞周期进程和致癌信号传导

Signal Transduction and Targeted Therapy

IF52.7

2025-11-06

OAAI

María Otero-Rosales; Miguel Álvarez-González; Irene Pazos; Beatriz de Luxán-Delgado; Sonia Del Marro; Esperanza Pozo-Agundo; Mar Rodríguez-Santamaría; Ana López-Fernández; Daniela Corte-Torres; Rocío Granda-Díaz; Saúl Álvarez-Teijeiro; Iván Fernández-Vega; Corina Lorz; Ramón García-Escudero; Juan P. Rodrigo; Konstantinos Tzelepis; George Vassiliou; Irene Ferrer; Mónica Álvarez-Fernández; Juana María García-Pedrero; Francisco Hermida-Prado

Epitranscriptomic advances in normal and malignant hematopoiesis 表观转录组学在正常和恶性造血中的进展

Leukemia

IF13.4

2025-09-19

OAAI

Maria Eleftheriou; James Russell; Konstantinos Tzelepis

Post-transcriptional depletion of ribosome biogenesis factors engenders therapeutic vulnerabilities in NPM1-mutant AML 转录后耗竭核糖体生物发生因子在NPM1突变AML中产生治疗易感性

Blood

IF23.1

2025-06-27

OAAI

Aristi Damaskou; Rachael Wilson; Malgorzata Gozdecka; George Giotopoulos; Ryan Asby; Maria Eleftheriou; Muxin Gu; Christian Récher; Véronique De Mas; Francois Vergez; Ambrine Sahal; Binje Vick; Evangelia K. Papachristou; Ashley Sawle; Eliza Yankova; Monika Dudek; Xiaoxuan Liu; James Russell; Justyna Rak; Christine Hilcenko; Clive D’ Santos; Irmela Jeremias; Jean-Emmanuel Sarry; Konstantinos Tzelepis; Brian J. P. Huntly; Alan J. Warren; Omid Tavana; George S. Vassiliou

Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein 通过靶向细胞表面RNA结合蛋白对急性髓系白血病模型的治疗

NATURE BIOTECHNOLOGY

IF41.7

2025-04-23

OAAI

George, Benson M.; Eleftheriou, Maria; Yankova, Eliza; Perr, Jonathan; Chai, Peiyuan; Nestola, Gianluca; Almahayni, Karim; Evans, Sian; Damaskou, Aristi; Hemberger, Helena; Lebedenko, Charlotta G.; Rak, Justyna; Yu, Qi; Bapcum, Ece; Russell, James; Bagri, Jaana; Volk, Regan F.; Spiekermann, Malte; Stone, Richard M.; Giotopoulos, George; Huntly, Brian J. P.; Baxter, Joanna; Camargo, Fernando; Liu, Jie; Zaro, Balyn W.; Vassiliou, George S.; Moeckl, Leonhard; de la Rosa, Jorge; Tzelepis, Konstantinos

RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry RNA结合蛋白和glycoRNAs在细胞表面形成域，以介导穿膜肽的进入

CELL

IF42.5

2025-02-01

PREAI

Perr, Jonathan; Langen, Andreas; Almahayni, Karim; Nestola, Gianluca; Chai, Peiyuan; Lebedenko, Charlotta G.; Volk, Regan F.; Detres, Diego; Caldwell, Reese M.; Spiekermann, Malte; Hemberger, Helena; Bisaria, Namita; Aiba, Toshihiko; Sanchez-Rivera, Francisco J.; Tzelepis, Konstantinos; Calo, Eliezer; Moeckl, Leonhard; Zaro, Balyn W.; Flynn, Ryan A.

Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages

LEUKEMIA

IF13.4

2023-07-19

OAAI

Sturgess, Katherine; Yankova, Eliza; Vijayabaskar, M. S.; Isobe, Tomoya; Rak, Justyna; Kucinski, Iwo; Barile, Melania; Webster, Natalie A.; Eleftheriou, Maria; Hannah, Rebecca; Gozdecka, Malgorzata; Vassiliou, George; Rausch, Oliver; Wilson, Nicola K.; Gottgens, Berthold; Tzelepis, Konstantinos

Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules 使用小分子靶向RNA降解的邻近诱导核酸降解剂 (PINAD) 方法

ACS CENTRAL SCIENCE

IF10.4

2023-04-26

OAAI

Mikutis, Sigitas; Rebelo, Maria; Yankova, Eliza; Gu, Muxin; Tang, Cong; Coelho, Ana R.; Yang, Mo; Hazemi, Madoka E.; de Miranda, Marta Pires; Eleftheriou, Maria; Robertson, Max; Vassiliou, George S.; Adams, David J.; Simas, J. Pedro; Corzana, Francisco; Schneekloth Jr, John S.; Tzelepis, Konstantinos; Bernardes, Goncalo J. L.

Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death

NATURE COMMUNICATIONS

IF15.7

2023-04-14

OAAI

Woodley, Keith; Dillingh, Laura S.; Giotopoulos, George; Madrigal, Pedro; Rattigan, Kevin M.; Philippe, Celine; Dembitz, Vilma; Magee, Aoife M. S.; Asby, Ryan; van de Lagemaat, Louie N.; Mapperley, Christopher; James, Sophie C.; Prehn, Jochen H. M.; Tzelepis, Konstantinos; Rouault-Pierre, Kevin; Vassiliou, George S.; Kranc, Kamil R.; Helgason, G. Vignir; Huntly, Brian J. P.; Gallipoli, Paolo

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs (May, 10.1038/s41588-018-0114-z, 2018)

NATURE GENETICS

IF31.8

2022-06-14

OAAI

Gozdecka, Malgorzata; Meduri, Eshwar; Mazan, Milena; Tzelepis, Konstantinos; Dudek, Monika; Knights, Andrew J.; Pardo, Mercedes; Yu, Lu; Choudhary, Jyoti S.; Metzakopian, Emmanouil; Iyer, Vivek; Yun, Haiyang; Park, Naomi; Varela, Ignacio; Bautista, Ruben; Collord, Grace; Dovey, Oliver; Garyfallos, Dimitrios A.; De Braekeleer, Etienne; Kondo, Saki; Cooper, Jonathan; Gottgens, Berthold; Bullinger, Lars; Northcott, Paul A.; Adams, David; Vassiliou, George S.; Huntly, Brian J. P.

RNA modifications detection by comparative Nanopore direct RNA sequencing 通过比较纳米孔直接RNA测序检测RNA修饰

NATURE COMMUNICATIONS

IF15.7

2021-12-10

198

OAAI

Leger, Adrien; Amaral, Paulo P.; Pandolfini, Luca; Capitanchik, Charlotte; Capraro, Federica; Miano, Valentina; Migliori, Valentina; Toolan-Kerr, Patrick; Sideri, Theodora; Enright, Anton J.; Tzelepis, Konstantinos; van Werven, Folkert J.; Luscombe, Nicholas M.; Barbieri, Isaia; Ule, Jernej; Fitzgerald, Tomas; Birney, Ewan; Leonardi, Tommaso; Kouzarides, Tony

Identification of SARS-CoV-2-induced pathways reveals drug repurposing strategies SARS-CoV-2-induced途径的识别揭示了药物再利用策略

SCIENCE ADVANCES

IF12.5

2021-07-02

OAAI

Han, Namshik; Hwang, Woochang; Tzelepis, Konstantinos; Schmerer, Patrick; Yankova, Eliza; MacMahon, Meabh; Lei, Winnie; Katritsis, Nicholas M.; Liu, Anika; Felgenhauer, Ulrike; Schuldt, Alison; Harris, Rebecca; Chapman, Kathryn; McCaughan, Frank; Weber, Friedemann; Kouzarides, Tony

SETBP1 overexpression acts in the place of class-defining mutations to drive FLT3-ITD-mutant AML

BLOOD ADVANCES

IF7.1

2021-05-06

OAAI

Pacharne, Suruchi; Dovey, Oliver M.; Cooper, Jonathan L.; Gu, Muxin; Friedrich, Mathias J.; Rajan, Sandeep S.; Barenboim, Maxim; Collord, Grace; Vijayabaskar, M. S.; Ponstingl, Hannes; De Braekeleer, Etienne; Bautista, Ruben; Mazan, Milena; Rad, Roland; Tzelepis, Konstantinos; Wright, Penny; Gozdecka, Malgorzata; Vassiliou, George S.

meCLICK-Seq, a Substrate-Hijacking and RNA Degradation Strategy for the Study of RNA Methylation Meclick-seq，用于研究RNA甲基化的底物劫持和RNA降解策略

ACS CENTRAL SCIENCE

IF10.4

2020-10-29

OAAI

Mikutis, Sigitas; Gu, Muxin; Sendinc, Erdem; Hazemi, Madoka E.; Kiely-Collins, Hannah; Aspris, Demetrios; Vassiliou, George S.; Shi, Yang; Tzelepis, Konstantinos; Bernardes, Goncalo J. L.

KAT7 is a genetic vulnerability of acute myeloid leukemias driven byMLLrearrangements

LEUKEMIA

IF13.4

2020-08-06

OAAI

Au, Yan Zi; Gu, Muxin; De Braekeleer, Etienne; Gozdecka, Malgorzata; Aspris, Demetrios; Tarumoto, Yusuke; Cooper, Jonathan; Yu, Jason; Ong, Swee Hoe; Chen, Xi; Tzelepis, Konstantinos; Huntly, Brian J. P.; Vassiliou, George; Yusa, Kosuke

Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML

NATURE COMMUNICATIONS

IF15.7

2020-03-16

OAAI

Basilico, Silvia; Wang, Xiaonan; Kennedy, Alison; Tzelepis, Konstantinos; Giotopoulos, George; Kinston, Sarah J.; Quiros, Pedro M.; Wong, Kim; Adams, David J.; Carnevalli, Larissa S.; Huntly, Brian J. P.; Vassiliou, George S.; Calero-Nieto, Fernando J.; Gottgens, Berthold

A small molecule inhibitor of the RNA m6A writer METTL3 inhibits the development of acute myeloid leukemia (AML) in vivo

MOLECULAR CANCER THERAPEUTICS

IF5.5

2019-12-01

PREAI

Albertella, Mark; Blackaby, Wesley; Fosbeary, Richard; Hendrick, Alan; Leggate, Dan; Ofir-Rosenfeld, Yaara; Sapetschnig, Alexandra; Tzelepis, Konstantinos; Yankova, Eliza; Kouzarides, Tony; Rausch, Oliver

Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality (vol 38, pg 998, 2019)

ONCOGENE

IF7.3

2019-11-21

OAAI

Szmyd, Radoslaw; Niska-Blakie, Joanna; Diril, M. Kasim; Nunes, Patricia Renck; Tzelepis, Konstantinos; Lacroix, Aurelie; van Hul, Noemi; Deng, Lih-Wen; Matos, Joao; Dreesen, Oliver; Bisteau, Xavier; Kaldis, Philipp

RNA-modifying enzymes and their function in a chromatin context

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2019-10-03

OAAI

Tzelepis, Konstantinos; Rausch, Oliver; Kouzarides, Tony

研究方向