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siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids Tadin-Strapps, Marija; Peterson, Laurence B.; Cumiskey, Anne-Marie; Rosa, Raymond L.; Mendoza, Vivienne Halili; Castro-Perez, Jose; Puig, Oscar; Zhang, Liwen; Strapps, Walter R.; Yendluri, Satyasri; Andrews, Lori; Pickering, Victoria; Rice, Julie; Luo, Lily; Chen, Zhu; Tep, Samnang; Ason, Brandon; Somers, Elizabeth Polizzi; Sachs, Alan B.; Bartz, Steven R.; Tian, Jenny; Chin, Jayne; Hubbard, Brian K.; Wong, Kenny K.; Mitnaul, Lyndon J. 分享 收藏
RNA-Induced Silencing Complex-Bound Small Interfering RNA Is a Determinant of RNA Interference-Mediated Gene Silencing in Mice Wei, Jie; Jones, Jeffrey; Kang, Jing; Card, Ananda; Krimm, Michael; Hancock, Paula; Pei, Yi; Ason, Brandon; Payson, Elmer; Dubinina, Natalya; Cancilla, Mark; Stroh, Mark; Burchard, Julja; Sachs, Alan B.; Hochman, Jerome H.; Flanagan, W. Michael; Kuklin, Nelly A. 分享 收藏
Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9 Ason, Brandon; Tep, Samnang; Davis, Harry R., Jr.; Xu, Yiming; Tetzloff, Glen; Galinski, Beverly; Soriano, Ferdie; Dubinina, Natalya; Zhu, Lei; Stefanni, Alice; Wong, Kenny K.; Tadin-Strapps, Marija; Bartz, Steven R.; Hubbard, Brian; Ranalletta, Mollie; Sachs, Alan B.; Flanagan, W. Michael; Strack, Alison; Kuklin, Nelly A. 分享 收藏
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Quantitative evaluation of siRNA delivery in vivo Pei, Yi; Hancock, Paula J.; Zhang, Hangchun; Bartz, Rene; Cherrin, Craig; Innocent, Nathalie; Pomerantz, Colin J.; Seitzer, Jessica; Koser, Martin L.; Abrams, Marc T.; Xu, Yan; Kuklin, Nelly A.; Burke, Paul A.; Sachs, Alan B.; Sepp-Lorenzino, Laura; Barnett, Stanley F. 分享 收藏
Application of an End-to-End Biomarker Discovery Platform to Identify Target Engagement Markers in Cerebrospinal Fluid by High Resolution Differential Mass Spectrometry Paweletz, Cloud P.; Wiener, Matthew C.; Bondarenko, Andrey Y.; Yates, Nathan A.; Song, Qinghua; Liaw, Andy; Lee, Anita Y. H.; Hunt, Brandon T.; Henle, Ernst S.; Meng, Fanyu; Sleph, Holly Funk; Holahan, Marie; Sankaranarayanan, Sethu; Simon, Adam J.; Settlage, Robert E.; Sachs, Jeffrey R.; Shearman, Mark; Sachs, Alan B.; Cook, Jacquelynn J.; Hendrickson, Ronald C. 分享 收藏
Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment Abrams, Marc T.; Koser, Martin L.; Seitzer, Jessica; Williams, Stephanie C.; DiPietro, Martha A.; Wang, Weimin; Shaw, Andrew W.; Mao, Xianzhi; Jadhav, Vasant; Davide, Joseph P.; Burke, Paul A.; Sachs, Alan B.; Stirdivant, Steven M.; Sepp-Lorenzino, Laura 分享 收藏
Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo Kenski, Denise M.; Cooper, Abby J.; Li, Jenny J.; Willingham, Aarron T.; Haringsma, Henry J.; Young, Tracy A.; Kuklin, Nelly A.; Jones, Jeffrey J.; Cancilla, Mark T.; McMasters, Daniel R.; Mathur, Melina; Sachs, Alan B.; Flanagan, W. Michael 分享 收藏
Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels (vol 86, pg 505, 2005) Cervino, Alessandra C.; Li, Guoya; Edwards, Steve; Zhu, Jun; Laurie, Cathy; Tokiwa, George; Lum, Pek Yee; Wang, Susanna; Castellani, Lawrence W.; Lusis, Aldons J.; Carlson, Sonia; Sachs, Alan B.; Schadt, Eric E. 分享 收藏
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LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease Majercak, John; Ray, William J.; Espeseth, Amy; Simon, Adam; Shi, Xiao-Ping; Wolffe, Carrie; Getty, Krista; Marine, Shane; Stec, Erica; Ferrer, Marc; Strulovici, Berta; Bartz, Steven; Gates, Adam; Xu, Min; Huang, Qian; Ma, Lei; Shughrue, Paul; Burchard, Julja; Colussi, Dennis; Pietrak, Beth; Kahana, Jason; Beher, Dirk; Rosahl, Thomas; Shearman, Mark; Hazuda, Daria; Sachs, Alan B.; Koblan, Kenneth S.; Seabrook, Guy R.; Stone, David J. 分享 收藏
Sequence variation in NPC1L1 and association with improved LDL-cholesterol lowering in response to ezetimibe treatment Simon, JS; Karnoub, MC; Devlin, DJ; Arreaza, MG; Qiu, P; Monks, SA; Severino, ME; Deutsch, P; Palmisano, J; Sachs, AB; Bayne, ML; Plump, AS; Schadt, EE 分享 收藏
Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels Cervino, AC; Li, GY; Edwards, S; Zhu, J; Laurie, C; Tokiwa, G; Lum, PY; Wang, S; Castellini, LW; Lusis, AJ; Carlson, S; Sachs, AB; Schadt, EE 分享 收藏
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An integrative genomics approach to infer causal associations between gene expression and disease Schadt, EE; Lamb, J; Yang, X; Zhu, J; Edwards, S; GuhaThakurta, D; Sieberts, SK; Monks, S; Reitman, M; Zhang, CS; Lum, PY; Leonardson, A; Thieringer, R; Metzger, JM; Yang, LM; Castle, J; Zhu, HY; Kash, SF; Drake, TA; Sachs, A; Lusis, AJ 分享 收藏
A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients Dai, HY; van't Veer, L; Lamb, J; He, YD; Mao, M; Fine, BM; Bernards, R; de Vijver, MV; Deutsch, P; Sachs, A; Stoughton, R; Friend, S 分享 收藏
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