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Mitochondrial chaperon TNF-receptor- associated protein 1 as a novel apoptotic regulator conferring susceptibility to Pneumocystis jirovecii pneumonia Amali, Aseervatham Anusha; Paramasivam, Kathirvel; Huang, Chiung Hui; Joshi, Abhinav; Hirpara, Jayshree L.; Ravikumar, Sharada; Sam, Qi Hui; Tan, Rachel Ying Min; Tan, Zhaohong; Kumar, Dilip; Neckers, Leonard M.; Pervaiz, Shazib; Foo, Roger; Chan, Candice Y. Y.; Zhu, Jin; Lee, Cheryl; Chai, Louis Yi Ann 分享 收藏
Bromodomain and extra-terminal protein inhibitors deplete nuclear factor 1C and reduce stemness and growth of human small cell lung cancer cells in vitro and in vivo Wang, Haitao; Wang, Ruihong; Villa-Hernandez, Frank; Shukla, Vivek; Varticovski, Lyuba; Baek, Songjoon; Echtenkamp, Frank; Gara, Sudheer Kumar; Zhang, Mary R.; Shiffka, Stephanie; Raziuddin, Razi; Neckers, Leonard M.; Linehan, W. Marston; Hager, Gordon L.; Carr, Shamus R.; Hoang, Chuong D.; Chen, Haobin; Schrump, David S. 分享 收藏
Second international symposium on the chaperone code, 2023 Buchner, Johannes; Alasady, Milad J.; Backe, Sarah J.; Blagg, Brian S. J.; Carpenter, Richard L.; Colombo, Giorgio; Gelis, Ioannis; Gewirth, Daniel T.; Gierasch, Lila M.; Houry, Walid A.; Johnson, Jill L.; Kang, Byoung Heon; Kao, Aimee W.; LaPointe, Paul; Mattoo, Seema; McClellan, Amie J.; Neckers, Leonard M.; Prodromou, Chrisostomos; Rasola, Andrea; Sager, Rebecca A.; Theodoraki, Maria A.; Truman, Andrew W.; Truttman, Matthias C.; Zachara, Natasha E.; Bourboulia, Dimitra; Mollapour, Mehdi; Woodford, Mark R. 分享 收藏
Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models McKay-Corkum, Grace B.; Collins, Victor J.; Yeung, Choh; Ito, Takeshi; Issaq, Sameer H.; Holland, David; Vulikh, Ksenia; Zhang, Yiping; Lee, Unsun; Lei, Haiyan; Mendoza, Arnulfo; Shern, Jack F.; Yohe, Marielle E.; Yamamoto, Kazutoshi; Wilson, Kelli; Ji, Jiuping; Karim, Baktiar O.; Thomas, Craig J.; Krishna, Murali C.; Neckers, Leonard M.; Heske, Christine M. 分享 收藏
Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hurthle Cell Carcinoma of the Thyroid Frank, Anderson R.; Li, Vicky; Shelton, Spencer D.; Kim, Jiwoong; Stott, Gordon M.; Neckers, Leonard M.; Xie, Yang; Williams, Noelle S.; Mishra, Prashant; McFadden, David G. 分享 收藏
Mitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer Echtenkamp, Frank J.; Ishida, Ryo; Rivera-Marquez, Genesis M.; Maisiak, Marisa; Johnson, Oleta T.; Shrimp, Jonathan H.; Sinha, Arnav; Ralph, Stephen John; Nisbet, Ian; Cherukuri, Murali Krishna; Gestwicki, Jason E.; Neckers, Leonard M. 分享 收藏
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Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription Liu, Lixia; Deng, Yaotang; Zheng, Zhenming; Deng, Zihao; Zhang, Jinxin; Li, Jieyou; Liang, Manfeng; Zhou, Xueqiong; Tan, Wenchong; Yang, Hongjun; Neckers, Leonard M.; Zou, Fei; Chen, Xuemei 分享 收藏
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The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition Mishra, Sanket J.; Liu, Weiya; Beebe, Kristin; Banerjee, Monimoy; Kent, Caitlin N.; Munthali, Vitumbiko; Koren, John, III; Taylor, John A., III; Neckers, Leonard M.; Holzbeierlein, Jeffrey; Blagg, Brian S. J. 分享 收藏
Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy 热休克蛋白90通过抑制自噬促进RNA解旋酶DDX5积累并加剧肝癌 Zhang, Ting; Yang, Xinrui; Xu, Wanping; Wang, Jing; Wu, Dawei; Hong, Zhixian; Yuan, Shengxian; Zeng, Zhen; Jia, Xiaodong; Lu, Shanshan; Safadi, Rifaat; Han, Sen; Yang, Zhihong; Neckers, Leonard M.; Liangpunsakul, Suthat; Zhou, Weiping; Lu, Yinying 分享 收藏
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties Rai, Ganesha; Urban, Daniel J.; Mott, Bryan T.; Hu, Xin; Yang, Shyh-Ming; Benavides, Gloria A.; Johnson, Michelle S.; Squadrito, Giuseppe L.; Brimacombe, Kyle R.; Lee, Tobie D.; Cheff, Dorian M.; Zhu, Hu; Henderson, Mark J.; Pohida, Katherine; Sulikowski, Gary A.; Dranow, David M.; Kabir, Md; Shah, Pranav; Padilha, Elias; Tao, Dingyin; Fang, Yuhong; Christov, Plamen P.; Kim, Kwangho; Jana, Somnath; Muttil, Pavan; Anderson, Tamara; Kunda, Nitesh K.; Hathaway, Helen J.; Kusewitt, Donna F.; Oshima, Nobu; Cherukuri, Murali; Davies, Douglas R.; Norenberg, Jeffrey P.; Sklar, Larry A.; Moore, William J.; Dang, Chi, V; Stott, Gordon M.; Neckers, Leonard; Flint, Andrew J.; Darley-Usmar, Victor M.; Simeonov, Anton; Waterson, Alex G.; Jadhav, Ajit; Hall, Matthew D.; Maloney, David J. 分享 收藏
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Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity Hermans, Dalton; Gautam, Sanjivan; Garcia-Canaveras, Juan C.; Gromer, Daniel; Mitra, Suman; Spolski, Rosanne; Li, Peng; Christensen, Stephen; Nguyen, Rosa; Lin, Jian-Xin; Oh, Jangsuk; Du, Ning; Veenbergen, Sharon; Fioravanti, Jessica; Ebina-Shibuya, Risa; Bleck, Christopher; Neckers, Leonard M.; Rabinowitz, Joshua D.; Gattinoni, Luca; Leonard, Warren J. 分享 收藏
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy 肿瘤中LDH抑制的动态成像揭示了快速的体内代谢重组和对联合治疗的脆弱性 Oshima, Nobu; Ishida, Ryo; Kishimoto, Shun; Beebe, Kristin; Brender, Jeffrey R.; Yamamoto, Kazutoshi; Urban, Daniel; Rai, Ganesha; Johnson, Michelle S.; Benavides, Gloria; Squadrito, Giuseppe L.; Crooks, Dan; Jackson, Joseph; Joshi, Abhinav; Mott, Bryan T.; Shrimp, Jonathan H.; Moses, Michael A.; Lee, Min-Jung; Yuno, Akira; Lee, Tobie D.; Hu, Xin; Anderson, Tamara; Kusewitt, Donna; Hathaway, Helen H.; Jadhav, Ajit; Picard, Didier; Trepel, Jane B.; Mitchell, James B.; Stott, Gordon M.; Moore, William; Simeonov, Anton; Sklar, Larry A.; Norenberg, Jeffrey P.; Linehan, W. Marston; Maloney, David J.; Dang, Chi V.; Waterson, Alex G.; Hall, Matthew; Darley-Usmar, Victor M.; Krishna, Murali C.; Neckers, Leonard M. 分享 收藏
Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma Yeung, Choh; Gibson, Anna E.; Issaq, Sameer H.; Oshima, Nobu; Baumgart, Joshua T.; Edessa, Leah D.; Rai, Ganesha; Urban, Daniel J.; Johnson, Michelle S.; Benavides, Gloria A.; Squadrito, Giuseppe L.; Yohe, Marielle E.; Lei, Haiyan; Eldridge, Sandy; Hamre, John, III; Dowdy, Tyrone; Ruiz-Rodado, Victor; Lita, Adrian; Mendoza, Arnulfo; Shern, Jack F.; Larion, Mioara; Helman, Lee J.; Stott, Gordon M.; Krishna, Murali C.; Hall, Matthew D.; Darley-Usmar, Victor; Neckers, Leonard M.; Heske, Christine M. 分享 收藏
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Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and Apoptosis in Esophageal Adenocarcinoma Feingold, Paul L.; Surman, Deborah R.; Brown, Kate; Xu, Yuan; McDuffie, Lucas A.; Shukla, Vivek; Reardon, Emily S.; Crooks, Daniel R.; Trepel, Jane B.; Lee, Sunmin; Lee, Min-Jung; Gao, Shaojian; Xi, Sichuan; McLoughlin, Kaitlin C.; Diggs, Laurence P.; Beer, David G.; Nancarrow, Derek J.; Neckers, Leonard M.; Davis, Jeremy L.; Hoang, Chuong D.; Hernandez, Jonathan M.; Schrump, David S.; Ripley, R. Taylor 分享 收藏
Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer Moses, Michael A.; Kim, Yeong Sang; Rivera-Marquez, Genesis M.; Oshima, Nobu; Watson, Matthew J.; Beebe, Kristin E.; Wells, Catherine; Lee, Sunmin; Zuehlke, Abbey D.; Shao, Hao; Bingman, William E., III; Kumar, Vineet; Malhotra, Sanjay V.; Weigel, Nancy L.; Gestwicki, Jason E.; Trepel, Jane B.; Neckers, Leonard M. 分享 收藏
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