未登录 Acasunlimab, an Fc-inert PD-L1x4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects Acasunlimab，一种Fc无活性PD-L1x4-1BB双特异性抗体，与PD-1阻断联合应用可通过互补的免疫调节效应增强抗肿瘤免疫。 Capello, Michela; Sette, Angelica; Plantinga, Theo; Thalhauser, Craig J.; Spires, Vanessa M.; Nuermberger, Kristina B.; Blum, Jordan M.; Higgs, Brandon W.; Garrido Castro, Patricia; Yu, Christina; Costa Sa, Carol; Fellermeier-Kopf, Sina; Burm, Saskia M.; Strumane, Kristin; Toker, Aras; Imle, Andrea; de Andrade Pereira, Bruna; Muik, Alexander; Ahmadi, Tahamtan; Tuereci, Oezlem; Fereshteh, Mark; Sahin, Ugur; Jure-Kunkel, Maria; Pencheva, Nora 分享 收藏
GEN1046 (DuoBody®-PD-L1x4-1BB) in combination with PD-1 blockade potentiates anti-tumor immunity Capello, Michela; Sette, Angelica; Plantinga, Theo; Spires, Vanessa; Nuermberger, Kristina; Blum, Jordan; Muik, Alexander; Sa, Carol Costa; Jabado, Omar; Burm, Saskia; Toker, Aras; Fellermeier-Kopf, Sina; Ahmadi, Tahi; Higgs, Brandon; Couto, Suzana; Tureci, Ozlem; Fereshteh, Mark; Sahin, Ugur; Jure-Kunkel, Maria; Pencheva, Nora 分享 收藏
GEN1042 (DuoBody-CD40x4-1BB)®in combination with PD-1 blockade reverses T-cell exhaustion in vivo Spires, Vanessa M.; Masters, Gregg; Yu, Christina; Hancock, Matt; Luijten, Monique N.; Muik, Alexander; Nuermberger, Kristina; Gieseke, Friederike; Ahmadi, Tahamtan; Tureci, Ozlem; Jure-Kunkel, Maria; Sahin, Ugur; Fereshteh, Mark; Adams, Homer C.; Blum, Jordan M. 分享 收藏
Tyrosine Phosphorylation of the Nuclear Receptor Coactivator AIB1/SRC-3 Is Enhanced by Abl Kinase and Is Required for Its Activity in Cancer Cells Oh, Annabell S.; Lahusen, John T.; Chien, Christopher D.; Fereshteh, Mark P.; Zhang, Xiaolong; Dakshanamurthy, Sivanesan; Xu, Jianming; Kagan, Benjamin L.; Wellstein, Anton; Riegel, Anna T. 分享 收藏
DUOBODY®-PD-L1X4-1BB (GEN1046) REVERSES T-CELL EXHAUSTION IN VITRO Blum, Jordan; Spires, Vanessa; Masters, Gregg; Yu, Christina; Burm, Saskia; Hancock, Matt; Jabado, Omar; Higgs, Brandon; Muik, Alexander; Nuermberger, Kristina; Gieseke, Friederike; Ahmadi, Tahamtan; Sasser, Kate; Tureci, Ozlem; Jure-Kunkel, Maria; Sahin, Ugur; Fereshteh, Mark; Pencheva, Nora 分享 收藏
COMPREHENSIVE IMMUNOPHENOTYPING AND GENOMICS FROM SINGLE BLOOD TUBE FOR T-CELL DYNAMICS IN CLINICAL TRIALS Ma-Edmonds, Manling; Masters, Gregg; Jabado, Omar; Grimm, Lisa; Bachu, Mahesh; Loya, Matthew; Suppa, Gabrielle; Blum, Jordan; Soong, David; Si, Han; Higgs, Brandon; Bottrel, Nicole; Henitz, Erin; Chiu, Christopher; Sasser, Kate; Fereshteh, Mark 分享 收藏
DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity DuoBody-CD40x4-1BB通过条件性CD40和4-1BB激动剂活性诱导树突状细胞成熟并增强T细胞活化 Muik, Alexander; Adams, Homer C., III; Gieseke, Friederike; Altintas, Isil; Schoedel, Kristina B.; Blum, Jordan M.; Sanger, Bianca; Burm, Saskia M.; Stanganello, Eliana; Verzijl, Dennis; Spires, Vanessa M.; Vascotto, Fulvia; Toker, Aras; Quinkhardt, Juliane; Fereshteh, Mark; Diken, Mustafa; Satijn, David P. E.; Kreiter, Sebastian; Ahmadi, Tahamtan; Breij, Esther C. W.; Tureci, Ozlem; Sasser, Kate; Sahin, Ugur; Jure-Kunkel, Maria 分享 收藏
Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors 靶向PD-L1和4-1BB (GEN1046) 的双特异性抗体在晚期难治性实体瘤患者中的临床前特征和I期试验结果 Muik, Alexander; Garralda, Elena; Altintas, Isil; Gieseke, Friederike; Geva, Ravit; Ben-Ami, Eytan; Maurice-Dror, Corinne; Calvo, Emiliano; LoRusso, Patricia M.; Alonso, Guzman; Rodriguez-Ruiz, Maria E.; Schoedel, Kristina B.; Blum, Jordan M.; Sanger, Bianca; Salcedo, Theodora W.; Burm, Saskia M.; Stanganello, Eliana; Verzijl, Dennis; Vascotto, Fulvia; Sette, Angelica; Quinkhardt, Juliane; Plantinga, Theo S.; Toker, Aras; van den Brink, Edward N.; Fereshteh, Mark; Diken, Mustafa; Satijn, David; Kreiter, Sebastian; Breij, Esther C. W.; Bajaj, Gaurav; Lagkadinou, Eleni; Sasser, Kate; Tureci, Ozlem; Forssmann, Ulf; Ahmadi, Tahamtan; Sahin, Ugur; Jure-Kunkel, Maria; Melero, Ignacio 分享 收藏
Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization Cherney, Emily C.; Zhang, Liping; Lo, Julian; Tram Huynh; Wei, Donna; Ahuja, Vijay; Quesnelle, Claude; Schieven, Gary L.; Futran, Alan; Locke, Gregory A.; Lin, Zeyu; Monereau, Laura; Chaudhry, Charu; Blum, Jordan; Li, Sha; Fereshteh, Mark; Li-Wang, Bifang; Gangwar, Sanjeev; Pan, Chin; Chong, Colin; Zhu, Xiao; Posy, Shana L.; Sack, John S.; Zhang, Ping; Ruzanov, Max; Harner, Mary; Akhtar, Fahad; Schroeder, Gretchen M.; Vite, Gregory; Fink, Brian 分享 收藏
A TRANSLATIONAL APPROACH TO CATALOG PANCREATIC CANCER HETEROGENEITY USING SPATIAL GENOMICS IN LARGE PATIENT COHORTS FOR TARGET VALIDATION AND RATIONAL COMBINATION SELECTION Jabado, Omar; Fan, Li; de Souza, Patricia Coutinho; Harris, Angelo; Chaparro, Arturo; Qutaish, Mohammed; Si, Han; Dannenberg, Jan-Hermen; Sasser, Kate; Couto, Suzana; Fereshteh, Mark 分享 收藏
Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors 构象分析指导的2，3-二取代吡啶IDO1抑制剂的发现 Cherney, Emily C.; Zhang, Liping; Guo, Weiwei; Huang, Audris; Williams, David; Seitz, Steven; Shan, Weifang; Zhu, Xiao; Gullo-Brown, Johnni; Maley, Derrick; Lin, Tai-an; Hunt, John T.; Huang, Christine; Yang, Zheng; D'Arienzo, Celia J.; Discenza, Lorell N.; Ranasinghe, Asoka; Grubb, Mary F.; Traeger, Sarah C.; Li, Xin; Johnston, Kathy A.; Kopcho, Lisa; Fereshteh, Mark; Foster, Kimberly A.; Stefanski, Kevin; Delpy, Diane; Dhar, Gopal; Anandam, Aravind; Mahankali, Sandeep; Padmanabhan, Shweta; Rajanna, Prabhakar; Murali, Venkata; Mariappan, T. Thanga; Pattasseri, Shabeerali; Nimje, Roshan Y.; Hong, Zhenqiu; Kempson, James; Rampulla, Richard; Mathur, Arvind; Gupta, Anuradha; Borzilleri, Robert; Vite, Gregory; Balog, Aaron 分享 收藏
Discovery of Imidazopyridines as Potent Inhibitors of Indoleamine 2,3-Dioxygenase 1 for Cancer Immunotherapy 咪唑并吡啶作为吲哚胺2，3-双加氧酶1的有效抑制剂用于癌症免疫治疗的发现 Zhang, Liping; Cherney, Emily C.; Zhu, Xiao; Lin, Tai-an; Gullo-Brown, Johnni; Maley, Derrick; Johnston-Allegretto, Kathy; Kopcho, Lisa; Fereshteh, Mark; Huang, Christine; Li, Xin; Traeger, Sarah C.; Dhar, Gopal; Anandam, Aravind; Mahankali, Sandeep; Padmanabhan, Shweta; Rajanna, Prabhakar; Murali, Venkata; Mariappan, Thanga; Borzilleri, Robert; Vite, Gregory; Hunt, John T.; Balog, Aaron 分享 收藏
Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1 BMS-986242的发现和临床前评估，一种有效的，选择性的Indoleamine-2，3-双加氧酶1抑制剂 Cherney, Emily C.; Zhang, Liping; Nara, Susheel; Zhu, Xiao; Gullo-Brown, Johnni; Maley, Derrick; Lin, Tai-An; Hunt, John T.; Huang, Christine; Yang, Zheng; Darienzo, Celia; Discenza, Lorell; Ranasinghe, Asoka; Grubb, Mary; Ziemba, Theresa; Traeger, Sarah C.; Li, Xin; Johnston, Kathy; Kopcho, Lisa; Fereshteh, Mark; Foster, Kimberly; Stefanski, Kevin; Fargnoli, Joseph; Swanson, Jesse; Brown, Jennifer; Delpy, Diane; Seitz, Steven P.; Borzilleri, Robert; Vite, Gregory; Balog, Aaron 分享 收藏
DUOBODY®-PD-L1x4-1BB (GEN1046) INDUCES SUPERIOR IMMUNE-CELL ACTIVATION, CYTOKINE PRODUCTION AND CYTOTOXICITY BY COMBINING PD-L1 BLOCKADE WITH CONDITIONAL 4-1BB CO-STIMULATION Muik, Alexander; Altintas, Isil; Kosoff, Rachelle; Gieseke, Friederike; Schoedel, Kristina; Salcedo, Theodora; Burm, Saskia; Toker, Aras; Kranz, Lena; Vormehr, Mathias; Eisel, David; Fereshteh, Mark; Tuereci, Oezlem; Breij, Esther; Ahmadi, Tahamtan; Sahin, Ugur; Jure-Kunkel, Maria 分享 收藏
MOLECULAR DISSECTION OF TUMOR-IMMUNE MICROENVIRONMENT FACTORS ASSOCIATED WITH RESPONSE TO CHECKPOINT INHIBITOR THERAPY IN NON-SMALL CELL LUNG CANCER PATIENTS USING NANOSTRING DIGITAL SPATIAL PROFILING Jabado, Omar; Couto, Suzana; Blum, Jordan; Franken, Patrick; de Souza, Patricia Coutinho; Jure-Kunkel, Maria; Pencheva, Nora; Higgs, Brandon; Sasser, Kate; Fereshteh, Mark 分享 收藏
Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis 烟酰胺作为有效和选择性IRAK4抑制剂的优化，在银屑病小鼠模型中具有疗效 Nair, Satheesh; Kumar, Sreekantha Ratna; Paidi, Venkatram Reddy; Sistla, Ramesh; Kantheti, Durgarao; Polimera, Subba Rao; Thangavel, Soodamani; Mukherjee, Amrita Jha; Das, Mitalee; Bhide, Rajeev S.; Pitts, William J.; Murugesan, Natesan; Dudhgoankar, Shailesh; Nagar, Jignesh; Subramani, Siva; Mazumder, Debarati; Carman, Julie A.; Holloway, Deborah A.; Li, Xin; Fereshteh, Mark P.; Ruepp, Stefan; Palanisamy, Kamalavenkatesh; Mariappan, T. Thanga; Maddi, Srinivas; Saxena, Ajay; Elzinga, Paul; Chimalakonda, Anjaneya; Ruan, Qian; Ghosh, Kaushik; Bose, Sucharita; Sack, John; Yan, Chunhong; Kiefer, Susan E.; Xie, Dianlin; Newitt, John A.; Saravanakumar, S. Pon; Rampulla, Richard A.; Barrish, Joel C.; Carter, Percy H.; Hynes, John, Jr. 分享 收藏
Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFβR1 Inhibitor as an Immuno-oncology Agent Velaparthi, Upender; Darne, Chetan Padmakar; Warder, Jayakumar; Liu, Peiying; Rahaman, Hasibur; Augustine-Rauch, Karen; Parrish, Karen; Yang, Zheng; Swanson, Jesse; Brown, Jennifer; Dhar, Gopal; Anandam, Aravind; Holenarsipur, Vinay K.; Palanisamy, Kamalavenkatesh; Wautlet, Barn S.; Fereshteh, Mark P.; Lippy, Jonathan; Tebben, Andrew J.; Sheriff, Steven; Ruzanov, Max; Yan, Chunhong; Gupta, Anuradha; Gupta, Arun Kumar; Vetrichelvan, Muthalagu; Mathur, Arvind; Gelman, Marina; Singh, Rajinder; Kinsella, Todd; Murtaza, Anwar; Fargnoli, Joseph; Vite, Gregory; Borzilleri, Robert M. 分享 收藏
Discovery of 4-Azaindole Inhibitors of TGFβRI as Immuno-oncology Agents Zhang, Yong; Zhao, Yufen; Tebben, Andrew J.; Sheriff, Steven; Ruzanov, Max; Fereshteh, Mark P.; Fan, Yi; Lippy, Jonathan; Swanson, Jesse; Ho, Ching-Ping; Wautlet, Barri S.; Rose, Anne; Parrish, Karen; Yang, Zheng; Donnell, Andrew F.; Zhang, Liping; Fink, Brian E.; Vite, Gregory D.; Augustine-Rauch, Karen; Fargnoli, Joseph; Borzilleri, Robert M. 分享 收藏
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Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGFβRI) Harikrishnan, Lalgudi S.; Warrier, Jayakumar; Tebben, Andrew J.; Tonukunuru, Gopikishan; Madduri, Sudhakara R.; Baligar, Vishweshwaraiah; Mannoori, Raju; Seshadri, Balaji; Rahaman, Hasibur; Arunachalam, P. N.; Dikundwar, Amol G.; Fink, Brian E.; Fargnoli, Joseph; Fereshteh, Mark; Fan, Yi; Lippy, Jonathan; Ho, Ching-Ping; Wautlet, Barri; Sheriff, Steven; Ruzanov, Max; Borzilleri, Robert M. 分享 收藏
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