未登录 Preclinical efficacy of azacitidine and venetoclax for infant KMT2A-rearranged acute lymphoblastic leukemia reveals a new therapeutic strategy Cheung, Laurence C.; Aya-Bonilla, Carlos; Cruickshank, Mark N.; Chiu, Sung K.; Kuek, Vincent; Anderson, Denise; Chua, Grace-Alyssa; Singh, Sajla; Oommen, Joyce; Ferrari, Emanuela; Hughes, Anastasia M.; Ford, Jette; Kunold, Elena; Hesselman, Maria C.; Post, Frederik; Faulk, Kelly E.; Breese, Erin H.; Guest, Erin M.; Brown, Patrick A.; Loh, Mignon L.; Lock, Richard B.; Kees, Ursula R.; Jafari, Rozbeh; Malinge, Sebastien; Kotecha, Rishi S. 分享 收藏
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Preclinical Evaluation of Carfilzomib for Infant KMT2A-Rearranged Acute Lymphoblastic Leukemia Cheung, Laurence C.; de Kraa, Rebecca; Oommen, Joyce; Chua, Grace-Alyssa; Singh, Sajla; Hughes, Anastasia M.; Ferrari, Emanuela; Ford, Jette; Chiu, Sung K.; Stam, Ronald W.; Kees, Ursula R.; Malinge, Sebastien; Kotecha, Rishi S. 分享 收藏
Exploiting the reactive oxygen species imbalance in high-risk paediatric acute lymphoblastic leukaemia through auranofin Karsa, Mawar; Kosciolek, Angelika; Bongers, Angelika; Mariana, Anna; Failes, Tim; Gifford, Andrew J.; Kees, Ursula R.; Cheung, Laurence C.; Kotecha, Rishi S.; Arndt, Greg M.; Haber, Michelle; Norris, Murray D.; Sutton, Rosemary; Lock, Richard B.; Henderson, Michelle J.; Somers, Klaartje 分享 收藏
The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution Anderson, Denise; Skut, Patrycja; Hughes, Anastasia M.; Ferrari, Emanuela; Tickner, Jennifer; Xu, Jiake; Mullin, Benjamin H.; Tang, Dave; Malinge, Sebastien; Kees, Ursula R.; Kotecha, Rishi S.; Lassmann, Timo; Cheung, Laurence C. 分享 收藏
Effective targeting of NAMPT in patient-derived xenograft models of high-risk pediatric acute lymphoblastic leukemia Somers, Klaartje; Evans, Kathryn; Cheung, Leanna; Karsa, Mawar; Pritchard, Tara; Kosciolek, Angelika; Bongers, Angelika; El-Ayoubi, Ali; Forgham, Helen; Middlemiss, Shiloh; Mayoh, Chelsea; Jones, Luke; Gupta, Mahima; Kees, Ursula R.; Chernova, Olga; Korotchkina, Lioubov; Gudkov, Andrei, V; Erickson, Stephen W.; Teicher, Beverly; Smith, Malcolm A.; Norris, Murray D.; Haber, Michelle; Lock, Richard B.; Henderson, Michelle J. 分享 收藏
Potent antileukemic activity of curaxin CBL0137 against MLL-rearranged leukemia Somers, Klaartje; Kosciolek, Angelika; Bongers, Angelika; El-Ayoubi, Ali; Karsa, Mawar; Mayoh, Chelsea; Wadham, Carol; Middlemiss, Shiloh; Neznanov, Nickolay; Kees, Ursula R.; Lock, Richard B.; Gudkov, Andrei; Sutton, Rosemary; Gurova, Katerina; Haber, Michelle; Norris, Murray D.; Henderson, Michelle J. 分享 收藏
Romidepsin enhances the efficacy of cytarabine in vivo, revealing histone deacetylase inhibition as a promising therapeutic strategy for KMT2A-rearranged infant acute lymphoblastic leukemia Cheung, Laurence C.; Cruickshank, Mark N.; Hughes, Anastasia M.; Singh, Sajla; Chua, Grace-Alyssa; Ford, Jette; Ferrari, Emanuela; Oommen, Joyce; Malinge, Sebastien; Lock, Richard B.; Kees, Ursula R.; Kotecha, Rishi S. 分享 收藏
A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction Somers, Klaartje; Wen, Victoria W.; Middlemiss, Shiloh M. C.; Osborne, Brenna; Forgham, Helen; Jung, MoonSun; Karsa, Mawar; Clifton, Molly; Bongers, Angelika; Gao, Jixuan; Mayoh, Chelsea; Raoufi-Rad, Newsha; Kusnadi, Eric P.; Hannan, Kate M.; Scott, David A.; Kwek, Alan; Liu, Bing; Flemming, Claudia; Chudakova, Daria A.; Pandher, Ruby; Failes, Tim W.; Lim, James; Angeli, Andrea; Osterman, Andrei L.; Imamura, Toshihiko; Kees, Ursula R.; Supuran, Claudiu T.; Pearson, Richard B.; Hannan, Ross D.; Davis, Thomas P.; McCarroll, Joshua; Kavallaris, Maria; Turner, Nigel; Gudkov, Andrei V.; Haber, Michelle; Norris, Murray D.; Henderson, Michelle J. 分享 收藏
New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironment Cheung, Laurence C.; Tickner, Jennifer; Hughes, Anastasia M.; Skut, Patrycja; Howlett, Meegan; Foley, Bree; Oommen, Joyce; Wells, Julia E.; He, Bo; Singh, Sajla; Chua, Grace-Alyssa; Ford, Jette; Mullighan, Charles G.; Kotecha, Rishi S.; Kees, Ursula R. 分享 收藏
Inhibition of NAMPT as a novel therapeutic strategy for infant leukemia Somers, Klaartje; Middlemiss, Shiloh; Biktasova, Asel; Karsa, Mawar; Cheung, Leanna; Kosciolek, Angelika; Evans, Kathryn; Mayoh, Chelsea; Kees, Ursula R.; Korotchkina, Lioubov; Chernova, Olga B.; Lock, Richard B.; Gudkov, Andrei V.; Haber, Michelle; Norris, Murray D.; Henderson, Michelle J. 分享 收藏
Silencing of GATA3 defines a novel stem cell-like subgroup of ETP-ALL Fransecky, L.; Neumann, M.; Heesch, S.; Schlee, C.; Ortiz-Tanchez, J.; Heller, S.; Mossner, M.; Schwartz, S.; Mochmann, L. H.; Isaakidis, K.; Bastian, L.; Kees, U. R.; Herold, T.; Spiekermann, K.; Goekbuget, N.; Baldus, C. D. 分享 收藏
Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin Cruickshank, M. N.; Ford, J.; Cheung, L. C.; Heng, J.; Singh, S.; Wells, J.; Failes, T. W.; Arndt, G. M.; Smithers, N.; Prinjha, R. K.; Anderson, D.; Carter, K. W.; Gout, A. M.; Lassmann, T.; O'Reilly, J.; Cole, C. H.; Kotecha, R. S.; Kees, U. R. 分享 收藏
Selective and rapid killing of mixed lineage leukemia and CALM-AF10 leukemia by SM7, a novel small molecule identified by chemical library screening Chudakova, Daria; Somers, Klaartje; Middlemiss, Shiloh; Wen, Victoria; Kwek, Alan; Liu, Bing; Clifton, Molly; Pan, Sukey; Cruikshank, Sarah; Scandlyn, Marissa; Failes, Tim; Hoang, Wendy; Kees, Ursula; Chernova, Olga; Gudkov, Andrei V.; Haber, Michelle; Norris, Murray; Henderson, Michelle 分享 收藏
High expression of connective tissue growth factor accelerates dissemination of leukaemia Wells, J. E.; Howlett, M.; Halse, H. M.; Heng, J.; Ford, J.; Cheung, L. C.; Samuels, A. L.; Crook, M.; Charles, A. K.; Cole, C. H.; Kees, U. R. 分享 收藏
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Effective Targeting of the P53-MDM2 Axis in Preclinical Models of Infant MLL-Rearranged Acute Lymphoblastic Leukemia Richmond, Jennifer; Carol, Hernan; Evans, Kathryn; High, Laura; Mendomo, Agnes; Robbins, Alissa; Meyer, Claus; Venn, Nicola C.; Marschalek, Rolf; Henderson, Michelle; Sutton, Rosemary; Kurmasheva, Raushan T.; Kees, Ursula R.; Houghton, Peter J.; Smith, Malcolm A.; Lock, Richard B. 分享 收藏
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A pre-clinical model of resistance to induction therapy in pediatric acute lymphoblastic leukemia Samuels, A. L.; Beesley, A. H.; Yadav, B. D.; Papa, R. A.; Sutton, R.; Anderson, D.; Marshall, G. M.; Cole, C. H.; Kees, U. R.; Lock, R. B. 分享 收藏
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