未登录 Anti-human TLR7 antibody for therapeutic intervention in systemic lupus erythematosus 抗人TLR7抗体用于系统性红斑狼疮的疗法干预 Fukui, Ryutaro; Murakami, Yusuke; Kanno, Atsuo; Motoi, Yuji; Manno, Atsushi; Honda, Tomohiro; Yamada, Shinnosuke; Ishiguro, Jun; Kagari, Takashi; Nakamura, Kensuke; Kadokura, Michinori; Isobe, Takashi; Tomimori, Yoshiaki; Tanaka, Jun; Senaldi, Giorgio; Shimizu, Toshiyuki; Miyake, Kensuke 分享 收藏
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PHARMACOKINETIC-PHARMACODYNAMIC RELATIONSHIP JUSTIFIES DOSE SELECTION OF DS-7011A, AN ANTI-TLR7 MONOCLONAL ANTIBODY, FORTHE TREATMENT OF ASIAN PARTICIPANTS IN AN ONGOING GLOBAL PHASE 1B STUDY OF DS-7011A IN SYSTEMIC LUPUS ERYTHEMATOSUS 药代动力学-药效动力学关系证实了DS-7011A（一种抗TLR7单克隆抗体）在系统性红斑狼疮的全球性1B期研究中，为亚洲受试者选择剂量的合理性。 Zhang, L.; Tanaka, J.; Gebhart, A.; Dodds, M.; Trame, M.; Xu, S.; Kumazaki, M.; Tomimori, Y.; Oka, T.; Igawa, Y.; Patel, S.; Mohan, A.; Senaldi, G.; Leil, T. 分享 收藏
A phase 1 safety and bioimaging trial of antibody DS-8895a against EphA2 in patients with advanced or metastatic EphA2 positive cancers Gan, Hui K.; Parakh, Sagun; Lee, F. T.; Tebbutt, Niall C.; Ameratunga, Malaka; Lee, Sze Ting; O'Keefe, Graeme J.; Gong, Sylvia J.; Vanrenen, Christine; Caine, Jaren; Giovannetti, Mara; Murone, Carmel; Scott, Fiona E.; Guo, Nancy; Burvenich, Ingrid J. G.; Paine, Cameron; Macri, Mary J.; Kotsuma, Masakatsu; Senaldi, Giorgio; Venhaus, Ralph; Scott, Andrew M. 分享 收藏
US Phase I First-in-human Study of Taletrectinib (DS-6051b/AB-106), a ROS1/TRK Inhibitor, in Patients with Advanced Solid Tumors Papadopoulos, Kyriakos P.; Borazanci, Erkut; Shaw, Alice T.; Katayama, Ryohei; Shimizu, Yuki; Zhu, Viola W.; Sun, Thomas Yang; Wakelee, Heather A.; Madison, Russell; Schrock, Alexa B.; Senaldi, Giorgio; Nakao, Naoki; Hanzawa, Hiroyuki; Tachibana, Masaya; Isoyama, Takeshi; Nakamaru, Kenji; Deng, Chenhui; Li, Meijing; Fan, Frank; Zhao, Qinying; Gao, Yanfei; Seto, Takashi; Janne, Pasi A.; Ou, Sai-Hong Ignatius 分享 收藏
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Phase 1 Study To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Oral Doses of DS-2969b, a Novel GyrB Inhibitor, in Healthy Subjects Vandell, Alexander G.; Inoue, Satoshi; Dennie, Justin; Nagasawa, Yasuo; Gajee, Roohi; Pav, Joe; Zhang, George; Zamora, Cynthia; Masuda, Nobuhisa; Senaldi, Giorgio 分享 收藏
Molecular imaging of T cell co-regulator factor B7-H3 with 89Zr-DS-5573a Burvenich, Ingrid Julienne Georgette; Parakh, Sagun; Lee, Fook-Thean; Guo, Nancy; Liu, Zhanqi; Gan, Hui Kong; Rigopoulos, Angela; O'Keefe, Graeme Joseph; Gong, Sylvia Jie; Goh, Yit Wooi; Tochon-Danguy, Henri; Scott, Fiona Elizabeth; Kotsuma, Masakatsu; Hirotani, Kenji; Senaldi, Giorgio; Scott, Andrew Mark 分享 收藏
First-in-human study of the antibody DR5 agonist DS-8273a in patients with advanced solid tumors Forero, Andres; Bendell, Johanna C.; Kumar, Prasanna; Janisch, Linda; Rosen, Michael; Wang, Qiang; Copigneaux, Catherine; Desai, Madhuri; Senaldi, Giorgio; Maitland, Michael L. 分享 收藏
First-in-human phase 1 dose-escalation study of DS-6051b, an oral ROS1 and NTRK inhibitor, in subjects with advanced solid tumors Papadopoulos, Kyriakos P.; Borazanci, Erkut; Von Hoff, Daniel; Gandhi, Leena; Patnaik, Amita; Tachibana, Masaya; Zahir, Hamim; Gajee, Roohi; Goldberg, Tern; Senaldi, Giorgio; Ou, Sai-Hong 分享 收藏
Molecular Imaging and Quantitation of EphA2 Expression in Xenograft Models with 89Zr-DS-8895a Burvenich, Ingrid J. G.; Parakh, Sagun; Gan, Hui K.; Lee, Fook-Thean; Guo, Nancy; Rigopoulos, Angela; Lee, Sze-Ting; Gong, Sylvia; O'Keefe, Graeme J.; Tochon-Danguy, Henri; Kotsuma, Masakatsu; Hasegawa, Jun; Senaldi, Giorgio; Scott, Andrew M. 分享 收藏
In Vitro and In Vivo Evaluation of 89Zr-DS-8273a as a Theranostic for Anti-Death Receptor 5 Therapy Burvenich, Ingrid J. G.; Lee, Fook-Thean; Guo, Nancy; Gan, Hui K.; Rigopoulos, Angela; Parslow, Adam C.; O'Keefe, Graeme J.; Gong, Sylvia J.; Tochon-Danguy, Henri; Rudd, Stacey E.; Dormelly, Paul S.; Kotsuma, Masakatsu; Ohtsuka, Toshiaki; Senaldi, Giorgio; Scott, Andrew M. 分享 收藏
A first-in-human Phase I study of DS-3078a, an oral TORC1/2 inhibitor, in patients with advanced solid tumors: Preliminary results. Capelan, Marta; Kumar, Prasana; Tolcher, Anthony W.; Zivi, Andrea; Desai, Madhuri; Papadopoulos, Kyriakos P.; Senaldi, Giorgio; Patnaik, Amita; Banerji, Udai; Rasco, Drew D. 分享 收藏
Immunohistochemical analysis of HB-EGF expression in breast, colon, gastric, hepatocellular, lung, ovarian, pancreatic and prostate cancer Halim, Abdel-baset; Dauffenbach, Lisa M.; Kerfoot, Christopher A.; Stull, William R.; Zwick-Wallasch, Esther; Scheyer, Richard; Senaldi, Giorgio 分享 收藏
Anti-CD45RB monoclonal antibody prolongs renal allograft survival in cynomolgus monkeys Chen, G.; Luke, P. P. W.; Yang, H.; Visser, L.; Sun, H.; Garcia, B.; Qian, H.; Xiang, Y.; Huang, X.; Liu, W.; Senaldi, G.; Schneider, A.; Poppema, S.; Wang, H.; Jevnikar, A. M.; Zhong, R. 分享 收藏
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RHuKGF ameliorates symptoms in DSS and CD4+CD45RBHi T cell transfer mouse models of inflammatory bowel disease Byrne, FR; Farrell, CL; Aranda, R; Rex, KL; Scully, S; Brown, HL; Flores, SA; Gu, LH; Danilenko, DM; Lacey, DL; Ziegler, TR; Senaldi, G 分享 收藏
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