未登录 CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety CDK4选择性抑制提高了临床前抗肿瘤疗效和安全性 Palmer, Cynthia L.; Boras, Britton; Pascual, Bernadette; Li, Na; Li, Danan; Garza, Scott; Huser, Nanni; Yuan, Jing Tang; Cianfrogna, Julie A.; Sung, Tae; Mcmillan, Elizabeth; Wei, Na; Carmody, Jason; Kang, Aubrey Nayeon; Darensburg, Seth; Dodd, Taran; Oakley, James, V; Solowiej, James; Nguyen, Lisa; Orr, Suvi T. M.; Chen, Ping; Johnson, Eric; Yu, Xiu; Diehl, Wade C.; Gallego, Gary M.; Jalaie, Mehran; Ferre, Rose Ann; Cho-Schultz, Sujin; Shen, Hong; Deal, Judith G.; Zhang, Qin; Baffi, Timothy R.; Xu, Meirong; Roh, Whijae; Lapira-Miller, Jennifer; Goudeau, Jerome; Yu, Yanke; Gupta, Rajat; Kim, Kimberly; Dann, Stephen G.; Kan, Zhengyan; Kath, John C.; Nair, Sajiv K.; Miller, Nichol; Murray, Brion W.; Nager, Andrew R.; Quinlan, Casey; Petroski, Matthew D.; Zhang, Cathy; Sacaan, Aida; Vanarsdale, Todd; Anders, Lars 分享 收藏
Longitudinal multi-omics study of palbociclib resistance in HR-positive/HER2-negative metastatic breast cancer Park, Yeon Hee; Im, Seock-Ah; Park, Kyunghee; Wen, Ji; Lee, Kyung-Hun; Choi, Yoon-La; Lee, Won-Chul; Min, Ahrum; Bonato, Vinicius; Park, Seri; Ram, Sripad; Lee, Dae-Won; Kim, Ji-Yeon; Lee, Su Kyeong; Lee, Won-Woo; Lee, Jisook; Kim, Miso; Kim, Hyun Seon; Weinrich, Scott L.; Ryu, Han Suk; Kim, Tae Yong; Dann, Stephen; Kim, Yu-Jin; Fernandez, Diane R.; Koh, Jiwon; Wang, Shuoguo; Park, Song Yi; Deng, Shibing; Powell, Eric; Ravi, Rupesh Kanchi; Bienkowska, Jadwiga; Rejto, Paul A.; Park, Woong-Yang; Kan, Zhengyan 分享 收藏
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development Gangloff, YG; Mueller, M; Dann, SG; Svoboda, P; Sticker, M; Spetz, JF; Um, SH; Brown, EJ; Cereghini, S; Thomas, G; Kozma, SC 分享 收藏
Serial genomic profiling reveals molecular mechanisms of breast cancer resistance to palbociclib Kan, Zhengyan; Im, Seock-Ah; Park, Kyunghee; Wen, Ji; Lee, Kyung-Hun; Choi, Yoon-La; Lee, Won-Chul; Min, Ahrum; Bonato, Vinicius; Park, Seri; Ram, Sripad; Lee, Dae-Won; Kim, Ji-Yeon; Lee, Su Kyeong; Lee, Won-Woo; Lee, Jisook; Kim, Miso; Weinrich, Scott L.; Ryu, Han Suk; Kim, Tae Yong; Dann, Stephen; Fernandez, Diane; Koh, Jiwon; Park, Song Yi; Deng, Shibing; Powell, Eric; Ravi, Rupesh Kanchi; Bienkowska, Jadwiga; Rejto, Paul A.; Park, Woong-Yang; Park, Yeon Hee 分享 收藏
Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer Freeman-Cook, Kevin D.; Hoffman, Robert L.; Behenna, Douglas C.; Boras, Britton; Carelli, Jordan; Diehl, Wade; Ferre, Rose Ann; He, You-Ai; Hui, Andrea; Huang, Buwen; Huser, Nanni; Jones, Rhys; Kephart, Susan E.; Lapek, John; McTigue, Michele; Miller, Nichol; Murray, Brion W.; Nagata, Asako; Nguyen, Lisa; Niessen, Sherry; Ninkovic, Sacha; O'Doherty, Inish; Ornelas, Martha A.; Solowiej, James; Sutton, Scott C.; Tran, Khanh; Tseng, Elaine; Visswanathan, Ravi; Xu, Meirong; Zehnder, Luke; Zhang, Qin; Zhang, Cathy; Dann, Stephen 分享 收藏
Palbociclib and Fulvestrant Act in Synergy to Modulate Central Carbon Metabolism in Breast Cancer Cells Warth, Benedikt; Palermo, Amelia; Rattray, Nicholas J. W.; Lee, Nathan, V; Zhu, Zhou; Hoang, Linh T.; Cai, Yuping; Mazurek, Anthony; Dann, Stephen; VanArsdale, Todd; Fantin, Valeria R.; Shields, David; Siuzdak, Gary; Johnson, Caroline H. 分享 收藏
A versatile drug delivery system targeting senescent cells 靶向衰老细胞的多功能药物递送系统 Munoz-Espin, Daniel; Rovira, Miguel; Galiana, Irene; Gimenez, Cristina; Lozano-Torres, Beatriz; Paez-Ribes, Marta; Llanos, Susana; Chaib, Selim; Munoz-Martin, Maribel; Ucero, Alvaro C.; Garaulet, Guillermo; Mulero, Francisca; Dann, Stephen G.; VanArsdale, Todd; Shields, David J.; Bernardos, Andrea; Murguia, Jose Ramon; Martinez-Manez, Ramon; Serrano, Manuel 分享 收藏
Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A Quinlan, Casey L.; Kaiser, Stephen E.; Bolanos, Ben; Nowlin, Dawn; Grantner, Rita; Karlicek-Bryant, Shannon; Feng, Jun Li; Jenkinson, Stephen; Freeman-Cook, Kevin; Dann, Stephen G.; Wang, Xiaoli; Wells, Peter A.; Fantin, Valeria R.; Stewart, Al E.; Grant, Stephan K. 分享 收藏
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Mechanistic basis of Palbociclib combinatorial activity in ER plus breast cancer and non-breast indications Dann, Stephen; Yuan, Jing; Chionis, John; Liu, Chaoting; Xie, Tao; Lee, Nathan V.; Chen, Enhong; Wei, Ping; Rejto, Paul A.; Shields, David J.; VanArsdale, Todd 分享 收藏
Efficacy of SERD/SERM Hybrid-CDK4/6 Inhibitor Combinations in Models of Endocrine Therapy-Resistant Breast Cancer Wardell, Suzanne E.; Ellis, Matthew J.; Alley, Holly M.; Eisele, Koleen; VanArsdale, Todd; Dann, Stephen G.; Arndt, Kim T.; Primeau, Tina; Griffin, Elizabeth; Shao, Jieya; Crowder, Robert; Lai, Jin-Ping; Norris, John D.; McDonnell, Donald P.; Li, Shunqiang 分享 收藏
Reciprocal regulation of amino acid import and epigenetic state through Lat1 and EZH2 Dann, Stephen G.; Ryskin, Michael; Barsotti, Anthony M.; Golas, Jonathon; Shi, Celine; Miranda, Miriam; Hosselet, Christine; Lemon, Luanna; Lucas, Judy; Karnoub, Maha; Wang, Fang; Myers, Jeremy S.; Garza, Scott J.; Follettie, Maximillian T.; Geles, Kenneth G.; Klippel, Anke; Rollins, Robert A.; Fantin, Valeria R. 分享 收藏
Epigenetic reprogramming by tumor-derived EZH2 gain of function mutants leads to aggressive 3D-cell morphologies in both epithelial and melanoma cells Rollins, Robert A.; Barsotti, Anthony M.; Ryskin, Michael; Zhong, Wenyan; Zhang, Wei-Guo; Giannakou, Andreas; Loreth, Christine; Diesl, Veronica; Follettie, Maximillian T.; Golas, Jonathon; Lee, Michelle; Nichols, Timothy; Fan, Conglin; Li, Gary; Dann, Stephen; Rejto, Paul A.; Arndt, Kim T.; Verhelle, Dominique 分享 收藏
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